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Journal : Science Midwifery

The immunomodulatory activity of dioscorea alata on spleen histology of rats induced with 50% alcohol Makiyah, Sri Nabawiyati Nurul; Zahra, Adelia Nabilah
Science Midwifery Vol 13 No 1 (2025): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i1.1865

Abstract

Dioscorea alata is frequently consumed and has several health advantages. The immune system-protecting spleen may be protected by bioactive substances in Dioscorea alata tubers. This study examined the influence of immunomodulatory ethanol extract of Dioscorea alata (EEDA) on the diameter of the white pulp of the spleen in 50% alcohol-induced rats (Rattus norvegicus). This research is quasi-experimental using post-test only controlled group design. Twenty-five Rattus norvegicus were separated into five groups. The normal control group (C) received Carboxymextyl Cellulose (CMC), the negative control group (NC) received CMC and 50% alcohol, and three groups received EEDA at doses of 50, 250, and 500 mg/kg for 14 days and 50% alcohol. The diameter of the white pulp of the spleen data analyzed with Kruskal-Wallis and Mann-Whitney tests. The study found a significantly increase in the diameter of the white pulp of the spleen (p<0.05) in the negative control group, EEDA doses of 50 and 250 mg/kg. The control group and EEDA doses 500 mg/kg groups had smaller the diameter of the white pulp of the spleen. The conclusions of this research proved that EEDA has an immunomodulatory activity, EEDA was immunostimulant at doses 50 and 250 mg/kg and immunosuppressant at doses 500 mg/kg.
Co-Authors Ahkam, Ahmad Hafidul Ahsanudin Attamimi Alysfiska Dhiffa Wijaya Anastasia Endar Widyaningsih Anjarwati Anjarwati, Anjarwati Ardiyanti, Devi Arie Nofariyandi Arief Darmawan Arifah, Rizka Ulfatin Asifa, Nadia Nur Belinda, Febri Akhmad Belinda, Febri Akhmad Cendhikalistya, Gustrin Oktaviayu Chapsoh, Zannuba Aisyah Danantika, Wiriasti Devi, Rizky Revinda Dewi Puspita Dewi Rokhanawati, Dewi Dewi, Melissa Kumala Fatmawati, Elis Favorenda, Adie Fitra Fitra, Bayu Kurniawan Fitra, Bayu Kurniawan Galih, Intan Kusuma Ayu Setyaning Gregia Salsabila Wulandari Haqiqoh, Habbatul Hendri Okarisman, Hendri HNFS, Marsetyawan HNFS, Marsetyawan Husain, Mayfuza Irwan Embang Walanda Irwan Embang Walanda Istianah, Siti Iswantiah . Iswantiah ., Iswantiah Kartini, Farida Kita, Masaki Laili Nur Hidayati, Laili Liza Wijaya Meilandani, Santin Moch Sasmito Djati Muhammad Iqbal Inshafuddin Rahmatullah Muhammad Izzatul Imaduddin Imaduddin Muhammad Kurniawan Nadirrafi, Muhammad Afif Nafi'ah, Fadila Nurun Noviarini, Yuriswati Nurul Hidayah, Fitria Pongoh, Senny Pravitasari, Ria Prinarbaningrum, Arinta Rahmadhia, Safinta Nurinda Rainy Iszamriach riansih, chici Risdiana, Nurvita Salsabila, Unik Hanifah Sartika Puspita Setyawati, Ika Sherly Usman Soedjono Aswin Sri Tasminatun Sriyati Sriyati Sucianto, A.B.I. Sukati Sarmin Suryandari, Galuh Tety Septiani Tinartayu, Seshy Tri Pitara Mahanggoro Tri Wulandari Kesetyaningsih Vania Rahmawati Wardhani, Ulinna'ma Hayati Warsiti Warsiti Willynia, Anggita Nur Cahya Wiwit Sugiarti Wulan Wijaya Wulan Wulandari, Estiyani Zahra, Adelia Nabilah Zamzam, Putra Alifa