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All Journal Health Science Journal of Indonesia Indonesian Journal of Cancer The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Gizi Klinik Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Amerta Nutrition Acta Biochimica Indonesiana World Nutrition Journal Jurnal Ners Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Cancer Makara Journal of Science
Novi Silvia Hardiany
Departemen Biokimia Fakultas Kedokteran Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Oxidative stress and antioxidant status among the elderly in Jakarta Novi Silvia Hardiany; Daniya Qanita Amani; Jasmine Virginia Anjani; Prima Christin Natalia; Rheina Tamara Tarigan
Acta Biochimica Indonesiana Vol. 7 No. 2 (2024): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.177

Abstract

Background: Indonesia is experiencing a demographic shift, with the elderly population comprising 9.92% (26.82 million) of the total population, 8.21% of whom reside in Jakarta. Oxidative stress is a key contributor to the development of degenerative diseases associated with aging, while antioxidant defenses can mitigate its effects. Objective: This study aimed to assess oxidative stress levels, measured by malondialdehyde (MDA), and antioxidant status, including catalase, reduced glutathione (GSH), and vitamin C, in the elderly population of Jakarta. Methods: A cross-sectional study was conducted with 91 elderly participants from three sub-districts in Jakarta. Erythrocyte lysate samples were analyzed to measure MDA, catalase, and GSH levels, while plasma was used to measure vitamin C. All parameters were quantified using a spectrophotometer. MDA levels and antioxidant status were categorized based on age, blood pressure, and the number of chronic diseases, with statistical analysis performed using the Kruskal-Wallis test. Results: The median MDA level was 2.68 (1.61–5.64) nmol/mL, with the highest levels observed in participants aged 60–64 and those with three chronic diseases. The mean catalase level was 2.41 ± 0.39 U/mL, the median GSH level was 6.16 (2.02–128.07) µmol/mL, and the mean vitamin C level was 10.87 ± 4.9 µg/mL. No significant differences in antioxidant status were observed based on age, blood pressure, or the number of chronic diseases. Conclusion: Oxidative stress is prevalent in the elderly and is particularly influenced by the presence of multiple chronic diseases. However, antioxidant status does not significantly vary with age, blood pressure, or disease burden in this population.
Association of vitamin E intake and malondialdehyde (MDA) levels with cognitive function in elderly residing at the Budi Mulia Tresna Werdha nursing home, East DKI Jakarta Ria Angelia Putri; Novi Silvia Hardiany; Erfi Prafiantini
World Nutrition Journal Vol. 10 No. 1 (2026): WNJ. Volume 10 Issue 1, Agustus 2026
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V10.i1.0015

Abstract

Background: Cognitive dysfunction is one of the health problems associated with elderly. Oxidative stress is thought to play a role in the neurodegenerative process through increased production of free radicals that cause nerve cell damage. Vitamin E is an antioxidant that protects cell membranes from oxidative damage, whereas malondialdehyde (MDA) is a biomarker of oxidative stress produced by lipid peroxidation. The objective of this study is to analyze the association of vitamin E intake and MDA levels with cognitive function among elderly residents of Budi Mulia 1 Nursing Home in DKI Jakarta, Indonesia. Methods: This secondary study employed a cross-sectional design using data derived from a primary study investigating the association between zinc intake, superoxide dismutase activity, and cognitive function among elderly. A total of 85 participants met the inclusion and exclusion criteria. Vitamin E intake was assessed using a Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ), plasma MDA levels were measured from stored plasma samples, and cognitive function was evaluated using the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina). Results: The median age of the participants was 69 years (range: 60–91 years). The median vitamin E intake, plasma MDA level, and cognitive function score were 3.7 mg/day (2.5–3.8), 2.85 nmol/mL (1.88–6.77), and 16 (1–30), respectively. No significant association was found between vitamin E intake and cognitive function (r = 0.027; p = 0.806), nor between plasma MDA levels and cognitive function (r = 0.096; p = 0.380). Conclusion: There was no significant association between vitamin E intake or plasma MDA levels and cognitive function among elderly.
Co-Authors Adisti Dwijayanti Agian Jeffilano Barinda Akbar Husaini Angkat Amalina Fakhriah Andayani, Diyah Eka Bagus Ramasha Amangku Chandra, Dian Novita Damayanti Angelina Daniya Qanita Amani Dewi Sumaryani Soemarko Dimas Priantono Engelbert Julyan Gravianto Erfi Prafiantini Fadhillah, Muhamad Rizqy Febriana Catur Iswanti Feby Fariska Savira Filda Vionita Irene de Lima Halim, Abdul Istiqomah Agusta Jasmine Virginia Anjani Karima Yudhistina Khatimah, Nurul Gusti Lusiyana Dwi Rahmawati Mohamad Sadikin Muchtaruddin Mansyur Nanda Fauziyana Nanda Fauziyana Nina Indriyani Nasruddin Nurfitri Nurfitri Nurfiyana, Wahyu Penantian, Raya Makarim Prima Christin Natalia Purnamasari, Yuti Radiana Dhewayani Antarianto Reni Paramita Reni Paramita Retno Wahyu Nurhayati Rheina Tamara Tarigan Ria Angelia Putri Septelia Inawati Wanandi SEPTELIA INAWATI WANANDI Septelia Inawati Wanandi Shimizu, Ippei Siregar, Fajri Marindra Sri Widia Azraki Jusman Stephanie Gosal Sucitra Sucitra Syaiful Ichwan Vivian Soetikno Wawaimuli Arozal Wawan Mulyawan Wiji Lestari Yohana Yohana Yudhistina, Karima