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Hubungan Masalah Perilaku pada Remaja dengan Irritable Bowel Syndrome Yudianita Kesuma
Sari Pediatri Vol 18, No 6 (2017)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Latar belakang. Â Irritable bowel syndrome (IBS) merupakan nyeri perut berulang pada remaja yang paling banyak terjadi. Pada remaja, IBS akan menimbulkan gangguan perilaku yang serius.Tujuan. Â Menganalisis hubungan antara masalah perilaku dengan IBS pada remaja.Metode. Penelitian potong lintang semua siswa SMA Nurul Iman. Pencatatan dilakukan meliputi karakteristik umum dan pemeriksaan fisis. Selanjutnya dilakukan uji Rome III (irritable bowel syndrome) dan PSC-17 (masalah perilaku). Analisis statistik digunakan analisis bivariat dengan uji chi-square.Hasil. Dari semua siswa SMA Nurul Iman didapatkan 180 subyek yang memenuhi kriteria inklusi dan tidak memenuhi kriteria eksklusi. Prevalensi Â IBS 58 (32,2%) subyek, terdiri atas 22 subtipe konstipasi, 23 subtipe diare, dan 13 subtipe campuran. Prevalensi Â masalah perilaku 40,6%, terdiri atas 28,9% masalah perilaku internalisasi, 2,8% masalah eksternalisasi, 0,6% masalah perilaku perhatian, dan 8,4% variasi dari 3 gangguan. Faktor risiko terjadinya IBS, antara lain, mengonsumsi daging olahan, teh, makan terburu-buru, serta di-bully. Terdapat hubungan yang bermakna antara IBS dengan masalah perilaku (p=0,001). Nilai Odds Ratio yang diberikan 3,015 (IK95%=1,580-5,754).Kesimpulan. Remaja yang mengalami IBS mempunyai risiko yang meningkat untuk terjadinya masalah perilaku.Â

Kejadian Demam Setelah Imunisasi DTwP-1 pada Anak yang Mendapat ASI dan Tidak Mendapat ASI di Kota Palembang Firdinand Firdinand; Rismarini Rismarini; Yudianita Kesuma; Kms Yakub Rahadiyanto
Sari Pediatri Vol 17, No 1 (2015)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp17.1.2015.52-8

Latar belakang. Di beberapa provinsi di Indonesia, cakupan imunisasi masih rendah. Salah satu alasan orang tua tidak memberikanimunisasi karena demam yang terjadi setelah imunisasi, khususnya imunisasi DPT. Penelitian sebelumnya menunjukkan bahwakejadian demam setelah vaksinasi dengan DTaP dapat dicegah dengan ASI eksklusif. Data mengenai pengaruh ASI terhadap kejadiandemam setelah imunisasi dengan vaksin DTwP masih sedikit.Tujuan. Mengetahui pengaruh pemberian ASI dalam mencegah demam pada anak setelah imunisasi DPT-1 di Kota Palembang.Metode. Penelitian merupakan studi kohort prospektif yang dilakukan di tujuh Puskesmas di Kota Palembang yang dipilih secara clustersampling. Sampel penelitian adalah anak usia 2-4 bulan yang mendapat imunisasi DPT-1. Anak dikelompokkan menjadi kelompokASI eksklusif, parsial, dan susu formula. Orang tua diajarkan cara mengukur suhu di rumah dan mencatat hasil pengukuran di kartuharian. Perbandingan kejadian demam antar kelompok dihitung dengan chi square test.Hasil. Didapatkan 379 bayi masuk dalam penelitian. Demam terjadi pada 246 (64,9%) anak. Jumlah anak yang mengalami demampada kelompok ASI eksklusif 73 (19,2%), ASI parsial 75 (19,7%), dan susu formula 98 (25,8%) anak (p=0,001). Risiko relatifterjadinya demam pada kelompok susu formula adalah 1,38 (IK95%: 1,16-1,65) dibandingkan kelompok ASI eksklusif dan 1,33(IK95%: 1,12-1,58) dibandingkan kelompok ASI parsial.Kesimpulan. Pemberian ASI dapat menurunkan kejadian demam setelah imunisasi DTwP-1.

Hubungan Defisiensi Besi dengan Perilaku Anak Usia Sekolah di Kota Palembang Desti Handayani; Rismarini Rismarini; Yudianita Kesuma; Rini Purnamasari; Syarif Husin
Sari Pediatri Vol 16, No 5 (2015)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Latar belakang. Prevalensi defisiensi besi anak usia sekolah di Indonesia sebesar 47,2%. Defisiensi besimenyebabkan perkembangan dan fungsi saraf terganggu, termasuk timbulnya masalah perilaku. Belum adapenelitian yang menilai hubungan defisiensi besi dan masalah perilaku anak usia sekolah di Palembang.Tujuan. Menganalisis hubungan defisiensi besi dengan masalah perilaku anak usia sekolah di Palembang.Metode. Desain penelitian deskriptif analitik dengan pendekatan cross sectional. Subjek penelitian adalahanak Sekolah Dasar (SD) usia 6-12 tahun di Palembang yang dipilih dengan multi stage random samplingpada bulan April sampai Juni 2013. Pada semua subjek penelitian dilakukan pemeriksaan fisis, laboratorium(hemoglobin, besi serum, dan saturasi transferin), dan penilaian perilaku menggunakan Pediatric SymptomChecklist (PSC) 17. Perbedaan kejadian masalah perilaku antara subjek dengan dan tanpa defisiensi besidianalisis dengan uji kai kuadrat. Faktor risiko lain yang berpengaruh dianalisis dengan regresi logistik.Hasil. Dari 125 subjek yang terpilih didapatkan prevalensi defisiensi besi 26,6%, anemia defisiensi besi25%, dan kejadian masalah perilaku 29%. Dari 33 subjek dengan defisiensi besi terdapat 20 yang memilikimasalah perilaku, sedangkan dari 81 subjek tanpa defisiensi besi terdapat 14 dengan masalah perilaku (ujikai kuadrat, p=0,001; OR 7,363; IK95%:2,978-18,203). Pada penilaian tipe perilaku, terdapat hubunganbermakna antara defisiensi besi dengan perilaku internalisasi (p=0,001, OR 7,604; IK95%:2,462-18,363).Ditemukan faktor yang paling berpengaruh terhadap perilaku, melalui analisis regresi logistik, yaitu defisiensibesi (p=0,001; adjusted OR 6,901; IK95%:2,816-16,914).Kesimpulan. Defisiensi besi merupakan faktor risiko terjadinya masalah perilaku, terutama perilakuinternalisasi.

Association between specific language impairment and behavioral disorders among preschool children Yudianita Kesuma; Rismarini Rismarini; Theodorus Theodorus; Mutiara Budi Azhar
Paediatrica Indonesiana Vol 54 No 1 (2014): January 2014
Publisher : Indonesian Pediatric Society

BackgroundSpecific language impairment (SU) is the mostcommon developmental disorder in preschool children, causingserious impairmentE on behavioral development. To date, there havebeen few studies on SU and behavioral disorders in Palembang.ObjectiveTo assess for an association between SU and behavioraldisorders in preschool children in Palembang.MethodsSubjects in this cross-sectional study were childrenwho attended kindergarten. Their general characteristics,developmental history and physical examination results (includingweight and height) were recorded. We administered the SpecificLanguage Impairment checklist for language impairment and thePediatric Symptom Checklist 17 (PSC 17) for behavioral disorders.Data was analyzed by Chi-square test.ResultsWe studied 1,340 children from21 kinderg:irtens in Palembang.Prevalence of SU was 12.9%, consisting of expressive languageimpairment (10.2%), receptive impairment (0.5%) and mixed languageimpairment (2 .2%). The prevalence of behavioral disorders was15.1 %, consisting of internalization disorder (6.0%), externalizationdisorder (5.0%), attentive disorder (0.4%), and various combinationsof three disorders (3. 7%). A highly significant association was foundbetween SU and behavioral disorders (P=0.000; OR=2.082; 95%CI 1. 419-3 .053. Expressive language impairment was associated withexternalization and mixed behavioral disorders. Mixed languageimpairment was associated with internalization, attentive, and mixedbehavioral disorders. Howevei; receptive language disorder was notassociated with any behavioral disorders.ConclusionSU is significantly as sociated with behavioraldisorders. With regards to the individual SU types, expressivelanguage impairment is associated with externalization and mixedbehavioral disorders; mixed language impairment is associatedwith internalization, attentive and mixed behavioral disorders;but receptive language disorder is not associated with behavioraldisorders.

Depression in children with thalassemia major: prevalence and contributing factors Venty Venty; Rismarini Rismarini; Dian Puspitasari; Yudianita Kesuma; Raden Muhammad Indra
Paediatrica Indonesiana Vol 58 No 6 (2018): November 2018
Publisher : Indonesian Pediatric Society

Background Thalassemia major is a chronic disease requiring lifetime treatment. A recent study showed that 11-62% of thalassemia patients developed depression, which is associated with high morbidity and mortality. Understanding the extent of the problem related to depression and its contributing factors is important for early management. Objective To determine the prevalence and contributing factors for depression in children with thalassemia major. Methods This cross-sectional observational analytic study included thalassemia major patients aged 7 to <18 years in the Department of Child Health, Dr. Moh. Hoesin General Hospital (RSMH) in Palembang from June to July 2018 and had received blood transfusions at least 3 times. Subjects completed the Children's Depression Inventory (CDI) questionnaire. Depression was defined as a total score > 13. Data were analyzed using SPSS for Windows ver. 22.0. Results There were 64 patients included in this study, with mean age 12 (SD 3) years and 82.8% female. Most subjects came from families with low socio-economic status and low parental education. Deferiprone was the most commonly used type of iron-chelating agent. Depression was detected in 34.4% of respondents. Multivariate analysis revealed that factors affecting depression in children with thalassemia major were low maternal education (OR 4.014; 95%CI 1.066 to 15.112) and use of deferasirox (OR 4.129; 95%CI 1.168 to 14.601). Conclusion Prevalence of depression in children with thalassemia major is 34.4%. Low maternal education and deferasirox use as an iron-chelating agent are associated with depression in children with thalassemia major.

The Diagnostic Value of Neutrophil-Lymphocyte Ratio in Diagnosis of Autism Spectrum Disorders Nurmalia Purnama Sari; Yudianita K; M. Rafli Haiqal; M. Fadill Akbar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 3 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i3.1597

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, progressive disruption of brain development and synaptic connections, which causes impaired communication and behavioral disorders. However, the etiology is unknown. A damaged perinatal environment causes chronic nerve inflammation in genetically susceptible children of ASD, dysregulation of the immune system, which leads to ASD. The ratio of Neutrophil to Lymphocyte (NLR) as one of the markers of inflammation is frequently associated with inflammation-related psychiatric diseases and is potentially used as a diagnostic instrument. A cross-sectional study was carried out from June to November 2019 by using medical records of Outpatients with growth and development disorders and ASD and involving 69 children. The diagnosis of ASD was confirmed by the fifth edition Diagnostic and Manual of Mental Disorders criteria (DSM-V). A routine hematology test was carried out with a flow cytometry method. Diagnostic tests were performed in 43 children with developmental disorders (mean NLR 1.01±0.07) and 26 ASD children (mean NLR 1.02±0.06), with a cut-off value of 0.68. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of NLR were 84.62%; 27.9%; 41.51%; 25%; and 50.2%, respectively. Neutrophil to lymphocyte is sensitive to diagnose ASD but its accuracy is low. Immune dysfunction and complex neurodevelopmental disorders that are affected by chronic inflammation play a role in the occurrence of ASD. Other inflammatory markers are needed to improve the accuracy of laboratory tests to diagnose ASD.

Effect of Screentime during School From Home Yudianita Kesuma
Conferences of Medical Sciences Dies Natalis Vol. 2 No. 1 (2020): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.714 KB)

The COVID-19 pandemic has significantly changed people's lives around the world. Thousands of millions of people around the world must stay at home to protect and prevent Covid-19 transmission. Covid-19 cases in children have also increased even though the prevalence rate is still lower than adult cases.The government through the Ministry of Education and Culture made recommendations during the Covid-19 pandemic to conduct distance / online learning, so that the teaching and learning process can still take place even though you don't have to come to school. This requires a separate adaptation process for the continuity of online learning to run well, with digital media as a learning tool. Screen time or staring at the screen for children has a recommended time limit, because if it is used beyond the safe time it will have a serious impact on the child's health and development. It takes the role of parents, teachers / schools, the community, and policy makers to oversee the process of using digital media in distance learning during the Covid-19 pandemic.In conclusion, the use of digital media during the pandemic is increasing, especially for children, apart from being a medium for distance learning as well as a medium for entertainment. This must be properly monitored by parents, teachers / schools, the community, and policy makers so that the adverse effects of using digital media do not occur according to WHO / IDAI recommendations.

SOCIAL SERVICE PROMOTION, COUNSELING AND EDUCATION COVID-19 VACCINATION FOR ADOLESCENTS Yudianita Kesuma
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (245.049 KB)

The increasing number of incidences and deaths of COVID-19 in Indonesia, especially in South Sumatra which ranks 3rd in Indonesia. For this reason, in addition to efforts to break the chain of transmission of COVID-19 in the form of the Enforcement of Restrictions on Community Activities, which causes all economic, educational, and religious activities to be hampered. For this reason, to reduce the incidence and mortality due to COVID-19, it is in the form of COVID-19 vaccination, in addition to increasing immunity, it also prevents the severity of the disease and reduces mortality due to COVID-19, as well as increasing herd immunity.Vaccination or immunization aims to make a person's immune system recognize and quickly fight bacteria or viruses that cause infection. The goal of the COVID-19 vaccine is to reduce morbidity and mortality due to this virus. Although not 100% able to protect a person from Coronavirus infection, this vaccine can reduce the possibility of severe symptoms and complications due to COVID-19.The Covid-19 vaccination for adolescents began to be carried out in Indonesia based on ten recommendations from IDAI (Indonesian Pediatrician Association) related to Covid-19 vaccination for children aged 12-17 years. For this reason, promotion, counseling, and education are needed to avoid doubts from parents and teenagers who will be vaccinated against COVID-19.

Effects of Fluoride Exposure During Pregnancy in Mice Brain Neurogenesis (Mus musculus) Siti Sarahdeaz Fazzaura Putri; Irfannuddin Irfannuddin; Krisna Murti; Yudianita Kesuma; Hardi Darmawan; Noriyuki Koibuchi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.720

Background: Fluoride is a type of micromineral found in teeth and bones. This mineral is also found in nature, such as in soil, water, plants, rocks, and even air. Fluoride can cross the placental barrier and diffuse into the cord blood, with a range from 60% to 91% of maternal fluoride. Maternal fluoride exposure during pregnancy and lactation can affect learning ability, memory, and expression of glutamate receptors. This study aimed to determine the effect of fluoride exposure during pregnancy and lactation on brain neurogenesis in vivo. Methods: In vivo, experimental study using mice (Mus musculus) C57BL/6 as many as 60 brood mice (20 males and 40 females) and as many as 30 offspring mice. Mice broodstock were first mated to produce offspring. During pregnancy, the female mice were exposed to fluoride (NaF). Exposure of broodstock mice to NaF was divided into 0 mg/L, 50 mg/L, 100 mg/L, and 150 mg/L exposure groups. Expression of PSD-95 protein was carried out by immunohistochemical examination of mouse brain tissue. Data analysis was carried out with the help of SPSS using univariate and bivariate methods. Results: There was a decrease in the expression of PSD-95 with increasing exposure to NaF doses during pregnancy and lactation. Giving NaF at a dose of 50 mg/L did not decrease PSD-95 expression because the results were not different from the control. In contrast, the administration of NaF doses that can reduce the expression of PSD-95 are doses of 100 and 150 mg/L. Conclusion: Fluoride exposure during pregnancy contributed to a decrease in mice brain neurogenesis, as indicated by the expression of the PSD-95 protein in the hippocampus area.

Effects of Fluoride Exposure During Pregnancy in Mice Brain Neurogenesis (Mus musculus) Siti Sarahdeaz Fazzaura Putri; Irfannuddin Irfannuddin; Krisna Murti; Yudianita Kesuma; Hardi Darmawan; Noriyuki Koibuchi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.720

Background: Fluoride is a type of micromineral found in teeth and bones. This mineral is also found in nature, such as in soil, water, plants, rocks, and even air. Fluoride can cross the placental barrier and diffuse into the cord blood, with a range from 60% to 91% of maternal fluoride. Maternal fluoride exposure during pregnancy and lactation can affect learning ability, memory, and expression of glutamate receptors. This study aimed to determine the effect of fluoride exposure during pregnancy and lactation on brain neurogenesis in vivo. Methods: In vivo, experimental study using mice (Mus musculus) C57BL/6 as many as 60 brood mice (20 males and 40 females) and as many as 30 offspring mice. Mice broodstock were first mated to produce offspring. During pregnancy, the female mice were exposed to fluoride (NaF). Exposure of broodstock mice to NaF was divided into 0 mg/L, 50 mg/L, 100 mg/L, and 150 mg/L exposure groups. Expression of PSD-95 protein was carried out by immunohistochemical examination of mouse brain tissue. Data analysis was carried out with the help of SPSS using univariate and bivariate methods. Results: There was a decrease in the expression of PSD-95 with increasing exposure to NaF doses during pregnancy and lactation. Giving NaF at a dose of 50 mg/L did not decrease PSD-95 expression because the results were not different from the control. In contrast, the administration of NaF doses that can reduce the expression of PSD-95 are doses of 100 and 150 mg/L. Conclusion: Fluoride exposure during pregnancy contributed to a decrease in mice brain neurogenesis, as indicated by the expression of the PSD-95 protein in the hippocampus area.

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