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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Berkala Ilmu Kesehatan Kulit dan Kelamin Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Berita Kedokteran Masyarakat Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
Fajar Waskito
Departement Of Dermatology And Venereology, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada/Dr Sardjito Hospital, Yogyakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Administration of vitamin D3 topical in increasing serum vitamin D level: A literature review Nafaisa, He Yeon Asva; Waskito, Fajar; Martien, Ronny; Danarti, Retno
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Vitamin D is an essential fat-soluble vitamin that is required daily by the body. Deficiency in vitamin D is experienced by most of the world's population. Vitamin D plays a role in maintaining the skin barrier by regulating keratinocyte proliferation and differentiation, promoting filaggrin formation, and intraepidermal lipids. Discussion: The vital role of vitamin D, non-compliance with supplement consumption, and poor nutritional status of adult patients and the elderly with deficiency and insufficiency of vitamin D encourage studies regarding vitamin D delivery via the transdermal route. The lipophilicity of vitamin D allows it to penetrate through the skin barrier. Conclusion: Research indicates that topical application of vitamin D3 is not only safe but also effective in increasing serum vitamin D levels. Thus, topical delivery is a promising alternative method for providing vitamin D supplementation or as a therapeutic option for specific conditions that leads to improved skin hydration and serum vitamin D levels.
RASIO NEUTROFIL LIMFOSIT DAN RASIO TROMBOSIT LIMFOSIT DENGAN DERAJAT KEPARAHAN PSORIASIS TIPE PLAK Yefta Yefta; Agnes Sri Siswati; Niken Trisnowati; Fajar Waskito; Niken Indriastuti; Sunardi Radiono; Dwi Retno Adi Winarni
Media Dermato-Venereologica Indonesiana Vol 50 No 3 (2023): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v50i3.441

Abstract

Abstrak Latar Belakang: Psoriasis merupakan gangguan inflamasi sistemik kronis dan rekuren yang mempengaruhi 2-3% populasi. Patogenesis psoriasis melibatkan neutrofil, limfosit, trombosit, sitokin dan kemokin. Penentuan derajat keparahan psoriasis tipe plak yang sering digunakan adalah Psoriasis Area Severity Index (PASI) memiliki kelemahan yaitu subyektivitas antar pemeriksa. Rasio neutrofil limfosit (N/L) dan rasio trombosit limfosit (T/L) adalah penanda sederhana respon inflamasi sistemik yang mudah diukur dan murah sebagai bagian dari pemeriksaan darah rutin dan umum digunakan dalam penyakit inflamasi kronis. Tujuan: mengetahui perbedaan dan hubungan antara rasio N/L dan rasio T/L dengan derajat keparahan psoriasis tipe plak berdasarkan PASI. Metode: Penelitian menggunakan rancangan potong lintang dengan subyek telah memenuhi kriteria inklusi dan eksklusi. Analisis komparatif dan korelatif digunakan untuk menilai perbedaan dan hubungan kedua rasio dengan skor PASI. Hasil: Jumlah subyek penelitian 48 orang dibagi menjadi 3 kelompok psoriasis (derajat ringan, sedang dan berat). Terdapat perbedaan antara rasio N/L dan rasio T/L dengan derajat keparahan psoriasis tipe plak (p<0,05). Terdapat hubungan antara rasio N/L dan rasio T/L dengan derajat keparahan psoriasis tipe plak berdasarkan PASI (p<0,05 dan r: 0,550, r: 0,314). Kesimpulan: terdapat perbedaan dan hubungan antara rasio N/L dan rasio T/L dengan derajat keparahan psoriasis tipe plak berdasarkan PASI. Kata Kunci: rasio neutrofil limfosit, rasio trombosit limfosit, psoriasis tipe plak, psoriasis area severity index (PASI)
The effectiveness of topical vitamin D3 for dry skin in elderly Nafaisa, He Yeon Asva; Waskito, Fajar; Martien, Rony; Danarti, Retno
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 01 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i01.11961

Abstract

Dry skin is one of the most common dermatoses found in the elderly. Vitamin D is an essential fat-soluble vitamin that has a role in repairing the skin barrier. Topical administration of vitamin D3 is expected to increase skin hydration in the elderly. Thirty-two participants were divided into two groups, namely 5000 IU vitamin D3 and the base lotion groups. The assessment was carried out by calculating the overall dry skin score (ODS), transepidermal water loss (TEWL), and skin capacitance every 4 wk for 12 wk. All groups showed an improvement in ODS, a decrease in TEWL, and an increase in skin capacitance value at the end of the measurement, and no significant side effects were reported. The 5000 IU vitamin D3 lotion group had the highest level of skin hydration compared to the other group (p>0,05). We conclude that the administration of 5000 IU vitamin D3 lotion may be administrated safely and improve skin hydration in the elderly but is not more effective than base lotion.
ONSET KEKAMBUHAN PADA PASIEN PSORIASIS VULGARIS PASKA TERAPI INJEKSI KE-8 SECUKINUMAB DI RSUP DR. SARDJITO YOGYAKARTA PERIODE 2022-2024 Harsono, Erliana Tantri; Waskito, Fajar; Siswati, Agnes Sri; Andayani, Raden Roro Rini; Khalidah, Miya
Media Dermato-Venereologica Indonesiana Vol 52 No 2 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i2.528

Abstract

   Pendahuluan: Psoriasis merupakan penyakit autoimun kulit inflamasi kronis yang ditandai oleh hiperproliferasi epidermis. Terapi agen biologis seperti secukinumab digunakan untuk psoriasis derajat berat dan sekitar 4,6% pasien psoriasis vulgaris di RSUP Dr. Sardjito mendapat terapi secukinumab. Terkait asuransi kesehatan nasional, pemberian injeksi subkutan Secukinumab diberikan sebanyak 8 kali untuk satu pasien. Setelah penghentian terapi agen biologis seringkali psoriasis mengalami kekambuhan. Mengetahui awitan kekambuhan pasien psoriasis pasca terapi injeksi ke-8 secukinumab 300 mg di RSUP Dr. Sardjito serta faktor yang mempengaruhi kekambuhan sehingga dapat menjadi data pendukung penelitian lebih lanjut. Metode: Rancangan penelitian adalah deskriptif. Data diperoleh dari catatan medik elektronik pasien dengan diagnosis psoriasis vulgaris yang telah selesai terapi secukinumab 300 mg sebanyak 8 kali injeksi di Poliklinik Kulit dan Kelamin RSUP Dr. Sardjito periode 2022-2024. Hasil: Total subyek pada studi ini adalah 12. Awitan kambuh ≤ 6 bulan paska terapi secukinumab didapatkan pada 8 pasien (66,7%). Pasien dengan awitan kambuh ≤ 6 bulan paska terapi secukinumab yang memiliki indeks massa tubuh ≥ 25 sebanyak 8 pasien (66,7%). Pasien dengan awitan kambuh ≤ 6 bulan paska terapi secukinumab dengan awitan terdiagnosis psoriasis dini < 40 tahun sebanyak 7 pasien (58,3%). Kesimpulan: Kekambuhan psoriasis paska terapi secukinumab dengan awitan kambuh ≤ 6 bulan lebih banyak terjadi dengan rerata awitan kekambuhan adalah 18 minggu. Awitan kambuh ≤ 6 bulan lebih banyak terjadi pada pasien dengan awitan dini psoriasis dan obesitas. Diperlukan penelitian lebih lanjut terkait faktor risiko kekambuhan dan mekanisme terjadinya kekambuhan paska terapi secukinumab atau agen biologis. 
Histopathology as a key to identify Sezary syndrome in patient with clinical erythroderma Diovani, Sonia; Irianiwati; Febriana, Sri Awalia; Waskito, Fajar; Rizkiani, Dwinanda Almira; Andayani, Raden Roro Rini; Rifko, Ani
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.17293

Abstract

Sezary syndrome (SS) is a rare and aggressive variant of cutaneous T-cell lymphoma (CTCL), characterized by clonal proliferation of malignant T lymphocytes with skin erythroderma. The incidence of CTCL in the United States from 2000 to 2010 reached 10 cases per million people per year, accounts for only 3% of all cases of cutaneous lymphoma. In Indonesia, lymphoma ranks sixth in terms of malignancies, alongside Hodgkin lymphoma and leukemia. We reported a case of 56 y.o. woman presented with blistering lesions that turned into wounds all over her body. Skin biopsy examination revealed characteristic histopathological features, including basket weave-type orthokeratosis, focal parakeratosis, focal acanthosis, and epidermotropism of atypical lymphoid cells with cerebriform nuclei (Sezary cells). Immunohistochemical examination using CD3, CD4, and CD8 showed positive staining in the membrane and cytoplasm of tumor cells within the dermis and epidermis. Sezary syndrome is characterized by clonal expansion of T-helper memory cells in the skin. Histopathology and immunohistochemistry could not differentiate SS from mycosis fungoides. However, histopathological examination could distinguish SS from other differential diagnoses. The diagnosis of SS can be established based on the triad of 1) generalized exfoliative dermatitis involving more than 80% of the body surface area, 2) lymphadenopathy, and 3) the presence of 5% or more malignant T-cells with cerebriform nuclei (Sezary or Lutzner cells) in peripheral blood lymphocytes. In conclusion, we present a case of SS, diagnosed based on the patient's history, physical examination, peripheral blood examination, histopathology, and immunohistochemistry.
Validity and Reliability of the Indonesian Version of Nordic Occupational Skin Questionnaire 2002 (NOSQ-2002) Paramita, Listya; Waskito, Fajar; Prawiratama, Dikky; Indrastuti, Niken; Rayinda, Tuntas; Febriana, Sri Awalia
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Epidemiological data on occupational hand eczema in Indonesia is still limited, partly because there are no valid and reliable instruments in the Indonesian language as a means of survey. This study aims to translate the Nordic Occupational Skin Questionnaire 2002 (NOSQ-2002) into the Indonesian language and assess the validity and reliability of the Indonesian NOSQ-2002 as an instrument for epidemiological surveys and screening of occupational hand eczema. Methods: The original English version of NOSQ-2002 was translated into the Indonesian language following the standard procedure of translation. The Indonesian NOSQ-2002 version, which had been collectively approved, was subsequently completed by a group of 194 textile employees from PT. Panca Persada Mulia-PANDATEX in Magelang, Central Java, Indonesia. Validity was assessed using Pearson correlation for each question with the total score. Reliability was evaluated using Cronbach's alpha values. The sensitivity and specificity of the Indonesian NOSQ-2002 screening were determined by comparing results with those of examination by the examining physician as the gold standard. Results: Pearson correlation values for each question range from 0.252 to 0.905, all surpassing the r table value, indicating questions in NOSQ-2002 are valid. Reliability NOSQ-2002 rated good (reliable), with a Cronbach's alpha of 0.933. The Indonesian NOSQ-2002 version demonstrates a sensitivity of 93.3% and specificity of 98.8% for screening occupational hand eczema. Conclusion: The Indonesian version of NOSQ-2002 is a valid and reliable instrument for use in epidemiological surveys and screening of occupational hand eczema.
The Effect of 0.2% Hyaluronic Acid Cream on the Severity of Acute Radiodermatitis in Breast Cancer Patients: a Double-Blind Randomized Controlled Trial Muchamad Apriyanto; Sigid Santosa, Novita Permatasari; Mira Oktarina, Dyah Ayu; Ekaputra, Ericko; Trisnowati, Niken; Budiyanto, Arief; Soebono, Hardyanto; Waskito, Fajar; Indrastuti, Niken
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.195-202

Abstract

Background: Radiotherapy is an essential treatment in reducing the risk of breast cancer but can cause side effects such as acute radiodermatitis. This condition is the result of ionizing radiation damaging deoxyribonucleic acid (DNA) through reactive oxygen species (ROS) and inducing inflammatory responses, which lead to variable degrees of skin damage. Hyaluronic acid (HA) plays a role in triggering cell proliferation and keratinocyte differentiation while inhibiting lipid peroxidation caused by oxidative stress. Purpose: This study aims to determine the effectiveness of hyaluronic acid in reducing the degree of acute radiodermatitis using the Radiation Therapy Oncology Group (RTOG) score in breast cancer patients undergoing radiotherapy. Methods: This study was a double-blind randomized controlled trial. The samples were from patients diagnosed with breast cancer receiving radiotherapy. The treatment group received 0.2% HA cream, while the control group received a placebo The clinical appearance was evaluated weekly from the beginning of radiotherapy until two weeks post-radiotherapy using the RTOG score. Result: A total of 41 subjects were divided into two groups. RTOG score evaluation with intention-to-treat analysis and per-protocol analysis at weeks 3, 4, and 5 showed that the hyaluronic acid cream group experienced delayed onset of acute radiodermatitis compared to the placebo group. The log-rank test showed a significant difference in effectiveness between 0.2% HA cream compared to base cream in reducing the degree of acute radiodermatitis (p=0.035). Conclusion: The use of 0.2% HA cream was effective in reducing the severity of acute radiodermatitis in breast cancer patients undergoing radiotherapy.
Co-Authors Abd. Halim Musahib, Abd. Halim Agnes Sri Siswati Alfieri, Alessandro Andayani, Raden Roro Rini Arief Budiyanto Diovani, Sonia Dwi Retno Adi Winarni Ekaputra, Ericko Endra Yustin E. S Erinda Maharani Rambu Moha Febriana, Sri Awalia Halim Musahib, Abd Hardyanto Soebono Harsono, Erliana Tantri He Yeon Asva Nafaisa Irianiwati Jeffrey Giantoro Khalidah, Miya Maria Sophiati Martien, Rony Mira Oktarina, Dyah Ayu Muchamad Apriyanto Niken Indrastuti Niken Indriastuti Niken Trisnowati Nur Syamsi Oktarina, Dyah Ayu Mira Paramita, Listya Prawiratama, Dikky Rayinda, Tuntas Rifko, Ani Rizkiani, Dwinanda Almira Ronny Martien Satiti Retno Pudjiati Satiti Retno Pudjiati Sigid Santosa, Novita Permatasari Sunardi Radiono Yefta Yefta Yohanes Widodo Wirohadidjojo