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All Journal SCHOOL EDUCATION JOURNAL PGSD FIP UNIMED Jurnal Ilmiah Administrasi Publik SPEKTRUM Jurnal Ilmu Politik Hubungan Internasional JURNAL AGRILAND Jurnal Pendidikan Matematika (JUDIKA EDUCATION) Prima: Jurnal Pendidikan Matematika Jurnal Studi Guru dan Pembelajaran JP2M (Jurnal Pendidikan dan Pembelajaran Matematika) Al-Ikhtibar : Jurnal Ilmu Pendidikan Jurnal Manajemen Pendidikan Al Hadi Jurnal Buana Farma Shihatuna : Jurnal Pengabdian Kesehatan Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Lanskap Politik Blantika : Multidisciplinary Journal PERSPEKTIF: Journal of Social and Library Science Relevan : Jurnal Pendidikan Matematika
Muhammad Nuh
Guru SMA Negeri 1 Panyabungan
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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SYSTEMATIC LITERATURE REVIEW: KANDUNGAN SENYAWA BIOAKTIF DAN AKTIVITAS SITOTOKSIK EKSTRAK ALANG-ALANG TERHADAP SEL KANKER Nuh, Muhammad; Ma’rifah; Haq, Nasrul; Akrom
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1452

Abstract

Imperata cylindrica (Imperata cylindrica) is a traditional medicinal plant long used in various countries and is known to contain various bioactive compounds with anticancer potential. Research on the cytotoxic activity of Imperata cylindrica continues to develop, but results are still varied, requiring a systematic review to summarize the available scientific evidence. This study aims to review the bioactive compound content and cytotoxic activity of Imperata cylindrica extract against various cancer cells. A systematic literature review method was conducted by searching articles from international and national databases using relevant inclusion and exclusion criteria. Of the total 410 articles found, 10 articles were selected to meet the requirements for analysis. The results of the study showed that cogongrass extract with various solvents (ethanol, methanol, water, n-hexane fraction, ethyl acetate fraction, and chloroform) has cytotoxic activity against various cancer cell lines, such as breast (MCF-7), cervical (HeLa), colon (HT-29), lung (A549), liver (HepG2), prostate (PC-3), and leukemia (HL-60). The identified cytotoxic mechanisms include induction of apoptosis, cell cycle arrest, inhibition of migration, antioxidant, anti-inflammatory, and immunomodulatory activities. The dominant compounds that play a role include flavonoids, alkaloids, terpenoids, saponins, and tannins. In conclusion, cogongrass extract has great potential as a candidate for natural anticancer agents, although further research in the form of in vivo tests and clinical trials is still very necessary to ensure its effectiveness and safety.
Co-Authors Akrom, Akrom Alistya, Laona Azka Ammamiarihta Ammamiarihta Bayu Pratama, Bayu Cahyasari, Erlita Fadzil Latifah, Fadzil Fahrozi, Fahrozi Fakira, Qania Athaya Faoji, Ahmad Fazira, Ira Finuya, Haftinia Fitri, Dahniar Gunawan Gunawan haq, Nasrul Jurani, Jurani Juwita, Tita Ratna Lastiti Veri Anggaini, Niken Lubis, Farhan Lubis, Shella Febrina Mayesti, Sabila Amelia Ma’rifah Mualim, Wisnu Nasution, Surya Atmaja RR. Ella Evrita Hestiandari Sabilah, Dwi Sartika Sabrina, Aura Salsabila, Ardana Saputra, Muhammad Reza Silalahi, Asti Dewianti Sitorus, Sry Rahayu Ningsih Sitorus, Syafriani Suhendra, Pepen Winoto, Suhartono Yayuk Purwaningrum Yenni Asbur