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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Diponegoro Journal of Nutrition College Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Journal of Biomedicine and Translational Research Mutiara Medika: Jurnal Kedokteran dan Kesehatan The Indonesian Biomedical Journal Paediatrica Indonesiana Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Bioscientia Medicina : Journal of Biomedicine and Translational Research Life Science
Nani Maharani
Department Of Pharmacology And Therapy, Faculty Of Medicine, Diponegoro University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : International Journal of Public Health Science (IJPHS)

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Maternal hair lead and cytokine pro-inflammatory effects in preterm birth Qolby, Qonita Nur; Dewantiningrum, Julian; Pramono, Besari Adi; Maharani, Nani; Nugraha, Eka Djatnika; Muniroh, Muflihatul
International Journal of Public Health Science (IJPHS) Vol 13, No 4: December 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i4.24146

Abstract

This case-control study analyzed the lead (Pb), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) levels in pregnant women with preterm birth (PTB) in Central Java, Indonesia. Hair samples from 72 pregnant women were collected non-invasively. The prenatal exposure to Pb was determined with the total reflection X-ray fluorescence (TXRF) method. Serum IL-6 and TNF-α were examined using enzyme-linked immunosorbent assays (ELISA). The Pb concentration in hair was slightly higher in women with PTB than those without PTB; however, this difference was not statistically significant. An elevated hair Pb level was not associated with increased PTB risk (OR 24.69, 95% CI 0.93–653.82, p>0.05). A serum TNF-α level ≥27 pg/ml, a serum IL-6 level ≥9 pg/ml, and the spouse’s smoking frequency were significantly associated with increased PTB risk (TNF-α OR 42.25, 95% CI 5.26–339.61; IL-6 OR 22.33, 95% CI 3.12–158.54; spouse’s smoking frequency OR 1.28, 95% CI 1.09–1.5), while the maternal hemoglobin concentration significantly decreased PTB risk (OR 0.43, 95% CI 0.2–0.927). This study demonstrates that maternal hair Pb concentration has no significant relationship with PTB. Serum TNF-α, IL-6, and the spouse’s smoking frequency potentially increased PTB risk, while the maternal hemoglobin level is a protective factor.
Co-Authors Abraham Talent Bawadi Sibarani Agustini Utari Aisy, Rihadatul Amin Husni Anjani, Gemala Ardyarini, Hikmatunnisa Tri Asri, Hairul Astika Widy Utomo, Astika Widy Awal Prasetyo Bahrudin Besari Adi Pramono Budiono, Bernardus Parish Cecilia Noviyanti Salim Dzaki Edmonda Setyawan Edi Dharmana Endang Mahati Endang Mahati Farmaditya EP Mundhofir Ferdy Kurniawan Cayami Ferry Sandra Gatot Irawan Sarosa, Gatot Irawan Hery Djagat Purnomo Hesti Triwahyu Hutami Hisatome, Ichiro Ika Pawitra Miranti Indriyati, Rita Intan Rahmania Eka Dini Jaeri, Santoso Julian Dewantiningrum Kuwabara, Masanari Li, Peili M Ali Sobirin Manda Petrina Martin Adhitya Subagio Meita Hendrianingtyas Muhammad Thifan Satyagraha Muniroh, Muflihatul Neni Susilaningsih Ninomiya, Haruaki Nugraha, Eka Djatnika Pratama, Reza Dian Qolby, Qonita Nur Qorina Putri Srisantoso Rahajeng, Herera Rayvita AN Meagratia Rebriarina Hapsari Retnaningsih Retnaningsih Reza Dian Pratama Rizky Aditya Fardhani Ryco Giftyan Ardika Selamat Budijitno Sihombing, Nydia Rena Benita Sultana MH Faradz Surya Utoyo, Frederick Taufiq, Fikri Tri Indah Winarni Udadi Sadhana, Udadi Udin Bahrudin Udin Bahrudin, Udin Wibowo, Erwin Widiastiti, Nyoman Suci Widyastuti, Esti Wiwik Lestari Yan Wisnu Prajoko Yora Nindita Yuriz Bakhtiar