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Journal : The Indonesian Biomedical Journal

Ethanol Extract of Spondias pinnata Leaves Reduce Parasite Number and Increase Macrophage Phagocytosis Capacity of Mice Infected by Plasmodium berghei Dewa Ayu Agus Sri Laksemi; I Gusti Kamasan Arijana; I Made Sudarmaja; Ni Luh Ariwati; Ketut Tunas; Putu Ayu Asri Damayanti; Ni Luh Putu Eka Diarthini; I Kadek Swastika; Ida Ayu Dewi Wiryantini
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1286

Abstract

BACKGROUND: Currently, there is no vaccine against malaria in humans, the development of resistance to anti-malarial drugs, causing the need to find new alternatives to overcome malaria infections. This study aimed to determine effect of Spondias pinnata in increasing cellular immunity, especially phagocytosis activity of peritoneal macrophages against Plasmodium berghei infection.METHODS: This was an experimental study with two stages of research, each stage requires 36 Balb/c mice, aged 2 months and weight 20-25 grams. After one week of acclimatization, the mice were put into 6 different groups, each group consisted of 6 mice. The negative control was a group of mice given distilled water for 14 days then infected by P. berghei in the 15th day. Meanwhile, T1, T2, T3, T4 and T5 groups were given S. pinnata leaves ethanol extract with dose of 25, 50, 100, 200 and 400 mg/kg body weight (BW)/day, respectively, and then infected by P. berghei in the 15th day.RESULTS: The results showed that the lowest parasitemia and the highest capacity of macrophage to phagocytose latex was found in treatment group T3 that received 50 mg/kg BW of S. pinnata leaves ethanol extract. Based on analysis of the Pearson correlation test, there was a significant correlation between percent phagocytosis and parasitemia (p<0.05).CONCLUSION: Ethanol extract of S. pinnata leaves lower the parasite number of P. berghei in Balb/c mice and increase the capacity of macrophage to phagocytose latex. However, the mechanisms of how S. pinnata leaves extract in activating phagocytosis capacity and reducing parasitemia still need further investigation.KEYWORDS: phagocytosis, Plasmodium berghei, parasite number, Spondias pinnata
Co-Authors Agus Susanta Anak Agung Ayu Mirah Adi Anak Agung Ngurah Ardha Dwikananda Angela, Christine Bisma Krisnanda, I Kadek Chandra, Angeline Damayanti S, Made Rini Dana, I Kadek Desak Made Widyanthari Desak Putu Yuni Sumaryani Dewa Ayu Agus Sri Laksemi Dewa Ayu Agus Sri Laksmi Dimas Aji Saputra Dyatmika, I Nyoman Adidana Jaya Eka Diarthini, Ni Luh Putu Eny Anggraini Fitriana Melinda Haritharan Ganesan I Dewa Ayu Inten Dwi Primayanti, I Dewa Ayu Inten Dwi I Gusti Kamasan Arijana I Kadek Swastika I Ketut Tunas I Made Sudarmaja I NYOMAN MANTIK ASTAWA Ida Ayu Dewi Wiryantini Ida Bagus Putra Adyatma Ida Bagus Satriya Wibawa Indah Mei Rahajeng Jody Erlangga Juniantara, I Kadek Ade Kadek Cahya Utami Kanaka Puspita, Ida Ayu Luh Gede Mira Swandewi Luh Putu Ratna Sundari Made Rini Damayanti Ni Kadek Rima Pebrianti Ni Luh Ariwati Ni Luh Ariwati Ni Luh Dian Mirayanti Ni Luh Putu Eka Diarthini Ni Luh Putu Eka Diarthini, Ni Luh Putu Eka Ni Luh Putu Eva Yanti Ni Luh Rustini Ni Made Pitri Susanti Ni Putu Apriliani Ekayanti Ni Putu Emy Darma Yanti Ni Putu Wardani Nurdiyanti, Nurdiyanti Pratisthita Sukadana, I Made Ananda Prajna Purantara, Anak Agung Gede Wiweka Winahya Putra, I Putu Bagus Krisna Pramana Putri, Luh Kadek Meilina Putu Indah Budi Apsari Putu Saras Widar Yuliantari Sanjiwani, Ida Arimurti Semara, I Nyoman Sudha Sri Laksemi, Dewa Ayu Agus Sujaya, I Made Pranawa Yogananda Suputra, I Wayan Bagus Abiyoga Surudarma, I Wayan Swastika, I Nengah Raka Tataraharja, I Putu Langgeng Sugih Tustiani, Ni Ketut Nining Aras William, Kristoforus