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All Journal ACTA VETERINARIA INDONESIANA Althea Medical Journal Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Global Medical and Health Communication Jurnal Manajemen Kesehatan Indonesia MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Integrasi Kesehatan dan Sains Jurnal Riset Kedokteran Bandung Conference Series : Medical Science Global Medical and Health Communication
Lelly Yuniarti
Department Of Biochemistry, Nutrition And Biomolecular, Faculty Of Medicine, Universitas Islam Bandung, Bandung
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Nuclear Changes Features in Buccal Mucosa Smear of Adult Male Smokers Using Pappaniculou Staining Kharisma, Yuktiana; Indriyanti, Raden Anita; Yuniarti, Lelly; Noormartany, Noormartany; Nur, Ismet Muchtar; Yenolinsky, Yolanda
Althea Medical Journal Vol 12, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n1.3486

Abstract

Background: Tobacco smoke contains a combination of chemicals that could be harmful to the buccal mucosa as the first part of the body that has been exposed. Damage to the buccal epithelial cells has the potential to become a malignant lesion. This study aimed to describe changes in the nuclear epithelial of the buccal mucosa using Pappaniculou staining as an indicator of mucosal damage in smokers.Methods: This was a descriptive analytical study, involving adult male participants from Bale Endah District, Bandung Regency, Indonesia aged >35 years, who had smoked for ≥10 years. Buccal mucosa smear was taken, and the features of nuclear epithelial changes were observed per 500 cells, each at 400x magnification with Pappaniculou stain to evaluate the features of micronucleus, broken egg, karyorrhexis, karyolysis. Those who did not smoke were recruited as a control group.Results: Smokers were mostly light active smokers or kretek cigarettes, with a smoking duration of ≥15 years. The frequency of micronucleus (p<0.001), broken eggs (p<0.001), karyorrhexis (p=0.001), karyolysis (p=0.003) in the buccal mucosal epithelial was significantly different between the smoker and non-smoker groups.Conclusions: All epithelial nuclear changes have shown significant differences between smoker and non-smoker groups. Nuclear epithelial features in smoker may be associated with future malignancies, therefore, smoking cessation programs are necessary to substantially reduce tobacco use, thus fostering a healthy lifestyle for everyone.
“Output Research Supporting Class” Manuscript Writing Training to Avoid Misconduct in an Islamic Perspective Yuniarti, Lelly; Batara, Triando; Garna, Herry; Tejasari, Maya
Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Vol. 23 No. 2 (2023)
Publisher : LP2M of Institute for Research and Community Services - UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/dms.2023.232.13495

Abstract

The tridharma point that is most challenging for a lecturer to achieve is research, and currently, the benchmark for the research field is scientific publications. However, in reality, there are still many lecturers who are hampered in fulfilling research outputs in the form of scientific publications, this is because lecturers experience difficulties in compiling manuscripts of research results for publication. There are currently 144 lecturers at the Tasikmalaya Health Engineering Polytechnic and around 50% of the lecturers still have the functional position of expert assistant and do not have a functional position or teaching staff. This PKM aims to improve the ability of Tasikmalaya Health Polytechnic lecturers to compile manuscripts, avoid misconduct, and publish the manuscript in the intended journal. PKM methodThis is done using an Asset Based Community-Driven Development (ABCD) approach, namely focusing on the assets, potential and strengths of the Health Polytechnic lecturers. Workshop and coaching clinic preparing manuscripts, using reference management, and submitting manuscripts to journals. The research results showed that of the 50 participants who took part in the workshop, 15 lecturers succeeded in compiling manuscripts of research results, avoiding misconduct, and improving the manuscripts according to reviewer input. This shows the need for ongoing training and stimulation activities for lecturers in compiling research output.
THE INFLUENCE OF SERVICE QUALITY AND HEALTH FACILITIES ON PATIENT SATISFACTION Pratama, Ryan Martin; Purnamasari, Pupung; Yuniarti, Lelly
Jurnal Manajemen Kesehatan Indonesia Vol 12, No 1 (2024): April 2024
Publisher : Magister Kesehatan Masyarakat, Fakultas Kesehatan Masyarakat, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jmki.12.1.2024.35-44

Abstract

Patient satisfaction with dental and oral health services is the key to the sustainability of a Dental and Oral Hospital (Rumah Sakit Gigi dan Mulut/RSGM). An important factor that can support patient satisfaction is the quality of services and health facilities available. The Dental and Oral Teaching Hospital has the potential to raise many views on the quality of services provided. One of the educational RSGMs that is frequently visited is the RSGM Universitas Padjadjaran (UNPAD). This study aims to examine and analyze the influence of service quality and health facilities on patient satisfaction of co-assistant young dentists at RSGM UNPAD. The type of research used is descriptive verification with a quantitative approach and survey method. The subjects of this research were patients treated by young co-assistant  dentists at RSGM UNPAD, with a sample size of 135 respondents. Data were analyzed using SEM PLS. The results of the study showed that service quality had no effect on patient satisfaction, health facilities had an effect on patient satisfaction, and service quality and health facilities simultaneously had an effect on patient satisfaction of young co-assistant dentists at RSGM UNPAD. The findings of this research have the impact that the management of RSGM UNPAD needs to evaluate and improve the quality of service in the form of financing, facilities in the form of vehicle parking space capacity, and the level of satisfaction in the form of a more up-to-date reservation system.Keywords: Health Facilities, Service Quality, Patient Satisfaction
The Efficacy of PEGylated Nanocarrier Extract of Red Ginger (Zingiber officinale var. sunti Valeton) and Lemongrass (Cymbopogon citratus) Combination on Fasting Blood Glucose and HbA1c Levels in Diabetes Mellitus Model Rats Widayanti; Eka Hendryanny; Lelly Yuniarti
Global Medical & Health Communication (GMHC) Vol. 13 No. 3 (2025): Accredited Sinta 2
Publisher : UPT Publikasi Ilmiah Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i3.8778

Abstract

Diabetes mellitus is a major global public health problem due to its serious complications. In addition to standard pharmacological therapy, herbal-based interventions are increasingly explored as complementary approaches to improve glycemic control. This study aimed to evaluate the effects of a PEGylated nanocarrier extract combining red ginger (Zingiber officinale var. sunti Valeton) and lemongrass (Cymbopogon citratus) on fasting blood glucose and HbA1c levels in a diabetes mellitus rat model. An experimental randomized controlled study was conducted from May to August 2024 at the Pharmacy Laboratory of Universitas Islam Indonesia, Yogyakarta, and the Food and Nutrition Laboratory of Universitas Gadjah Mada, Yogyakarta. Experimental rats were randomly allocated into six groups: a healthy control group, a negative control group, a positive control group receiving glibenclamide (0.45 mg/kg body weight) and simvastatin (0.9 mg/kg body weight), and three treatment groups administered the PEGylated nanocarrier ginger lemongrass extract orally at doses of 20, 40, and 80 mg/kg body weight/day. Fasting blood glucose levels were measured using a GOD-PAP method, while HbA1c levels were assessed by immunoassay. Data were analyzed using one-way ANOVA followed by Tukey post hoc testing. The results demonstrated that the treatment group receiving 80 mg/kg body weight/day showed the most significant reductions in fasting blood glucose (172.44±4.49 mg/dl) and HbA1c (3.79±0.15%). These reductions were statistically significant compared with the control groups (p<0.001). In conclusion, the PEGylated nanocarrier combination of red ginger and lemongrass significantly improved glycemic parameters in diabetic rats. This formulation may represent a potential complementary strategy for glycemic control, supporting further investigation in mechanistic and translational studies before clinical application.
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Profiling for Quinolinone Alkaloids and Phenolic Metabolites in a Bioactive Fraction of Indonesian Yacon (Smallanthus sonchifolius) Tuber Extract Eka Hendryanny; Widayanti; Lelly Yuniarti
Global Medical & Health Communication (GMHC) Vol. 13 No. 3 (2025): Accredited Sinta 2
Publisher : UPT Publikasi Ilmiah Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i3.8796

Abstract

Yacon (Smallanthus sonchifolius) is a functional tuber rich in fructooligosaccharides, phenolic compounds, and diverse secondary metabolites with potential health-promoting properties. Despite its increasing use, the comprehensive characterization of its bioactive constituents, particularly those derived from plants cultivated in Indonesia, remains limited. This study aims to identify and characterize the major bioactive components of ethanolic yacon tuber extract using liquid chromatography-tandem mass spectrometry (LC-MS/MS). This descriptive, exploratory investigation of natural product phytochemistry was conducted from June to July 2025—fresh tubers were collected from Lembang, West Bandung. The samples were subjected to ethanol maceration, and LC-MS/MS analysis was performed on a bioactive fraction (Rf 0.52) obtained from preliminary thin-layer chromatography (TLC) fractionation of the crude ethanolic extract, using positive electrospray ionization and gradient elution. Compound annotation was performed using UNIFI software. LC–MS/MS profiling revealed 15 predominant secondary metabolites, with retention times ranging from 5.41 to 13.18 minutes and mass-to-charge (m/z) ratios of 255.35–459.48. Early-retention peaks comprised polar constituents, such as sucrose and nicotianamine, a metal-chelating amino acid known to enhance iron bioavailability. Mid-retention peaks included phenolic acids and flavonoids, notably chlorogenic acid and jaceosidin. High-retention peaks were dominated by hydrophobic alkaloids, with 4,7,8-trimethyl-3-(3-methylbut-2-enyl)-1H-quinolin-2-one identified as the most abundant compound (56.42%), followed by senecionine (9.36%) and nonadecan-2-amine (6.75%). In conclusion, West Bandung yacon tubers contain a diverse spectrum of alkaloids, flavonoids, and phenolic derivatives that may contribute to their pharmacological potential. The results provide an essential phytochemical foundation for future studies evaluating bioactivity and toxicological assessment using targeted in vitro and in vivo approaches.
Co-Authors Abdul Hadi Hassan Agly Adithya Agly Adithya, Agly Ahmad, Sadiah Althaafvashti Trixie Niadi Andi Fajri Rahmat Andriane, Yuke Anggit Yanuaristi Anissha Fitry Oktavianita Anissha Fitry Oktavianita Apen Afgani Ariko Rahmat Putra Athar Fathur Rafi Azmi Putri Azzahra Azri Iskandar Azri Iskandar, Azri Bachti Alisjahbana Batara, Triando Bhatara, Tryando Clara Juniasari Dean Wahjudi Satyaputra Dida Ahmad Gurnida Dika Rifky Fernanda Dika Rifky Fernanda Eka Hendryanny Endang Sutedja Enggar Hestu Enggar Hestu, Enggar Gibran Bramasta Dirgavansya Gibran Bramasta Dirgavansya Herri S. Sastramihardja Herry Garna Heru Haerudin Hilmi Sulaiman Rathomi Hur'iynazzahra Kariima Romli Ida Parwati Ismet Muchtar Nur Julia Hartati Julia Hartati Kharisma, Yuktian Maulani Nurmuji Atmapratiwi Maya Tejasari Miranti Kania Dewi Muhamad Rizky Pratama Kurniawan Rizky Mutia Nana Nadiya Amalia Nanan Sekarwana Noormartany Nugraha Sutadipura Nurizzatun Nafsi Pratama, Ryan Martin Pupung Purnamasari Raden Anita Indriyanti Revina Mayra Salsabila Hasyim Sadeli Masria Sadiah Achmad Salma Nur Afina Samsudin Surialaga Silmi Hizba Hunafa Siti Annisa Devi Trusda, Siti Annisa Devi Suganda Tanuwijaya Suganda Tanuwijaya, Suganda Susan Fitriyana Susanti Dharmmika Tety H. Rahim Titik Respati Tryando Bhatara Uci Ary Lantika Umar Islami Wida Purbaningsih Widayanti Yani Triyani Yenolinsky, Yolanda Yuktiana Kharisma Zulmansyah , Zulmansyah