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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) WARTA MPI (Media Pharmaceutica Indonesiana) Adi Widya : Jurnal Pengabdian Masyarakat Pharmasipha Intan Husada : Jurnal Ilmiah Keperawatan Jurnal Farmasi dan Sains Indonesia (JFSI) Kunir: Jurnal Farmasi Indonesia (KJFI)
Puspitasari, Ismi
Program Studi Farmasi, Fakultas Farmasi, Universitas Setia Budi Surakarta
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Anti-Acne Activity of Robusta Green Coffee Bean Extract against Cutibacterium acnes Putri, Cinthiya Ekwinta; Puspitasari, Ismi; Novita, Mega; Marlina, Dian
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7857

Abstract

Acne vulgaris, a common chronic skin disorder, is primarily caused by the overgrowth of Cutibacterium acnes and often treated with synthetic agents that may cause side effects and resistance. The increasing demand for therapeutics with improved safety profiles and natural alternatives has encouraged the exploration of herbal remedies, including robusta green coffee beans (Coffea canephora). This study aimed to evaluate the anti-acne activity of robusta coffee bean ethanol extract against C. acnes. The extract was prepared through maceration and subsequently evaluated using to phytochemical screening, thin layer chromatography, and in vivo testing on New Zealand rabbits. Results confirmed the presence of flavonoids, alkaloids, tannins, steroids, and triterpenoids. In vivo assays demonstrated that the 75% extract concentration achieved a 96.69% reduction of acne lesions, comparable to the positive control at 99.35%, while lower concentrations showed moderate activity. These findings highlight the potential of robusta coffee bean extract as a promising natural anti-acne agent. The study implies that robusta extract can be further developed into herbal-based dermatological formulations, although future research should focus on isolating active compounds and conducting clinical trials for broader application.
Co-Authors Adrianto, Madyo Ana Indrayati Dewi Arum Sari Dwi A, Santi Ghani Nurfiana Fadma Sari Gunawan Pamudji Widodo Hayu W, Jena Ismi Rahmawati Kurniasari, Fitri Madyo Adrianto Marlina, Dian Mega Novita Meta Kartika Untari Meta Kartika Untari Nuraini Harmastuti Patricia Alfayu Velix Putri, Cinthiya Ekwinta Sari Astuti Sari Astuti Suhartinah Vina Desti Ashari Waty, Carolina Eka Wiwin Herdwiani