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Journal : Neurona

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Hubungan Kadar Plasma Leptin dan Fungsi Kognitif pada Lanjut Usia di Jakarta Pratiwi, Sandi Puspita; Mudjihartini, Ninik; Lestari, Wiji; Prawirohajo, Pukovisa
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 3 (2024): Volume 40, No 3 - Juni 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i3.544

Abstract

Introduction: The increasing of elderly population often accopanied by a rise in cognitive disorders. Leptin is known to have a protective function against cognitive dectine in elderly. However, current finding regarding the role of leptin in cognitive function is vary, and has not been extensively discussed in Indonesia. Food record and antropometric assesment is conducted as an aditional analyses on subject. Aim: To determine the relationship between plasma leptin levels and cognitive function in the elderly in Jakarta. Methods: This is a cross sectional descriptive analytical research using purposive sampling as the sampling method. Subject are elderly residing in social welfare home, and being assessed using MOCA-INA instrument, IADL and GPAQ questionnaire, plasma leptin, body composition, antropometric and Food Record are measured. The data is analyzed through univariate, bivariate and multivariate analysis. Results: Subject characteristic of age ranging from 60-74 years, with female as the majority (67.5%), normal nutritional status (46.2%), body fat ranging from 18.10 to 57.10 %, muscele mass 20.20 to 57.50 kg. Majority of subject do not smoke, have a low education level (≤ 12 year of education), engage in moderate physical activity, and having independent functional capacity. A total of 96.2% of the subject experience cognitive impairment. Plasma leptin levels ranging from 1.4 to 8.5 ng/mL, with median of 5.9 ng/mL. There is a significant relationship between leptin levels, body mass index, body weight, total body fat, education and IADL with cognitive function in the elderly in Jakarta. Discussion: The correlation between plasma leptin levels and cognitive function in the elderly in Jakarta, shows a moderately positive correlation with r value of 0.47 and a significance of 0.000. Keywords: Cognitive function, Elderly, Leptin
Co-Authors Afifa, Nadhira Nuraini Agustin, Heidy Akmal, Baasith Khoiruddin Al-am, Maftah Rozani Anissa, Lidya Ariasti, Dinar Asa Wahyu Purnama, Theodorus Atho’urrohman, Wifqi Atima, Vihi Awang Long, Zalizah binti Azizah, Nikmatul binti Rahmat, Azizah Cahya, Bambang Dwi Chandra, Dian Novita Dhiana, Azis Sukma Diana Sunardi Fadhillah, Dian Agil Farid Faqih, Muhammad Fariz, Nurwidya Florencia Grifit Joiner, Da Costa Hornay Hanafi, Christi Giovani Anggasta Hasanah, Herliyani Helena Fabiani Herawati Herawati Irawan, Rosyid Rafi Ismawati, Mega Yuniar Istiqomariyah, Ernita Jamaludin, Bani Lin, Kenzie Hara Maria Kanan Maulindar, Joni Muhtarom, Moh Mulyanto, Hari Nibras Faiq Muhammad Ninik Mudjihartini Novemy Triyandari Nugroho Pipin Widyaningsih Pradana, Afu Ichsan Prasetiyo, Dwi Pratiwi, Sandi Puspita Prawirohajo, Pukovisa Putra, Fendi Ardya Rahmawati, Anni Ray March Syahadat Reni Widyastuti Rifa'i, Rifan Ronaldi, Abon Rubeda, Syukril Agaba Kalis Rudi Susanto Saidek, Abdul Rahim Shirly Rizki Kusumaningrum Silviana Pebruary Soe, Calvin Johnson Cannavaro Sondang Ratnauli Sianturi Steffi Sonia Sudarsa, Caca Sulisyowati, Sulisyowati Sumarlinda, Sri Surya, Clarissa Winata Syahputra, Paisal Syam, Shaogi Tai, Jacky Anderson Thantawi, Tubagus Rifqy Victoria, Chelsea zulfa, nely