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Journal : INDONESIAN JOURNAL OF PHARMACY

ANTIMICROBIAL METABOLITES FROM A MARINE-DERIVED FUNGUS Wilmar Maarisit; Katsuhiro Ueda
Indonesian Journal of Pharmacy Vol 24 No 3, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (397.513 KB) | DOI: 10.14499/indonesianjpharm0iss0pp163-169

Abstract

A marine fungus was separated from the surface of a marine red algae. Ethyl acetate extract of the cultivated marine fungus inhibited the growth of the pathogenic bacteria E.coli and S.aureus, and the phytopathogenic fungus C. cucurbitarum. Separation of the EtOAc extract gave four compounds, which were identified as new anthraquinonederivatives 3 and 4, and the known chrysophanol (1) and rubelin A (2) by the extensive analysis of NMR data. Compounds 1-4 inhibited the growth of the gram negative bacteria E. coli and gram positive bacteria S. aureus. Compound 3 also inhibited the fungus C. cucurbitarum.Key words: marine-derived fungus, structure elucidation, anthraquinone, antimicrobial activity
ANTIANGIOGENESIS AND ANTIBACTERIAL ACTIVITIES FROM AN INDONESIAN MARINE-DERIVED FUNGUS Dactylaria sp Wilmar Maarisit; Dicki Huga Tangiono; Reinhard Pinontoan; Marstella Minelko; Joke Luis Tombuku; Tan Tjie Jan
Indonesian Journal of Pharmacy Vol 24 No 2, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (639.561 KB) | DOI: 10.14499/indonesianjpharm24iss2pp100-106

Abstract

Marine-derived fungi have been proven to be rich sources of chemically diverse natural products with a broad range of biological activities. The aim of this study was to determine the antibacterial and antiangiogenesis activities of marine derived fungi Dactylaria sp. Cultivation of the fungus Dactylaria sp (strain TID 24041021-1) was isolated from the marine invertebrate sponge. Culture of marine fungus was macerated with acetone and partitioned with ethyl acetate. The ethyl acetate extracts with 50, 100, and 200µg/mL concentrations, were assayed for their antiangiogenic activity by using chorioallantoic membrane in vivo. At the same time, ethyl acetate extracts at levels of 5, 10, 15, and 20mg/mL were assayed to pathogenic bacteria Bacillus subtilis, Escherichia coli, and Staphylococcus aureus using well diffusion method. The result of this study showed that ethyl acetate extract at concentration 50µg/mL could inhibit angiogenesis. The best antiangiogenic activity was showed at concentration of 200µg/mL ethyl acetate extract. Antibacterial activity from ethyl acetate extract inhibited the growth of B. subtilis (2.25-5mm), E. coli (0.63-3.50mm) and S. aureus (01.75mm) bacteria. Key words: Marine sponge-derived fungi, antiangiogenesis activity, antibacterial activity
Co-Authors . RUSTIKAWATI Aditia Biasa Alice Valencia Alice Valencia Amal Ginting Amal Ginting Ana Neman Anti, Reski ARIANDANA WANTHO Asmiati Mulkin Asmuruf, Yunice Besin, Cecilia S. M. Carolina, Saroinsong F. Christin, Andriany M. Citra Mentari Payow Debora Christy Palit Debora J.A Tumbel Deby Mongi dengen, Alvina maria Deo Tampongangoy Desi E. Gusungi Desmita Muada Dicki Huga Tangiono Douglas N. Pareta Effie Karlin Nathania Einstein Karundeng Einstein Z. Karundeng Einstein Z. Z. S. Karundeng Esterlina J. Watung Febrilia Mangirang Ferdinand Palit Frengky Mawea Friska Mery Montolalu Gideon A. R. Tiwow Ginting, Margaretha S. Glaudia Tawi Glorya Sevani Pongoh Greti M. Kurama Hanna M. Rumagit, Hanna M. Hariyadi Hariyadi Haryadi Haryadi Indriani Maitulung Iteke Tuda Jabes Wolter Kanter Jeane Mongi Jeivia Matialo Jesica N. Bawondes Julianti Julianti Kalalo, Michael R. C. Kalalo, Reine Kalangi, Only Imando Karauwan, Ferdy Katsuhiro Ueda Kojongian, Cliveno Kristian Stefano Pinatik Lengkey, Yessie Maarisit, Abigail F. Marsela Pauner Marshella Mokoagouw Marstella Minelko Marstella Minelko, Marstella Meisy Permata Citra Nayoan Misran Lawani Nerni Potolangi Nesti F. Sianipar Nesti F. Sianipar NESTI FRONIKA SIANIPAR Olvie Datu Olvie S. Datu Paat, Vlagia Indira Pakingki, Priska Pangkei, Octry M. Pareta, Douglas Natan Patrick Rambe Pelealu, Nancy C. Priska Juanita Pakingki Rahmat S. Santoso Rallia Binuni Randi Tampa’i Rawung, Intan J. F. Reinhard Pinontoan Rivaldy Lobot Rondonuwu, Tesalonika Royke R. Palandi Rudy Pareda Sambou, Christel N. Sarah Sambow Sheren J. Bermula Silvana L. Tumbel Simanjuntak, Alfared S. Sonny Untu Sumagando, Adolfina Supit, Arter Tampa'i, Randy Tan Tjie Jan, Tan Tjie Tenci Lie Sarbunan Tombuku, Joke Luis Tulandi, Selvana Stien Veronica Davis Yapi Saroinsong Yappi Saroinsong Yosna Yundu Yuliana Polopadang Yunita Syawal Yusuf Tapehe