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The Effectiveness of Giving Growth Hormone to Children with Chronic Kidney Disease: Systematic Literature Review Afdhila , Irhamni Nur; Fitrisia Amelin; Gardenia Akhyar
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.537

Abstract

Chronic Kidney Disease (CKD) can cause growth problems in children. This condition will affect children’s social life and increase morbidity and mortality. Growth hormone (GH) is one of medication that has been used for treatment of impaired growth in children with chronic kidney disease. In Indonesia, this management has not been provided, because it is expensive and its effectiveness is uncertain. This research was conducted to determine the effectiveness of growth hormone in increasing linear growth in children with CKD. This study is a systematic review of the Randomized Controlled Trial (RCT) study to determine the effectiveness of growth hormone as a treatment for children with CKD. Literature search was conducted using five databases, namely Pubmed, Google Scholar, DOAJ, BMC and CENTRAL that matched the inclusion and exclusion criteria. The guide used in the literature selection was the PRISMA flow chart. A Total of 10 studies were included in the systematic review. Growth hormone is effective in increasing linear growth in children with CKD. Generally there was a significant increase in height (standard deviation (SD)), high velocity (SD or cm) in the therapy group compared to the control group. The dose of growth hormone that is given varies, but the most is 4 IU / m2 / day, once a day, by subcutaneous injection. The duration of growth hormone administration varied from 6 months to 5 years with an average of 1.7 years. Growth hormone did not aggravate kidney problems in children with CKD and can increase important factors in bone formation, namely alkaline phosphatase and osteocalcin.
Hypertension Due To Renal Artery Stenosis Devi Novriyanti; Aumas Pabuti; Fitrisia Amelin
Jurnal Kesehatan Andalas Vol 8, No 4 (2019): Online December 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i4.1110

Abstract

Sebagian besar etiologi hipertensi pada anak adalah sekunder dengan kelainan yang mendasari, berbeda dengan dewasa yang biasanya primer. Renovascular hypertension (RVH) terjadi lebih sering pada remaja daripada usia dewasa. Stenosis arteri renalis adalah istilah umum yang merujuk pada lesi vaskuler yang menyebabkan penyempitan arteri renalis sehingga mengganggu aliran darah ke ginjal. Proses untuk mengidentifikasi hipertensi sekunder dan mencari penyebabnya selalu menjadi tantangan pada remaja. Dilaporkan kasus hipertensi akibat stenosis arteri renalis pada remaja perempuan, usia 15 tahun 3 bulan yang didiagnosis berdasarkan gejala klinis, USG doppler dan CT angiografi.
Serum Cystatin C dan Kreatinin dalam Mendiagnosis Gangguan Ginjal Akut pada Anak Sakit Kritis Pratita Jati Permatasari; Aumas Pabuti; Eti Yerizel; Fitrisia Amelin
Sari Pediatri Vol 20, No 2 (2018)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (222.608 KB) | DOI: 10.14238/sp20.2.2018.95-100

Abstract

Latar belakang. Gangguan ginjal akut (GgGA) berhubungan dengan mortalitas dan morbiditas yang tinggi di antara anak sakit kritis. Cystatin C adalah protease inhibitor yang menurut beberapa penelitian merupakan biomarker yang baik untuk mendeteksi gangguan ginjal akut pada anak sakit kritis.Tujuan. Mengetahui sensitivitas, spesifisitas, nilai prediksi positif, dan nilai prediksi negatif cystatin C serum dan kreatinin serum dalam mendiagnosis gangguan ginjal akut pada anak sakit kritis.Metode. Penelitian potong lintang pada 70 subjek di HCU dan PICU RSUP. Dr. M. Djamil Padang dari Mei 2017 – Juni 2017. Subjek penelitian laki-laki 55,71%, median usia 16,50 bulan. Subjek dipilih dengan teknik konsekutif. Dilakukan pemeriksaan cystatin C serum dengan ELISA dan kreatinin dengan kolorimetrik. Baku emas menggunakan estimasi laju filtrasi glomerulus berdasarkan formula Schwartz. Gangguan ginjal akut terjadi bila terjadi penurunan laju filtrasi glomerulus minimal 25% berdasarkan kriteria pRIFLE. Kurva receiver operating characteristic (ROC) digunakan untuk menilai cystatin C dan kreatinin dalam mendiagnosis GgGA.Hasil. Rerata cystatin C dan kreatinin serum pada GgGA 0,88±0,14 mg/L, 1,13±0,59 mg/dL berturut-turut. Tiga puluh tujuh pasien didiagnosis GgGA. Cut off point cystatin C serum 0,56 mg/L, sensitivitas 85,19%, spesifisitas 60,47%, nilai prediksi positif 57,50%, nilai prediksi negatif 13,33%. Cut off point kreatinin serum 0,95 mg/dL, sensitivitas 51,85%, spesifisitas 100%, nilai prediksi positif 100%, nilai prediksi negatif 23,21%.Kesimpulan. Cystatin C serum sensitif untuk mendiagnosis GgGA tetapi kurang spesifik.
DETEKSI DINI KOMPLIKASI KEHAMILAN, PERILAKU HIDUP BERSIH DAN SEHAT SERTA DETEKSI DINI GANGGUAN PERTUMBUHAN DAN PERKEMBANGAN BAYI DAN BALITA DI WILAYAH KERJA PUSKESMAS PEGAMBIRAN KOTA PADANG Aldina Ayunda Insani; Erda Mutiara; Fitrisia Amelin; Yulizawati Yulizawati; Lusiana El Sinta Bustami; Feni Andriani
BULETIN ILMIAH NAGARI MEMBANGUN Vol 2 No 4 (2019)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (663.176 KB) | DOI: 10.25077/bina.v2i4.129

Abstract

Puskesmas Pegambiran is located in Lubuk Begalung Sub-district, Padang City has five villages with a pregnancy complication rate of 19.9% and neonatal complications of 11.74% (2016). The general objective that will be achieved is to increase the number of better health degrees for pregnant women, infants, toddlers, and pre-school age children through promotive and preventive activities. The method used is by conducting surveys and interviews, conduct counseling, demonstrate clean and healthy living habits, anthropometric measurements of infants, toddlers, and pre-school children, observation, pregnancy checks, hemoglobin checks, and counseling. The results obtained were counseling and demonstrations on clean and healthy living behaviors in pre-school age children at Alya Zahira Kindergarten, which all students could participate in and run smoothly. 98% of kindergarten students demonstrated healthy hygiene habits, including washing hands, brushing teeth, and mentioning healthy snacks. Anthropometric measurements of infants and toddlers and pre-school age children showed that weight for age was within normal limits, height/length according to age, and expected limits. 3.7% thin and short toddlers and 1.2% of toddlers have speech delays, 1.2% children under five with a history of epilepsy, and need further treatment, so referrals are made. 1.2% of children under five were referred to because they did not recognize colors. All pregnant women (100%) have normal hemoglobin levels (10 g / dl), and pregnancy conditions are appropriate for their gestational age. It is hoped that further community service activities will be carried out by applying the partnership midwifery practice model (mentoring) to the above targets for several months. There are changes in behavior patterns for promotive and preventive actions that have been given.
Faktor-Faktor yang Berhubungan dengan Perilaku Pemberian Asi Eksklusif Pada Ibu yang Memiliki Bayi Usia 6-12 Bulan di Wilayah Kerja Puskesmas Andalas Yollanda Vonitania; Fitrisia Amelin; Yulizawati Yulizawati
Journal of Midwifery Vol 2, No 2 (2017): Published on December 2017
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (276.339 KB) | DOI: 10.25077/jom.2.2.82-92.2017

Abstract

Di Indonesia target cakupan ASI eksklusif  sebesar 80% dan target ini masih sulit dicapai. Cakupan ASI eksklusif di Sumatera Barat (75%), di kota Padang (70,7%) dan di puskesmas Andalas (55,17%). Tujuan penelitian ini adalah untuk mengetahui faktor faktor yang berhubungan dengan perilaku pemberian ASI Eksklusif pada ibu yang memiliki bayi usia 6-12 bulan di wilayah kerja Puskesmas Andalas.Jenis penelitian ini adalah analitik dengan desain cross sectional. Penelitian dilakukan di wilayah kerja puskesmas Andalas pada ibu yang memiliki bayi usia 6-12 bulan yang berjumlah 90 orang. Teknik pengambilan sampel yang digunakan adalah  proportional random sampling. Pengumpulan data menggunakan kuesioner. Analisis data menggunakan analisis univariat dan bivariat dengan uji chi square, dianggap signifikan jika p<0,05.Hasil penelitian menunjukkan pemberian ASI eksklusif (21,1%), ibu berpengetahuan baik (48,9%), pendidikan menengah (51,1%), tidak bekerja (65,6%), tidak mengalami masalah pada payudara (51,1%), dan tertarik pada promosi susu formula (57,8%). Hasil analisis bivariat menunjukkan adanya hubungan antara pendidikan (p=0,048) dan masalah pada payudara (p=0,000) dan tidak adanya hubungan antara pekerjaan (p=0,98) dengan pemberian ASI eksklusif. Terdapat kecenderungan semua ibu berpengetahuan rendah dan tertarik promosi susu formula tidak memberikan ASI eksklusifDari hasil penelitian dapat disimpulkan terdapat hubungan antara pendidikan dan masalah pada payudara dengan pemberian ASI eksklusif, tidak terdapat hubungan antara pekerjaan dengan pemberian ASI eksklusif, terdapat kecenderungan semua ibu berpengetahuan rendah dan tertarik promosi susu formula tidak memberikan ASI eksklusif. Untuk  peneliti selanjutnya bisa menambahkan variabel lain, untuk tenaga kesehatan agar lebih giat melakukan penyuluhan dan kepada masyarakat agar lebih banyak mengikuti penyuluhan.
Peningkatan Komitmen Penanggulangan Covid-19 Mahasiswa melalui Webinar dan Deklarasi SIAGA SAKATO Liganda Endo Mahata; Fitrisia Amelin; Fathiyyatul Khaira; Denada Florencia Leona; Andani Eka Putra; Rizanda Machmud; Irvan Medison; Hardisman Hardisman; Yefri Zulfiqar; Fenty Anggraini; Linosefa Linosefa; Desy Nofita Sari; Rahmat Syawqi
Warta Pengabdian Andalas Vol 28 No 3 (2021)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.28.3.225-231.2021

Abstract

The Covid-19 virus is transmitted from human to human through close contact with infected people through their respiratory droplets. A person can also be infected by touching an object contaminated with SARS-CoV-2 and then followed by reaching the eyes, nose, or mouth. Implementing the health protocol is necessary to reduce the number of virus transmissions. In addition, to increase the community's immune against Covid-19, WHO and the government have been developing a vaccination program. However, the recommendation from the latest research stated that people still have to obey the health protocol even after being vaccinated. The purpose of this community service was to help the government to increase people's understanding of the importance of implying health protocols, even after vaccination, to suppress Covid-19 cases. The method used is by holding an online event called a Webinar. It followed by a statement with audiences to commit to implementing the health protocol led by the Rector of Andalas University, then called a SIAGA SAKATO declaration. The activity began with a pre-test questionnaire for initial information collection, followed by education about Covid-19 prevention from the experts to the 512 students. The activity ended with the final data collection using a posttest questionnaire to test the student knowledge after the education. Paired t-test analysis showed a significant increase in student commitment after attending the Webinar (P≤0.05). Based on these results, the Webinar increases students' understanding of the importance of the health protocol in reducing the Covid-19 cases.
Studi Kualitatif Pengetahuan Perawat terhadap Reaksi Obat yang Tidak Dikehendaki (ROTD) di Bangsal Rawat Inap Anak RSUP Dr. M. Djamil Padang Santilla Lovia; Yelly Oktavia Sari; Dedy Almasdy; Fitrisia Amelin
Jurnal Sains Farmasi & Klinis Vol 6, No 2 (2019): J Sains Farm Klin 6(2), Agustus 2019
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (519.648 KB) | DOI: 10.25077/jsfk.6.2.95-103.2019

Abstract

Adverse Drug Reaction (ADR) atau Reaksi Obat yang Tidak Dikehendaki (ROTD) merupakan suatu persoalan kompleks bagi tenaga kesehatan. Anak-anak menjadi salah satu populasi yang beresiko mengalami reaksi ini. Belum sempurnanya perkembangan farmakologi dan sistem imun pada anak, kekurangan formulasi sediaan yang sesuai, penggunaan obat off-label, tingginya tingkat polifarmasi, paparan akibat penggunaan obat oleh ibu hamil atau melalui ASI dan kesulitan dalam berkomunikasi menjadi faktor resiko terjadinya ROTD pada anak. Perawat sebagai tenaga kesehatan yang berinteraksi paling banyak dengan pasien dituntut untuk dapat mengenali dan berkontribusi dalam memantau dan melaporkan segala reaksi yang terjadi pada pasien akibat penggunaan obat, sehingga dilakukanlah penelitian untuk mengetahui pengetahuan perawat di bangsal rawat inap SMF Anak RSUP.DR.M. Djamil Padang terhadap kejadian, penanganan dan pelaporan ROTD di bangsal tersebut. Penelitian ini merupakan penelitian deskriptif dengan metoda kualitatif. Pengumpulan data dilakukan dengan cara wawancara semi terstruktur terhadap 14 orang responden yang dipilih berdasarkan purposive sampling dan bersifat konservatif. Hasil penelitian menunjukan pengetahuan perawat yang bertugas di bangsal rawat inap SMF anak RSUP Dr.M.Djamil Padang tentang kejadian, penanganan dan pelaporan ROTD masih kurang. Keterbatasan pengetahuan perawat menyebabkan sangat sedikit sekali pelaporan kasus ROTD yang pernah dilaporkan sesuai dengan prosedur.
Dilated Cardiomyopathy Concomitant with Acute Rheumatic Fever and Sporadic Hereditary Spherocytosis Fitrisia Amelin; Didik Hariyanto; Amizah Zatil Izzah
Health and Medical Journal Vol 2, No 2 (2020): HEME July 2020
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.324 KB) | DOI: 10.33854/heme.v2i2.460

Abstract

Background: Dilated cardiomyopathy (DCM) is a heart muscle disorder defined by the presence of a dilated and poorly functioning left ventricle in the absence of abnormal loading conditions (hypertension, valve disease) or ischaemic heart disease sufficient to cause global systolic impairment. Case report: A 5 years old and 6 months old girl with unremarkable cardiac history hospitalized for congestive heart failure due to dilated cardiomyopathy concomitant with acute rheumatic fever and sporadic hereditary spherocytosis. Acute rheumatic fever diagnosed based on the presentation of carditis, fever, high erythrocyte sedimentation rate, C-Reactive Protein (+), and antistreptolysin titer O (+). DCM was diagnosed after echocardiography. Sporadic hereditary spherocytosis was diagnosed based on anamnesis of pale and jaundice, splenomegaly on physical examination, hemolytic anemia, reticulocytosis, spherosit (+). Both parents reveals normal hematologic finding and the osmotic resistance test showed increasing of osmotic fragility. Conclusion: Prognosis of this patient remains worse because of inadequate left ventricle-right ventricle (LV-RV) function and highly increasing The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) level.
Analisis Faktor yang Berhubungan dengan Kejadian Hipertensi pada Pasien Glomerulonefritis Akut Pasca Streptococcus Sylvia Alicia Salim; Nice Rachmawati Masnadi; Fitrisia Amelin
In Proses
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.381 KB)

Abstract

Pendahuluan: Glomerulonefritis akut pasca Streptococcus (GNAPS) merupakan bentuk glomerulonefritis terbanyak pada anak dengan angka kejadian tinggi di negara berkembang. Manifestasi klinis GNAPS pada anak bisa beragam, mulai hipertensi ringan sampai krisis, dan berbagai komplikasi seperti gangguan ginjal akut dan hipertensi ensefalopati.Tujuan penelitian: Untuk mengetahui faktor-faktor yang berhubungan dengan kejadian hipertensi pada pasien GNAPS di Bagian Ilmu Kesehatan Anak RSUP DR M.Djamil Padang tahun 2015-2017  Metode: Penelitian dilakukan pada Desember 2017 – Maret 2018 di Bagian Ilmu Kesehatan Anak RSUP Dr. M Djamil Padang. Penelitian deskriptif analitik retrospektif dengan desain cross sectional dan teknik total sampling. Sampel penelitian berjumlah 27 pasien. Analisis yang digunakan yaitu uji Fisher’s Exact dan regresi logistik. Hasil: Hasil penelitian mendapati rasio laki-laki dan perempuan 1,5:1. Umur, jenis kelamin, status gizi, hematuria, proteinuria, LFG, ASTO positif tidak signifikan berpengaruh terhadap kejadian hipertensi (p=0,64; p=1,00; p=1,00; p=0,05; p=0,30; p=0,58; p=0,61, berurutan). Edema terdapat pada 74,1% pasien, dengan 90% yang mengalami hipertensi (p=0,02). Analisis multivariat terhadap edema dan hematuria menunjukkan edema adalah faktor yang paling berpengaruh terhadap kejadian hipertensi (p=0,033). Kesimpulan: Edema adalah faktor yang signifikan dan paling berpengaruh terhadap kejadian hipertensi pada pasien GNAPS. Diperlukan kewaspadaan akan terjadinya hipertensi pada pasien GNAPS yang datang dengan edema.
The Effectiveness of Giving Growth Hormone to Children with Chronic Kidney Disease: Systematic Literature Review Irhamni Nur Afdhila; Fitrisia Amelin; Gardenia Akhyar
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Vol 7, No 3, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.537

Abstract

Chronic Kidney Disease (CKD) can cause growth problems in children. This condition will affect children’s social life and increase morbidity and mortality. Growth hormone (GH) is one of medication that has been used for treatment of impaired growth in children with chronic kidney disease. In Indonesia, this management has not been provided, because it is expensive and its effectiveness is uncertain. This research was conducted to determine the effectiveness of growth hormone in increasing linear growth in children with CKD. This study is a systematic review of the Randomized Controlled Trial (RCT) study to determine the effectiveness of growth hormone as a treatment for children with CKD. Literature search was conducted using five databases, namely Pubmed, Google Scholar, DOAJ, BMC and CENTRAL that matched the inclusion and exclusion criteria. The guide used in the literature selection was the PRISMA flow chart. A Total of 10 studies were included in the systematic review. Growth hormone is effective in increasing linear growth in children with CKD. Generally there was a significant increase in height (standard deviation (SD)), high velocity (SD or cm) in the therapy group compared to the control group. The dose of growth hormone that is given varies, but the most is 4 IU / m2 / day, once a day, by subcutaneous injection. The duration of growth hormone administration varied from 6 months to 5 years with an average of 1.7 years. Growth hormone did not aggravate kidney problems in children with CKD and can increase important factors in bone formation, namely alkaline phosphatase and osteocalcin.