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Journal : JFIOnline

Aktivitas Antibakteri dan Antimitotik dari Fungi yang Bersimbiosis dengan Spons Maarisit, Wilmar; Minelko, Marstella; Jan, Tan Tjie
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 2 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (667.295 KB)

Abstract

Sponge-derived fungi are source of natural bioactive compounds. The aim of this research is to test the anti-bacterial and anti-mitotic activities from marine sponge-derived fungus. The sponge-derived fungus (strain TID.24041021-2) has been successfully isolated from sponge (strain TID.24041021-2) collected from the sea around Tidung Island. The morphology of this fungus has been identified and classified in the genus Wangiella sp. This fungus was cultivated in PDA with salinity 25 ppm for 21 days at room temperature, extracted with acetone, partitioned with ethyl acetate, and tested the anti-bacterial activity against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus, and also tested the anti-mitotic activity using root tip cells of Allium cepat. The results showed that crude extract of ethyl acetate could inhibit the growth of B. subtilis 91.30-2.30 mm), E.coli (1.50-3.03 mm) dan S.aureus (2.80-5.0 mm) bacteria. Also, antimitotic activity from crude extract of ethyl acetate showed that there is chromosome abnormalities of 0.76 and 1.38 in extract concentration of 20% and 25%, respectively.Keywords : Sponge-derived fungi, anti-bacterial, anti-mitotic, chromosome abnormalities.
Aktivitas Antibakteri dan Antimitotik dari Fungi yang Bersimbiosis dengan Spons Maarisit, Wilmar; Minelko, Marstella; Jan, Tan Tjie
Jurnal Farmasi Indonesia Vol 6, No 2 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (667.295 KB) | DOI: 10.35617/jfi.v6i2.130

Abstract

Sponge-derived fungi are source of natural bioactive compounds. The aim of this research is to test the anti-bacterial and anti-mitotic activities from marine sponge-derived fungus. The sponge-derived fungus (strain TID.24041021-2) has been successfully isolated from sponge (strain TID.24041021-2) collected from the sea around Tidung Island. The morphology of this fungus has been identified and classified in the genus Wangiella sp. This fungus was cultivated in PDA with salinity 25 ppm for 21 days at room temperature, extracted with acetone, partitioned with ethyl acetate, and tested the anti-bacterial activity against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus, and also tested the anti-mitotic activity using root tip cells of Allium cepat. The results showed that crude extract of ethyl acetate could inhibit the growth of B. subtilis 91.30-2.30 mm), E.coli (1.50-3.03 mm) dan S.aureus (2.80-5.0 mm) bacteria. Also, antimitotic activity from crude extract of ethyl acetate showed that there is chromosome abnormalities of 0.76 and 1.38 in extract concentration of 20% and 25%, respectively.Keywords : Sponge-derived fungi, anti-bacterial, anti-mitotic, chromosome abnormalities.
Co-Authors . RUSTIKAWATI Aditia Biasa Alice Valencia Alice Valencia Amal Ginting Amal Ginting Ana Neman ARIANDANA WANTHO Asmiati Mulkin Asmuruf, Yunice Besin, Cecilia S. M. Carolina, Saroinsong F. Christin, Andriany M. Citra Mentari Payow Debora Christy Palit Debora J.A Tumbel Deby Mongi dengen, Alvina maria Deo Tampongangoy Desi E. Gusungi Desmita Muada Dicki Huga Tangiono Douglas N. Pareta Effie Karlin Nathania Einstein Karundeng Einstein Z. Karundeng Einstein Z. Z. S. Karundeng Esterlina J. Watung Febrilia Mangirang Ferdinand Palit Frengky Mawea Friska Mery Montolalu Gideon A. R. Tiwow Ginting, Margaretha S. Glaudia Tawi Glorya Sevani Pongoh Greti M. Kurama Hanna M. Rumagit, Hanna M. Hariyadi Hariyadi Haryadi Haryadi Indriani Maitulung Iteke Tuda Jabes Wolter Kanter Jeane Mongi Jeivia Matialo Jesica N. Bawondes Julianti Julianti Kalalo, Michael R. C. Kalangi, Only Imando Karauwan, Ferdy Katsuhiro Ueda Kristian Stefano Pinatik Lengkey, Yessie Marsela Pauner Marshella Mokoagouw Marstella Minelko Marstella Minelko, Marstella Meisy Permata Citra Nayoan Misran Lawani Nerni Potolangi Nesti F. Sianipar Nesti F. Sianipar NESTI FRONIKA SIANIPAR Olvie Datu Olvie S. Datu Paat, Vlagia Indira Pakingki, Priska Pangkei, Octry M. Pareta, Douglas Natan Patrick Rambe Priska Juanita Pakingki Rahmat S. Santoso Rallia Binuni Randi Tampa’i Reinhard Pinontoan Rivaldy Lobot Royke R. Palandi Rudy Pareda Sambou, Christel N. Sarah Sambow Sheren J. Bermula Silvana L. Tumbel Sonny Untu Sumagando, Adolfina Tampa'i, Randy Tan Tjie Jan, Tan Tjie Tenci Lie Sarbunan Tombuku, Joke Luis Tulandi, Selvana Stien Veronica Davis Yapi Saroinsong Yappi Saroinsong Yosna Yundu Yuliana Polopadang Yunita Syawal Yusuf Tapehe