Article Per Year (5 Year)
p-Index From 2021 - 2026
3.625
P-Index
This Author published in this journals
All Journal Jurnal Bios Logos BERKALA SAINSTEK Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) BIOEDUKASI Jurnal Biologi Tropis JPBIO (Jurnal Pendidikan Biologi) Bioscientist : Jurnal Ilmiah Biologi InSTEM Life Science and Biotechnology Bioeksperimen Jurnal Bioteknologi & Biosains Indonesia (JBBI) Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Jurnal Bioteknologi & Biosains Indonesia Berita Biologi Biodiversitas Journal of Biological Diversity
Lelono, Asmoro
Department Of Biology, Faculty Of Mathematics And Natural Sciences, Universitas Jember. Jl. Kalimantan 37, Kampus Tegalboto, Jember 68121, East Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Mathematics Medicine & Pharmacology Physics Social Sciences Other

Published : 22 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 22 Documents
Search

 1   2   3 
IN-SILICO ANALYSIS OF THE INTERACTION BETWEEN D7 PROTEIN FROM THE SALIVARY GLAND OF Ae. albopictus AND Thromboxane A2 FOR DEVELOPING ANTIPLATELET AGENT Syubbanul Wathon; Kartika Senjarini; Rike Oktarianti; Asmoro Lelono
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.8176

Abstract

The salivary glands of mosquito vector diseases contain various biological components which facilitate blood-feeding into the host's body. These components are mostly protein molecules. Numerous protein molecules in the salivary glands have gained substantial research emphasis to determine their role and function, including those in the salivary glands of Ae. albopictus. D7 protein is the main component in Aedes salivary glands, which aids in inhibiting platelet aggregation by binding to the Thromboxane A2 (TxA2) during the blood-feeding. TxA2 is a eicosanoid molecule that stimulates platelet aggregation. The protein's ability to bind TxA2 shows that this protein has potential as a new antiplatelet agent. The examination of the D7 protein in binding TxA2 was performed through an in-silico approach using the molecular docking method. This research included selecting the 3D model of the D7 protein and the TxA2 ligand, preparing the 3D model of the D7 protein, native ligands, and test ligands, targeted molecular docking method, validating the molecular docking, analysis and visualization of the docking results. The molecular docking validation shows an RMSD value of 1.657 Å. The results of molecular docking show an ΔG value of -5.60 kcal/mol, meaning that the D7 protein can bind to the TxA2 ligand stably and spontaneously. The active site of the D7 protein in binding the TxA2 ligand consists of several amino acid residues, namely THR 190, GLU 268, TYR 178, PHE 154, ILE 175, ARG176, VAL 293, TYR 248, and TYR 178. The ability of D7 protein to bind TxA2 as an inducer of platelet aggregation has demonstrated its potential as a novel antiplatelet agent. These results can pave further development of drug discovery in the medical and pharmaceutical fields.
The female red jungle fowl (Gallus gallus gallus) reproductive investment stimulated by male attractiveness ASMORO LELONO; BERND RIEDSTRA; TON GROOTHUIS
Biodiversitas Journal of Biological Diversity Vol. 25 No. 7 (2024)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d250714

Abstract

Abstract. Lelono A, Riedstra B, Groothuis T. 2024. The female red jungle fowl (Gallus gallus gallus) reproductive investment stimulated by male attractiveness. Biodiversitas 25: 2931-2936. To maximize their capacity for reproduction, mothers are expected to modify their investment in offspring based on the quality of their mates. A recent study showed that females in female-care only species do so by investing more in egg mass when mated with attractive males rather than in other reproductive traits. In our study, we investigated how red jungle fowl (Gallus gallus gallus) mothers invest in clutch production based on the size of the male's comb, a trait signaling attractiveness. We randomly paired 14 females with 14 males of either large or small combs and monitored their egg laying, clutch completion, and brood rearing. Following the initial clutch, we exchanged male partners and permitted females to establish up second generation. We found that females who were partnered with males who had bigger combs laid down their eggs earlier after pairing compared to those paired with males with smaller combs. However, there were no variations in egg mass or clutch size that we could find. Furthermore, the size of the male's comb influenced the growth and body condition of female chicks, with those sired by males with larger combs being heavier and in better condition at twenty-four weeks old. These data support the premise of the positive Differential Allocation (DA) hypothesis, where maternal investment varies with mate quality, rather than the negative DA, where females more investment in offspring from lower quality mates.
Co-Authors Achmad Sjaifullah Adelia Nur Fahmi Adi Sucipto, Adi Akhmad Rikhwan Alfiyani, Nur Asyia Arif Mohammad Siddiq Arofa, Resmining Mega Arumiannisa Altamaputri Aurellia, Naurah Septa BERND RIEDSTRA Dewi, Rosita Fitrah Dwi Nur Rikhma Sari Eva Tyas Utami Farahdillah Rafiatul Nurhasanah Hari Sulistyowati Hidayat Teguh Wiyono Hidayatur Rohmah Hidayatur Rohmah Intani, Rini Nur Kartika Senjarini Kartika Senjarini Kholiq, Nur Laensugi, Agatha Dei Gratia Nailatur Rifdah Nihayah, Husnatun Nur Aisyah Septiana Nur Asyia Alfiyani Nurul Fajril Azizah Purwatiningsih Purwatiningsih Purwatiningsih Purwatiningsih Puspitasari, Reni Putra, Iguh Widigda Rahmawati, Itsna Reni Puspitasari Rike Oktarianti Rini Nur Intani Rizky Surya Wijaya Sattya Arimurti Siti Nafi’atul Muta’alimah Surya, Rizky Susantin Fajariyah Syubbanul Wathon Tabah Wibisono, Hariyo TON GROOTHUIS Wathon, Syubbanul Wijaya, Rizky Surya Wimbaningrum, Retno Yudha Nurdian