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All Journal Majalah Obstetri dan Ginekologi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Health Sains eJournal Kedokteran Indonesia Makara Journal of Health Research
Junita Indarti
Department Of Obstetrics And Gynecology, Faculty Of Medicine, University Of Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Association Between High-risk HPV Infection and Cervical Precancerous Lesions indarti, Junita; Bonifasius, Bonifasius; Wiguna, Sandra
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 2 April 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i2.2937

Abstract

AbstractIntroduction: More than 70% of cervical cancer cases are associated with high-risk HPV infections, especially those of type 16/18. Persistent high-risk HPV infection can cause cervical lesions and develop into cancer; therefore, early detection of HPV infection is important. Screening using HPV DNA tests, either as a single test or combined with a cervical cytological test, is recommended. This study aimed to determine the association between high-risk HPV infection and the development of cervical precancerous lesions.Methods: This cross-sectional study was conducted on 104 patients at RSUPN Dr. Cipto Mangunkusumo in 2020-2022 using secondary data from HPV DNA test results with the DiagCor GenoFlow Human Papilloma Virus Array Test and cervical cytology results from liquid-based cytology. The data were presented in tables and analyzed using SPSS version 26.Results: The prevalence of high-risk HPV infection was 30.8%, with the most common genotypes being HPV 18 & 52 (15.6%), HPV 51 (12.5%), and HPV 58 (9.4%). Cytological results from the high-risk HPV types showed that 16 out of 32 (50%) were abnormal. High-risk HPV caused 11 (78.6%) low-grade squamous intraepithelial lesions and 5 (83.3%) high-grade squamous intraepithelial lesions. It is known by the statistical analysis test that there was a significant relationship between high-risk HPV infection and cervical precancerous lesions (p=0.000).Conclusion: A significant association was observed between the occurrence of high-risk HPV infection and the development of cervical precancerous lesions. Appropriate management and supervision can be carried out in accordance with risk stratification based on screening results.Keywords: cervical precancerous lesions, high-risk HPV infection, screening
Risk Factors of Intrauterine Fetal Death in Cipto Mangunkusumo General Hospital, Indonesia Indarti, Junita; Mardhatillah, Syifa; Alda, Kristian; Vitasatria, Arresta; Solihin, Affan; Sumulyo, Ganot; Ikhsan, Muhammad; Agassi Antoniman, Mohammad
Jurnal Health Sains Vol. 5 No. 11 (2024): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i11.1394

Abstract

Intra Uterine Fetal Death ( IUFD ) results from various disorders of the mother, fetus, and placenta. This study aimed to explore factors contributing to IUFD, knowing the risk factors will prevent this case in the future time. In 2016-2018, patients diagnosed with IUFD at 22 weeks of gestation were included. One hundred twenty-five patients with IUFD and 125 controls with alive fetuses were enrolled. Data were collected from the medical records of participants. Factors that may have contributed to IUFD were explored. Comparisons between various risk factors and outcomes of the two groups were made. P-value was statistically significant if ≤0.05. We found several factors that contribute to IUFD. Some factors like BMI, ANC provider, referred from tertiary health facility, and congenital anomaly increased the risk of IUFD by 2.86, 5.86, 6.26 and 9.45 times respectively. In contrast, some factors like a number of ANC ≥ 6 times and gestational age >36 weeks decrease the risk of IUFD. Regular and intensive ANC ≥ 6 times during pregnancy, number of pregnancy and gestational age ≥ 36 weeks significantly decreases the risk of IUFD with OR 0.12, 0.4, and 0.23 respectively. High-quality ANC to identify IUFD risk factors may lead to a significant decrease in its occurrences. Some factors like BMI, ANC provider, referred from tertiary health facility, and congenital anomaly increased the risk of IUFD, but Number of ANC≥ 6 times, number of pregnancy ≥2 and gestational age ≥36 weeks can reduce risk of IUFD.
Tatalaksana Skizofrenia Pada Kehamilan: Laporan Kasus Junita Indarti; Dwiana Ocviyanti; Erda Ayu Umami
Majalah Kedokteran Indonesia Vol 69 No 12 (2019): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.69.12-2019-168

Abstract

Schizophrenia is a severe mental disorder, characterized by deep thinking disturbances, affecting language, perception, and sense of self. This often includes psychotic experiences, such as hearing sounds or delusions. The most common age of onset for schizophrenia in women is from ages 25-35 (reproductive age). We report a case of a 27-year-old woman with pregnancy and schizophrenia paranoid. Reproductive age women with schizophrenia need comprehensive management during their reproductive years, including contraception, prenatal care, antenatal care, postnatal care, as well as safe and effective parenting.
Insidensi Inspeksi Visual Asam Asetat Positif di RSUP Dr Cipto Mangunkusumo Dilanjutkan dengan Pemeriksaan Sitologi, Tes HPV DNA dan Kolposkopi: Sebuah Studi Cross Sectional Junita Indarti; Heru Prasetyo; Kristian Alda
Majalah Kedokteran Indonesia Vol 72 No 1 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.1-2022-750

Abstract

Introduction : Cervical cancer is most common cancer in women in Asia Oceania and worldwide. VIA(Visual Inspection after Acetic acid) is being used as an alternative in low- and middle-income countries due to the minimal equipment required. Data from recent systematic reviews and multicentre trials show that VIA to be moderately sensitive for precancerous lesions, as compared with Pap testing. This study aim to determine the incidence of positive VIA, LBC, HPV DNA testing and colposcopy findings obtained from positive VIA cases in Dr. Cipto Mangunkusumo General Hospital.Methods: This was a cross-sectional study. Data was collected from cervical cancer screening by VIA examination at Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia in 2017. Age, VIA results were recorded. The results showed abnormal and predictive cancer lesions (acetowhite lesion) were defined as a “positive test.” The positive VIA result followed by LBC, HPV DNA testing, and Colposcopy. Only 25 performed LBC and HPV DNA test, and 30 of the VIA positive were performed Colposcopy. Results: A total of 1.960 subjects were recruited for this study. The mean age of the subjects was 34.5 years, and 908 (46 %) subjects belong to the 30-40 years age group. Negative VIA result were found in 1893 subjects (96,58%) and 67 subjects (3,42%) had positive results. From 25 VIA positive subject whose gone through LBC and HPV test, 9 subjects (36%) had abnormal LBC, 3 subjects (12%) had positive HPV DNA test. From 30 positive VIA whose got colposcopy examination 17 subjects (56,6 %) had abnormal colposcopy.Conclusions: The number of VIA screening participants in RSCM, Jakarta, Indonesia with positive VIA results is low. Further studies regarding the validation of VIA are required to evaluate its diagnostic value.
Age at Sexual Debut as a Determinant of HPV Infection in Women with Clinically Normal Cervix in Indonesia Tofan Widya Utami; Laila Nuranna; Gatot Purwoto; Junita Indarti; Najmarani Devi Firdaus; Arisda Oktalia; Nuni Sulastri; Aria Kekalih
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 1 January 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i1.2745

Abstract

Objectives: This study examined the association between sexual debut and HPV infection in Indonesian women with a clinically normal cervix, contextualized within the Sustainable Development Goals (SDGs). Methods: This prospective cohort study utilized primary data from structured interviews and gynecological exams conducted by the Female Cancer Program (FCP) team across public and private health providers in Jakarta (January 2012–July 2018). Cervical cancer risk factors, including early sexual debut, were analyzed using odds ratios (ORs). Results: A total of 1,390 women with a clinically normal cervix were enrolled in this study, with 52 (3.7%) testing positive for HPV-DNA. Statistical analysis indicated an odds ratio (OR) of 1.176 (95% CI: 0.598–2.316, p = 0.601) for early sexual debut. Conclusion: This study showed that there was an insignificant association between sexual debut and HPV infection in clinically normal cervix. According to the SDGs, early sexual debut and cervical cancer are highly associated. In order to meet the SDGs by 2030, more research is required to validate this finding and assess additional co-factors connected to cervical cancer.
High-risk Human Papillomavirus Detection in Self-Sampling compared to Clinician Sampling: A Cross-Sectional Study Andrijono Andrijono; Junita Indarti; Gumilang Gumilang; Kristian Alda
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 2 April 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i2.3376

Abstract

AbstractObjective: To evaluate the diagnostic accuracy of high-risk human papillomavirus (HPV) DNA detection using the Hybrid Capture II assay in self-collected samples compared with clinician-collected samples.Methods: This cross-sectional diagnostic accuracy study enrolled women with abnormal cervical cytology or positive visual inspection with acetic acid (VIA) results at Dr. Cipto Mangunkusumo General Hospital, Jakarta. Participants performed self sampling followed by clinician-collected sampling. High-risk HPV DNA was detected using the Hybrid Capture II assay. Clinician-collected samples served as the reference standard.Results: High-risk HPV prevalence was 44.9%. Self-sampling showed substantial agreement with clinician-collected sampling (κ = 0.76), with 88.41% accuracy, 80.65% sensitivity, 94.74% specificity, 92.59% PPV, and 85.71% NPV.Conclusion: Self-sampling demonstrated comparable diagnostic performance to clinician-collected sampling and may be a reliable alternative for improving cervical cancer screening coverage in Indonesia.Keywords: cervical cancer screening; clinician-collected sampling; high-risk human papillomavirus; Hybrid Capture II; selfsampling
Co-Authors Abror Irsan Adithya Weladatika Aditya, Reyhan Adri Dwi Anggayana Affan Solihin Agassi Antoniman, Mohammad Ajeng Larasati Alda, Kristian Aldri Frinaldi Alida Harahap Andi Yasmon Andrijono Andrijono Anggara Mahardika Aria Kekalih Arietta Pusponegoro Arini Setiawati Ario B. Hanggono Arisda Oktalia Arresta V. Suastika Bambang Sutrisna Bethy Suryawati Boeyoeng E.A.P Dalimunte Bonifasius, Bonifasius Budidarmo, Utomo Caesar Nurfiansyah Caroline Caroline Chakti A. Swastika Cherysa Rifiranda Dalri Suhartomo Darrell Fernando David Eka Prasetya Diana Natalia Diana Natalia Ditha Loho Dwiana Ocviyanti Dwiyana Ocviyanti Dyah P. Wardhani Effiana Effiana Effiana, Effiana Elizabeth Novita Erda Ayu Umami Erda Ayu Umami Ferry Y Irawan Finish Fernando Fitriyadi Kusuma Gatot Purwoto Gumilang Gumilang Handika Zulimartin Hanny Nilasari Hari Sandi Henny S. Wonodihardjo Heru Prasetyo Hesti N. Rizqi I Putu G Kayika Imam Rahmadi Iwan Darmansjah Jan Susilo JM Seno Adjie Kristian Alda Kristian Alda Kristian Alda Kristian Alda Kristian Alda Laila Nuranna Leonita T. A. Sutrisna Leonita Triwachyuni Agustina Sutrisna Lisnawati Rachmadi Lucas Christiawan Maemonah, Maemonah Mardhatillah, Syifa Mardhia, Mardhia Mardhia, Mardhia Mohammad A.F Dilmy Mohammad F. Aziz Muhammad Azmi Muhammad Ikhsan Muhammad Ikhsan Muhammad T. Ramadhani Najmarani Devi Firdaus Natasya Prameswari Nova V. Wijaya Nuni Sulastri Nuryati C. Siregar Ocviyanti, Dwiyana Omo Abdul Madjid Prasetyo, Sandy Pratama, Yuven S Quamila F. Afdi Rahmadhany, Rizky Raymond Surya Rendy Pratama Reyhan Aditya Ribkhi A. Putri Riyan H Kurniawan Riyan H Kurniawan, Riyan H Rizky Rahmadhany RR. Ella Evrita Hestiandari Sandy Prasetyo Sari Rahmayanti Shinta Pangestu Sigit Purbadi Simon Fongana Siti R. F. Harun Siti R.F Harun Solihin, Affan Sumulyo, Ganot Surya, Ilham Utama Syaharutsa, Danny Maesadatu Syifa M. Syafitri Tofan W Utami Utomo Budidarmo Vitasatria, Arresta Wiguna, Sandra Yuven S Pratama