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Melani Melani
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Journal : Jurnal Sehat Indonesia (JUSINDO)

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Differences in the Effects of Chlorhexidine on Optical Density and Colony Count Between Carbapenem-Sensitive and Carbapenem-Resistant Acinetobacter baumannii Strains Melani, Melani
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 2 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

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Abstract

Acinetobacter baumannii is a significant nosocomial pathogen with increasing carbapenem resistance. Chlorhexidine is a widely used antiseptic, but its efficacy against carbapenem-resistant strains remains unclear. This study aimed to compare the effects of chlorhexidine on optical density (OD) and colony count between carbapenem-sensitive and carbapenem-resistant A. baumannii strains. An experimental laboratory study was conducted using A. baumannii strains (sensitive and carbapenem-resistant). The strains were exposed to chlorhexidine (0.25% and 0.5%) for 20–120 seconds. OD was measured spectrophotometrically, and colony counts (CFU/mL) were determined after incubation. Data were analyzed using the Kruskal-Wallis test. Carbapenem-resistant strains showed higher tolerance to chlorhexidine, with slower reductions in OD and colony counts compared to sensitive strains. Significant differences were observed in colony counts after exposure to 0.5% chlorhexidine for ≥60 seconds (p < 0.05). OD values were less sensitive to exposure duration but varied significantly with concentration (p < 0.05). Chlorhexidine remains effective against carbapenem-resistant A. baumannii, but higher concentrations (0.5%) and longer exposure times (≥60 seconds) are required for optimal eradication. These findings support tailored antiseptic protocols in clinical settings with high resistance prevalence.
Co-Authors ADHE SAPUTRA, ADHE Aprilla, Nia Daud Siliwangi Saribun Disemadi, Hari Sutra Divianis, Giatri Eka Danik Prahastiwi Esti Margiyanti Utami Fadli, Bagus Muhammad Feny Wartisa Grafitte Decheline, Grafitte Ikra, Ikra Iwa, Jatmika Jaya, Nyoman Serikat Putra Karimah, Rima Hikmatul Khuzaima, Nabila D. Kormil Saputra Kurniyanto, Alif Madani, Awanda OP. Mieke Rochimi Setiawati Muhamad Azis Firdaus Mutho'a, Achmad Yudhistira Nislawaty, Nislawaty Putra, Aldo Yuliano Mas Rachmatullaily Tinakartika Rinda Rif’an, Muhammad Riki, Wicaksono Aditya Septiani, Wini Sobana, Dadang Husen Sofyan, Annisa Putri Sumarna Sumarna Suryati, Ida Susanti, Illa Syihabudin, Dedeng Wahyudin Wahyudin Wartisa, Feny Wulandari, Herlina Yayat Sudrajat Zalfa Ramadhan, Muhammad Fais