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All Journal Sari Pediatri Paediatrica Indonesiana eJournal Kedokteran Indonesia
Dina Muktiarti, Dina
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia-Rumah Sakit Cipto Mangunkusumo
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Interleukin-6 and disease activity in childhood systemic lupus erythematosus Satria, Cahya Dewi; Kurniati, Nia; Muktiarti, Dina
Paediatrica Indonesiana Vol. 63 No. 6 (2023): November 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.6.2023.456-63

Abstract

Background Systemic lupus erythematosus (SLE) is a complex disease with various manifestations. Interleukin-6 (IL-6) is a pleiotropic cytokine with a wide range of biological activities which plays an important role in immune regulation and inflammation. Serum level of IL-6 may be used as a parameter of disease activity, especially in pediatric SLE patients with mild disease activity or total remission with conflicting clinical manifestations and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores. Objective To identify the characteristics of serum IL-6 concentration in pediatric SLE with mild disease activities and total remission. Methods This case-control study was performed at the allergy-immunology outpatient clinic, Department of Child Health Dr. Cipto Mangunkusumo Hospital, Jakarta and Dr. Sardjito Hospital, Yogyakarta. Serum IL-6 concentration and disease activity were assessed in all pediatric SLE patients aged 1-18 years old. Disease activity was assessed with SLEDAI scores and serum level of IL-6 was measured by enzyme-linked immunosorbent assay. Results Among 60 subjects included in this study, 30 subjects with mild activities were in the case group and 30 subjects with total remissions were in the control group. There was no difference in serum IL-6 concentration between the case and control group (OR 0.483; 95%CI 0.041to 5.628; P=0.500). In this study, 2 subjects with urinary tract infection had high serum IL-6 concentrations. Conclusion There is no difference in serum IL-6 concentration between pediatric SLE patients with mild disease activities compared to total remissions.
Sindrom Nefrotik Monogenik: Pendekatan Klinis dan Diagnosis Fahlevi, Reza; Trihono, Partini Pudjiastuti; Muktiarti, Dina; Wahidiyat, Pustika Amalia; Hidayati, Eka Laksmi; Hafifah, Cut Nurul
Sari Pediatri Vol 26, No 3 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.3.2024.189-96

Abstract

Sindrom nefrotik merupakan penyakit ginjal yang sering ditemukan pada anak-anak, dengan insiden 1-3 per 100.000 anak di bawah usia 16 tahun. Sekitar 10-20% anak dengan sindrom nefrotik mengalami sindrom nefrotik resisten steroid (SNRS), dan 10-30% dari kasus ini disebabkan oleh kelainan genetik. Pada SNRS monogenik, terdapat dua jenis yaitu sindromik (dengan gejala ekstra-renal) dan non-sindromik (tanpa gejala ekstra-renal). Penanganan SNRS memerlukan pendekatan klinis yang berbeda tergantung pada etiologi genetiknya. Pemeriksaan genetik, termasuk gen tunggal, panel multigen, dan genomik komprehensif, dapat mengidentifikasi varian patogenik, menetapkan diagnosis yang akurat, menyesuaikan terapi (termasuk penghentian terapi imunosupresan dan pemberian terapi yang lebih spesifik) konseling genetik, serta penanganan komprehensif terhadap manifestasi ekstra-renal terkait. Oleh karena itu, pendekatan klinis yang efektif harus didasarkan pada hasil pemeriksaan genetik untuk pengelolaan yang optimal dan konseling yang lebih tepat.
Co-Authors Alan R. Tumbelaka Anang Endaryanto Arini Setiawati Arwin Akib Arwin AP Akib Bambang Supriyatno Budi Setiabudiawan Cahya Dewi Satria, Cahya Dewi Dewi Kartika Suryani Dwi Lestari Pramesti Edy Novery Eka Laksmi Hidayati, Eka Laksmi Fransiska Kaligis Hafifah, Cut Nurul Ismail, Raden Irawati Iswari Setianingsih Ita M. Nainggolan Johannes Hudyono Ketut Dewi Kumara Wati Melva Louisa Mulya Rahma Karyanti, Mulya Rahma Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Nia Kurniati Partini Pudjiastuti Trihono, Partini Pudjiastuti Pustika Amalia Wahidiyat Pustika Amalia Wahidiyat, Pustika Amalia REZA FAHLEVI Rizqi Amalia Rizqi Amalia Safira A Tjandrasari Sudung O Pardede, Sudung O Sumadiono Sumadiono Tjhin Wiguna Zakiudin Munasir Zakiudin Munasir