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Journal : Indonesian Journal of Medicine

Precision and Accuracy of Thyroid Dysfunction Questionnaire (TDQ) for Hyperthyroidism Screening in Childbearing Age Women -, Mutalazimah; Mulyono, Budi; Murti, Bhisma; Azwar, Saifuddin
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Community-based case finding efforts of hyperthyroidism rather not to do, but constrained because accurate markers measurements using hormones.  TDQ as a screening in­strument which meets several criteria for diagnostic tests, provide more convenience for the patient, cheaper, easier and simpler. This study aimed to determine the precision and accuracy of the diagnostic test of hyperthyroidism screening in childbearing age women.Subjects and Method: The study was a diagnostic study with the cross-sectional design. It conducted in Prambanan, Sleman, Yogyakarta. The sample consisted of 112 randomly selected of childbearing age women. Clinical symptoms of hyperthyroidism were measured using the TDQ, thyroid status measured by thyroid stimulating hormone (TSH) and free thyroxin (FT4). TDQ diagnostic precision and accuracy were tested using the percent agreement (PA), Kappa coefficient, sensitivity (Se), specificity (Sp), LR (+), LR (-), Youden’s index, the area under the curve (AUC) in the receiver operating curve (ROC) and diagnostic odds ratio (DOR).Results: The best value in diagnostic precision is TDQ score with the cutoff point score of 40, with PA 81.2 % and Kappa coefficient 0.62. Similarly, the best accuracy value Se 90%, Sp 76%, LR(+) 3.75, LR(-) 0.13, Youden’s index 0.66, AUC 0.831 and DOR 28.8.Conclusion: The values and the optimal accuracy obtained from the best score of 40 and this cut off point of the score is sufficient to be used as a threshold determination of a diagnosis of hyperthyroidism by TDQ scores. Keywords: diagnostic tests, thyroid dysfunction questionnaire (TDQ), hyperthyroidism, child­bearing age women.Correspondence: Mutalazimah. Department of Nutritional, Muhammadiyah University of SurakartaIndonesian Journal of Medicine (2016), 1(1): 34-43https://doi.org/10.26911/theijmed.2016.01.01.05
Co-Authors A.A. Ketut Agung Cahyawan W Agus Anggoro Sigit AGUS WIDODO Ahmad Ari Shodikin Ajeng Puspa Buana Ali Djamhuri Anindya, Vani Annissa Mustika Ayu Appannah, Geeta Arif Pristianto Arwida, Neriya Atika Putri Indrasari Atika Putri Wijayanti Ayu, Annissa Mustika Bana Handaga Bhisma Murti Buana, Ajeng Puspa Budi Mulyono Budi Mulyono Chan Kok Meng Dewi Kumalasari Dwi Astuti Dyah Intan Puspitasari Fadhilah Nufus Muthmainah, Nur Faqihuddin, Faqihuddin Farida Nur Isnaeni Hermawati Soetomo Indrasari, Atika Putri Intan Puspitasari, Dyah Islamiyati, Putri Lutffiah Isnaini Herawati Jannah, Nadhifa Uzlifatul Khairuna Hamida Khasanah, Dini Afriani Khoirina Ngizzati Pujiani Linda Ayu Permatasari Luluk Ria Rakhma Mahadir Ahmad Mahardika, Alviannisa Rizqi Mardiyati, Nur Lathifah Mohd Nordin, Nor Azlin Mohd Sham Bin Othman Muhammad Da'i Mulyono, Budi Muwakhidah Muwakhidah Muwakhidah, M Nadhifa Uzlifatul Jannah Niken Asih Pangastuti Nisa Rachmah Nur Anganthi Norma Diena Amalia Normah Awang Nur Lathifah Mardiyati Nur Lathifah Mardiyati Nurul Farahana Binti Kamaludin Okti Sri Purwanti Permatasari, Linda Ayu Pramudya Kurnia Puspitasari, Dyah Intan Putri Lutffiah Islamiyati R. Radyan Yaminar Saifuddin Azwar Saifuddin Azwar Saifuddin Azwar Saifuddin Azwar Setia Asyanti Setia Asyanti Setiyaningrum, Zulia Setiyo Purwanto Sintya Bella Pratiwi Siti Zulaekah Siti Zulaekah Siti Zulekah Syaninditha, Ajeng Fasha Tiara Fatmarizka Toto Suharto W Wahyuni Wachid Yahya Wijayanti, Atika Putri Yaminar, R. Radyan Yuli Kusumawati Zaini Said Zulia Setiyaningrum