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All Journal Journal of Experimental and Clinical Pharmacy (JECP) Pharmaceutical Reports Jurnal Abdi Negeriku
Andi Muflihunna
Fakultas Farmasi, Universitas Muslim Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Antioxidant Activity of Black Turmeric Rhizome (Curcuma caesia Roxb.) Extract Using DPPH Radical Scavenging Assay Muflihunna, Andi; Rahmawati, Rahmawati; Rahmah, Nurul
Pharmaceutical Reports Vol 5, No 1 (2026): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v5i1.399

Abstract

Free radicals are highly reactive molecules that contribute to the development of various diseases, particularly degenerative disorders such as cancer, cardiovascular diseases, and aging-related conditions. Antioxidants play a crucial role in neutralizing free radicals and preventing oxidative damage. Black turmeric (Curcuma caesia Roxb.) is a medicinal plant widely used in traditional medicine and is known for its rich content of bioactive compounds, including alkaloids, flavonoids, phenolics, curcuminoids, terpenoids, tannins, and proteins, which contribute to its therapeutic potential. This study aimed to evaluate the antioxidant activity of ethanol extracts of black turmeric rhizomes using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method, with a comparison of different extraction techniques. The extracts were obtained using maceration and water bath-assisted maceration methods with 96% ethanol as the solvent. Antioxidant activity was expressed in terms of the half-maximal inhibitory concentration (IC₅₀). The results demonstrated that the extraction method significantly influenced antioxidant activity. The maceration method yielded an IC₅₀ value of 9.2503 µg/mL, indicating very strong antioxidant activity (10 µg/mL). In contrast, the water bath-assisted maceration method produced an IC₅₀ value of 12.9274 µg/mL, which falls within the strong antioxidant category (10–50 µg/mL). In conclusion, black turmeric (Curcuma caesia Roxb.) rhizome extract exhibits potent antioxidant activity, with the maceration method providing superior results compared to water bath-assisted maceration. These findings suggest that black turmeric has significant potential as a natural antioxidant source and that extraction methods play a critical role in optimizing its bioactive properties.
Co-Authors A. Irma Suryani Abdul Rasyid, Faradiba Alimuddin Ali Ariani, Luysi Dewi Yuliana Halifah Pagarra Hidayah, Selfi Idris, Irma Suryani Mu'nisa, Andi Muhammad Luthfi Muhiddin Palennari Nani Kurnia, Nani Patongai, Dian Dwi Putri Ulan Sari Pratiwi, Andi Citra Rachmawaty Rachmawaty, Rachmawaty Rahmah, Nurul Rahmawati, Rahmawati Rezki Amriati Syarif, Rezki Amriati Sarmila, Sarmila Sukmawati Sukmawati Syamsiah, Syamsiah Syamsu, Andi Mu'nisa Yusuf, Yusnaeni