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MOHAMAD FADJAR
Fakultas Perikanan Dan Ilmu Kelautan, Universitas Brawijaya
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Antibacterial Ability of Rhizophora mucronata Leaf Extract Against Bacterial Infections of Edwardsiella tarda Rizal Rifa'i, Ramanda Ahmad; Andayani, Sri; Fadjar, Mohamad
The Journal of Experimental Life Science Vol. 13 No. 1 (2023)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2023.013.01.02

Abstract

Edwardseilla tarda is a group of gram-negative bacteria with facultative anaerobic properties that can infect both cultivated and wild fish. Edwardseilla tarda infection causes considerable economic losses in the world. Rhizopora mucronata is a plant that is known to have the ability to produce secondary metabolites such as alkaloids and flavonoids. This study aims to determine the ability of R. mucronata to inhibit the growth of E. tarda as indicated by the presence of an inhibition zone and the absorbance value in the tube dilution test. The method used in this study is the disc diffusion test and the tube dilution test. The results of the phytochemical analysis showed the presence of flavonoid and alkaloid compounds in the crude extract of R. mucronata leaves. A concentration of 15.6 mg.L-1 showed a minimal inhibitory response in inhibiting the growth of E. tarda bacteria. In comparison, the concentration of 56 mg.L-1 showed the highest inhibitory response in inhibiting the growth of E. tarda bacteria. It indicates that the compounds contained in R. mucronata can be used as alternative ingredients in medicine to treat E. tarda bacterial infections. Keywords: Alkaloid, Antibacterial, E. tarda, Flavonoid, R. mucronata.
Uji Viabilitas Kandidat Vaksin Bakteri Aeromonas Hydrophila Menggunakan Metode Formalin-Killed dengan Konsentrasi Berbeda: Viability Assay of Aeromonas Hydrophila as Candidate Vaccine Using Formalin-Killed Method at Different Concentration Herlina, Cucun; Maftuch, Maftuch; Fadjar, Mohamad
JFMR (Journal of Fisheries and Marine Research) Vol. 9 No. 1 (2025): JFMR on March
Publisher : Faculty of Fisheries and Marine Science, Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jfmr.2025.009.01.7

Abstract

Salah satu upaya pencegahan yang dapat dilakukan untuk mengatasi penyakit pada ikan yaitu menumbuhkan kekebalan seperti vaksinasi karena kekebalan tubuh yang meningkat pada ikan dapat mencegah infeksi penyakit. upaya telah dilakukan untuk mengembangkan program imunisasi yang efektif dengan menggunakan vaksin yang dibuat dari sel utuh bakteri yang diinaktivasi menggunakan formalin dan/atau pemanasan Tujuan penelitian ini untuk mengetahui hasil uji viabilitas dan hasil uji adhesi sel epitel usus menggunakan vaksin inaktif formalin dengan konsentrasi berbeda. Metode dalam penelitian ini adalah metode eksperimen dengan rancangan percobaan menggunakan rancangan acak lengkap (RAL) terdiri dari 3 perlakuan (A=2%, B=3%, dan C=4%) dan kontrol dengan 3 kali ulangan. Hasil penelitian diperoleh hasil kandidat vaksin inaktif bakteri A.hydrophila sebanyak 9 ml/tabung falcon. Infeksi bakteri A. hydrophila dengan kepadatan 109 cfu/ml sebanyak 0,1 ml dengan masa pemeliharaan 1 minggu ditandai terjadi pengerasan di bagian perut dan terdapat kerusakan pada sirip punggung pada hari ketujuh. Hasil uji viabilitas menunjukkan tidak terdapat pertumbuhan koloni bakteri A. hydrophila dibandingkan dengan kontrol. Hasil uji adhesi sel epitel usus pada kontrol dan perlakuan A, B, C diperoleh rata-rata 10.3, 0.73, 0.43, dan 0.23 bakteri/10 sel epitel. Analisis uji ANOVA diperoleh nilai uji F Hitung > F Tabel, artinya perlakuan memberikan pengaruh sangat berbeda signifikan antar semua perlakuan. Hasil analisa regresi diperoleh (R2) sebesar 0.66 bahwa hubungan keterkaitan antara vaksin inaktif konsentrasi formalin berbeda dengan jumlah bakteri A. hydrophila yang menempel pada sel epitel sebesar 66%.   One preventive effort to tackle diseases in fish is by boosting immunity, such as through vaccination, as increased immunity in fish can prevent disease infections. Efforts have been made to develop effective immunization programs using vaccines made from whole bacterial cells inactivated using formalin and/or heat. The objective of this study was to determine the results of viability tests and intestinal epithelial cell adhesion tests using formalin-inactivated vaccines with different concentrations. The method used in this study was an experimental approach with a completely randomized design (CRD) consisting of three treatments (A=2%, B=3%, and C=4%) and a control, each with three replications. The study results showed that the candidate inactivated vaccine of A. hydrophila bacteria was obtained at 9 ml/falcon tube. A. hydrophila bacterial infection with a density of 10⁹ CFU/ml at 0.1 ml and a maintenance period of one week was characterized by abdominal hardening and dorsal fin damage on the seventh day. The viability test results showed no bacterial colony growth of A. hydrophila compared to the control. The intestinal epithelial cell adhesion test results for the control and treatments A, B, and C showed average bacterial adhesion of 10.3, 0.73, 0.43, and 0.23 bacteria/10 epithelial cells, respectively. ANOVA test analysis showed that the calculated F-value was greater than the table F-value, indicating a highly significant effect among all treatments. Regression analysis resulted in an R² value of 0.66, suggesting that 66% of the variation in the adhesion of A. hydrophila bacteria to epithelial cells was associated with different formalin concentrations in the inactivated vaccine.
Perbandingan Efisiensi Energi Sistem Aerasi Dan Sirkulasi Air Pada Budidaya Skala Kecil Dengan Kondisi Oksigen Terlarut Awal Berbeda Pramudia, Zulkisam; Valina, Rahmi; Fadjar, Mohamad; Rangkuti, Rizky Fadilla Agustin; Kurniawan, Andi
Jurnal Aquaculture Indonesia Vol 4, No 2 (2025)
Publisher : Prodi Akuakultur Fakultas Perikanan Universitas Dharmawangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46576/jai.v4i2.6757

Abstract

Efisiensi sistem aerasi menjadi aspek krusial dalam budidaya perikanan skala kecil, terutama untuk menjaga kadar oksigen terlarut atau Dissolved Oxygen (DO) tetap optimal. Penelitian ini bertujuan membandingkan performa dan efisiensi energi aerator diffuser dan pompa sirkulasi dalam meningkatkan DO pada kolam fiber 1000 L selama 24 jam, dengan kondisi DO awal rendah. Dua perlakuan (P1: aerator diffuser dan P2: pompa sirkulasi) masing-masing diulang tiga kali, serta satu kontrol tanpa perlakuan. Hasil pengukuran DO dianalisis menggunakan ANOVA satu arah dengan uji lanjut BNT. Hasil menunjukkan bahwa terdapat perbedaan yang signifikan (p < 0,05) antar perlakuan. Aerator diffuser (ΔDO = 3,50 mg/L) memberikan peningkatan DO tertinggi dan efisiensi energi 4,17 mg/L per kWh, lebih baik dibanding pompa sirkulasi (ΔDO = 2,70 mg/L; 3,21 mg/L per kWh). Kontrol menunjukkan penurunan DO alami sebesar 0,72 mg/L. Temuan ini menunjukkan bahwa aerator diffuser lebih efektif dan efisien secara energi dalam meningkatkan DO, serta lebih cocok diterapkan pada unit budidaya skala kecil
EFECT OF LASERPUNCTURE INDUCTION TO INCREASE GSI AND HSI MALE CATFISH BROODSTOCKS Hariani, Dyah; Purnama, Erlix Rachmad; Purnama, Tarsan; Fadjar, Mohamad
JFMR (Journal of Fisheries and Marine Research) Vol. 4 No. 1 (2020): JFMR
Publisher : Faculty of Fisheries and Marine Science, Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jfmr.2020.004.01.11

Abstract

Induction of laser puncture in the male catfish broodstock has a positive influence by increasing reproductive activity which is very helpful for the process of gonadal maturation. The contribution of laser puncture induction in accelerating gonadal maturation can be seen with an increasing in the value of Gonado Somatic Index (GSI) and Hepato Somatic Idex (HIS) indicators. The purpose of this study was to examine the effect of laser puncture induction on increasing the value of GSI and HIS male catfish broodstock. This experimental study used 48 broodstocks of one year old male catfish with a body weight of 1000-1200 g maintained in a concrete pond. The treatment consisted of 2 groups i.e. without induction and induction of laser puncture, each treatment was repeated 4 times. Laser puncture induction was performed every 15 days at the point of reproduction for 15 seconds until the 75th day. The parameters observed were GSI and HIS. The results showed that there was a highly significant increase (P <0.002) in the value of GSI and HSI in male male catfish broodtock after induced by laser puncture. Conclusion for this research was laser punctur induction at the point of reproduction in male catfish can accelerate gonadal maturation with indicators of increasing GSI and HIS values. 
TINGKAT TRANSFER OKSIGEN KINCIR AIR SELAMA PERIODE BLIND FEEDING BUDIDAYA INTENSIF UDANG PUTIH (Litopenaeus vannamei) Ariadi, Heri; Wafi, Abdul; Fadjar, Mohamad; Mahmudi, Mohammad
JFMR (Journal of Fisheries and Marine Research) Vol. 4 No. 1 (2020): JFMR
Publisher : Faculty of Fisheries and Marine Science, Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jfmr.2020.004.01.2

Abstract

Efektifitas penggunaan kincir air selama masa periode blind feeding budidaya intensif udang vannamei (Litopenaeus vannamei) merupakan salah satu kegiatan penting yang harus diperhatikan demi kelangsungan siklus budidaya yang stabil. Tujuan dari penelitian ini adalah untuk mengetahui tingkat transfer oksigen oleh kincir air serta hubunganya terhadap parameter harian kualitas air tambak. Peneltian ini dilakukan dengan konsep desain kausal ex-post facto selama 30 hari awal masa budidaya intensif udang vannamei (Litopenaeus vannamei) atau selama periode blind feeding budidaya. Hasil penelitian menunjukan bahwa nilai parameter kualitas air di lokasi tambak masih sesuai ambang batas. Sedangkan tingkat transfer oksigen oleh kincir air bersifat fluktuatif selama 30 hari masa pengamatan. Sementara dari hasil uji korelasi menunjukan bahwa hanya variabel suhu dan salinitas air memiliki keeratan hubungan yang kuat terhadap proses transfer oksigen oleh kincir. Sehingga dapat disimpulkan bahwa fluktuasi tingkat transfer oksigen oleh kincir air akan berpengaruh ataupun dipengaruhi oleh kondisi suhu dan salinitas air tambak.
In Silico Study of Betaine, Isoleucine, and DL-Stachydrine Compounds in Shipworm (Spathoteredo obtusa) Extract as an Antibacterial Agent of Aeromonas hydrophila Andi Al Furqan; Fadjar, Mohamad; Maimunah, Yunita
Journal of Aquaculture and Fish Health Vol. 14 No. 3 (2025): JAFH Vol. 14 No. 3 September 2025
Publisher : Department of Aquaculture

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jafh.v14i3.72940

Abstract

The rapid increase in freshwater commodity production is accompanied by various obstacles that pose challenges for farmers, namely, disease infections. Bacterial infection by Aeromonas hydrophila is the pathogenic agent causing Motile Aeromonas Septicemia (MAS), which can result in 100% mortality within a short period. The AhlC toxin protein in A. hydrophila bacteria plays the most critical role in the Ahl tripartite toxin, as AhIC acts as a protomer and inserts itself into one membrane layer, then binds to AhlB and AhlA to form pores in both membrane layers. Active compounds found in marine mussel extracts (Spathoteredo obtusa), particularly betaine, isoleucine, and DL-stachydrine, have the potential to inhibit the AhlC toxin protein produced by A. hydrophila bacteria. This study aims to predict the interaction between the AhlC receptor protein in A. hydrophila bacteria and the active compounds identified from the extract of shipworms (S. obtusa) using molecular docking methods. The test results showed that all three compounds met all ADME predictions, with the best binding affinity value of -4.2 kcal/mol for isoleucine and DL-stachydrine, followed by -3.5 kcal/mol for betaine. Based on the test results, there are appropriate, stable, and effective hydrogen and electrostatic charge interactions with the ligand-receptor complex (ASN:32, GLN:35, ARG:112, and ASP:116), which play a crucial role as active sites in ligand binding to the receptor.
Co-Authors Abdul Rahem Faqih Abdul Wafi Abdul Wafi, Abdul Andi Al Furqan Andi Kurniawan Asep Awaludin Prihanto Asus Maizar Suryanto H Attabik M. Amrillah Attabik Mukhammad Amrillah Ayu Winna Ramadhani BAGUS DWI HARI SETYONO Bimo Aji Nugroho Diana Aisyah Dwi Retno Andriani Dyah Hariani Happy Nursyam Heri Ariadi Herlina, Cucun Isroni, Wahyu Jefri Anjaini Jonathan Christian Wibowo Maftuch Maftuch Mohammad Mahmudi Mr. I Gede Eko Putra Sri Sentanu Ni Nyoman Dian Martini Novalina Serdiati Nuri Muahiddah Pramudia, Zulkisam Purnama, Erlix Rachmad Purnama, Tarsan R Adharyan Islamy Rangga Idris Affandi Rangkuti, Rizky Fadilla Agustin Rizal Rifa'i, Ramanda Ahmad setya widi ayuning permanasari Sri Andayani Sri Sentanu, I Gede Eko Putra Sukoso Sukoso Supriatna Tohap Simangunsong Valina, Rahmi Veryl Hasan Yuni Kilawati Yunita Maimunah