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All Journal Pharmaciana: Jurnal Kefarmasian Pharmasipha Jurnal Jamu Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Farmasi Farmasyifa HERBAPHARMA : Journal of Herb Farmacological Jurnal farmasi UIN Alauddin Makassar Jurnal Mandala Pengabdian Masyarakat Mattawang: Jurnal Pengabdian Masyarakat Jurnal AFAMEDIS Medical Sains : Jurnal Ilmiah Kefarmasian Acta Holistica Pharmaciana Journal of Public Health and Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Syafika Alaydrus
Program Studi D3 Farmasi, Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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UJI EKSTRAK ETANOL DAUN MIMBA (Azadirachta indica.A juss) TERHADAP KADAR KREATININ DAN UREUM TIKUS PUTIH JANTAN YANG DIINDUKSI STREPTOZOTOCIN Syafika Alaydrus; Indah Kurnia Utami; Fajar Aprilia
HERBAPHARMA : Journal of Herb Farmacological Vol 5 No 1 (2023): Volume 5 Nomor 1 Juni 2023
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v5i1.395

Abstract

terjadi menyebabkan kerusakan glumerolus ginjal sehingga fungsi ginjal menurun. Kreatinin dan ureum merupakam parameter fungsi ginjal. Penelitian ini bertujuan untuk mengetahui efek dan dosis ekstrak etanol daun mimba (Azadirachta indica.A Juss) terhadap kadar kreatinin dan ureum yang diinduksi streptozotocin. Tikus dibagi menjadi 5 kelompok terdiri dari kontrol normal, kontrol negatif, kelompok perlakuan ekstrak etanol daun mimba (Azadirachta indica.A Juss) dosis 50 mg/kg BB, 100 mg/kg BB dan 150 mg/kg BB. Parameter yang diamati adalah kadar kreatinin dan ureum pada hari ke-0, 7,14, 21 dan 28. Data kreatinin dan ureum yang diperoleh dianalisis menggunakan uji one way ANOVA pada taraf kepercayaan 95% dan dilanjutkan dengan uji Post Hoc LSD. Hasil penelitian menunjukkan ekstrak etanol daun mimba pada dosis 150 mg/kg BB dapat memberikan efek terhadap penurunan kadar kreatinin dan ureum pada tikus yang diinduksi STZ, dengan nilai rata-rata kreatinin 0,72 mg/dL dan ureum 41,56 mg/dL.
UJI EFEK EKSTRAK ETANOL BIJI LABU KUNING (Cucurbita moschata Duch) TERHADAP KADAR KREATININ UREUM TIKUS PUTIH JANTAN (Rattus norvegicus) HIPERKOLESTEROLEMIA-DIABETES Syafika Alaydrus; Ayu Wulandari
Acta Holistica Pharmaciana Vol 2 No 1 (2020): Acta Holistica Pharmaciana
Publisher : School of Pharmacy Mahaganesha (Sekolah Tinggi Farmasi Mahaganesha)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Nefropatik Diabetes merupakan penyakit gagal ginjal yang disebabkan oleh Diabetes Mellitus. Kondisi hiperglikemik menyebabkan kerusakan glomerulus ginjal sehingga fungsi filtrasi ginjal menurun. Ureum dan kreatinin digunakan sebagai parameter fungsi ginjal. Biji labu kuning (Cucurbita moschata Duch) mengandung alkaloid, tanin dan polifenol yang berfungsi sebagai antioksidan yang dapat memperbaiki kerusakan glomerulus ginjal akibat kondisi hiperglikemik. Penelitian ini bertujuan mengetahui efek dan menentukan dosis ekstrak etanol tbiji labu kuning terhadap kadar ureum dan kreatinin. Pengujian menggunakan 25 ekor tikus dibagi menjadi 5 kelompok terdiri dari 1 kelompok normal dan 4 kelompok yang diinduksi pakan tinggi Kolesterol dan streptozotocin dosis 35 mg/kg BB. Tikus Nefropati Diabetik dibagi dalam kelompok yang diberi Na-CMC 0,5%, kelompok yang diberi ekstrak etanol biji labu kuning dengan dosis masing-masing 270 mg/kg BB, 360 mg/kg BB dan 450 mg/kg BB. Data hasil pengukuran kadar ureum dan kreatinin dianalisis menggunakan uji statistik One Way Anova dan uji lanjut Post Hoc Least Significant Differences (LSD).Hasil uji statistik (α = 0,05) menunjukkan bahwa ekstrak etanol biji labu kuning memberikan efek terhadap kadar ureum dan kreatinin dengan dosis 270 mg/kg BB tidak memberikan perbedaan yang nyata dengan kelompok normal.
Penyuluhan Stunting: Upaya Pencegahan BALITA Stunting Niluh Puspita Dewi; Syafika Alaydrus; Indah Kurnia Utami; Sri Wahyuni Khalik; Magfirah Magfirah; Nur Azizah
Jurnal Mandala Pengabdian Masyarakat Vol. 4 No. 2 (2023): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v4i2.327

Abstract

Penyuluhan merupakan suatu cara yang dilakukan oleh seseorang untuk memperoleh informasi kesehatan atau derajat kesehatan secara maksimal.  Stunting merupakan penggambaran dari status gizi kurang yang bersifat kronik pada masa pertumbuhan dan perkembangan sejak awal kehidupan. Banyak faktor yang dapat menyebabkan terjadinya stunting pada balita seperti karakteristik balita maupun faktor sosial ekonomi. Stunting menjadi permasalahan karena berhubungan dengan meningkatnya risiko terjadinya kesakitan dan kematian, perkembangan otak suboptimal sehingga perkembangan motorik terlambat dan terhambatnya pertumbuhan mental. Penyuluhan ini bertujuan membantu meningkatkan pengetahuan masyarakat terutama ibu-ibu tentang pencegahan stunting pada balita dan merupakan salah satu bentuk Tri Dharma Perguruan Tinggi.  Penyuluhan diberikan dengan metode ceramah interaktif melalui pembagian leaflet, dan bakti sosial. Efektifitas penyuluhan diuji dengan pemberian kuisioner kepuasan mitra terhadap kegiatan yang dilaksanakan. Hasil pengamatan kegiatan menunjukkan bahwa Mitra merasa puas dengan kegiatan penyuluhan yang dilakukan.
Enzymatic virgin coconut oil effect on urea and creatinine levels of hypercholesterolemia-diabetics induced Wistar male rats Niluh Puspita Dewi; Syafika Alaydrus; Nadila Nadila; Magfirah Magfirah; Joni Tandi; Viani Anggi; Nani Astria
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27489

Abstract

Coconut (Cocos nucifera) is an Indonesian commodity that has high economic value tall. Virgin Coconut Oil (VCO) is one of the processed coconut products whose selling value is very high, because The composition of VCO consists of medium-chain fatty acids that can maintain a healthy body and prevent various diseases. The process of making VCO used in This research is an enzymatic method using pineapple weevil as a bromelain enzyme. This study aims to determine the effect of enzymatic administration of VCO and an enzymatic dose of VCO which is effective in reducing urea and creatinine levels in hypercholesterolemic-diabetic male white rats (Rattus norvegicus). This study was an experimental laboratory with a modified pretest and posttest randomized controlled group design using 30 test animals which were divided into 6 treatment groups. Each group consisted of 5 test animals, namely normal control, negative control, and positive control, with doses of 0.2, 0.4, and 0.8 mL/kg BW. The data obtained were analyzed using a One Way Anova and non- parametric statistical test by Kruskal Wallis. test and followed by a further Mann Whitney test to determine differences between treatments. The results showed that enzymatic VCO at a dose of 0.8 mL/kg BW was an effective dose in reducing urea and creatinine levels with an average decrease of 17.40 mg/dL and 0.36 mg/dL. The novelty in this study showed that the enzymatic VCO had an effect on reducing urea and creatinine levels in diabetic hypercholesterolemic male white rats.
ANALISIS BIAYA PENGOBATAN PENYAKIT JANTUNG KORONER PADA PASIEN RAWAT INAP DI RUMAH SAKIT X Syafika Alaydrus
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 4 No 2 (2020)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v4i2.132

Abstract

Coronary heart disease (CHD) is one of the most common types of heart disease. The number of sufferers causes the amount of costs incurred. The purpose of this study is to see the effectiveness of CHD costs based on INA-CBGs financing. The analysis used was descriptive analysis, ANOVA test One sample t analysis. test and correlation test, the respondents used were CHD patients in the UNDATA PALU Hospital as many as 56 people. The sample uses purposive sampling. Data collection uses observation through medical records. Based on the results of the study for the average real cost of using Mandiri BPJS of Rp. 2,681,681.0. For payments using PBI BPJS of Rp. 2.791,870.2. For payments using PNS BPJS of Rp. 2,778,843.0. Where as the payment uses the PENSION PENSION PNS for Rp. 2,933,510.8. Kata kunci : Penyakit Jantung Koroner (PJK), Pembiayaan INA-CBGs 
Study of Treatment in Heart Disease Patients Installation in Undata Hospital, Central Sulawesi Puspita Dewi, Niluh; Kurnia Utami, Indah; Gunawan, Al'vira; Tahir, Muh. Thamrin; Alaydrus, Syafika; Polontalo, Nani Astria
Journal of Public Health and Pharmacy Vol. 4 No. 1: MARCH 2024
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v4i1.4951

Abstract

Introduction: Heart diseasesis a disorder of heart functionsdue to lack of bloods in the heart muscles due to narrowingsof the coronary artery. The purposesof this study was to describe t he characteristics and use of heart disease drugs based on parameters of rationality of drug use in Undata Hospital, Central Sulawesi Province including gender, age, heart drug class, complementary drug class, length of hospitalization, laboratory data, comorbidities , appropriate indications, the right drugs and the right dose. Methods: This researchsis a non-experimental type of research conducted prospectively during February-April 2022. The sampling technique in this study was purposive sampling, namely sampling based on established criteria. All samples that met the requirements who came to the hospital were used as research samples according to the required sample size of 40 respondents and based on the available data collection time. Results: The results of the study were 40 patients with hearts disease, the most heart disease sufferers were male with a percentage of 67.5%, in the age range of 56-65 years 32.5%, the most commonly used companion drug was Alprazolam as much as 17%, the most length of hospitalization was 4-6 days (55%), the most laboratory results were Hemoglobin/HGB examination as many as 21 patients (14.38%), the most comorbidities namely Hypertension with a percentage of 60% Conclusion: Appropriate use of heart disease drugs based on drug rational parameters in hospitals Undata of the right indication 100%, the right drug selection 100% and the right dose 100%. Recommendedsfor further researchersscan conduct research on cardiac drug interactions.
Antioxidant, analgetic, and anti-inflammatory activity test of purple leaf ethanol extract (Graptophyllum pictum L. Griff) in vitro and in vivo Ocvinta, Sisca; Dewi, Niluh Puspita; Utami, Indah Kurnia; Darmayanti, Darmayanti; Alaydrus, Syafika; Anwarudin, Wawang
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.29070

Abstract

Purple leaves are one of the plants that are widely used as medicine. Purple leaves have 3 types of plant varieties, namely purple leaves, green leaves, and white mottled leaves.  Purple leaves have pharmacological activities that can be used as medicine, including antioxidants (improving the deterioration of cells in the body), anti-inflammatory (reducing or suppressing inflammation), antidiabetic (lowering blood glucose levels), analgesics (relieving pain), immunomodulators (increasing the work of the immune system in the body), antihemorrhoids (treating symptoms and complaints of hemorrhoids), and antibacterial (as an antiseptic). The purpose of this study was to determine the antioxidant activity of purple leaf ethanol extract (Graphtophyllum pictum (L.) Griff) in vitro using the DPPH method and to determine its effectiveness as an analgesic and anti-inflammatory against Wistar rats.The results showed that antioxidant activity showed an IC50 value of 72.31 ppm (strong antioxidant). Meanwhile, in the analgetic test, the highest percentage of analgesic effectiveness was found at a dose of 100 mg/kg BW (129.64%) and showed anti-inflammatory activity at a dose of 100 mg/kgBW with a percentage decrease in edem volume of 28.73% at the sixth hour.
Co-Authors AYU WULANDARI Ayu Wulandari Darmayanti Darmayanti Dermiati T Erni Febriyanti Nikmah Ervianingsih Ervianingsih Fajar Aprilia Fajria Rezky Priyanti Amara Pagal Gunawan, Al'vira Indah Kurnia Utami Indah Kurnia Utami Indah Kurnia Utami Joni Tandi, Joni Kurnia Utami, Indah Magfirah Nadila Nadila Nani Astria Natalia Toding Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi, Niluh Puspita Nur Azizah Ocvinta, Sisca Polontalo, Nani Astria Puspita Dewi, Niluh Putri Pratiwi Ronaldy Nobertson Sri Wahyuni Khalik Tahir, Muh. Thamrin Utami, Indah Kurnia Viani Anggi Wawang Anwarudin Wayan Wirawan Wayan Wirawan