Article Per Year (5 Year)
p-Index From 2021 - 2026
1.116
P-Index
This Author published in this journals
All Journal The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Indonesian Journal of Cardiology Narra J Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Aryono Hendarto
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia RS Dr. Cipto Mangunkusumo Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 30 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : The Indonesian Biomedical Journal

 1 
Glucose and Lipid Profiles in Adolescents with Thalassemia Major and Its Association with Iron Overload in Specific Organs Aryono Hendarto; Teny Tjitra Sari; Ludi Dhyani Rahmartani; Anggia Widyasari; Stephen Diah Iskandar
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.693

Abstract

BACKGROUND: Organ damage due to iron toxicity is one factor that increases the risk of getting cardiovascular and metabolic diseases in thalassemia patient. This study aims to determine glucose and lipid profiles in adolescents with thalassemia major and its association with iron overload in pancreas and liver.METHODS: This was a cross sectional study. Subjects were thalassemia major adolescents without any confounding factors that may affect glucose and lipid levels. Blood samples were collected to measure the glucose level, lipid profiles, ferritin level and transferrin saturation. T2-Magnetic Resonance Imaging was used to evaluate the iron overload in organs.RESULTS: From a total of 60 subjects, diabetes mellitus was diagnosed in 1 subject and impaired fasting glucose was diagnosed in 3 subjects. All subjects had high triglycerides/ high density lipoprotein-cholesterol (HDL-C) ratio, 59 subjects (98%) had low HDL-C, 18 subjects (30%) had hypertriglyceridemia, and none had abnormal high level of low density lipoprotein-cholesterol (LDL-C). The majority of subjects had ferritin ≥2,500 ng/mL (70%), mild pancreatic iron overload (56.6%), and moderate hepatic iron overload (43.8%). Degree of hyperferritinemia was not associated with glucose and lipid profiles. Blood glucose profiles were not associated with various degree of pancreatic iron overload. Similar result was also observed between lipid profiles and hepatic iron overload.CONCLUSION: Abnormal glucose and lipid profiles in thalassemia major can be found in adolescence. Normal blood glucose level isn’t necessarily associated with normal pancreatic iron deposition. Hepatic iron overload may worsen dyslipidemia in thalassemia major patients.KEYWORDS: glucose profile, lipid profile, pancreatic iron overload, hepatic iron overload, thalassemia major
Co-Authors Abdul Latief Alan R Tumbelaka Ali Khomaini Alhadar Ali Khomaini Alhadar Aman B Pulungan Anggia Widyasari Anjar Setiani Annang Giri Moelyo Antonius H. Pudjiadi Ardi Findyartini, Ardi Aria Kekalih Arwin A. P. Akib Atut Vebriasa Bambang Tridjaja AAP, Bambang Tridjaja Cut Nurul Hafifah Dadi Suyoko Dahlan Ali Musa Dalima Ari Wahono Astrawinata Damayanti Rusli Sjarif Darmawan B Setyanto Dewi Wulandari Dilawar, Ismail Dina Muktiarti, Dina Djajadiman Gatot Endang Windiastuti Fathy Pohan Frieda Handayani Kawanto Hartono Gunardi Henny Adriani Puspitasari Heri Wibowo Herlina Dimiati Hindra Irawan Satari I Dewa Gede Ariputra Irawan Mangunatmadja Irma Annisa Jeanne Vidianty Kemas Firman Ketut Dewi Kumara Wati Lisnawati Rachmadi Ludi Dhyani Rahmartani Luh Karunia Wahyuni, Luh Karunia Marsubrin, Putri Maharani Tristanita Merry Angeline Halim Mulya Rahma Karyanti, Mulya Rahma Mulyadi M. Djer Murni, Indah K. Muzal Kadim Najib Advani Najib Advani Ni Ketut Prami Rukmini Nia Kurniati Nina Dwi Putri Novie Amelia Chozie Partini P Trihono Piprim B. Yanuarso, Piprim B. Pramita Gayatri Primo Parmato Reni Fahriani Retno Asti Werdhani Rhyno Febriyanto Riki Alkamdani Rinawati Rohsiswatmo Risma K. Kaban RR Putri Zatalini Sabila Rubiana Sukardi, Rubiana Rumaisha Hasnah Ibrahim Santoso, Dara Ninggar Saptawati Bardosono Soedjatmiko Sondang Sidabutar Sri S Nasar Sri Sudaryati Nasar Stanislaus Djokomuljanto Stephen Diah Iskandar Sudigdo Sastroasmoro Sudigdo Sastroasmoro Sudung O. Pardede Sukman Tulus Putra Sukman Tulus Putra Supriatna, Novianti Susanti, Dhama S. Tania Paramita Teny Tjitra Sari, Teny Tjitra Tety Nidiawati Velanie Frida Batubara Yessi Yuniarti Yogi Prawira, Yogi Zakiudin Munasir