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All Journal Jurnal Ilmu Dasar MPI (Media Pharmaceutica Indonesiana) Jurnal Kimia Riset Jurnal Farmasi Sains dan Komunitas Warta Pengabdian JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Inovasi Teknik Kimia Jurnal Riset Kefarmasian Indonesia Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Ilmiah Farmasi Akademi Farmasi Jember Indonesian Chimica Letters Dedication : Jurnal Pengabdian Masyarakat Dental Agromedis

Hadi Barru Hakam Fajar Siddiq

Akademi Farmasi Jember

Author-ID : 3069574

Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Other

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KARAKTERISASI SENYAWA ANALGETIKA-ANTIINFLAMASI N-(4t-BUTILBENZOIL)-p-AMINOFENOL YANG DISINTISES DENGAN KATALIS ASAM Hadi Barru Hakam Fajar Siddiq, Dewi Rashati, Farida Suryaningsih
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

The N-(4t-Butylbenzoyl)-p-Aminophenol compound was a synthesis compound between p-aminophenol and 4t-Butylbenzoyl chloride by using H2SO4 catalyst. The addition of H2SO4 catalyst purposed to accelerate the rate of rection in the synthesis of the compound and increased yield of product. The N-(4t-Butylbenzoil)-p-Aminophenol compound is beneficial as an antiinflammatory analgesic. This research were proposed to determine characteristics of the anti-inflammatory analgesic synthesis of N-(4t-Butylbenzoyl)-p-Aminophenol compound by using H2SO4 catalyst. Characterization conducted in this research were physical and chemical characterization. The physical characterization were organoleptic test, crystal form test and melting point test. While chemical characterization were UV-Vis spectrophotometry and FTIR. Result of organoleptic test showed sample had powder form, white-gray colour and not taste. Melting point of N-(4t-Butylbenzoyl)-p-Aminophenol compound was 193.33 °C. The optimum wavelength of UV-Vis spectrophotometry got 2 peaks at the wavelengths 290 and 295 nm. The result of FTIR showed that N-(4t-Butylbenzoyl)-p-Aminophenol compound had peaks.Keywords: N-(4t-butyl benzoil)-p-aminophenol, catalyst

SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA TURUNAN AMOKSISILIN TERHADAP Escherichia coli Hadi Barru Hakam Fajar Siddiq, Siti Nur Azizah, Amaliyah Nurul Hidayah, Dewi Riskha Nurmalasari, Mau
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2019: Desember - Vol.3 No.2
Publisher : AKADEMI FARMASI JEMBER

Amoxicillin derivate compounds from the reaction of amoxicillin with p-aminophenol are synthesized compounds by reacting amoxicillin and p-aminophenol. . Escherichia coli is a flora normal bacteria that can causing infectious diseases. This research aimed to determine the antibiotic activity of amoxicillin derivat compound (amoxicillin with p-aminophenol) on the growth of E. coli. This research was conducted using the disc diffusion method. amoxicillin derivat compound (amoxicillin with p-aminophenol) were characterized by organoleptic test, melting point determination, pH test determination, Rf value, and maximum wavelength. The results of the organoleptic test showed that amoxicillin derivates from amoxicillin and p-aminophenol reaction is crystal powder, dark brown and bit bitter. Melting point of amoxicillin derivates from amoxicillin and p-aminophenol reaction was 160ºC. pH test of amoxicillin derivates from amoxicillin and p-aminophenol reaction was 6,5. Rf value of amoxicillin derivates from amoxicillin and p-aminophenol reaction was 0,79. The results of UV wavelength scanning showed that amoxicillin derivates from amoxicillin and p-aminophenol reaction at 295 nm. Antibiotic activity showed by the clear zone form around the paper disk. The results showed that E. coli was resistant to pure amoxicillin. Amoxicillin derivat compound (amoxicillin with p-aminophenol) with concentrations of 100% and 12,5% have the largest inhibitory zones (6,33 mm) compared with concentrations of 50% and 25%, 5,33 and 6,00 mm respectively. Based on these results it can be concluded that derivat compound of amoxicillin (amoxicillin with p-aminophenol) has antibiotic activity against the growth of E. coli that has been resistant to pure amoxicillin.Keywords: Derivate compound of amoxicillin, Escherichia coli, antibiotic activity

SYNTHESIS, CHARACTERIZATION, AND ACTIVITY ASSESSMENT OF AMOXICYLIN/CuO COMPOUNDS AGAINST PATHOGENIC BACTERIA Hadi Barru Hakam Fajar Siddiq; Siti Nur Azizah
Jurnal Kimia Riset Vol. 7 No. 2 (2022): December
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v7i2.36816

Infection is a disease caused by bacteria. Some bacteria that can cause infection are Escherichia coli, Salmonella typhi, Staphylococcus aureus, and Bacillus subtilis. Infection can be prevented by antibiotic therapy. Excessive use of antibiotics such as misuse of indications, free use in the community, inappropriate doses, and timing of application will cause new problems such as increasing bacterial resistance to antibiotics. The prevalence of drug-resistant bacteria is increasing in many parts of the world. However, this increase is accompanied by a downward trend in the development of new antibiotics. Thus, to overcome this problem new antibiotics have to be developed. This study aimed to synthesize a new antibiotic, namely to test amoxicillin/CuO and its antibacterial activity against E. coli, S. typhi, S. aureus, and B. subtilis. Antibacterial activity test using disc diffusion method. The XRD characterization results showed that the diffraction peaks of amoxicillin/CuO in the image above started from 21.13; 29.54; 30.67; 36.82; 39.5; 42.05; and 47.88. The SEM results of the Amoxicillin/CuO compound showed that the particle size of the compound was still in the form of a graph of 196-345 nm. The results of testing the antibacterial activity of amoxicillin/CuO compounds against E. coli, S. typhi, B. subtilis, and S. aureus showed that amoxicillin/CuO compounds had activity against all bacterial samples. Thus, amoxicillin/CuO compounds can be used as antibacterial therapy.

TINGKAT PENGETAHUAN IBU TENTANG PENGGUNAAN ORALIT PADA BALITA DI RW 006 DESA BAGOREJO KECAMATAN SRONO KABUPATEN BANYUWANGI Dewi - Rashati; Hadi Barru Hakam Fajar Siddiq
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 5, No 2 (2022): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53864/jifakfar.v5i2.113

Knowledge is the result of "knowing" that occurs after someone senses a certain object. Diarrhea is the discharge of loose stools with a soft to liquid consistency with a frequency of three or more times a day. This study aims to determine the level of knowledge of mothers about the use of ORS in infants in RW 006 Bagorejo Village, Srono District, Banyuwangi Regency. The type of research used is descriptive quantitative. The method used is cross-sectional an accidental sampling of data carried out in RW 006 Bagorejo Village, Srono District, Banyuwangi Regency for the period June - July 2022 by distributing questionnaires to 72 respondents according to the inclusion criteria. Mother's level of knowledge about the use of ORS in infants in RW 006 Bagorejo Village, Srono District, Banyuwangi Regency can be seen in the categories of know, understanding, and application. Based on the results of research on 72 respondents obtained a good percentage in the know category, understanding category, and application category.

Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl Amoxicillin Hadi Barru Hakam Fajar Siddiq; Dewi Rashati; Siti Nur Azizah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 1 (2022)
Publisher : Sanata Dharma University

The synthesis of 4-tert-butylbenzoyl amoxicillin has been done by reacting amoxicillin with 4-tert-butylbenzoyl chloride. The product was characterized using proton and carbon-13 spectrometry. Antibacterial activity of 4-tert-butylbenzoyl amoxicillin against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus was tested using paper disk diffusion method. Results showed that 4-tert-butylbenzoyl amoxicillin had a specific spectrum activity. Antibacterial test of 4-tert-butylbenzoyl amoxicillin showed clear zones around the disc paper for Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. The study results indicated 4-tert-butylbenzoyl amoxicillin has antimicrobial properties but is categorized as a less-effective antibiotic agent based on the response to bacterial growth inhibition.

PENGARUH VARIASI KONSENTRASI HPMC TERHADAP SIFAT FISIK GEL EKSTRAK KULIT PISANG AGUNG SEMERU (Musa paradisiaca L.) Mikhania Christiningtyas Eryani; Hadi Barru Hakam Fajar Siddiq; Dewi Rashati; Risma Khoiro Safitri
Jurnal Riset Kefarmasian Indonesia Vol 5 No 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.320

The aims of this study was to determine the effect of HPMC variation concentration to the physical properties of Semeru Agung banana (Musa paradisiaca L.) skin extract gel. Gel was formulated with various HPMC concentration namely F1 (2%), F2 (3%) and F3 (4%). Gel was evaluated organoleptic, homogeinity, pH, viscosity, spreadbility and adhesion value. The results showed that F2 meet the organoleptic requirements while F1 and F3 did not meet. All formulas are homogeneous. The results of the pH test showed that the pH value of F1 was 5.9 ± 0; F2 of 5.8± 0 ; F3 of 5.9 ± 0. The results of the viscosity test showed that the viscosity value of F1 was 150 ± 0 dPas; F2 of 250 ± 0 dPas; F3 of 300 ± 0 dPas. The results of the dispersion test showed that the dispersion value of F1 was 5.6 ± 0.06 cm; F2 of 5.3 ± 0.29 cm ; F3 is 4.0 ± 0.12 cm. The results of the adhesion test showed that the value of the F1 adhesiveness was 11.04 ± 0.43 seconds; F2 of 17.4 ± 1.47 seconds; F3 is 24.2 ± 2.44 seconds. It is known that variations in HPMC concentration affect gel texture, viscosity, spreadability and adhesion, and have no effect on gel smell, color and pH.

ANALISIS TOTAL SUSPENDED SOLID (TSS) DAN AMONIA TOTAL (NH3-N) PADA ALIRAN AIR SUNGAI BEDADUNG DI DAERAH ARJASA JEMBER Denok Risky Ayu Paramita; Fiki Jazilah; Anies Rohman Dwijayanti; Hadi Barru Hakam Fajar Siddiq
Jurnal Inovasi Teknik Kimia Vol 8, No 2 (2023)
Publisher : Fakultas Teknik Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/inteka.v8i2.8155

Beberapa wilayah di Indonesia mengalami kasus penurunan mutu air, salah satunya adalah daerah Jember dimana warga sekitar Arjasa mulai kekurangan stok air bersih serta mengalami gatal-gatal setelah menggunakan air sungai terutama pada musim hujan. Penelitian ini bertujuan utuk menanggapi keluhan masyarakat melalui kesesuaian hasil analisis parameter TSS (Total suspended solid) dan NH3-N (ammonia total) terhadap baku mutu standar air sungai kelas 1. Metode yang digunakan untuk parameter TSS adalah gravimetri sedangkan parameter NH3-N menggunakan spektrofotometer secara fenat. Sampel yang diuji adalah air sungai yang diambil pada tiga lokasi di wilayah Arjasa. Hasil penelitian menunjukkan bahwa semua sampel tidak memenuhi standar baku mutu. Kadar parameter TSS yang diperoleh pada titik 1, 2, dan 3 berturut-turut adalah 200 mg/L, 280 mg/L, 260 mg/L sedangkan baku mutunya adalah 40 mg/L. Kadar parameter NH3-N yang diperoleh pada titik 1, 2, dan 3 berturut-urut adalah 1,69 mg/L; 0,51 mg/L; 0,42 mg/L sedangkan baku mutu NH3-N adalah 0,1 mg/L.

PENGARUH VARIASI KONSENTRASI NATRIUM HIDROKSIDA TERHADAP SIFAT FISIK SEDIAAN SABUN PADAT EKSTRAK DAUN NANGKA (Artocarpus heterophyllus Lam.) Mikhania Christiningtyas Eryani; Hadi Barru Hakam Fajar Siddiq; Asa Falahi; Noer Layla Fitri Ani
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 12 No 1 (2023): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v12i1.161

The aim of this study was to determine the variataion concentration effect of sodium hydroxide (NaOH) on the physical properties of jackfruit leaf extract solid soap (Artocarpus heterophyllus Lam.). The concentration of NaOH used were 2.5% (F1); 5% (F2) and 7.5% (F3). The physical evaluation was carried out in the form of an organoleptic test, homogeneity test, pH test, water content test, and foam height test. The results showed that variations in NaOH concentration had no effect on the organoleptic physical properties (odor, shape, color) and homogeneity of solid soap but had an effect on the physical properties of pH, water content, and foam height of solid soap

Synthesis Analgetic-Antiiflammation N-(4t-Buthylbenzoil)-p-Aminophenol by Using MgF2 Catalist Siddiq, Hadi Barru Hakam Fajar; Eryani, Mikhania Christiningtyas; Suryaningsih, Farida
Jurnal ILMU DASAR Vol 19 No 1 (2018)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Synthesis of N-(4t-buthylbenzoyl)-p-aminophenol has been done by reacting p-aminophenol and 4-tert- buthylbenzoyl chloride compounds with 1% MgF2 catalyst. N-(4t-buthylbenzoyl)-p- aminophenol as an antiinflamatory analgesic. Products were characterized by organoleptic test, melting point determination, TLC, UV/Vis Spectrophotometry, and infrared spectrophotometry. The results of the organoleptic test showed that N- (4t-butylbenzoyl) -p- aminophenol is powdered, gray and tasteless. Melting point of N-(4t- buthylbenzoyl)-p- aminophenol was 193 – 194 °C. TLC results showed that N-(4t-buthylbenzoyl)-p- aminophenol had two Rf values of 0.73 – 0.76 and 0.89 – 0.91. The results of UV wavelength scanning showed that N- (4t-butylbenzoyl) -p-aminophenol had two peaks at 290 and 294 wavelengths. Yield of N-4t- butylbenzoyl-p-aminophenol was 24.35%. Keywords: N-(4t-buthylbenzoyl)-p-aminophenol, MgF2, catalyst, an antiinflamatory analgesic

The Efficacy of Watermelon (Citrullus lanatus) Rind Extract in Healing Burns in Balb/C Male Mice Megahandayani, Siti Wahyuputri; Mahastari, Nur Lailiyah Yoan; Lasmono, Roisa Zakia Zahra; Jannah, Siti Nur; Affifah, Virmin Rahma; Siddiq, Hadi Barru Hakam Fajar
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 1 (2023): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i1.5241

Burns are skin tissue damage that occurs as a result of direct contact with a heat source. One of the natural treatments for burns is watermelon (Citrullus lanatus) rind. Watermelon rind contains citrulline, an alkaloid that plays a role in wound healing. This study aims to explore the potential of watermelon rind to become extract gel as a burn remover in male Balb/C strain mice. This research method is a true experiment that begins with the preparation of watermelon rind extract by maceration with ethanol. Furthermore, the polyphenol, flavonoid, saponin, and alkaloid content of the extract was identified through the phytochemical screening. The next stage was the preparation of a gel with three variations of extract concentrations, namely 25%, 50%, and 75% w/v. The gels were characterized by organoleptic, pH, and spreadability. The final stage tested the gel’s activity as a burn wound healing in male Balb/C strain mice. The results showed that the extract contained saponins, polyphenols, flavonoids, and alkaloids. The spreadability test results of the gel showed that all gels met the requirements. All gels had activity against burns in male Balb/C strain mice. Thus, watermelon rind extract can be used as a medicine for burns.

Co-Authors Affifah, Virmin Rahma Agnis Pondineka Ria Aditama Anies Rohman Dwijayanti Asa Falahi Asa Falahi Azizah , Siti Nur Denok Risky Ayu , Paramita Denok Risky Ayu Paramita Dewi Rashati Dewi Rashati Dewi Riskha Nurmalasari Dewi Riskha Nurmalasari Eryani, Mikhania Christiningtyas Fiki Jazilah Ika Putri Apriliyanti Kukuh Judy Handojo Lasmono, Roisa Zakia Zahra Mahastari, Nur Lailiyah Yoan Megahandayani, Siti Wahyuputri Noer Layla Fitri Ani Rashati, Dewi Risma Khoiro Safitri rosida hari Rosida Rosida Rossetyowati , Diyan Ajeng Siti Nur Azizah Siti Nur Azizah Siti Nur Jannah Suryaningsih, Farida

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