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PEMBINAAN KESADARAN PANGAN THOYIB YANG AMAN PENGAWET SINTETIS PADA PENGURUS CABANG â€˜AISYIYAH WIROBRAJAN Amalya Nurul Khairi; Titisari Juwitaningtyas; Iin Narwanti
Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Vol. 2 No. 2 (2018)
Publisher : Universitas Ahmad Dahlan, Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jp.v2i2.446

Ibu-ibu anggota PCA Wirobrajan sebagian besar adalah pengusaha makanan dan minuman yang terampil dalam pengolahan panganan basah tradisional maupun street food. Kondisi ini merupakan akibat dari banyaknya jumlah sekolah dan adanya Pasar Klitihikan yang khusus menjual makanan jenis camilan di Kecamatan Wirobrajan. Pengabdian ini bertujuan untuk meningkatkan kesadaran Ibu-ibu anggota PCA Wirobrajan terhadap bahaya penggunaan pengawet sintetis sekaligus membekali dengan keterampilan membuat pengawet dari bahan alami dan deteksi sederhana kandungan formalin. Metode yang dilakukan adalah dengan pelatihan dan pemaparan materi. Kegiatan tersebut dilaksanakan dalam tiga kali sesi. Dari hasil pembinaan yang dilakukan diperoleh hasil antusiasme keikutsertaan Ibu-ibu PCA Wirobrajan dan semangat mereka untuk memperbaiki proses pengolahan pangan dengan meminimalisir penggunaan bahan tambahan pangan (BTP) sintetis yang berbahaya.Â

SUBCRONIC TOXICITY TEST COMBINATION OF Phyllanthus niruri AND Centella asiatica EXTRACT AT HEMATOLOGY IN RATS Siti Fatmawati Fatimah; Endang Darmawan; Iin Narwanti; Dzulhaifa Dzulhaifa; Ira Aprilia Wulandari; Ria Putri Salma
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art8

Background: Meniran (Phyllathus niruri) and pegagan (Centella asiatica) are well-known medicinal plants in Indonesia. Uses of meniran and pegagan as herbal medicines need to be examined for their subchronic activity to assure their safety. Objective: This study aimed to evaluate subchronic effects of a combination of extracted meniran and pegagan on Wistar rats through haematological parameters (erythrocytes, haemoglobin, haematocrit, MCV, MCH, and MCHC).Methods: Animal models used were 56 male and female Wistar rats and were divided randomly into 4 groups. Group 1 received CMC-Na 1% (control group). Group 2 received extracts of meniran and pegagan (50:50 mg/kgBW). Group 3 received extracts of meniran and pegagan (250:250 mg/kgBW). Group 4 received extracts of meniran and pegagan (1250:1250 mg/kgBW). Subchronic test of meniran and pegagan was conducted by providing treatments for the Wistar rats for 28 days. Their haematological substances were analysed statistically by using one way ANOVA and Kruskal-Wallis method with confidence interval of 95% and post-hoc. Results: This study found that the haematological substances in male Wistar rats were normal and did not significantly change (p>0,05). It also showed that haemoglobin and haematocrit substances in female rats were normal and did not significantly change (p>0,05). Erythrocytes, MCV, MCH, and MCHC in female rats indicated significant change (p<0,05), but they were still in normal ranges.Conclusion: It could be concluded that administration of the combination of extracted meniran and pegagan was not toxic to haematology of the rats in all doses.

Inovasi Pemanfaatan Daun Kakao: Pelatihan Pembuatan Seduhan Herbal untuk Pemberdayaan Ekonomi Komunitas Petani Kakao Utami, Budi Barata Kusuma; Narwanti, Iin; Rokhmayanti, Rokhmayanti; Hanum, Farrah Fadhillah; Rusdianto, Rusdianto; Putra, Gea Permana Antara; Rahmadani, Nur Izati; Adestu, Zakiyya Salwa; Fatmala, Eva; Lestari, Rimadina Sukmasuci
Jurnal Peduli Masyarakat Vol 7 No 4 (2025): Jurnal Peduli Masyarakat: Juli 2025
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jpm.v7i4.6861

Indonesia memiliki potensi besar dalam pemanfaatan daun kakao (Theobroma cacao L.) sebagai bahan baku seduhan herbal bernilai ekonomi. Namun hingga kini, pemanfaatannya masih terbatas dan belum terintegrasi dalam kegiatan produksi masyarakat. Kegiatan pengabdian ini dilakukan sebagai respons atas kurangnya pengetahuan dan keterampilan masyarakat terhadap pengolahan limbah daun kakao, khususnya di Kalurahan Bunder, Gunungkidul, yang merupakan salah satu sentra pertanian kakao. Tujuan kegiatan adalah untuk meningkatkan keterampilan teknis dan kesadaran kewirausahaan masyarakat melalui pelatihan pengolahan daun kakao menjadi seduhan fungsional. Pelatihan dilakukan secara luring dengan melibatkan 25 peserta yang terdiri dari unsur petani, UMKM, dan ibu rumah tangga. Materi mencakup pengenalan senyawa bioaktif, teknik pengolahan, dan praktik pembuatan produk. Evaluasi dilakukan melalui pre-post test dan uji organoleptik. Hasil menunjukkan peningkatan pengetahuan peserta sebesar 10% dan teridentifikasinya formula yang disukai panelis berdasarkan karakteristik sensori. Pelatihan berbasis praktik langsung dan partisipatif terbukti efektif dalam meningkatkan kapasitas teknis dan kesadaran kewirausahaan masyarakat. Kegiatan ini memberikan dasar yang kuat untuk pengembangan usaha lokal berbasis limbah pertanian secara berkelanjutan.

Red Seaweeds as Resource of Bioactive Compounds and Therapeutic Potential: a Review on Anticancer Agents Warsi, Warsi; Narwanti, Iin; Ahmed, Qamar Uddin
Clinical and Pharmaceutical Sciences Journal Vol. 1 No. 2 (2025)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v1i2.378

The use of natural compounds derived from macroalgae constitute an alternating strategy in the creation of anticancer medications. Seaweed refers to macroalgae. Red seaweeds are rich in bioactive compounds, including alkaloids, carotenoids, mycosporine-like amino acids, phycobiliproteins, polyphenols, polysaccharides (carrageenan, porphyran), and lipids. Some of these bioactive compounds have demonstrated a unique chemical framework. The bioactive compounds have been investigated as an anticancer potential in vitro studies. Among these compounds content, polyphenols are the most promising as an anticancer, due to their abundance in the red seaweeds. This review provides bioactive compounds from red seaweeds and their natural sources. The review involves papers published from 2010 to 2025. The study might be used as a reference in development of red seaweed extracts in the future which include preclinical and clinical investigations, standardizations and formulations, molecular mechanisms as anticancer and toxicity studies. Keywords: Anticancer, bioactive compound, macroalgae, pharmacological activity, seaweed

Pengembangan Produk Tablet Oral Disintegrasi Piroksikam Rohmiati, Rohmiati; Wahyuningsih, Iis; Guntarti, Any; Narwanti, Iin; Putri, Hilma; Anwar, Shinta Desy; Rahmadani, Firda; Rustandi, Tedi; Islamy, Muhammad Rido
Media Farmasi: Jurnal Ilmu Farmasi Vol. 15 No. 1: Maret 2018
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v15i1.12307

Piroksikam digunakan sebagai analgetik dan antiinflamasi yang sering dialami oleh kalangan lansia yang mempunyai kesulitan menelan. Salah satu upaya yang dapat dilakukan untuk mengatasi masalah tersebut yaitu dengan sediaan Orally Disintegrating TabletÂ (ODT). Avicel PH 102 merupakan bahan disintegran yang biasa digunakan sebagai penyusun ODT, karena mempunyai daya disintegran yang sangat baik. Tujuan penelitian ini untuk mengembangkan piroksikam menjadi bentuk sediaan ODT. Metode pembuatan ODT dilakukan dengan metode kempa langsung. Variasi konsentrasi Avicel PH 102 yang digunakan untuk formula 1 sebesar 15% dan formula 2 sebesar 20%. Tablet hasil formulasi diperiksa karakteristik fisik yang meliputi identifikasi tablet, kerapuhan, kekerasan, ketebalan, waktu hancur, bentuk dan ukuran tablet, laju disolusinya serta dilakukan penetapan kadar. Metode analisa kadar piroksikam baik pada penentuan disolusi maupun pada penentuan kadar, dilakukan verifikasi metode spektrofotometri UV-Vis terlebih dahulu meliputi spesifisitas, presisi, dan akurasi. Formula terbaik selanjutnya dilakukan uji hedonik. Hasil verifikasi untuk ketiga uji memenuhi persyaratan sehingga dikatakan metode uji valid. Hasil uji fisik tablet dikatakan memenuhi syarat kecuali untuk uji kerapuhan. Data laju disolusi dan penetapan kadar tablet piroksikam memenuhi syarat FI V yaitu laju disolusi tidak kurang dari 75%(Q + 5%) dan hasil penetapan kadar F1 dan F2 berturut-urut sebesar 95,22 Â± 3,09% dan 95,14 Â± 4,26%. Dari penelitian ini dapat disimpulkan bahwa piroksikam dapat dibuat dalam bentuk sediaan ODT karena menghasilkan sediaan tablet dengan sifat fisik yang baik kecuali pada uji kerapuhan. Formula yang dipilih yaitu formula 2, karena waktu hancur dan disolusi tablet lebih baik dibandingkan dengan formula 1.

Antioxidant Activity of Essential Oil of Baeckea frutescens L. (Ujung Atap) and GC-MS (Gas Chromatography-Mass Spectrometery) Analysis Mahfudh, Nurkhasanah; Apriyani, Silvi; Narwanti, Iin
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21163

Ujung Atap plant (Baeckea frutescens L.) is a shrub that resembles a pine tree and is usually found in tropical hills, mountains, and coastal environments. B. frutescens contains flavonoids and phenolic compounds which have known as potential antioxidants. B. frutescens also contains essential oils which have been used as various treatments and aromatherapy. This study aims to measure the effectiveness of antioxidants in Ujung atap essential oils based on the IC50 value with the ABTS method and identify the chemical compound components of Ujung atap essential oils with the GC-MS. The stages of this research method consist of making Ujung atap essential oil using the steam-water distillation method, measuring the antioxidant activity of Ujung atap leaf essential oil using the ABTS method (2,2-azinobis (3-ethyl-benzothiazoline-6-sulfonate)) and analysis of the chemical compound components of Ujung atap essential oil using the GC-MS (Gas Chromatography and Mass Spectroscopy). Based on the results of this research, it is known that the antioxidant activity of the ujung atap (Baeckea frutescens L.) is included in the very weak category with an IC50 of 481.525 ± 5.455 μl/L or equivalent to 435.154 ± 4.930 ug/mL. Meanwhile, the comparative antioxidant activity of quercetin has an IC50 value of 2.846 ± 0.156 μg/mL, which is included in the very strong category. In the analysis test of the essential oil compound content of the ujung atap (Baeckea frutescens L.), it was discovered that there were six main components of the essential oil compound of the ujung atap (Baeckea frutescens L.) who had a concentration of more than 5%.) who have concentration more than 5%, namely, 1-beta- Pinene (21.62%), 1,8-Cineole (17.73%), alpha-pinene (14.93%), Gamma-Terpinene (6.84%), 3- Cyclohexene-1-methanol,α,α,4-trimethyl-(CAS) (5.78%), and Bicyclo[3.1.1]hept-2- ene,3,6,6 trimethyl-(CAS) (5.02%).

Antioxidant Activity of Essential Oil of Baeckea frutescens L. (Ujung Atap) and GC-MS (Gas Chromatography-Mass Spectrometery) Analysis Mahfudh, Nurkhasanah; Apriyani, Silvi; Narwanti, Iin
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21163

Ujung Atap plant (Baeckea frutescens L.) is a shrub that resembles a pine tree and is usually found in tropical hills, mountains, and coastal environments. B. frutescens contains flavonoids and phenolic compounds which have known as potential antioxidants. B. frutescens also contains essential oils which have been used as various treatments and aromatherapy. This study aims to measure the effectiveness of antioxidants in Ujung atap essential oils based on the IC50 value with the ABTS method and identify the chemical compound components of Ujung atap essential oils with the GC-MS. The stages of this research method consist of making Ujung atap essential oil using the steam-water distillation method, measuring the antioxidant activity of Ujung atap leaf essential oil using the ABTS method (2,2-azinobis (3-ethyl-benzothiazoline-6-sulfonate)) and analysis of the chemical compound components of Ujung atap essential oil using the GC-MS (Gas Chromatography and Mass Spectroscopy). Based on the results of this research, it is known that the antioxidant activity of the ujung atap (Baeckea frutescens L.) is included in the very weak category with an IC50 of 481.525 ± 5.455 μl/L or equivalent to 435.154 ± 4.930 ug/mL. Meanwhile, the comparative antioxidant activity of quercetin has an IC50 value of 2.846 ± 0.156 μg/mL, which is included in the very strong category. In the analysis test of the essential oil compound content of the ujung atap (Baeckea frutescens L.), it was discovered that there were six main components of the essential oil compound of the ujung atap (Baeckea frutescens L.) who had a concentration of more than 5%.) who have concentration more than 5%, namely, 1-beta- Pinene (21.62%), 1,8-Cineole (17.73%), alpha-pinene (14.93%), Gamma-Terpinene (6.84%), 3- Cyclohexene-1-methanol,α,α,4-trimethyl-(CAS) (5.78%), and Bicyclo[3.1.1]hept-2- ene,3,6,6 trimethyl-(CAS) (5.02%).

Edukasi Penggunaan Bahan Tambahan Makanan yang Aman Bagi Kesehatan di Panjatan Kulon Progo Warsi, Warsi; Sunarti, Sunarti; Narwanti, Iin
Jurnal Pengabdian dan Pemberdayaan Kesehatan Vol. 2 No. 4 (2025): Desember 2025
Publisher : Menara Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70109/jupenkes.v2i4.95

Keamanan pangan saat ini masih menjadi sorotan publik, terutama keamanan pangan pada makanan jajanan. Penggunaan bahan tambahan makanan sintetis sering menjadi permasalahan terutama pada produksi pangan non pabrikan. Lansia merupakan salah satu kelompok rentan sehingga kemanan pangan lansia harus selalu di jaga. Pengabdian Masyarakat ini bertujuan untuk memberikan edukasi penggunaan bahan tambahan makanan yang aman dengan sasaran lansia di wilayah Pimpinan Cabang Muhammadiyyah (PCM) Panjatan Kulon Progo. Pengabdian ini bertujuan memberikan edukasi tentang penggunaan bahan tambahan makanan untuk kelompok lansia di wilayah PCM Panjatan Kulon Progo. Metode yang digunakan ceramah dan diskusi interaktif. Hasil pengabdian ini terdapat peningkatan pengetahuan dari median 40 menjadi 90 dengan nilai p value 0.001. Simpulan; Edukasi penggunaan bahan tambahan makanan pada lansia meningkatkan pengetahuan lansia tentang penggunaan bahan tambahan makanan yang aman.

Synthesis of 4-Hydroxycinnamic Acid from Malonic Acid and 4-Hydroxybenzaldehyde as Starting Materials with the Variation of the Reflux Time Narwanti, Iin; Abdillah, Fahmi Humaidi
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.9356

Cinnamic acid derivatives, naturally occurring compounds found in plants and also synthetically produced, exhibit diverse biological activities, including antioxidant, antiplasmodial, tyrosinase-inhibitory, antibacterial, anti-inflammatory, antitumor, and anticancer properties, with 4-hydroxycinnamic acid representing a particularly valuable derivative for pharmaceutical development. However, the successful synthesis of these compounds requires careful optimization of reaction conditions, particularly the reflux time, which must balance complete reactant conversion against product degradation that may occur with excessive heating to achieve maximum yield and purity. This study aimed to optimize the reaction yield in the synthesis of 4-hydroxycinnamic acid by varying the reflux time. 4-Hydroxycinnamic acid was synthesized via a reaction between malonic acid and 4-hydroxybenzaldehyde using pyridine-piperidine as a catalyst. The reflux time was varied at 3, 5, and 7 hours. The mixture was refluxed at 70–80°C with constant stirring at 900 rpm. After the reaction, the crude product was recrystallized and dried, and the yield was calculated. TLC was employed to compare the product's Rf value with that of the starting material using various eluents. Furthermore, the synthesized product was characterized by Fourier-Transform Infrared and Nuclear Magnetic Resonance spectroscopy to elucidate its structure. The results revealed that the average yields at reflux times of 3, 5, and 7 hours were 58.6, 66.78, and 63.87%, respectively, with the optimal yield achieved at 5 hours. Physicochemical and spectral data confirmed that the obtained product was 4-hydroxycinnamic acid. Purity analysis showed that the synthesized compound had a purity level of 95%.

Regioselective Synthesis of 5-Nitronaphtalene-1,4-dione Derivatives in Various Solvents and Their Characterization Narwanti, Iin; Warsi, Warsi; Sethy, Bidyadhar
Jurnal Riset Kimia Vol. 17 No. 1 (2026): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v17i1.837

Regioselective synthesis is a crucial strategy in the development of bioactive molecules, as regioisomers may exhibit distinctly different biological activities. Heterocyclic naphthoquinones are a promising class of bioactive scaffolds with potential anticancer properties that might be influenced by their regiochemical configuration. This study aimed to investigate the regioselective synthesis of 5-nitronaphthalene-1,4-dione with an amine using various solvents and to characterize the target compounds. The synthesis was initiated with the nitration of 2,3-dichloronaphthalene-1,4-dione using a mixture of HNO3/H2SO4, generating compound 2 in a moderate yield. Next, compound 2 was subsequently reacted with N, N-dimethylethane-1,2-diamine under alkaline conditions at ambient temperature, affording two regioisomeric target compounds (compounds 4 and 5). The characterization confirmed the successful synthesis of compounds 4 and 5, with findings indicating that aprotic solvents facilitated the formation of compound 4, while protic solvents slightly favored the formation of compound 5. In conclusion, the results reveal that the solvent governs regioselective synthesis of 5-nitronaphthalene-1,4-dione derivatives, providing a basis for controlling substitution patterns in these scaffolds. Further, the successful synthesis and isolation of regioisomerically pure compounds establishes a foundation for further exploration of their biological activities.

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