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All Journal Jurnal Veteriner Majalah Kedokteran Bandung Althea Medical Journal Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Universa Medicina Paediatrica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Narra J Cermin Dunia Kedokteran Jurnal Neuroanestesi Indonesia Makara Journal of Health Research Cermin Dunia Kedokteran
Ramdan Panigoro
Biochemistry And Molecular Biology Division, Department Of Biomedical Sciences, Faculty Of Medicine, Universitas Padjadjaran, Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Jurnal Veteriner

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The Effect of Sappan Wood Extract (Caesalpinia sappan L.) on Fetal and Placenta Histopathology of White Rat Jeri Nobia Purnama; Erick Khristian; Mas Rizky A.A Syamsunarno; Ramdan Panigoro; Ratu Safitri
Jurnal Veteriner Vol 23 No 2 (2022)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.705 KB) | DOI: 10.19087/jveteriner.2022.23.2.166

Abstract

Histomorphological assessment of the placenta and fetus was more effective in assessing fetal development on a research scale for determined an active substance during the gestation period in experimental animals. The placenta and fetus connect in the development process. This study aimed to analyze the effect of giving ethanol extract of sappanwood on white rats’ placenta and fetal organs, which were examined histologically at 20 days pregnant rats. The pregnant rats were divided into six groups: The negative group was given aquadest, and treatment groups were given an ethanolic Sappan wood extract 100;200;300;400;500 mg/kg BW. Euthanized with CO2 and cesarian section was performed on pregnant rats on the 20th gestational day. Observation to record fetal body weight, body length, mean placental weight, and the histology of the placental area. Histomorphometry was used to measure the area of the fetal placental region. The group with sappan wood extract had no statistically significant difference in fetal body weight, fetal body length, fetal tail length, the weight placenta, and histomorphometry of the placenta compared to the control group (p > 0.05); this showed that the ethanolic extract of sappan wood does not have a toxic effect on the development of the placenta, which can interfere with fetal development during pregnancy. Sappan wood extract had a nontoxic effect on the placenta and fetal rat development on histological examination, even at the highest dose of 500 mg.kg-1 bw.
Co-Authors Adi Imam Cahyadi ahmad rizal Ahmad Rizal Aih Cahyani Al Rasyid Alif Bagus Rakhimullah Alvinsyah Adhityo Pramono Anam Ong Anam Ong Anggraini Widjajakusuma Ani Melani Maskoen Asep Nugraha Hermawan Bashari, Muhammad H. Cissy B. Kartasasmita Cissy B. Kartasasmita Dewanto, Julius B Dewantoro, Julius Broto Diah Dhianawaty Dias Aryani Dwi Agustian Edhyana Sahiratmadja Edhyana Sahiratmadja Edhyana Sahiratmadja Elsa Pudji Setiawati Erick Khristian Fadhal M. Ahmad Fanny Adhy Putri Haryono Tansah, Haryono Heda M. Duddy Heda Melinda Duddy Helena Napitu, Helena Herman Susanto Ida Parwati Ina Setiowati Ina Setiowati Irianto, Gunawan Jeri Nobia Purnama Julius B Dewanto Julius Broto Dewanto, Julius Broto Kevin Dominique Tjandraprawira Khristian, Erick Lailiyya, Nushrotul Lelani Reniarti Lisda Amalia Lohghinee Khrisnan Lohghinee Khrisnan, Lohghinee Mas Rizky A.A Syamsunarno Mas Rizky A.A. Syamsunarno Masahiko Kurabayasi Mohammad Ghozali Mohammad Ghozali, Mohammad Mugia Bayu Rahardja Mugia Bayu Raharja Muhammad, Rifqi Y Neni Anggraeni Novi Vicahyani Utami Nur Atiik Nurul Setia Rahayu Nushrotul Lailiyya Pandji Irani Fianza Penggoam, Simeon Pramono, Alvinsyah Adhityo Pricilla Purushothman Purnama, Jeri N. Putri, Fanny Adhy Ratu Safitri Ratu Safitri Ratu Safitri Reni Ghrahani Rifqi Y Muhammad Rini Widyastuti Samsudin Surialaga Sari Puspa Dewi Shenny Dianathasari Santoso Simeon Penggoam Sunaryati Sudigdoadi Sunaryati Sudigdoadi Surbakti, Indra Murty Tatsuya Iso Tri H. Ahmad Tri Hanggono Achmad Tri Hanggono Ahmad Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani, Uni Wardoyo, Chandra Calista Wijaya, Michelle Angelica Yudi Mulyana Hidayat Yusuf Wibisono Yusuf Wibisono