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All Journal The Indonesian Biomedical Journal Jurnal Penelitian Sains Syntax Literate: Jurnal Ilmiah Indonesia Majalah Kedokteran Andalas Jurnal Ilmu Kesehatan Indonesia (JIKSI) Innovative: Journal Of Social Science Research Jurnal Sains, Teknologi dan Kesehatan
Suchitra, Avit
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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TINGKAT PENGETAHUAN DAN SIKAP PEGAWAI BANK NEGARA INDONESIA KANTOR LAYANAN NASABAH JALAN AHMAD YANI KOTA PADANG MENGENAI COVID-19 Salsabila, Vasya Maharani; Bahar, Elizabeth; Suchitra, Avit
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.984

Abstract

The Covid-19 pandemic, which discovered in the city of Wuhan, China, infects through respiratory droplets that are released when an infected person coughs, sneezes, or talks. The importance of education, isolation, preventative measures, prevention of transmission control, and treatment are important steps to control Covid-19 according to the World Health Organization (WHO). The government's efforts to control Covid-19 is by issuing guidelines over Covid-19 and health protocol regulations in workplaces that have a high risk of Covid-19 transmission, such as banking. The importance of implementing health protocols in the form of knowledge and attitudes from banking employees regarding Covid-19 can reduce the level of Covid-19 cases and prevent new cases. This research is a descriptive observational study with a total sampling technique of 76 permanent employees of Bank Negara Indonesia Ahmad Yani Service Office using primary data obtained using a questionnaire which is then analyzed using a computerized system. The results showed that respondents with a good and sufficient level of knowledge about Covid-19 had the same percentage (46.1%) and the majority of employees (43.4%) had a good attitude towards Covid-19. The conclusion of this study is that the majority of respondents have a good percentage of knowledge and attitude in dealing with Covid-19
Analisis Karakteristik Klinikopatologi Kanker Kolorektal di Laboratorium Patologi Anatomi RSUP Dr. M. Djamil 2020-2022 Aden, Kuntum Annisa Tiara; Mulyani, Henny; Suchitra, Avit; Hilbertina, Noza; Nurhayati, Nurhayati
Jurnal Penelitian Sains Vol 27, No 1 (2025)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v27i1.1181

Abstract

 Kanker kolorektal adalah kanker yang tumbuh di kolon (usus besar) dengan kejadian yang terus meningkat setiap tahun. Faktor yang menentukan prognosis kanker kolorektal adalah usia, jenis kelamin, jenis keganasan, topografi, dan histopatologi. Penelitian ini bertujuan untuk mengenali jenis – jenis kanker kolorketal dan bagaimana karakteristik klinikopatologinya di Laboratorium Patologi Anatomi RSUP Dr. M. Djamil Padang tahun 2020 - 2022. Penelitian dilakukan dengan metode deskriptif observasional dengan teknik total sampling dari rekam medis. Kriteria inklusi sampel adalah seluruh pasien kanker kolorektal yang menjalani reseksi tahun 2020 - 2022 dengan diagnosis pertama kali dengan jumlah sampel 196 sampel. Hasil penelitian menunjukkan bahwa kanker kolorektal paling banyak terjadi pada pasien pada usia lebih dari 50 tahun (63,3%), jenis kelamin perempuan (51%), dan lokasi kanker kolorektal yang paling banyak dijumpai di rektum (44,9%), dengan ukuran tumor berkisar dari 4 sampai 6 cm (34,7%). Jenis keganasan yang paling sering ditemukan adalah Adenocarcinoma NOS di rektum. Kesimpulan penelitian ini adalah bahwa dalam rentang tahun 2020 – 2022, insiden kanker kolorektal terbanyak di Laboratorium Patologi Anatomi RSUP Dr. M. Djamil Padang adalah perempuan usia di atas 50 tahun dengan jenis keganasan berupa Adenocarcinoma NOS di rektum.
Hubungan Kanker Payudara Tripel Negatif dengan Kejadian Metastasis Aksila dan Metastasis Jauh di RSUP Dr. M. Djamil Padang Nindita, Priska Audina; Handayani, Tuti; Suchitra, Avit; Khambri, Daan; Mulyani, Henny; Rustam, Erlina
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1137

Abstract

Latar Belakang: Lebih dari 90% kematian terkait kanker payudara disebabkan oleh tumor sekunder di organ yang jauh akibat metastasis. Kanker payudara tripel negatif atau triple negative breast cancer (TNBC) merupakan subtipe paling agresif diantara subtipe lainnya. Secara klinis TNBC memiliki ukuran tumor yang lebih besar, melibatkan kelenjar getah bening, dan memiliki derajat keganasan yang lebih buruk. Pasien TNBC lebih berisiko mengalami metastasis dan kematian dibandingkan dengan jenis subtipe lainnya sehingga prognosisnya juga lebih buruk. Objektif: Mengetahui hubungan kanker payudara tripel negatif dengan kejadian metastasis aksila dan metastasis jauh di RSUP Dr. M. Djamil Padang. Metode: Penelitian analitik observasional dengan desain penelitian cross-sectional bersifat retrospektif. Jumlah sampel penelitian sebanyak 11 pasien TNBC dan 99 pasien non-TNBC di RSUP Dr. M. Djamil Padang tahun 2016 – 2021. Digunakan analisis uji Chi Square. Hasil: Kejadian metastasis aksila pada pasien TNBC sebesar 45,5% dan kejadian metastasis jauh sebesar 90,9% dengan lokasi metastasis terbanyak pada organ paru. Tidak terdapat hubungan antara kanker payudara tripel negatif dengan kejadian metastasis aksila (p=0,071) dan terdapat hubungan bermakna antara kanker payudara tripel negatif dengan kejadian metastasis jauh (p=0,018). Kesimpulan: Penelitian ini dapat disimpulkan bahwa tidak terdapat hubungan antara kanker payudara tripel negatif dengan kejadian metastasis aksila dan terdapat hubungan antara kanker payudara tripel negatif dengan kejadian metastasis jauh. Kata kunci: kanker payudara, tripel negatif, metastasis
Lactococcus lactis D4 Decreases NF-κB and α-SMA in Rat Models of Obstructive Jaundice Suchitra, Avit; Alvarino, Alvarino; Darwin, Eryati; Harun, Harnavi; Rivai, Muhammad Iqbal; Sukma, Ade
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3384

Abstract

BACKGROUND: Obstructive jaundice, often due to choledocholithiasis or malignancies, leads to immune suppression, intestinal damage, and bacterial translocation, worsening outcomes. Some inflammatory mediators like nuclear factor kappa B (NF-κB), alpha-smooth muscle actin (α-SMA), and interleukin-6 (IL-6) are important in this process. Current treatments remain inadequate, highlighting the need for novel approaches. Probiotics, such as Lactococcus lactis D4 (LLD4), may help reduce inflammation and bacterial translocation, thus offering a potential therapeutic option. This study was conducted to evaluate the effects of LLD4 on NF-κB, α-SMA, and IL-6 in obstructive jaundice rat models.METHODS: This post-test randomized controlled study involved 15 male Wistar rats divided into three groups: sham, bile duct ligation (BDL), and BDL+LLD4 groups. The rats were maintained for 7–10 days, with the rats in BDL+LLD4 group received fermented milk containing LLD4 via gavage at a dose of 112 mg/20 gBW per day for 7 days. The expression levels of NF-κB, α-SMA, and IL-6 were analyzed using immunohistochemistry.RESULTS: Administration of LLD4 were able to significantly reduced NF-κB expression compared to the BDL group (40.20±21.276 vs. 53.60 ± 20.403) in obstructive jaundice rat models. Though not significant, BDL+LLD4 group showed lower α-SMA expression compared to BDL group (58.40±14.271 vs. 63.20±9.16). However, administration of LLD4 did not give any significant effect on IL-6 expression.CONCLUSION: LLD4 reduces inflammation in models of obstructive jaundice by lowering the NF-κB and α-SMA expression. This indicates that LLD4 might be potential as an adjunct therapy for reducing morbidity in obstructive jaundice cases.KEYWORDS: obstructive jaundice, bile duct ligation, Lactococcus lactis D4, NF-κB, α-SMA, IL-6
Lactococcus lactis D4 Restores Gut Microbiota Balance in Azoxymethane and Dextran Sulfate Sodium-induced Colorectal Cancer Rat Model Suswita, Rini; Rivai, Muhammad Iqbal; Iqbal, Muhammad; Irwan, Irwan; Suchitra, Avit
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3311

Abstract

BACKGROUND: Gut microbiota plays a crucial role in the initiation and progression of colorectal cancer (CRC), with various bacterial species including Lactococcus lactis implicated in this process. However, there is a lack of studies reporting the specific effects of L. lactis on microbiota balance in the context of CRC, especially strain D4. Therefore, this study was conducted to evaluate the effect of L. lactis D4 administration on gut microbiota balance in a rat model of CRC.METHODS: This experimental study involved Sprague Dawley rats that were separated into untreated control (CO group), CRC-induced (CA group), and L. lactis D4-treated CRC-induced (LLD group). The CRC induction was performed by giving azoxymethane (AOM) and dextran sulfate sodium (DDS). Gut microbiota profile was analyzed using next generation sequencing (NGS), and microbial community dynamics were assessed through alpha and beta diversity metrics.RESULTS: L. lactis D4 restored gut microbiota balance by regulating Firmicutes/Bacteroidota ratio, and changing the microbiota composition by increasing the number of bacteria from the phylum Actinobacteria and decreasing bacteria from the phylum Bacteroidota and Proteobacteria. Alpha diversity was reduced in the LLD group, suggesting a decreased bacterial diversity post-treatment, but more closely aligned with the CO group than the CA group. Beta diversity analysis showed that the microbial composition of the treated group was similar to the CO group, while the CA group exhibited a distinct microbiota profile, characterized by higher abundance of pathogenic bacteria and reducing beneficial microbial species.CONCLUSION: L. lactis D4 administration effectively modulates gut microbiota in CRC model, enhancing the presence of beneficial bacteria from the Firmicutes and Bacteroidota phylum while suppressing pathogenic species from the Proteobacteria phylum.KEYWORDS: colorectal cancer, gut microbiota, next generation sequencing, Lactococcus lactis D4 
Hubungan Kejadian Infeksi Blastocystis sp dengan Profil Leukosit Darah Pada Penderita Kanker Kolorektal Zulmitra, Elsa; Nofita, Eka; Suchitra, Avit; Adrial, Adrial; Rofinda, Zelly Dia; Masnadi, Nice Rachmawati
Innovative: Journal Of Social Science Research Vol. 5 No. 3 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i3.19469

Abstract

Penelitian ini dilakukan dengan tujuan guna mengkaji hubungan hubungan antara infeksi Blastocystis sp dengan profil leukosit darah pada pasien yang menderita kanker kolorektal. Jumlah sampel yang digunakan sebanyak 22 sampel, yang dilaksanakan di RSUP Dr. M. Djamil Padang. Hasil Penelitian ini menyatakan bahwa dalam 22 pasien penyakit kanker kolorektal paling banyak ditemui pada lelaki dibandingkan wanita, dengan rata-rata umur 50,6 tahun. Sebesar 27,3% ditemukan pada pasien kanker kolorektal yang terkena infeksi Blastocystis sp. Rata-rata nilai leukosit pada pasien yang terkena infeksi Blastocystis sp pada penyakit kanker kolorektal sebanyak 9.792/mm3 dengan p value 0,9. Rata-rata jenis basofil / eosinophil / neutrofil / limfosit / monosit pada pasien yang terkena infeksi Blastocystis sp pada penyakit kanker kolorektal sebanyak 0/3/0/72/21/8, sedangkan pada pasien yang tidak terkena infeksi Blastocystis sp sebanyak 0/2/0/66/14/8 dengan p value lebih dari 0,05. Dengan demikian, hasil akhir dalam penelitian ini menyatakan bahwa tidak adanya hubungan antara infeksi Blastocystis sp dengan profil leukosit darah pada pasien yang menderita kanker kolorektal.
Exploring the Link Between Oxidative Stress Reduction and Liver Function Improvement in Jaundiced Rats with Lactococcus lactis D4 Suchitra, Avit; Alvarino; Darwin, Eryati; Harnavi Harun, Harnavi Harun; Rivai, M. iqbal; Anami, Hannan Khairu; Putri, Reza Yuneri; Hemilton, Suci Berlian
Majalah Kedokteran Andalas Vol. 48 No. 1 (2025): MKA January 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i1.p55-62.2025

Abstract

Objective: To explore the correlation between the reduction of oxidative stress and liver enzyme function in rats with obstructive jaundice, using malondialdehyde (MDA) levels as a biochemical marker, and its impact on serum glutamic oxaloacetic transaminase (SGOT) levels; Method: This experimental study used a post-test only randomized control group design in three groups of Rattus norvegicus strain Wistar rats with an obstructive jaundice model. The rats underwent biliary duct ligation and received Lactococcus lactis D4 starter fermented milk for 7 days. Oxidative stress was assessed by measuring MDA levels and Liver function was assessed by measuring levels of SGOT ; Result: The correlation analysis show an r-value of 0.886 revealed that there a very strong positive correlation between MDA and SGOT levels after LLD4 administration; Conclusion: Lactococcus lactis D4 starter fermented milk can improve liver function, indicated by decreased MDA levels and SGOT  levels in experimental animals.
Giant Liver Abscess pada Usia Muda: Sebuah Laporan Kasus Sari, Atika Indah; Suchitra, Avit
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i3.15427

Abstract

Abses hati amuba disebabkan infeksi Entamoeba histolytica yang bermanifestasi amebiasis ekstraintestinal invasif dan sering ditemukan di negara tropis termasuk Indonesia. Abses hati amuba menyebabkan 50.000 kematian di dunia. Penegakkan diagnosis membutuhkan pencitraan hati dan serologis. Penemuan parasit Entamoeba histolytica penting dalam penentuan etiologi abses hati amuba. Tujuan dari penelitian ini adalah untuk melaporkan kasus seorang pria 20 tahun dengan gejala nyeri perut kanan atas, demam, mual, dan anoreksia, serta mengevaluasi efektivitas drainase abses laparoskopik sebagai metode penanganan. Metode yang digunakan adalah analisis data klinis dan evaluasi hasil terapi. Hasilnya menunjukkan bahwa pasien mengalami perbaikan klinis setelah pengobatan dengan metronidazole dan drainase laparoskopik, dengan tidak adanya komplikasi fisik tambahan. Entamoeba histolytica merupakan amuba yang ditransmisikan melalui jalur fecal-oral dan masuk ke sirkulasi darah yang selanjutnya membentuk abses di hati. Pasien datang dengan ukuran abses hati besar dan memerlukan tindakan drainase secara operatif. Abses hati amuba umumnya berespon baik dengan pengobatan medikamentosa. Namun, pada kasus tertentu seperti ukuran abses yang besar dibutuhkan tindakan drainase perkutaneus untuk mencegah ruptur abses. Pasien ditatalaksana dengan pemasangan drainase secara laparaskopik. Pemasangan drainase laparaskopik memiliki cedera fisik yang lebih sedikit. Tatalaksana yang tepat dapat menghindari komplikasi pecahnya abses hati.
Co-Authors Ade Sukma Adelia Rachmita, Prima Aden, Kuntum Annisa Tiara Adrial Adrial, Adrial Alvarino Alvarino Alvarino Anami, Hannan Khairu Atika Indah Sari Daan Khambri Elizabeth Bahar Erlina Rustam Eryati Darwin Harnavi Harun, Harnavi Harun Harun Harnavi Hemilton, Suci Berlian henny Mulyani Husna Yetti Irwan Irwan Masnadi, Nice Rachmawati Muhammad Iqbal Nindita, Priska Audina Noza Hilbertina, Noza Nurhayati Nurhayati Prima Astuti Handayani Putri, Reza Yuneri Rivai, M. Iqbal Rivai, Muhammad Iqbal Salmiah Agus Salsabila, Vasya Maharani Suswita, Rini Yenita . Zelly Dia Rofinda Zulmitra, Elsa