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All Journal VALENSI Jurnal Kimia (Journal of Chemistry) Jurnal MIPA CHEMISTRY PROGRESS agriTECH Molekul: Jurnal Ilmiah Kimia The Studies of Social Sciences Makara Journal of Science Molekul: Jurnal Ilmiah Kimia
Dewa Gede Katja
Jurusan Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Sam Ratulangi, Kampus Unsrat, Bahu Manado 95115
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Materials Science & Nanotechnology Mathematics Physics Social Sciences

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Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD Dewa Gede Katja; Desi Harneti; Tri Mayanti; Nurlelasari Nurlelasari; Rani Maharani; Yoshihito Shiono; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 5, No. 2, November 2019
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.577 KB) | DOI: 10.15408/jkv.v5i2.12132

Abstract

In the course of our continuing search for anticancer compounds from Chisocheton species, three steroids, stigmast-5-en-3β-ol (1), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (2) and stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (3), were obtained from the stembark of Chisocheton celebicus. The structures of compound 1-3 were identified with spectroscopic data including IR, 1D-NMR, 2D-NMR and TOF-MS, as well as by comparing with those spectral data previously. Compounds 1-3, were evaluated for their cytotoxic effects against P-388 murine leukemia cells and displayed the cytotoxicity activity with IC50 values of 12.45 ± 0.050, 52.27 ± 0.031 and 62.52 ± 0.076 µg/mL, respectively.
Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines Tri Mayanti; Nur Insani Amir; Dewa Gede Katja; Sofa Fajriah; Ahmad Darmawan; Unang Supratman; Khlaijah Awang; Yoshihito Shiono
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 2, November 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i2.15976

Abstract

Three steroids, 3α-hydroxystigmast-5(6), 22-diene-7-one (1), stigmasterol (2) and 3-hydroxy-7β-methoxystigmast-5(6)-ene (3), were isolated from the stem bark of Dysoxylum nutans. The chemical structures were identified by spectroscopic data, which includes IR, 1D-NMR, 2D-NMR, and HR-TOFMS as well as by comparing previously reported spectral data. Compounds 1-3 were tested for cytotoxic effect against MCF-7 breast cancer cell lines and compound 1 showed the strongest cytotoxic activity with an IC50 value of 20.13 ± 0.06 μM.
Co-Authors Abigael, Reliana Ace Tatang Hidayat Ahmad Darmawan Andre A. Sonda Ba'u, Defrikson Desi Harneti Putri Huspa Edi Suryanto Edi Suryanto Erwin Sitorus Euis Julaeha Farabi, Kindi Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Frenly Wehantouw Harry S. J. Koleangan Henry Aritonang Hilmayanti, Erina Johnly A Rorong Johnly A. Rorong Junito, Junito Khalijah Awang Khlaijah Awang Kindi Farabi Kindi Farabi Kindi Farabi Koleangan, Harry Steven Julius Lidya I. Momuat Lidya Irma Momuat Mantiri, Sisilia A Max R.J Runtuwene Max Revolta John Runtuwene Meiske S. Sangi Naini, Al Arofatus Novita Thaib, Novita Nur Insani Amir Nurlelasari Nurlelasari Paulina yamlean Pettanaga, Putri Firania Pollo, Hard Napoleon Rani Maharani Rani Maharani Salim, Muhammad Fajrin Saranaung, Andika Sari, Aprilia Permata Sinaga, Jonathan Cavin Ezra Sinaga, Siska Elisahbet Sofa Fajriah Sofa Fajriah Stevi G. Dungir Sujana, Kinaya Vizria Tri Mayanti Tri Mayanti Tri Mayanti Tri Mayanti Tri Mayanti Unang Supratman Vanda S Kamu Vanda S. Kamu Vanda Selvana Kamu Yenny Tambunan Yoshihito Shiono Yoshihito Shiono