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All Journal Health Science Journal of Indonesia Indonesian Journal of Cancer The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Gizi Klinik Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Amerta Nutrition Acta Biochimica Indonesiana Bioscientia Medicina : Journal of Biomedicine and Translational Research World Nutrition Journal Jurnal Ners Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Cancer eJournal Kedokteran Indonesia Makara Journal of Science
Novi Silvia Hardiany
Departemen Biokimia Fakultas Kedokteran Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Andrographis paniculata Ethanol Extract Alleviates High Glucose-induced Senescence of Human Umbilical Vein Endothelial Cells via the Regulation of mTOR and SIRT1 Pathways Khatimah, Nurul Gusti; Arozal, Wawaimuli; Barinda, Agian Jeffilano; Antarianto, Radiana Dhewayani; Hardiany, Novi Silvia; Shimizu, Ippei; Fadhillah, Muhamad Rizqy
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3067

Abstract

BACKGROUND: Chronic exposure of high glucose (HG) in endothelial cell induces senescence which may contribute to the development and progression of age-related diseases including insulin resistance. Andrographis paniculata improves insulin resistance in recent in vitro and in vivo studies. Anti-inflammatory and antioxidant properties of A. paniculata may be the new therapeutic approach to inhibiting premature senescence. However, the senolytic effect of A. paniculata on endothelial cells has not been investigated comprehensively. This study was conducted to evaluate the effect of A. paniculata extract on HG-induced endothelial cell senescence and the underlying mechanisms.METHODS: Human umbilical vein endothelial cells (HUVECs) were treated with 33 mM HG and 7.5 μg/mL A. paniculata extract for 48 hours. The expressions of p16, p21, interleukin (IL)-6, IL-8, insulin receptor substrate (IRS)-1, mammalian target of rapamycin, and sirtuin 1 (SIRT1) were measured by performing real-time quantitative polymerase chain reaction (RT-qPCR). The senescence-associated-β-galactosidase (SA-β-gal) staining was performed to observe the positive-stained senescent cells, while the cell surface expression of IL-1α was examined with flow cytometry method.RESULTS: A. paniculata extract reversed senescence in HUVECs under HG conditions by reducing mRNA expressions of p16 and p21, the number of SA-β-gal-positive-stained cells, and the expression of IL-1α on cell surface, which decreased the activation of IL-6 and IL-8. In addition, A. paniculata extract decreased the mRNA expression of mTOR and increased the mRNA expressions of IRS-1 as well as SIRT1.CONCLUSION: A. paniculata extract ameliorated senescence and improved insulin sensitivity by regulating the mTOR, SIRT1, and IRS-1 mRNA expressions on HG-treated HUVECs.KEYWORDS: Andrographis paniculata, endothelial cell, senescence, high glucose, nutrient-sensing pathways
Korelasi antara Kadar Vitamin C Plasma dengan Tekanan Darah pada Lansia di Jakarta Timur Purnamasari, Yuti; Andayani, Diyah Eka; Hardiany, Novi Silvia
Jurnal Ners Vol. 8 No. 1 (2024): APRIL 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v8i1.18580

Abstract

Introduction: The elderly population in developing countries is increasing every year.. In the elderly with increasing age, physiological functions decrease due to degenerative processes, therefore many non- communicable diseases appear in old age. Blood pressure is a parameter used to assess cardiovascular health, which is influenced by oxidative stress. Vitamin C is a strong antioxidant to reduce oxidative stress and maintain endothelial function by producing nitirc oxide. The aim of this study was to analyze the correlation between plasma vitamin C levels and blood pressure in the elderly in East Jakarta.Methods: This study used a Cross-sectional method conducted on 60 elderly members both females and males age > 60 years old in Panti Sosial Tresna Werdha Budi Mulia 1. Vitamin C intake was assessed by semi quantitative food frequency questionnaire, blood pressure was measured by sphygmomanometer and plasma vitamin C levels were detected by spectrophotometer. Analysis correlation between plasma vitamin C level and blood pressure was performed using Spearmen test. Result: This research shows that systolic blood pressure is 125 (90-160) mmHg and diastolic blood pressure is 80 (60-110) mmHg. Median Vitamin C content 0,44 (0,08- 1,81). Results bivariate analysis between plasma vitamin C levels and systolic blood pressure. obtained P>0.05. Conclusion: There was no correlation between plasma vitamin C levels and systolic and diastolic blood pressure.
Freediving, Hypoxia, and Inflammation: Physiological Adaptations and Interactions between HIF and NF-κB Amalina Fakhriah; Novi Silvia Hardiany; Iswanti, Febriana Catur
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1026

Abstract

Freediving presents a unique set of physiological challenges and adaptations, making it a subject of interest for researchers studying the effects of extreme environmental conditions on the human body. There is a complex interplay between freediving, hypoxia, immune responses, and inflammation, shedding light on the physiological effects of freediving on the human body. This article describes how HIF and NF-κB interact during hypoxia and inflammation, including their synergistic effects and signaling pathways. The regulatory loop involving these transcription factors is highlighted, providing insight into their linked roles in modulating the cellular response to hypoxia and inflammation.
Co-Authors Adisti Dwijayanti Agian Jeffilano Barinda Akbar Husaini Angkat Amalina Fakhriah Andayani, Diyah Eka Antarianto, Radiana Dhewayani Bagus Ramasha Amangku Chandra, Dian Novita Christin Natalia, Prima Damayanti Angelina Dewi Sumaryani Soemarko Dimas Priantono Engelbert Julyan Gravianto Erfi Prafiantini Erni Hernawati Purwaningsih, Erni Hernawati Fadhillah, Muhamad Rizqy Febriana Catur Iswanti Feby Fariska Savira Filda Vionita Irene de Lima Halim, Abdul Istiqomah Agusta Karima Yudhistina Khatimah, Nurul Gusti Lusiyana Dwi Rahmawati Mohamad Sadikin Muchtaruddin Mansyur Nanda Fauziyana Nanda Fauziyana Nina Indriyani Nasruddin Nurfitri Nurfitri Nurfiyana, Wahyu Penantian, Raya Makarim Purnamasari, Yuti Qanita Amani, Daniya Radiana Dhewayani Antarianto Reni Paramita Reni Paramita Retno Wahyu Nurhayati Septelia Inawati Wanandi Septelia Inawati Wanandi SEPTELIA INAWATI WANANDI Shimizu, Ippei Siregar, Fajri Marindra Sri Widia Azraki Jusman Stephanie Gosal Sucitra Sucitra Syaiful Ichwan Tamara Tarigan, Rheina Virginia Anjani, Jasmine Vivian Soetikno Wawaimuli Arozal Wawan Mulyawan Wiji Lestari Yohana Yohana Yudhistina, Karima