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All Journal Jurnal Veteriner Majalah Kedokteran Bandung Althea Medical Journal Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Universa Medicina Paediatrica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Narra J Cermin Dunia Kedokteran Jurnal Neuroanestesi Indonesia Makara Journal of Health Research Cermin Dunia Kedokteran
Ramdan Panigoro
Biochemistry And Molecular Biology Division, Department Of Biomedical Sciences, Faculty Of Medicine, Universitas Padjadjaran, Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Intravenous administration of iron dextran as a potential inducer for hemochromatosis: Development of an iron overload animal model Khristian, Erick; Ghozali, Mohammad; Bashari, Muhammad H.; Purnama, Jeri N.; Irianto, Gunawan; Panigoro, Ramdan; Safitri, Ratu
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1003

Abstract

Iron overload in transfusion-dependent thalassemia patients represents a significant public health challenge due to its high mortality rate and risks of severe complications. Therefore, developing safe and effective therapeutic modalities for managing iron overload is critical, as current animal models inadequately replicate human conditions. The aim of this study was to investigate the effects of intravenous iron dextran on hepatocyte morphology, liver iron concentration, and serum iron profile changes as a model for hemochromatosis. An experimental design with a post-test-only control group method was conducted using animal models. Fifty rats were used and divided into ten groups, nine received different intravenous doses of iron dextran: 10, 20, 30, 40, 50, 60, 80, 100, and 120 mg/kg body weight (BW) and a control group received no treatment. The results showed that intravenous iron dextran starting at a dose of 10 mg/kg BW caused significant changes in liver iron concentration while starting at 20 mg/kg BW significantly affected hepatocyte morphology, transferrin levels, unsaturated iron binding capacity, serum iron levels, and transferrin saturation. Intravenous iron dextran starting at 40 mg/kg BW resulted significant changes in the level of total iron binding capacity compared to control group. In conclusion, intravenous iron dextran significantly altered hepatocyte morphology, increased liver iron concentration, and modified the serum iron profile, reflecting changes that might be observed in patients with transfusion-dependent thalassemia.
Co-Authors Adi Imam Cahyadi ahmad rizal Ahmad Rizal Aih Cahyani Al Rasyid Alif Bagus Rakhimullah Alvinsyah Adhityo Pramono Anam Ong Anam Ong Anggraini Widjajakusuma Ani Melani Maskoen Asep Nugraha Hermawan Bashari, Muhammad H. Cissy B. Kartasasmita Cissy B. Kartasasmita Dewanto, Julius B Dewantoro, Julius Broto Diah Dhianawaty Dias Aryani Dwi Agustian Edhyana Sahiratmadja Edhyana Sahiratmadja Edhyana Sahiratmadja Elsa Pudji Setiawati Erick Khristian Fadhal M. Ahmad Fanny Adhy Putri Haryono Tansah, Haryono Heda M. Duddy Heda Melinda Duddy Helena Napitu, Helena Herman Susanto Ida Parwati Ina Setiowati Ina Setiowati Irianto, Gunawan Jeri Nobia Purnama Julius B Dewanto Julius Broto Dewanto, Julius Broto Kevin Dominique Tjandraprawira Khristian, Erick Lailiyya, Nushrotul Lelani Reniarti Lisda Amalia Lohghinee Khrisnan Lohghinee Khrisnan, Lohghinee Mas Rizky A.A Syamsunarno Mas Rizky A.A. Syamsunarno Masahiko Kurabayasi Mohammad Ghozali Mohammad Ghozali, Mohammad Mugia Bayu Rahardja Mugia Bayu Raharja Muhammad, Rifqi Y Neni Anggraeni Novi Vicahyani Utami Nur Atiik Nurul Setia Rahayu Nushrotul Lailiyya Pandji Irani Fianza Penggoam, Simeon Pramono, Alvinsyah Adhityo Pricilla Purushothman Purnama, Jeri N. Putri, Fanny Adhy Ratu Safitri Ratu Safitri Ratu Safitri Reni Ghrahani Rifqi Y Muhammad Rini Widyastuti Samsudin Surialaga Sari Puspa Dewi Shenny Dianathasari Santoso Simeon Penggoam Sunaryati Sudigdoadi Sunaryati Sudigdoadi Surbakti, Indra Murty Tatsuya Iso Tri H. Ahmad Tri Hanggono Achmad Tri Hanggono Ahmad Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani, Uni Wardoyo, Chandra Calista Wijaya, Michelle Angelica Yudi Mulyana Hidayat Yusuf Wibisono Yusuf Wibisono