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Journal : Universa Medicina

In-vivo antimalarial activity of Holothuria scabra simplicia in Plasmodium berghei-infected mice Sri Laksemi, Dewa Ayu Agus; Asri Damayanti, Putu Ayu; Sudarmaja, I Made; Tunas, I Ketut; Ratna Sundari, Luh Putu; Rustini, Ni Luh; Budi Apsari, Putu Indah
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.195-201

Abstract

BACKGROUNDMalaria remains one of the major causes of death worldwide. Holothuria scabra has a high nutritional content and many biological effects. The development of alternative anti-malarial drugs is necessary, considering that resistance to the newest anti-malarial drugs has been reported. This research study aimed to determine the anti-malarial effects of Holothuria scabra in mice infected with Plasmodium berghei. METHODSThis was a post-test only control group study conducted on 24 Balb/c mice. Peter’s four-day suppressive test was employed to ascertain the claimed anti-plasmodial effect of the simplicia. Following inoculation with P. berghei, all 24 mice were infected and randomized into 4 groups, namely 3 treatment groups and 1 control group. The control group was given carboxymethyl cellulose, two of the treatment groups were given doses of 10 and 100 mg/kg BW Holothuria scabra, respectively, using Peter’s four-day suppressive test, while the remaining treatment group received a dose of 100 mg/kgBW using the prophylactic method. Data were analyzed using One way ANOVA. RESULTSThe results showed by using both the four-day suppressive test and the prophylactic method, that Holothuria scabra has antimalarial activity. Holothuria scabra at a dose of 100 mg/kg BW was significantly effective in decreasing the percentage of parasitemia (p=0.000) and tended to inhibit the growth of Plasmodium berghei in mice (p=0.054). CONCLUSIONThis study demonstrated that Holothuria scabra possesses anti-plasmodial activity in mice. Hence, the sea cucumber could serve as a potential source of a newer antimalarial agent.
Co-Authors A.A Indah Suadnyani A.A Indah Suadnyani Abdulhadi FA Adiputra, I Komang Hotra Agilan Sethupathy Amaral, Meriana Barreto Amelia, Irene Anak Agung Ayu Mirah Adi Ariwati, Ni Luh Ayu Surasmiati, Ni Made Bagus Komang Satriyasa Cokorda Agung Wahyu Purnamasidhi Daondy Friarsa Soeharto Dewa Ayu Agus Sri Laksemi Dewa Ayu Agus Sri Laksmi Divya Nirmala, Putu Ayu Edwin Adrianta Surijah Eka Sutyawan, I Wayan I Gusti Agung Ayu Chintya Cahyarini I Gusti Agung Dwi Putri Anjani I Gusti Ayu Prapti Adnyani I Gusti Ayu Prapti Adnyani I Gusti Kamasan Arijana I Kadek Swastika I Ketut Tunas I Made Bakta I Made Jawi I NYOMAN MANTIK ASTAWA I Putu Dema Prasetya I Putu Dodik Supartha I Wayan Ardyan Sudharta Putra I Wayan Putu Sutirta Yasa I Wayan Sugiritama Ida Ayu Dewi Wiryantini Ida Ayu Ide Larassanthi Pratiwi Ida Ayu Sintya Pratiwi Ida Bagus Putra Manuaba Ivy Cerelia Valerie Kadek Adit Wiryadana Kadek Yuda Dira Pratama Ketut Suryana Ketut Teddy Bayu Pradinata kumara, i made bagus bayu L. Ariwati Luh Ariwati Luh Putu Ratna Sundari Lusi Martha Indrayani Made Lady Adelaida Made Martha Pradnyana Made Sushmita Dharmasuari Maretta Rosabella Purnamasari Maretta Rosabella Purnamasari Maria Krishnandita N.L Ariwati N.L.P.E. Diarthini Ni Luh Ariwati Ni Luh Ariwati Ni Luh Jayanti Wulan Sari Ni Luh Komang Sumi Arcani Ni Luh Putu Eka Diarthini Ni Luh Putu Eka Diarthini, Ni Luh Putu Eka Ni Luh Rustini Ni Made Laksmi Utari Ni Made Linawati Ni Made Suasti Wulanyani Ni Nyoman Agustianingsih Ni Putu Akopita Devi Ni Putu Tamara Bidari Suweta Nurulhuda Binti Embong P.A.A. Damayanti Pandango, Ivana Griselarosa Koni Pratisthita Sukadana, I Made Ananda Prajna Putu Ari Paramitha Widiani Putu Ayu Asri Damayanti Putu Ayu Larasati Putu Bagus Onicha Baskaranatha Putu Diah Saraswati Rahayu Putu Indah Budi Apsari REFAYANTI, NI MADE ERNITA Saraswati Devi, Ni Made Kumbha Mella Shabrina Inderjit Sri Laksemi, Dewa Ayu Agus SugengO Juwono Mardihusodo Widiyanti, I Gusti Ayu Wulansari Manuaba, Ida Ayu Ratih Wulanyani Wulanyani