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All Journal Journal of Food and Pharmaceutical Science El-Hayah : Jurnal Biologi EGALITA Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Journal of Islamic Medicine Journal of Food and Pharmaceutical Sciences Journal of Research on Community Engagement
Anik Listiyana
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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The Profile of Anticancer Activities of Sambiloto Extract (Andrographis paniculata Nees) from Several Locations in East Java Roihatul Mutiah; Fina Luthfiana; Arief Suryadinata; Wirda Anggraini; Anik Listiyana
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.647

Abstract

Sambiloto (Andrographis paniculata Nees) contains andrographolid compound which has potentialas an anticancer. The difference of growth location has affected the distinction of metabolite content. Thisstudy aims to determine the profile of anticancer activities of A. paniculata extract from several locations inEast Java. The extracts from several locations were tested for activity on T47D cancer cell using MTT assaymethod. Thus, the result of this study describes that A. paniculata extract from several different locations doesnot provide significantly different anticancer activities with the amount of (p>0.05). The extracts which havemoderate anticancer activity were A. paniculata extracts from Selopuro Subdistrict Blitar Regency, SingosariSubdistrict Malang Regency, Lowokwaru Subdistrict Malang City, Klojen Subdistrict Malang City,Purwodadi Subdistrict Pasuruan Regency, Purwosari Subdistrict Pasuruan Regency, and PandaanSubdistrict Pasuruan Regency
Pemanfaatan Sabun Antiseptik Herbal sebagai Upaya Menjaga Kesetabilan Ekonomi dan Kesehatan Selama Pandemi di Kelurahan Merjosari Malang Kusmiyati, Nur; Listiyana, Anik; Zahroh, Nuzulul Furoida Imarotu; Wicaksono, Septian Tri
JRCE (Journal of Research on Community Engagement) Vol 3, No 1 (2021): Journal of Research on Community Engagement
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jrce.v3i1.15099

Abstract

Ibu-ibu di Kelurahan Merjosari RW 05 Lowokwaru Malang merupakan ibu rumah tangga dan rata-rata memiliki penghasilan rendah. Masyarakat tersebut mengeluhkan tentang sulitnya mendapatkan penghasilan dan mencari pekerjaan di masa pandemi seperti ini karena sebagian besar suami (kepala keluarga) terkena PHK. Untuk itu, masyarakat dituntut melakukan usaha secara mandiri salah satunya dengan pembuatan sabun antiseptik dengan memanfaatkan tanaman herbal yang tumbuh di depan rumah sebagai upaya menjaga kesetabilan ekonomi keluarga dan kesehatan selama pandemi. Metode yang digunakan adalah persiapan kegiatan, sosialisasi, pelatihan dan pendampingan. Evaluasi dilakukan dengan cara mengamati kinerja setiap peserta pada akhir kegiatan. Indikator pencapaian yang digunakan untuk menyatakan keberhasilan pengabdian adalah apabila setiap peserta sudah dapat membuat atau menghasilkan minimal satu sabun antiseptik dari tanaman herbal. Selain itu, juga dinilai dari hasil pre test dan post testnya. Masyarakat RW 05 Kelurahan Merjosari, Kecamatan Lowokwaru, Kota Malang dapat memanfaatkan tanaman-tanaman herbal berkhasiat secara etnofarmasi. Peserta telah berhasil memproduksi sabun antiseptik dari taman herbal yang ditanam di sekitar rumah sebagai produk lokal. Pelaksanaan program dengan tema atau topik yang dilakukan oleh Tim dapat direkomendasikan ke tempat lain atau sekolah maupun dilakukan di pondok pesantren.
Effects of Leaf Extract from Kesambi on TGF-B levels and Liver Histology in Rat Exposed to CCL4 Griana, Tias Pramesti; Holil, Kholifah; Vicki, Andrean; Aathifah, Aathifah; Listiyana, Anik
El-Hayah:Jurnal Biologi Vol 10, No 4 (2026): EL-HAYAH (VOL 10, NO 4 Maret 2026)
Publisher : Program Study of Biology, Science and Technology Faculty, UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v10i4.37044

Abstract

CCL4 exposure on rat resulted hepatocyte cell necrosis and activated macrofages to produce TGF-β which induced liver fibrosis. Kesambi (Schleichera oleosa (Lour.) Oken) plants have active compounds that affect the inflammatory process. The purpose of this study was to determine the effects of methanol leaf extracts from Kesambi on TGF-β levels and histologycal feature of liver in rat exposed to CCL4. Thirty male Wistar rat were divided into 5 groups, K- (injected with corn oil i.p), K+ (injected with CCL4 0,5µl/grb.w. i.p, 2x a week), and the treatment group injected with CCL4 0,5µl/grb.w. i.p, 2x a week and administrated methanol leaf extracts from kesambi dose 200mg/kgb.w. (P1), 400mg/kgb.w. (P2), and 600mg/kgb.w. (P3), everyday. After 6 weeks, the rats were dissected. Liver was taken for TGF-β levels measurement by flowcytometri, necrotizing hepatocyte cells calculation and fibrosis score by METAVIR method. TGF-β level of P3 (4,21%) was significantly different (p0,05) compared to K- (6,34%), K+ (7,21%), P1 (7,80%), and P2 (8,45%). The number of cell necrosis of K+ (54,39%) was significantly different from K- (9,62%), P2 (29,37%), and P3 (18,75%). METAVIR score calculation showed fibrosis in K+ (score 2), P1 (score 2), and P2 (score 1). The administration of methanol leaf extracts from kesambi reduced TGF-β levels and the number of necrotic hepatocyte cells and prevented the formation of liver fibrosis. 
Co-Authors AA Sudharmawan, AA Aathifah, Aathifah Alfiyah Laily Inayatin Annisa, Rahmi Arief Suryadinata Fina Luthfiana Irawati, Santia Kholifah Holil Lestari, Nia Ayu Ma'arif, Burhan Muti'ah, Roihatul Nafisa, Belia Bima Nur Kusmiyati Rahmi Annisa Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Salsabilla, Farida Rahma Suyadinata, Arief Tias Pramesti Griana Vicki, Andrean Weka Sidha Bhagawan Wicaksono, Septian Tri Wirda Anggraini Yen Yen Ari Indrawijaya Zahroh, Nuzulul Furoida Imarotu