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This Author published in this journals
All Journal Jurnal Farmasi Klinik Indonesia Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Majalah Farmaseutik JFIOnline Jurnal Layanan Masyarakat (Journal of Public Service)
Zamrotul Izzah
Department Of Clinical Pharmacy, Faculty Of Pharmacy Universitas Airlangga, Surabaya
Humanities Chemistry Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Medicine & Pharmacology Social Sciences Other

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Drug – Drug Interaction of Dolutegravir and Fluconazole in HIV Patients with Oral Candidiasis – A Literature Review Fauzia, Rizqi Dinni; Izzah, Zamrotul
Majalah Farmaseutik Vol 22, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i1.110914

Abstract

Currently, dolutegravir (with tenofovir and lamivudine or emtricitabine) is the first-line treatment of HIV/AIDS in Indonesia. Considering the 90% prevalence of oral candidiasis as an opportunistic infection in people living with HIV, fluconazole has been used to treat this infection. However, research into the potential for fluconazole drug interactions in people using dolutegravir-based therapy is still limited. Therefore, this study aimed to review published journals of drug-drug interaction between fluconazole and dolutegravir in people living with HIV/AIDS being treated for oral candidiasis. A review was conducted from official journal databases such as PubMed and Google Scholar, only for original studies from 2014 to 2024 with HIV-positive patients were included. Only two out of 313 identified articles met the inclusion criteria. Neither study specifically discussed dolutegravir-fluconazole interaction. Up until now, strong evidence regarding dolutegravir-fluconazole interaction is sufficient. The drug interaction database classified them with no interaction, which was based on a lack of data rather than certain data. Prospective pharmacokinetic studies are required to assess this interaction conclusively and ensure the safety of this common co-administration.
Co-Authors Andarsari, Mareta R. Aniek S. Budiatin Anisa Lailatul Fitria Arief Bachtiar Budi Suprapti Budiatin, Aniek S. Budiatin, Aniek Setiya Budiatin, Aniek Setya Budiatin, Aniek Setya Dewi W. Shinta Dewi Wara Shinta Fathia Ramadiani Fauzia, Rizqi Dinni Firmansyah Ardian Ramadhani Gamar, Fahmi Haitsami Ibnu Gratia, Veronica Hapsari, Pharmasinta P. Idha Kusumawati Khoirotin Nisak Khoirotin Nisak Mahardian Rahmadi Mareta R. Andarsari Mareta Rindang Andarsari Pattymahu, Charlyna Veronika Puspitasari Pharmasinta P. Hapsari Prastuti Asta Wulaningrum Pratiwi Soesilawati Puspitasari, Hanni Prihhastuti Rahmawati Raising Ramadiani, Fathia Ruzainah Ali Shinta, Dewi W. Subhan Rullyansyah Suharjono Toetik Aryani Veronica Gratia WENNY PUTRI NILAMSARI, WENNY PUTRI Yulistiani Yulistiani Yusuf Alif Pratama