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All Journal KOMUNITAS: INTERNATIONAL JOURNAL OF INDONESIAN SOCIETY AND CULTURE Medical Journal of Indonesia Teknosains: Media Informasi Sains dan Teknologi Jurnal Online Mahasiswa (JOM) Bidang Keguruan dan Ilmu Pendidikan Profesi Pendidikan Dasar Indonesian Journal of Chemical Science Academica : Journal of Multidisciplinary Studies Jurnal Arsitektur ZONASI International Journal of Visual and Performing Arts Jurnal Inovasi Pembelajaran di Sekolah Polinomial : Jurnal Pendidikan Matematika PESHUM Journal Governance Bureaucratic Review
Indah Puji Lestari
Jurusan Administrasi Publik, Fakultas Ilmu Administrasi, Universitas Brawijaya, Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Education Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Potensi senyawa metabolit sekunder dari beluntas (Pluchea indica) sebagai penghambat arabinosyltransferase (embA) Kharomain, Muhammad Imam; Lestari, Indah Puji; Panda, Alifia Amalia; Sinaga, Reza Avika Aleyda; Noordiya, Maulfi Elsa
Teknosains Vol 18 No 2 (2024): Mei-Agustus
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v18i2.46810

Abstract

Tuberkulosis (TB) merupakan penyakit menular yang merupakan penyebab kematian tertinggi sebelum HIV/AIDS. Fenomena resistensi obat dari Mycobacterium tuberculosis menimbulkan permasalahan besar sehingga perlu dilakukan pencarian obat tradisional dengan cara menyeleksi metabolit sekunder tanaman obat. Salah satu tanaman obat yang mempunyai senyawa metabolit sekunder adalah tanaman beluntas (Pluchea indica) karena memiliki manfaat salah satunya sebagai antibakteri. Tujuan dari penelitian ini adalah untuk memvalidasi kemampuan aktivitas antibakteri dari Pluchea indica melalui metode in silico. Pada penelitian ini, proses docking dilakukan pada software PyRx dengan memanfaatkan protein arabinosyltransferase yang bersumber dari bakteri. Mycobacterium tuberculosis. Senyawa uji yang digunakan merupakan metabolit sekunder dari tanaman beluntas (Pluchea indica) dan obat pembanding Ethambutol. Kemudian hasil docking skor metabolit sekunder dibandingkan dengan skor docking Ethambutol. Hasil docking Ethambutol sebagai pembanding mempunyai ikatan afinitas sebesar -4,1 kkal/mol sedangkan Plucheoside E (-7,0 kkal/mol) mempunyai nilai ikatan afinitas yang lebih rendah dibandingkan Ethambutol dan mempunyai ikatan asam amino yang sama dengan Ethambutol sebagai kontrol sehingga Plucheoside E dapat dianggap sebagai senyawa yang efektif dalam menghambat enzim arabinosyltransferase.
Komparatif Efektivitas Model Problem Based Learning Berbantuan Media Diagram Pintar (DIPIN) dan Pembelajaran Konvensional Terhadap Kemampuan Pemahaman Konsep Matematika Siswa Kelas 5 SD Sari, Duwike Wulan; Putri, Audita Nelisa; Lestari, Indah Puji; Aulia, Nadhira Agfifaza; Amaliyah, Fitriyah
Polinomial : Jurnal Pendidikan Matematika Vol. 4 No. 3 (2025)
Publisher : Papanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56916/jp.v4i3.1890

Abstract

This study aims to examine the effectiveness of the Problem-Based Learning (PBL) model assisted by DiPin media on students' conceptual understanding in the topic of data collection. The research employed a quantitative method with a quasi-experimental design involving two classes at SD Tanwirul Qulub Kudus: class 5A as the experimental group using the PBL model assisted by media, and class 5B as the control group using only the conventional model. The instruments used were pre-test and post-test questions designed to measure students' mathematical conceptual understanding. Data analysis was conducted using five statistical tests: normality test, homogeneity test, ANOVA, Paired Sample t-Test, N-Gain, and Independent Samples t-Test. The results showed that learning with visual aids was more effective in improving students’ conceptual understanding and numerical abilities compared to conventional learning. The test data from classes 5A and 5B were normally distributed (p > 0.05) and had homogeneous variances (p = 0.411), fulfilling the requirements for parametric testing. The ANOVA test showed a significant difference between the two classes (p = 0.000; F = 31.370). In class 5A, the Paired Sample t-Test indicated a significant increase from pre-test to post-test (a 25-point increase; p = 0.000). The N-Gain score in class 5A was also higher (63.79%) compared to class 5B (23.51%). The Independent Samples t-Test confirmed these findings with significant results (p = 0.000), and the average post-test score was higher in class 5A (84.67) compared to 5B (65.67). Thus, learning using visual aids has been proven to be more effective in improving student learning outcomes.
Art therapy facilities as a supportive environment for teen mental health recovery Farida, Ariesa; Lestari, Indah Puji; Haristianti, Vika; Rangga, Firmansyah; Liritantri, Widyanesti
International Journal of Visual and Performing Arts Vol 7, No 1 (2025)
Publisher : ASSOCIATION FOR SCIENTIFIC COMPUTING ELECTRICAL AND ENGINEERING (ASCEE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31763/viperarts.v7i1.1797

Abstract

The prevalence of mental health issues among adolescents in Indonesia has significantly increased; however, this rise has not been accompanied by adequate recovery facilities, particularly for this vulnerable age group. Existing mental health recovery facilities predominantly emphasize conventional psychotherapy methods. In contrast, art therapy provides a more engaging and interactive approach by utilizing art as a medium to facilitate the recovery process. Therefore, this study aims to identify the essential facilities required in an art therapy center, particularly in supporting the recovery of mental health disorders among adolescents in Indonesia. The research approach was conducted using an inductive qualitative method, including observation and field surveys at established art therapy facilities. This method, is analyzes data, essentially involving producing an overall summary of the content of the data set. The findings indicate that art therapy is a deeply personal experience for each individual, as it involves expressing emotions. Because of this, the approach should be personalized to each person's unique needs and supported with a variety of art media and appropriate facilities to support a meaningful and effective creative process. Due to the complexity of various methods that can be used in art therapy, further research is needed to explore the relationship between art therapy methods and the design of specialized art therapy spaces.
Stakeholder Analysis Waste Management in Tanjungpinang City Hutahaean, Permata Pebester Natalia; Simangunsong, Damayanti; Mardiyanti, Elisa; Okta, Auliana; Lestari, Indah Puji
Journal Governance Bureaucratic Review Vol. 1 No. 1 (2024): December, 2024
Publisher : Center for Maritime Policy Governance Studies (CMPGS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31629/jgbr.v1i1.7139

Abstract

Solid waste management in urban areas has become a pressing environmental and governance issue, particularly in rapidly developing secondary cities such as Tanjungpinang, Indonesia. Despite the existence of regulatory frameworks like Regional Regulation No. 3 of 2015, the city's waste management system remains underdeveloped, marked by inefficient collection services, inadequate infrastructure, and limited public participation. This study aims to examine the stakeholder landscape in Tanjungpinang’s waste governance to identify institutional gaps, coordination challenges, and opportunities for improved collaboration. The research employs a qualitative and interpretive methodology, combining document analysis and stakeholder mapping using Eskerod & Jepsen’s influence-interest matrix and the Friedman and Miles stakeholder salience framework. Findings indicate that the Department of Environment (DLH) holds the highest level of authority but often lacks the urgency and resources needed for effective intervention. Meanwhile, actors with high urgency, such as informal waste workers and local communities, lack legitimacy and power, leading to their exclusion from formal governance processes. The stakeholder network is characterized by low mutuality and fragmented relationships, particularly between state and non-state actors. Waste banks and NGOs operate with limited support despite their significant roles in community outreach and recycling initiatives. The study concludes that sustainable urban waste management in Tanjungpinang requires inclusive governance reforms that build institutional capacity, strengthen stakeholder interdependence, and integrate informal actors into formal waste systems. These findings offer practical insights for enhancing stakeholder engagement and aligning local waste policies with Sustainable Development Goal 11 on sustainable cities and communities.
Pengaruh Teknik Silent Reading With A Timer Terhadap Konsentrasi dan Pemahaman Membaca Siswa SD NU Tanwirul Qulub Sari, Duwike Wulan; Putri, Audita Nelisa; Lestari, Indah Puji; Aulia, Nadhira Agfifaza
PESHUM : Jurnal Pendidikan, Sosial dan Humaniora Vol. 4 No. 6: Oktober 2025
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/peshum.v4i6.10599

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh teknik Silent Reading with a Timer terhadap konsentrasi dan pemahaman membaca siswa kelas 5A dan 5B SD NU Tanwirul Qulub. Metode yang digunakan dalam penelitian ini adalah pendekatan kuantitatif dengan desain eksperimen pretest-posttest control group design, di mana siswa dibagi menjadi dua kelompok: kelompok eksperimen yang menerapkan teknik Silent Reading with a Timer dan kelompok kontrol yang menggunakan metode pembelajaran konvensional. Pengumpulan data dilakukan melalui tes pemahaman membaca dan observasi terhadap konsentrasi siswa selama kegiatan membaca. Hasil analisis menunjukkan bahwa penerapan teknik Silent Reading with a Timer secara signifikan meningkatkan konsentrasi dan pemahaman membaca siswa. Dengan adanya batasan waktu yang terstruktur, siswa dapat lebih fokus dan efisien dalam memahami teks yang dibaca. Oleh karena itu, teknik ini dapat dijadikan sebagai alternatif yang efektif dalam pembelajaran membaca di sekolah dasar.
Effect of a high-calorie diet on pro- to anti-inflammatory macrophage ratio through fat accumulation in rat lung tissue Lestari, Indah Puji; Chozin, Iin Noor; Sartono, Teguh Rahayu; Sasiarini, Laksmi; Yudhanto, Hendy Setyo
Medical Journal of Indonesia Vol. 32 No. 4 (2023): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.236991

Abstract

BACKGROUND A high-calorie diet increases the risk of obesity. Accumulation of fat causes inflammation, as seen by the increased ratio of pro- to anti-inflammatory macrophages in a high-calorie diet. The pro-inflammatory shift in macrophage polarization may result in hypoxia, fibrosis, emphysema, and asthma. This study aimed to determine the effect of a high-calorie diet on pro- to anti-inflammatory macrophage ratio through fat accumulation. METHODS This experimental study used in vivo test in 16 male Sprague-Dawley rats aged 10–12 weeks. The rats were divided into high-calorie and normal diet groups for 16 weeks. Obesity in rats was defined as having a body mass index (BMI) of >0.68 g/cm2. Examination of lung fat accumulation was done through oil red O staining, while pro- to anti-inflammatory macrophage ratio was tested through CD11c and CD206 expressions by immunohistochemical method. RESULTS The high-calorie diet group had higher BMI (0.72 [0.02] versus 0.62 [0.03]; p<0.001), lung fat accumulation (32.73 [10.55] versus 0.37 [0.38]; p<0.001), and pro- to anti-inflammatory macrophage ratio (0.83 [0.02] versus 0.24 [0.006]; p<0.001). The higher the fat accumulation, the higher the pro- to anti-inflammatory macrophage ratio (r = 0.933; p<0.001). CONCLUSIONS The ratio of pro- to anti-inflammatory was higher in the high-calorie diet group, indicating polarization of macrophages toward pro-inflammatory macrophages.
Co-Authors Agus Dody Purnomo Amaliyah, Fitriyah Aulia, Nadhira Agfifaza Chozin, Iin Noor Dewi, Rida Fironika Kusuma F Widhi Mahatmanti Farida, Ariesa Febriyanti, Yuliana Hambali Hambali Hutahaean, Permata Pebester Natalia Iin Purnamasari Kharomain, Muhammad Imam Mardiyanti, Elisa Narwastu, Lira Angger Noordiya, Maulfi Elsa Nuhyal Ulia, Nuhyal Okta, Auliana Panda, Alifia Amalia Pri Iswati Utami Putri, Audita Nelisa Rangga Firmansyah Sari, Devinna Tamaya Sari, Duwike Wulan Sartono, Teguh Rahayu Sasiarini, Laksmi Simangunsong, Damayanti Sinaga, Reza Avika Aleyda Sri Haryani Supentri Veryliana Purnamasari, Veryliana Vika Haristianti Wardani, Fatimah Sindi Widyanesti Liritantri Wiranti Sri Rahayu Wulandari, Ni'matul Umamah Tri Yudhanto, Hendy Setyo