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All Journal PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman UNEJ e-Proceeding Jurnal Kimia Riset Indonesia Chimica Acta Chimica et Natura Acta Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmiah Farmasi Farmasyifa Jurnal Abdi: Media Pengabdian Kepada Masyarakat Acta Chimica Asiana Bubungan Tinggi: Jurnal Pengabdian Masyarakat Berkala Penelitian Hayati Jurnal Ilmiah Berkala Sains dan Terapan Kimia al Kimiya : Jurnal Ilmu Kimia dan Terapan Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Journal of Pharmascience
Mulyadi Tanjung
Department Of Chemistry, Faculty Of Science And Technology, Airlangga University, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Alkaloid Kuinolin dari Melicope denhamii dan Uji Aktivitas Antikankernya Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Sains dan Kesehatan Vol. 1 No. 9 (2018): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i9.61

Abstract

Dua senyawa alkaloid kuinolin terisoprenilasi yakni N-metilflindersin (1) dan flindersin (2) telah diisolasi dari daun Melicope denhamii. Struktur kedua senyawa ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antikanker senyawa 1–2 terhadap murin leukemia P-388 memperlihatkan IC50 21,06 ± 0,85 dan 4,86 ± 0,30 µg/ml dan senyawa 2 mempunyai aktivitas moderat
Alkaloid Furokuinolin dan Asam Sinamat Ter-O-Geranilasi dari Kulit Batang Melicope hookeri T.G. HARTLEY Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Sains dan Kesehatan Vol. 2 No. 1 (2019): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i1.93

Abstract

One furokuinoline alkaloid, evolitrine (1), and one cinnamate acid, trans 3-methyl-4-geranil caffeic acid (2) were isolated from the stem bark of Melicope hookeri. The structures of both compounds were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their anticancer activity against murin leukemia P-388 cells, showing their IC50 were 4,06 ± 0,15 and 4,86 ± 0,30 µg/ml, and two compounds showed moderate activity.
Senyawa Alkaloid Furokuinolin dari Kulit Batang Zanthoxylum acanthopodium DC Tjitjik Tjahjandarie; Alfiah Nur Irza Gunawan; Ratih Dewi Saputri; Mulyadi Tanjung
Jurnal Sains dan Kesehatan Vol. 2 No. 2 (2019): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i2.121

Abstract

Dua senyawa alkaloid furokuinolin, diktammin (1) dan skimmianin (2) telah berhasil diisolasi dari kulit batang Zanthoxylum acanthopodium DC. Penentuan struktur kedua senyawa alkaloid ditetapkan berdasarkan analisis spektrum UV, IR, MS, 1D dan 2D NMR. Uji aktivitas antikanker senyawa 1–2 terhadap sel murine leukemia P-388 memperlihatkan nilai IC50 10,41 dan 4,85 µg/ml.
Isolasi, Karakterisasi, dan Uji Aktivitas Antioksidan Senyawa Turunan Kuersetin dari Kulit Batang Melicope quercifolia Abror Rahman; Ifana Mahardika; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

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Abstract

Two quercetin derivatives, pachypodol (1) and ayanin (2) were isolated from the stem bark of Melicope quercifolia (B.S. William) Ridl. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antioxidant against DPPH radical showing their IC50 were 254 ± 10 and 38.55 ± 0.02 µg/mL, respectively.
Aktivitas Antimalaria Senyawa Flavanon Terisoprenilasi Dari Kulit Batang Erythrina fusca L Novi Fatmawati; Novi Anggreini; Ratih Dewi Saputri; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
Journal of Pharmascience Vol. 5 No. 1 (2018): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v5i1.5786

Abstract

ABSTRAK Dua senyawa flavanon terisoprenilasi yakni lonkokarpol A (1) dan lupinifolin (2) telah diisolasi dari kulit batang Erythrina fusca L. Struktur senyawa flavanon terisoprenilasi ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antimalarial senyawa 1–2 terhadap Plasmodium falciparum strain 3D7 memperlihatkan IC50 1,18 dan 0,82 µg/ml yang dikategorikan sangat aktif. Kata kunci : Erythrina fusca L., lonkokarpol A, lupinifolin, antimalaria ABSTRACT Two isoprenylated flavanones namely as lonchocarpol A (1) dan lupinifolin (2) were isolated from the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity. Keywords : Erythrina fusca L., lonchocarpol A, lupinifolin, antimalarial
The larvicidal activity of auraptene: oxygeranylated coumarin from Limonia acidissima L. Siti Mariyatul Ulfah; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung; Ratih Dewi Saputri; Eva Marliana
Acta Chimica Asiana Vol. 9 No. 1 (2026)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v9i1.288

Abstract

Limonia acidissima  L. (Rutaceae) is a plant rich in coumarin compounds and has been used in traditional medicine. One of the main coumarin compounds reported from the roots of this plant is auraptene (7-oxygeranylcoumarin), which has previously been reported to have antioxidant activity. With increasing cases of vector-borne diseases, especially dengue fever transmitted by Aedes aegypti, the development of effective and environmentally friendly natural larvicides is needed. This study aimed to evaluate the larvicide activity of auraptene, building on previous research. The larvicide test was carried out using the WHO larval bioassay method on third-instar A. aegypti larvae at concentrations of 25–500 ppm within an exposure time of 24 h. Mortality data were analyzed using probit analysis to determine the Lethal Concentration 50% (LC50) value. The results showed that auraptene increased larval mortality with an LC50 of 145.29 ± 0.02 ppm after 24 h of exposure. This value indicates that auraptene is classified as an active natural larvicide. In conclusion, auraptene has the potential to be developed as a natural larvicidal candidate against A. aegypti and may expand the spectrum of biological activity of coumarin compounds from L. acidissima L.
Co-Authors A. Budi Prasetyo Abror Rahman Ahmadi Jaya Permana Aldin, Muhammad Fajar Alfiah Nur Irza Gunawan Arif Yachya Devina Oktari Rahayu Dewi, Bella Kurniawati Diana Merna Eksan Ar Rasyid Eva Marliana Eva Marliana, Eva Fatiha Khairunnisa Giman Giman Hamizah Haula' Handoko Darmokoesoemo Harsasi Setyawati Hartati Hartati Ifana Mahardika Indatul Fitriyah Issaora Juni Annisa Tiara Kasih Ria Halim Jemima Syahrotul Iffah Kautsar Ul Haq Mahmiah Muhamad Fajar Aldin Muhammad Fadjar Aldin Muhammad Fajar Aldin Nanik Siti Aminah Ni’matuzahroh Ni’matuzahroh Novi Anggreini Novi Fatmawati Pratiwi Pudjiastuti Purkan Purkan Putri, Nathasa Aquila Qurrota A’yuni Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Ratih Dewi Saputri Rico Ramadhan, Rico Rino Wanandri Salam Rewa Ryan Ayub Wahjoedi Saputri, Ratih Dewi Saputri, Ratih Dewi Siti Mariyatul Ulfah Sofijan Hadi Sri Sumarsih Tjitjik Sri Tjahjandarie Tjitjik Srie Tjahjandarie Tjitjik Srie Tjahtjandarie Tjitjik Tjahjandarie Tjittik Srie Tjahjandarie Yanuardi Raharjo, Yanuardi