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All Journal ACTA VETERINARIA INDONESIANA Althea Medical Journal Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Global Medical and Health Communication Jurnal Manajemen Kesehatan Indonesia MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Integrasi Kesehatan dan Sains Jurnal Riset Kedokteran Bandung Conference Series : Medical Science
Lelly Yuniarti
Department Of Biochemistry, Nutrition And Biomolecular, Faculty Of Medicine, Universitas Islam Bandung
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Literature Riview: Analisis Capaian KB Aktif dan Kontrasepsi pada Masa Pandemik Covid-19 Anggit Yanuaristi; Dean Wahjudi Satyaputra; Lelly Yuniarti
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6460

Abstract

Abstract: The government established a PSBB policy in 2020 to break the chain of distribution of COVID-19 by limiting people's mobility towards social contact, this has an impact on limited access to health services. This study aims to examine the achievements of active family planning and contraception programs during a pandemik by using the literature review method to identify published literature using relevant keywords. Based on the literature review produced, active KB acceptors decreased during a pandemik, contraceptive methods that experienced a decrease included MOP, pills, injections and MOW. Contraceptives that have increased in IUDs, Implants and Condoms. In conclusion, the results of active family planning decreased due to COVID-19, the distribution of contraceptives was made easier for the community and family planning services were further improved to prevent the "baby boom" at the end of the COVID-19 pandemic. Abstrak: Pemerintah menetapkan kebijakan PSBB pada tahun 2020 utuk memutus mata rantai penyebaran COVID-19 dengan cara membatasi mobilitas masyarakat terhadap kontak sosial, hal tersebut berdampak pada terbatasnya masyarakat mendapatkan layanan kesehatan. Penelitian ini bertujuan untuk meneliti capaian program KB aktif dan kontrasepsi pada masa pandemik dengan menggunakan metode literature review untuk mengidentifikasi literature yang telah dipublish dengan menggunakan kata kunci yang relevan. Berdasarkan dari literature riview dihasilkan, Akseptor KB aktif menurun pada saat pandemik, alat kontrasepsi yang mengalami penurunan diantaranya MOP, Pil, Suntik dan MOW. Alat kontrasepsi yang mengalami peningkatan pada IUD, Implant dan Kondom. Simpulan, capaian KB aktif menurun dipengaruhi oleh COVID-19, distribusi alat kontrasepsi dipermudah untuk masyarakat dan pelayanan KB lebih ditingkatkan untuk mencegah “baby boom” pada akhir masa pandemik COVID-19.
Pengembangan Obat Kanker dari Daun Kelor (Moringa Oleifera) Silmi Hizba Hunafa; Yuke Andriane; Lelly Yuniarti
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6638

Abstract

Abstract. Colon cancer ranks third most common in the world with the second highest mortality rate. Colon cancer therapy, one of which can be through chemotherapy using doxorubicin. Single use of doxorubicin has significant side effects. One effort to reduce side effects and increase its effectiveness is to combine doxorubicin with Moringa leaves (Moringa oleifera). Moringa leaves contain many active ingredients such as flavonoids, D-allose, and eugenol. Another effort that can be made to increase the effectiveness of drugs is by developing nanoparticles. The literature review method was carried out by searching the literature through national and international literature searches as well as data on articles and scientific journals that focused on colon cancer, doxorubicin, the mechanism of action of doxorubicin, the content of Moringa leaves, the anti-cancer effects of Moringa leaves. The results of this study are: There is a cytotoxic effect produced by Moringa leaves (Moringa oleifera) against colon cancer cells and there is a synergistic effect between the combination of doxorubicin and Moringa leaves (Moringa oleifera) against colon cancer cells. Abstrak. Kanker kolon menempati urutan ketiga tersering di dunia dengan tingkat kematian tertinggi kedua. Terapi kanker kolon salah satunya dapat melalui kemoterapi menggunakan doxorubicin. Penggunaan tunggal doxorubicin memiliki efek samping yang signifikan. Salah satu upaya untuk mengurangi efek samping dan meningkatkan efektivitasnya adalah dengan mengkombinasikan doxorubicin dengan daun kelor (Moringa oleifera). Daun kelor memiliki banyak kandungan bahan aktif seperti flavonoid, D-allose, dan eugenol. Upaya lain yang dapat dilakukan untuk meningkatkan efektivitas obat adalah dengan pengembangan nanopartikel. Metode literatur review ini dilakukan dengan pencarian literatur melalui pencarian literatur nasional maupun internasional serta data artikel dan jurnal ilmiah yang berfokus pada kanker kolon, doxorubicin, mekanisme aksi doxorubicin, kandungan daun kelor, efek anti-kanker daun kelor. Hasil dari penelitian ini adalah: Terdapat efek sitotoksik yang dihasilkan daun kelor (moringa oleifera) terhadap sel kanker kolon dan terdapat efek sinergis antara kombinasi doxorubicin dengan daun kelor (Moringa oleifera) terhadap sel kanker kolon.
Systematic Review: Efektivitas Siprofloksasin Topikal pada Pengobatan Otitis Media Supuratif Kronik Anissha Fitry Oktavianita; Lelly Yuniarti
Jurnal Riset Kedokteran Volume 2, No.2, Desember 2022, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.vi.1506

Abstract

Abstract. Chronic suppurative otitis media or CSOM is an chronic inflammatory process that occurs in the middle ear, which is caused by bacteria with perforation of the tympanic membrane and the presence of ottorhoea. The most common causative bacteria is Pseudomonas aeruginosa. Topical antibiotic using ciprofloxacin can be used to treat for CSOM. Several studies have shown topical antibiotic to be more effective than systemic antibiotics. The aim of this study was to analyze the effectiveness of ciprofloxacin in the treatment of chronic suppurative otitis media. The study was conducted using systematic review method and database used in this study were Google Scholar, Science Direct, Proquest, Springer Link, Cochrane Library, and EBSCO HOST with 599 articles of journals obtained. The screening result on articles in accordance with the inclusion citeria were 344 articles and the exclusion criteria were 340 articles. The results of critical appraisal as many 4 articles.The study was conducted during March–December 2020. The results of review dan analysis from 4 articles of each study, topical ciprofloxacin was more effective topical neomycin, framycetin gramicidin-dexamethasone (FGD), and boric acid in the treatment of chronic suppurative otitis media. The parameters for relieving of symptomatic symptoms, perforation of tympanic membrane, and hearing quality. The conclusion of this study is that ciprofloxacin topical is more effective in the treatment of chronic suppurative otitis media. Abstrak. Otitis media supuratif kronik atau OMSK merupakan proses inflamasi kronik yang terjadi pada telinga bagian tengah yang diakibatkan oleh bakteri, ditandai dengan perforasi membran timpani serta ottorhoea yang terjadi secara terus menerus. Bakteri penyebab paling umum adalah Pseudomonas aeruginosa. Pengobatan OMSK dapat menggunakan antibiotik topikal siprofloksasin. Beberapa penelitian menunjukkan antibiotik topikal lebih efektif dibanding dengan antibiotik sistemik. Tujuan peneltian ini adalah menganalisis efektivitas siprofloksasin topikal pada pengobatan otitis media supuratif kronik. Penelitian ini merupakan systematic review dengan database yang digunakan adalah Google Scholar, Science Direct, Proquest, Springer Link, Cochrane Library, dan EBSCO HOST dengan jumlah artikel yang didapat sebanyak 599 artikel. Hasil skrining pada artikel yang sesuai dengan kriteria inklusi sebanyak 344 artikel dan kriteria eksklusi sebanyak 340 artikel. Setelah dilakukan telaah kritis, artikel yang di-review sebanyak empat artikel. Penelitian dilakukan pada periode Maret–Desember 2020. Hasil telaah dan analisis dari empat artikel menunjukkan bahwa siproflokasin topikal lebih efektif dibanding dengan topikal neomisin, framisetin gramisidin-deksametason (FGD), dan asam borik pada pengobatan otitis media supuratif kronik. Parameter kesembuhan gejala ottorhoea, perforasi membran timpani, serta kualitas pendengaran. Kesimpulan penelitian ini adalah siprofloksasin topikal efektif pada pengobatan otitis media supuratif kronik.
“Output Research Supporting Class” Manuscript Writing Training to Avoid Misconduct in an Islamic Perspective Yuniarti, Lelly; Batara, Triando; Garna, Herry; Tejasari, Maya
Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Vol 23, No 2 (2023)
Publisher : LP2M of Institute for Research and Community Services - UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/dms.2023.232.13495

Abstract

The tridharma point that is most challenging for a lecturer to achieve is research, and currently, the benchmark for the research field is scientific publications. However, in reality, there are still many lecturers who are hampered in fulfilling research outputs in the form of scientific publications, this is because lecturers experience difficulties in compiling manuscripts of research results for publication. There are currently 144 lecturers at the Tasikmalaya Health Engineering Polytechnic and around 50% of the lecturers still have the functional position of expert assistant and do not have a functional position or teaching staff. This PKM aims to improve the ability of Tasikmalaya Health Polytechnic lecturers to compile manuscripts, avoid misconduct, and publish the manuscript in the intended journal. PKM methodThis is done using an Asset Based Community-Driven Development (ABCD) approach, namely focusing on the assets, potential and strengths of the Health Polytechnic lecturers. Workshop and coaching clinic preparing manuscripts, using reference management, and submitting manuscripts to journals. The research results showed that of the 50 participants who took part in the workshop, 15 lecturers succeeded in compiling manuscripts of research results, avoiding misconduct, and improving the manuscripts according to reviewer input. This shows the need for ongoing training and stimulation activities for lecturers in compiling research output.
Spray Preparation Nanoemulsion Containing Butterfly Pea Flower (Clitoria ternatea L) Ethanol Extract as an Antiaging Nanocosmetic Yuniarti, Lelly; Bhatara, Tryando; Tejasari, Maya; Dewi, Miranti Kania; Ahmad, Sadiah; Kharisma, Yuktian
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.189-197

Abstract

Background:  Nanotechnology has the potential to produce innovations in drug formulation and drug delivery systems. Nanocosmetics and nanocosmeceuticals containing natural ingredients have been proven to overcome the weaknesses of traditional cosmetics and also add value to their formulations.Objective: This study aims to analyze the application of nanocosmeceutical technology based on ethanol extract of butterfly pea flower (Clitoria Ternatea L) in the preparation of nanoemulsion spray as a skin antiaging agent for the growth of collagen, elastin and extracellular matrix.Methods Method used true experimental design with posttest control group with random allocation to model mice given UVB radiation. The levels of collagen, elastin, and cellular matrix extract were assessed using Verhoef staining and observed by two experts,Results: The results of this research show that a nanoemulsion spray preparation of ethanol extract of butterfly pea flower (Clitoria Ternatea L) improves skin damage in aging model mice by increasing the production of extra cellular matrix, collagen and elastin. Conclusion: The preparation of butterfly pea flower flower extract nanoemulsion sprey (Clitoria Ternate L) has antiaging, collagen and elastin formation activities  
Efektivitas Pemberian Metformin terhadap Perbaikan Manifestasi Klinis pada Pasien Sindrom Polikistik Ovarium Maulani Nurmuji Atmapratiwi; Lelly Yuniarti; Ariko Rahmat Putra
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.10975

Abstract

Abstract. Polycystic Ovarian Syndrome (PCOS) is a common endocrine disorder characterized by ovulatory dysfunction, hyperandrogenism, and the presence of polycystic ovaries. Metformin, which is an insulin sensitizer agent, is the most widely used therapy in the management of PCOS. This research aims to explore and analyze articles discussing the effectiveness of metformin in improving clinical manifestations in polycystic ovarian syndrome patients. This research is a Scoping Review of articles published in 2012-2022 from the Pubmed, Springer Link, ScienceDirect, and Taylor and Francis databases that meet the criteria of Population (women with PCOS), Intervention (administration of metformin), Comparison (therapy other than metformin), Outcome (improvement of ovarian dysfunction and size of polycystic features, improved fertility, reduced body weight, reduced insulin resistance, improved menstrual cycle, hyperinsulinemia, hyperandrogenism, and abnormal metabolic disorders), Study (randomized controlled trials). The PRISMA diagram method was used in this research. From the four databases, 7,389 articles were obtained, which were then screened according to the inclusion criteria, feasibility test, and critical review according to the Joanna Briggs Institute checklist, resulting in 11 articles. Based on the results of the analysis of 11 articles, 10 articles stated that single metformin therapy was superior in reducing BMI, waist circumference, blood glucose, HOMA index, and improving the menstrual cycle compared to myoinositol therapy, rosiglitazone, letrozole, oral contraceptive pills, clomiphene citrate, cupping fennel seeds, and ovaries. There is 1 article that states that metformin therapy can improve ovulatory dysfunction. Abstrak. Polycystic Ovarian Syndrome (PCOS) merupakan gangguan endokrin umum yang ditandai dengan disfungsi ovulasi, hiperandrogen, dan adanya polikistik pada ovarium. Metformin merupakan agen sensitizer insulin adalah terapi yang paling banyak digunakan dalam penatalaksanaan PCOS. Tujuan dari penelitian adalah untuk mengeksplorasi dan menganalisis artikel yang membahas efektivitas metformin terhadap perbaikan manisfestasi klinis pada pasien polycystic ovarian syndrome. Penelitian ini merupakan Scoping Review artikel yang terbit tahun 2012-2022 dari database Pubmed, Springer Link, SienceDirect, dan Taylor and Francis yang sesuai dengan kriteria dengan Population (wanita penderita PCOS), Intervention (pemberian metformin), Comparison (terapi selain metformin), Outcome (perbaikan disfungsi ovarium dan ukuran gambaran polikistik, perbaikan fertilitas, menurunkan berat badan, mengurangi resistensi insulin, memperbaiki siklus menstruasi, hyperinsulinemia, hiperandrogenisme, dan kelainan metabolisme abnormal), Study (randomized controlled trials). Metode diagram PRISMA digunakan dalam penelitian ini, dari keempat database didapat 7,389 artikel yang kemudian dilakukan skrinning sesuai dengan kriteria inklusi, uji kelayakan, dan telaah kritis sesuai dengan checklist Joanna Briggs Institute dihasilkan 11 artikel. Berdasarkan hasil analisis dari 11 artikel terdapat 10 artikel yang menyatakan bahwa terapi metformin tunggal lebih unggul dalam menurunkan BMI, lingkar pinggang, glukosa darah, HOMA indeks, dan memperbaiki siklus menstruasi dibandingkan dengan terapi myoinositol, rosiglitazone, letrozole, pil kontrasepsi oral, clomiphene citrate, bekam biji adas dan ovarium. Terdapat 1 artikel yang menyatakan bahwa terapi metformin dapat memperbaiki disfungsi ovulasi.
Riwayat Pengobatan Tuberkulosis dan Penyakit Komorbid Sebagai Faktor Risiko Multi-Drugs Resistant Pasien Tuberkulosis Paru Andi Fajri Rahmat; Lelly Yuniarti; Nugraha Sutadipura
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.11565

Abstract

Abstract. Multidrug Resistant Tuberculosis (MDR-TB) is a type of tuberculosis that is resistant to at least two first-line antibiotics isoniazid (INH) and rifampicin (RMP) with or without resistance to other anti-tuberculosis drugs (OAT). This study aims to explore and analyze articles that discuss the history of tuberculosis treatment as a risk factor for multi-drug resistance in adult pulmonary tuberculosis patients. The research used literature studies between 2012-2022 from the Pubmed, Springer Link, ScienceDirect, Proquest, and Taylor and Francis databases. Based on the results of the analysis and discussion of the descriptions of the research articles reviewed, it can be concluded that a history of previous TB treatment is the main risk factor for increasing the incidence of MDR-TB. Abstrak. Multidrug Resistant Tuberculosis (MDR-TB) merupakan jenis tuberkulosis yang resisten terhadap setidaknya dua antibiotik lini pertama isoniazid (INH) dan rifampisin (RMP) dengan atau tanpa resistensi terhadap obat anti tuberkulosis (OAT) lain. Penelitian ini bertujuan untuk mengeksplorasi dan menganalisis artikel yang membahas riwayat pengobatan tuberkulosis sebagai faktor risiko terjadinya multi-drugs resistant pada pasien tuberkulosis paru dewasa. Penelitian menggunakan studi literatur antara tahun 2012-2022 dari database Pubmed, Springer Link, ScienceDirect, Proquest, dan Taylor and Francis. Berdasarkan hasil analisis dan pembahasan dari uraian artikel penelitian yang di-review dapat disimpulkan bahwa riwayat pengobatan TB sebelumnya menjadi faktor risiko utama dari meningkatnya kejadian MDR-TB.
Hubungan Tempat Kejadian dan Jenis Trauma Mekanik pada Mata dengan Tipe Ocular Trauma Berdasarkan Klasifikasi Birmingham Eye Trauma Terminology Mutia Nana; Lelly Yuniarti; Nugraha Sutadipura
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.11920

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Abstract. Eye trauma is a worldwide health problem that reduces productivity and quality of life. The World Health Organization reports that every year 23 million patients experience unilateral visual impairment. Eye trauma is one of the most common types of trauma in Indonesia. The aim of this study was to determine the relationship between the location of the incident and the type of mechanical trauma to the eye with the Birmingham Eye Trauma Terminology (BETT) classification in 2020-2022 at RSM Cicendo Bandung. This research is a quantitative observational analytical study with a cross sectional approach and total sampling technique from medical records at RSM Cicendo Bandung. Statistical analysis was carried out using the Fisher Exact test. Findings showed that 85.8% of ocular trauma patients were men, the most common age range for these patients was 36–55 years. Home (43.1%) is the most frequent place of occurrence. More people experienced open globe injuries (54.8%) than close globe injuries (45.8%). The relationship between the location of the incident and the type of ocular trauma has a P-value of 0.000 (P<0.05), the relationship between mechanical trauma to the eye and the type of ocular trauma has a P-value of 0.000 (P<0.05). The conclusion of this study is that there is a relationship between the location of the incident and the type of mechanical trauma with the type of ocular trauma. This study offers information for creating prevention tactics in a variety of activities that pose a risk of everyday eye injury. Abstrak. Trauma mata adalah masalah kesehatan di seluruh dunia yang menurunkan produktivitas dan kualitas hidup. Organisasi Kesehatan Dunia melaporkan setiap tahunnya 23 juta pasien mengalami gangguan penglihatan unilateral. Trauma mata merupakan salah satu jenis trauma yang paling banyak terjadi di Indonesia. Tujuan penelitian ini untuk mengetahui hubungan antara tempat kejadian dan jenis trauma mekanik pada mata dengan klasifikasi Birmingham Eye Trauma Terminology (BETT) pada tahun 2020-2022 di RSM Cicendo Bandung. Penelitian ini merupakan studi kuantitatif observasional analitik dengan pendekatan cross sectional dan teknik total sampling dari rekam medis di RSM Cicendo Bandung. Analisis statistik dilakukan dengan uji Fisher Exact. Temuan menunjukkan 85,8% pasien ocular trauma adalah laki-laki, rentang usia paling banyak bagi pasien ini adalah 36–55 tahun. Rumah (43,1%) merupakan tempat paling sering terjadinya. Lebih banyak orang yang mengalami kejadian open globe injury (54,8%) dibandingkan close globe injury (45,8%). Hubungan tempat kejadian dengan tipe ocular trauma memperoleh nilai P-value sebesar 0,000 (P<0,05), hubungan antara trauma mekanik pada mata dengan tipe ocular trauma nilai P-value sebesar 0,000 (P<0,05). Kesimpulan penelitian ini, terdapatnya hubungan tempat kejadian dan tipe trauma mekanik dengan tipe ocular trauma. Studi ini menawarkan informasi untuk menciptakan taktik pencegahan di berbagai kegiatan yang memiliki risiko cedera mata sehari-hari.
Gangguan Kognitif sebagai Efek Samping Penggunaan Steroid Anabolik Androgenik Athar Fathur Rafi; Sadiah Achmad; Lelly Yuniarti
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.11993

Abstract

Abstract. Adolescent and adult men are relatively satisfied with a muscular body shape. Efforts to increase muscle mass are the main strategy for achieving your dream body shape. One method used to increase muscle mass is using anabolic-androgenic steroids. However, androgenic anabolic steroids have side effects that can harm several body organs. This study aimed to explore and analyze the side effects of using anabolic-androgenic steroids as a supplement to increase muscle mass in adult men. This research is a systematic review to identify and analyze articles using ScienceDirect, PubMed, and Taylor and Francis, Proquest, and SpringerLink database sources. The eligibility criteria used are Population (adult men who use anabolic-androgenic steroids or their derivatives), Exposure (anabolic-androgenic steroids or their derivatives), Comparison (individuals who do not use anabolic-androgenic steroids or their derivatives), Outcome (side effects related to use anabolic-androgenic steroids or their derivatives), Study (cohort, case-control, cross-sectional study). Critical review was carried out using JBI critical appraisal, the PRISMA diagram method was used in this research and resulted in sixteen articles that met the inclusion and eligibility criteria. From 5 databases, 1,153 articles were obtained that met the inclusion criteria, and 16 articles were produced that met the eligibility criteria. Based on the results of the analysis of sixteen articles, thirteen articles were found which stated that supplementation with androgenic anabolic steroids had significant side effects on several body organs in adult men, while three other studies concluded that there were no significant differences or side effects. Based on the results of the analysis and discussion of the descriptions of the research articles reviewed, it can be concluded that the use of androgenic anabolic steroids has side effects on various organs in adult men such as organs in the nervous system, heart, kidneys, reproductive organs and periodontal. Abstrak. Pria remaja dan dewasa relatif memiliki kepuasaan terhadap bentuk tubuh yang berotot. Upaya meningkatkan masa otot merupakan strategi utama untuk memperoleh bentuk tubuh idaman. Salah satu cara yang digunakan untuk meningkatkan masa otot adalah menggunakan steroid anabolik-androgenik. Namun, steroid anabolik androgenik memiliki efek samping yang dapat membahayakan beberapa organ tubuh. Tujuan penelitian ini adalah untuk mengeksplorasi dan menganalisis efek samping penggunaan steroid anabolik-androgenik sebagai suplementasi penambah masa otot pada laki-laki dewasa. Penelitian ini merupakan systematic review untuk mengidentifikasi dan menganalisis artikel melalui sumber database ScienceDirect, PubMed, dan Taylor and Francis,Proquest, dan Springerlink. Kriteria kelayakan yang digunakan yaitu Populasi (pria dewasa pengguna steroid anabolik-androgenik atau turunannya), Exposure (steroid anabolik-androgenik atau turunannya), Comparison (individu yang tidak menggunakan steroid anabolik-androgenik atau turunannya), Outcome (efek samping yang berhubungan dengan penggunaan steroid anabolik-androgenik atau turunannya), Study (cohort, case-control, cross-sectional study). Telaah kritis dilakukan dengan menggunakan JBI critical appraisal, Metode diagram PRISMA digunakan dalam penelitian ini dan menghasilkan enam belas artikel yang memenuhi kriteria inklusi dan kelayakan. Dari 5 database didapatkan 1.153 artikel sesuai dengan kriteria inklusi, dan dihasilkan 16 artikel yang memenuhi kriteria kelayakan. Berdasarkan hasil analisis dari enam belas artikel, didapatkan tiga belas artikel yang menyebutkan pemberian suplementasi steroid anabolik androgenik memiliki efek samping signifikan terhadap beberapa organ tubuh pada laki-laki dewasa, sedangkan tiga penelitian lainnya menyimpulkan bahwa tidak ada perbedaan atau efek samping yang signifikan. Berdasarkan hasil analisis dan pembahasan dari uraian artikel penelitian yang di-review, dapat disimpulkan bahwa penggunaan steroid anabolik androgenik memiliki efek samping terhadap berbagai macam organ pada pria dewasa seperti organ pada sistem saraf, jantung, ginjal, organ reproduksi, dan periodontal.
Analisis Penyalahgunaan Zat sebagai Faktor Risiko Kejadian Gangguan Bipolar pada Orang Dewasa Nadiya Amalia; Lelly Yuniarti; Sadiah Achmad
Bandung Conference Series: Medical Science Vol. 4 No. 1 (2024): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v4i1.12024

Abstract

Abstract. Bipolar disorder is an emotional disorder with recurrent episodes of mood swings and depression, followed by changes in activity or energy and associated with characteristic cognitive, physical, and behavioral symptoms. Age, genetics, psychology, environment, and substance and alcohol abuse are risk factors for bipolar disorder. This study aimed to explore and analyze articles regarding substance abuse as a risk factor for bipolar disorder in adults. This research uses the Systematic Review method to identify and analyze articles regarding substance abuse as a risk factor for bipolar disorder in adults. The databases used were Pubmed, SpringerLink, ScienceDirect and Taylor and Francis, the PRISMA diagram method was used in this research. The PICOS suitability used in this study is Population (adults), Exposure (substance abuse (alcohol, cannabis, nicotine)), Comparison (control group or group that does not abuse substances), Outcome (incidence of bipolar disorder, manic episodes, depressive episodes, or mixed episode), Study (observational (cohort, case-control, or cross-sectional)), and critical review were carried out using the JBI checklist. From 5 databases, 5,493 articles were obtained that met the inclusion criteria and after conducting a feasibility test, 5 articles were suitable. Based on the results of the analysis, 4 articles state that substance abuse is a risk factor for bipolar disorder in adults. Marijuana and alcohol abuse are the substances that are most often risk factors for bipolar disorder in adults, and marijuana abuse carries a higher risk of developing bipolar disorder than abuse of other substances. Substance abuse influences the age at which manic, depressive and psychotic symptoms first appear. Abstrak. Gangguan bipolar adalah gangguan emosi dengan episode berulang pada perubahan suasana hati dan depresi, yang diikuti dengan adanya perubahan aktivitas atau energi dan berhubungan dengan karakteristik gejala kognitif, fisik, dan perilaku. Usia, genetik, psikologis, lingkungan, penyalahgunaan zat dan alkohol merupakan faktor risiko terjadinya gangguan bipolar. Tujuan penelitian ini adalah untuk mengeksplorasi dan menganalisis artikel mengenai penyalahgunaan zat sebagai faktor risiko gangguan bipolar pada orang dewasa. Penelitian ini menggunakan metode Systematic Review untuk mengidentifikasi dan menganalisis artikel mengenai penyalahgunaan zat sebagai faktor risiko kejadian gangguan bipolar pada orang dewasa. Database yang digunakan Pubmed, SpringerLink, ScienceDirect dan Taylor and Francis, metode diagram PRISMA digunakan dalam penelitian ini. Kesesuaian PICOS yang digunakan pada penelitian ini adalah Population (orang dewasa), Exposure (penyalahgunaan zat (alcohol, cannabis, nicotine)), Comparison (kelompok kontrol atau kelompok yang tidak menyalahgunakan zat), Outcome (kejadian bipolar disorder, manic episode, depressive episode, atau mixed episode), Study (observational (cohort, case-control, atau cross-sectional)), dan telaah kritis dilakukan menggunakan checklist JBI. Dari 5 database didapatkan 5.493 artikel yang sesuai dengan kriteria inklusi dan setelah dilakukan uji kelayakan terdapat 5 artikel yang sesuai. Berdasarkan hasil analisis, terdapat 4 artikel yang menyatakan bahwa penyalahgunaan zat merupakan faktor risiko kejadian gangguan bipolar pada orang dewasa. Penyalahgunaan ganja dan alkohol merupakan zat yang paling sering menjadi faktor risiko terjadinya gangguan bipolar pada orang dewasa, dan penyalahgunaan ganja beresiko lebih tinggi untuk berkembang menjadi gangguan bipolar dibanding dengan penyalahgunaan zat lain. Penyalahgunaan zat memengaruhi usia pertama kali timbulnya gejala manik, depresif dan psikosis yang timbul.
Co-Authors Abdul Hadi Hassan Agly Adithya Agly Adithya, Agly Ahmad, Sadiah Althaafvashti Trixie Niadi Andi Fajri Rahmat Andriane, Yuke Anggit Yanuaristi Anissha Fitry Oktavianita Anissha Fitry Oktavianita Apen Afgani Ariko Rahmat Putra Athar Fathur Rafi Azmi Putri Azzahra Azri Iskandar Azri Iskandar, Azri Bachti Alisjahbana Batara, Triando Bhatara, Tryando Clara Juniasari Dean Wahjudi Satyaputra Dida Ahmad Gurnida Dika Rifky Fernanda Dika Rifky Fernanda Endang Sutedja Enggar Hestu Enggar Hestu, Enggar Gibran Bramasta Dirgavansya Gibran Bramasta Dirgavansya Herri S. Sastramihardja Herry Garna Heru Haerudin Hilmi Sulaiman Rathomi Hur'iynazzahra Kariima Romli Ida Parwati Ismet Muchtar Nur Julia Hartati Julia Hartati Kharisma, Yuktian Maulani Nurmuji Atmapratiwi Maya Tejasari Miranti Kania Dewi Muhamad Rizky Pratama Kurniawan Rizky Mutia Nana Nadiya Amalia Nanan Sekarwana Noormartany Nugraha Sutadipura Nurizzatun Nafsi Pratama, Ryan Martin Pupung Purnamasari Raden Anita Indriyanti Revina Mayra Salsabila Hasyim Sadeli Masria Sadiah Achmad Salma Nur Afina Samsudin Surialaga Silmi Hizba Hunafa Siti Annisa Devi Trusda, Siti Annisa Devi Suganda Tanuwijaya Suganda Tanuwijaya, Suganda Susan Fitriyana Susanti Dharmmika Tety H. Rahim Titik Respati Tryando Bhatara Uci Ary Lantika Umar Islami Wida Purbaningsih Yani Triyani Yani Triyani Yenolinsky, Yolanda Yuktiana Kharisma Zulmansyah , Zulmansyah