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Systematic Literature Review: Efektivitas Ekstrak Kopi sebagai Antioksidan dalam Mengatasi Photoaging Ratri, Oktavia Lestyaning; Ebtavanny, Tamara Gusti; Puspita, Oktavia Eka
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.9

Aging of the skin due to exposure of UV rays is referred as photoaging.Â Photoaging causes dry skin, wrinkles, darker skin pigmentation, and reduced skin firmness. The effect of photoaging can be treated by compounds that have antioxidant activity. Coffee contains polyphenols (caffeic acid and chlorogenic acid) which can inhibit the formation of ROS free radicals. This makes coffee an antioxidant potential in photoaging treatment. This study aims to determine the effectiveness of coffee extract as an antioxidant in photoaging treatment. The method used in this study is Systematic Literature Review. A comprehensive literature search was conducted using the Harzing's Publish or Perish application on several databases, such as Google Scholar, PubMed, Scopus, and Crossref using the keywords "coffee AND antioxidant AND ultraviolet AND photoaging". The article selection flow used the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) protocol. The total search results were 1202 articles, and there were 6 research articles that matched the inclusion and exclusion criteria that had been set. The results of this study concluded that coffee extract can be used as an antioxidant in photoaging treatment. The effectiveness of coffee extract as an antioxidant in photoaging treatment was demonstrated by reducing the expression of MMPs, increasing the expression of type 1 procollage, reducing the area of wrinkles, and reducing TEWL. Coffee leaf extract decreased the expression of MMPs (MMP-1 Â¯ 50%, MMP-3 Â¯ 10% to 60%, MMP-9 Â¯ 30% to 50%) and increased type 1 procollagen 60%. Coffee bean extract decreased the expression of MMPs (MMP-1 Â¯ 5% to 60%, MMP-2 Â¯ 20% to 60%, MMP-3 Â¯ Â 30%, MMP-9 Â¯ 20% to 70%, MMP-13 Â¯ 30% to 45%), increased type 1 procollagen 10% to 60%, reduced wrinkle area 20% to 88%, and decreased TEWL 10% to 20%.

Hubungan Antara Tingkat Pengetahuan dan Ketepatan Apoteker Dalam Mengelola Obat Sisa, Obat Rusak, dan Obat Kedaluwarsa di Apotek Malang Raya Ebtavanny, Tamara Gusti; Firdauzia, Dhiana; Rachma Pramestuti, Hananditia; Lawuningtyas, Ayuk; Kurnia Illahi, Ratna
Pharmaceutical Journal of Indonesia Vol. 9 No. 1 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.009.01.8

Obat adalah komponen kefarmasian penting dalam bidang pelayanan kesehatan yang harus dijaga mutu dan kualitasnya agar tetap dalam kondisi baik sampai di tangan pasien. Dalam hal ini apoteker memiliki andil dalam menjaga mutu obat melalui pengelolaan obat yang baik dan benar. Apoteker harus memiliki pengetahuan dan ketepatan dalam pengelolaan obat sisa, obat rusak dan obat kedaluwarsa untuk mencegah penumpukannya di lingkup apotek dan masyarakat. Sehingga penelitian ini dilakukan dengan tujuan untuk mengetahui hubungan antara tingkat pengetahuan apoteker dengan ketepatannya dalam mengelola obat sisa, obat rusak dan obat kedaluwarsa di Apotek Wilayah Malang Raya. Metode penelitian observasional analitik dengan pendekatan cross sectional dilaksanakan kepada 106 Apoteker yang bekerja di apotek Wilayah Malang Raya. Kuesioner yang telah lulus uji validitas dan reliabilitas, digunakan sebagai alat ukur tingkat pengetahuan dan ketepatan dari apoteker. Penelitian ini disetujui oleh Komite Etik Penelitian Kesehatan Fakuktas Kedokteran Universitas Brawijaya dengan nomor sertifikat 114/EC/KEPK/06/2020. Penelitian menunjukkan rata-rata tingkat pengetahuan responden apoteker berada pada kategori “baik” dengan nilai 81,6%, namun pada kuesioner ketepatan dengan indikator tepat cara penyimpanan obat dan tepat cara pemusnahan obat, menunjukkan bahwa tidak terdapat responden yang masuk dalam kategori “tepat”. Analisis korelasi antara tingkat pengetahuan dan ketepatan apoteker menunjukkan nilai signifikansi (p) >0,05, yaitu sebesar 0,425. Disimpulkan dari penelitian ini, bahwa tidak ada hubungan antara tingkat pengetahuan apoteker dengan ketepatan pengelolaan obat sisa, obat rusak dan obat kedaluwarsa di Apotek wilayah Malang Raya. Kata Kunci : Apoteker, Tingkat Pengetahuan, Ketepatan, Obat Sisa, Obat Rusak, Obat Kedaluwarsa

Self-Medication using Chlorpheniramine Maleate in Karanganyar Regency, Central Java, Indonesia Fathoni, Rifqilya Nurul; Ebtavanny, Tamara Gusti; Yunita, Ema Pristi
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3207

Self-medication refers to the use of medications by a person without consulting health professionals and prescription. One of the common drugs used for self-medication is chlorpheniramine maleate (CTM), a drug indicated to relieve symptoms of allergy. However, the lack of knowledge about the indications of CTM leads to its significant misuse. Long-term effects of CTM misuse include heart rate regularity disorder, central nervous system disorders, and even coma. The purpose of this study was to analyze the correlation between sociodemographic factors and the appropriateness of CTM use for self-medication from the perspective of the experience of using CTM for self-medication. This cross-sectional study was performed in Karanganyar Regency, Central Java, Indonesia, from October to November 2022 on 117 respondents sampled randomly using cluster sampling method. A questionnaire that was already proven as valid and reliable was used. Results for the appropriateness of CTM use showed that 95.7% of respondents were in good category, 3.4% were in fair category, and 0.9% were in poor category. The hypothesis tests, which were the Somers’d test and the contingency coefficient, showed no correlation between age (p=0.242), gender (p=0.307), income level (p=0.789), experience (p=0.176), and the appropriate use of CTM for self-medication. However, there is a correlation between education level (p=0.048) and the appropriate use of CTM for self-medication, albeit very weak (r=0.065). Therefore, only the level of education affects the appropriate use of CTM for self-medication.

Workshop dan Edukasi Pemanfaatan Herbal sebagai Upaya Peningkatan Kesehatan Keluarga pada Anggota PKK: Workshop and Education on Herbal Utilization to Enhance Family Health for PKK Members Ebtavanny, Tamara Gusti; Hariadini, Ayuk Lawuningtyas; Firdaus, Favian Rafif; Achmad, Anisyah; Amalia, Thia; Nabilah, Varna Amalia; Fauzan, Evan; Azis, Umar Abdul; Wibowo, Andriani Abigail
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 4 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i4.8709

The Family Welfare Empowerment (PKK) is a community group dedicated to fostering family and societal well-being, with health being one of its key focus areas. PKK members are pivotal in enhancing family immunity, particularly during heightened risk from bacterial, viral, and other infections. The community's preference for traditional medicine, which has been empirically proven to be safe and effective, such as *Andrographis paniculata* (sambiloto) and *Curcuma longa L.* (turmeric), serves as a viable solution for boosting family immunity. This program aimed to provide education and workshops to 50 PKK members in Kendalpayak Village through education sessions, pre-and post-tests, a herbal drink preparation workshop, and follow-up consultations. The education covered topics on the immune system, the definition and application of traditional medicine, and the rational use of herbal remedies. The program results revealed a significant improvement in participants' knowledge, with average pre-test scores of 81.71 rising to 93.90 in post-tests, reflecting a 12.19% increase. Furthermore, the proportion of participants with "Good" knowledge levels rose from 75.61% to 92.68%. The workshop successfully trained participants in practical herbal preparation by demonstrating the production of three types of immune-boosting herbal drinks, supported by educational materials that had obtained intellectual property rights. Participant satisfaction with the program was notably high, averaging 96.06%. These results demonstrate the program's tangible benefits in enhancing community knowledge and skills, potentially supporting family health and well-being in the future.

The Knowledge and Practice in the Self-Medication Use of Topical Benzoyl Peroxide and Clindamycin Anjarwati, Riska Auliah; Hariadini, Ayuk Lawuningtyas; Ebtavanny, Tamara Gusti
Pharmaceutical Journal of Indonesia Vol. 10 No. 2 (2025)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Acne vulgaris or acne is a condition of chronic inflammation of the pilosebaceous unit. Topical clindamycin and topical benzoyl peroxide (BP) are therapy with antibacterial and anti-inflammatory effects. The pharmacist's role during self-medication services and the knowledge possessed by the patient are needed to produce the correct drug use. This study aimed to determine the relationship between knowledge and accuracy of using topical benzoyl peroxide and clindamycin self-medication either alone or in combination with students of Brawijaya University with Acne vulgaris. This research was conducted online which is observational analytic with a cross-sectional design. The sampling technique used was a purposive sampling technique based on inclusion and exclusion criteria and 105 respondents were obtained. Student knowledge was measured using a Guttman scale questionnaire with right and wrong answer choices. The accuracy of student use was measured using semi-open questions with multiple-choice answers and essays. The results showed that the respondents had good knowledge (79.05%), sufficient (20.95%), and less (0.00%). Meanwhile, the results of the accuracy of the use of therapy showed that students were correct (60.00%) and not correct (40.00%). The results of the Spearman correlation test showed a significant positive relationship between knowledge and the accuracy of using self-medicated topical benzoyl peroxide and clindamycin therapy (p = 0.012; r = 0.245). Based on the study results, it is concluded that there is a significant positive relationship between knowledge and the accuracy of using self-medicated topical benzoyl peroxide and clindamycin therapy in Brawijaya University students with Acne vulgaris. Keyword: Acne vulgaris, knowledge, practice, benzoyl peroxide, clindamycin

Pharmacist-Led Pediatric Diarrhea Management: A Systematic Review of Knowledge and Recommendation Appropriateness Ebtavanny, Tamara Gusti; Fitri, Salsabilah Aida; Suhartono, Suhartono; Hariadini, Ayuk Lawuningtyas
Pharmaceutical Journal of Indonesia Vol. 10 No. 2 (2025)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Diarrhea remains a leading cause of morbidity and mortality among children, particularly in areas with inadequate sanitation. Community pharmacists often serve as the first point of care, making their role crucial in ensuring appropriate, guideline-based management of pediatric diarrhea. This systematic review aimed to evaluate pharmacists’ knowledge and the appropriateness of their recommendations for treating pediatric diarrhea. A systematic literature review was conducted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol. Searches were performed via Harzing’s Publish or Perish on Google Scholar, PubMed, and Crossref using keywords: "diarrhea" AND "pediatric" OR "children" AND "treatment" AND "pharmacist" AND "knowledge". Ten articles met the inclusion criteria. Among five studies assessing knowledge, three reported generally good pharmacist knowledge, while two showed significant improvements post-intervention (P < 0.001 and P < 0.01). Pharmacists demonstrated good understanding of ORS use, treatment options, and non-pharmacological advice. However, they showed limited ability to identify signs of dehydration. In terms of treatment recommendations, six of nine studies reported inappropriate use of antibiotics, with few pharmacists recommending WHO-recommended therapies (ORS and zinc). In contrast, five studies found that non-pharmacological advice was the primary approach. Three factors significantly influenced knowledge and appropriateness: patient assessment (P = 0.006), self-medication training (P < 0.0005), and year of graduation (P = 0.004). Pharmacists generally possess good knowledge in certain aspects of pediatric diarrhea management, but often make inappropriate treatment recommendations. Structured education and training are needed to improve clinical decision-making and adherence to treatment guidelines.

The Knowledge and Practice in the Self-Medication Use of Topical Benzoyl Peroxide and Clindamycin Anjarwati, Riska Auliah; Hariadini, Ayuk Lawuningtyas; Ebtavanny, Tamara Gusti
Pharmaceutical Journal of Indonesia Vol. 10 No. 2 (2025)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Acne vulgaris or acne is a condition of chronic inflammation of the pilosebaceous unit. Topical clindamycin and topical benzoyl peroxide (BP) are therapy with antibacterial and anti-inflammatory effects. The pharmacist's role during self-medication services and the knowledge possessed by the patient are needed to produce the correct drug use. This study aimed to determine the relationship between knowledge and accuracy of using topical benzoyl peroxide and clindamycin self-medication either alone or in combination with students of Brawijaya University with Acne vulgaris. This research was conducted online which is observational analytic with a cross-sectional design. The sampling technique used was a purposive sampling technique based on inclusion and exclusion criteria and 105 respondents were obtained. Student knowledge was measured using a Guttman scale questionnaire with right and wrong answer choices. The accuracy of student use was measured using semi-open questions with multiple-choice answers and essays. The results showed that the respondents had good knowledge (79.05%), sufficient (20.95%), and less (0.00%). Meanwhile, the results of the accuracy of the use of therapy showed that students were correct (60.00%) and not correct (40.00%). The results of the Spearman correlation test showed a significant positive relationship between knowledge and the accuracy of using self-medicated topical benzoyl peroxide and clindamycin therapy (p = 0.012; r = 0.245). Based on the study results, it is concluded that there is a significant positive relationship between knowledge and the accuracy of using self-medicated topical benzoyl peroxide and clindamycin therapy in Brawijaya University students with Acne vulgaris. Keyword: Acne vulgaris, knowledge, practice, benzoyl peroxide, clindamycin

Pharmacist-Led Pediatric Diarrhea Management: A Systematic Review of Knowledge and Recommendation Appropriateness Ebtavanny, Tamara Gusti; Fitri, Salsabilah Aida; Suhartono, Suhartono; Hariadini, Ayuk Lawuningtyas
Pharmaceutical Journal of Indonesia Vol. 10 No. 2 (2025)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Diarrhea remains a leading cause of morbidity and mortality among children, particularly in areas with inadequate sanitation. Community pharmacists often serve as the first point of care, making their role crucial in ensuring appropriate, guideline-based management of pediatric diarrhea. This systematic review aimed to evaluate pharmacists’ knowledge and the appropriateness of their recommendations for treating pediatric diarrhea. A systematic literature review was conducted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol. Searches were performed via Harzing’s Publish or Perish on Google Scholar, PubMed, and Crossref using keywords: "diarrhea" AND "pediatric" OR "children" AND "treatment" AND "pharmacist" AND "knowledge". Ten articles met the inclusion criteria. Among five studies assessing knowledge, three reported generally good pharmacist knowledge, while two showed significant improvements post-intervention (P < 0.001 and P < 0.01). Pharmacists demonstrated good understanding of ORS use, treatment options, and non-pharmacological advice. However, they showed limited ability to identify signs of dehydration. In terms of treatment recommendations, six of nine studies reported inappropriate use of antibiotics, with few pharmacists recommending WHO-recommended therapies (ORS and zinc). In contrast, five studies found that non-pharmacological advice was the primary approach. Three factors significantly influenced knowledge and appropriateness: patient assessment (P = 0.006), self-medication training (P < 0.0005), and year of graduation (P = 0.004). Pharmacists generally possess good knowledge in certain aspects of pediatric diarrhea management, but often make inappropriate treatment recommendations. Structured education and training are needed to improve clinical decision-making and adherence to treatment guidelines.

Penguatan Kelompok Kader dan Produksi Produk Sabun dan Hand sanitizer Homemade di Dusun Gondang, Singosari Puspita, Oktavia Eka; Adianingsih, Oktavia Rahayu; Ihsan, Bachtiar Rifai Pratita; Yurina, Valentina; Ebtavanny, Tamara Gusti
TRI DHARMA MANDIRI: Dissemination and Downstreaming of Research to the Community (Journal of Community Engagement) Vol 2 No 1 (2022)
Publisher : SMONAGENES Research Center, Univeritas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2022.002.01.30

Kegiatan mencuci tangan dengan air mengalir dan sabun atau menggunakan hand sanitizer berbasis alkohol merupakan bagian dari protokol kesehatan sebagai upaya yang dilakukan untuk mencegah penyebaran virus penyebab COVID-19. Untuk menanggapi kebutuhan masyarakat mengenai ketersediaan sabun dan hand sanitizer, maka dilakukan kegiatan pengabdian kepada masyarakat yang bertujuan untuk meningkatkan kemampuan masyarakat dalam memproduksi sabun dan hand sanitizer secara mandiri. Kegiatan ini dilakukan selama bulan Juni hingga Oktober 2021 dengan target sasaran yaitu kelompok Karang Taruna Ketup4t dan PKK di Dusun Gondang, Desa Randuagung, Kecamatan Singosari, Kabupaten Malang, Jawa Timur. Metode pelaksanaan kegiatan adalah participation action research dengan cara pemberian edukasi pembuatan produk dan pendampingan anggota kelompok kader dalam proses pembuatan produk. Hasil utama kegiatan ini adalah kader mampu memproduksi sabun dan hand sanitizer homemade. Kesimpulan dari kegiatan ini adalah Kelompok Kader di Dusun Gondang mampu memproduksi sabun dan hand sanitizer homemade.

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