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Amelin, Fitrisia
Fakultas Kedokteran Universitas Andalas
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Calcitriol levels and the stage of chronic kidney disease in children Diska Yulia Trisiana; Finny Fitry Yani; Fitrisia Amelin; Aumas Pabuti
Paediatrica Indonesiana Vol 62 No 5 (2022): September 2022
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi62.5.2022.318-23

Abstract

Background Kidney damage in chronic kidney disease (CKD) disrupts the 1?-hydroxylase enzyme, preventing the conversion of vitamin D into the active form of calcitriol. To our knowledge, no previous studies have assessed calcitriol levels in children with CKD. Decreased vitamin D levels may occur at an early stage of the disease, so it is important to evaluate calcitriol levels in children with early stage CKD. Objective To assess calcitriol levels in children with CKD according to disease stage and other characteristics. Methods This cross-sectional study was conducted on 43 pediatric CKD patients at Dr. M Djamil Hospital, Padang, Indonesia. We recorded patient characteristics and performed laboratory tests, including routine hematology, blood urea nitrogen (BUN), creatinine, uric acid, electrolytes, calcium, and calcitriol levels. Based on estimated glomerular filtration rate (GFR), patients were grouped into either early-stage (stages I and II), or advanced-stage (stages III to V) CKD. Univariate and multivariate analyses were conducted to determine the association between calcitriol levels with disease stage and other characteristics. Results The overall mean calcitriol level of our subjects was 108.77 (SD 10.79) pmol/L. Mean levels at each CKD stage from I to V were 164.28 (SD 160.90), 94.14 (SD 50.63), 72.16 (SD 13.18), 62.92 (SD 4.87), and 67.51 (SD 4.87) pmol/L, respectively. Calcitriol levels did not differ significantly by CKD stage (P=0.114) when each stage from I to V was considered separately. There was no significant difference in calcitriol levels by growth characteristics (P=0.944), etiology (P=0.311), or anemic status (P=0.104). However, low calcitriol levels were found in all subjects with advanced stage CKD, compared to 63.6% subjects with early stage CKD (P=0.004). Mean calcitriol levels were significantly lower in CKD stage IV (P=0.049) and stage V (P=0.027) compared to stage I. Conclusions The decrease in calcitriol level occurs at an early stage in CKD. Calcitriol levels are significantly lower in advanced stage than in early stage CKD.
Perbandingan Pola Kepekaan Antibiotik Bakteri Penghasil Extended Spectrum Beta-Lactamase Penyebab Infeksi Saluran Kemih di Rumah Sakit Umum Pusat Dr. M. Djamil Padang Evita Pratiwi; Linosefa Linosefa; Fitrisia Amelin
Sari Pediatri Vol 25, No 3 (2023)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.3.2023.163-9

Abstract

Latar belakang. Infeksi saluran kemih merupakan salah satu penyakit infeksi bakteri yang umum terjadi pada anak. Kultur urin dan uji sensitivitas antibiotik diperlukan sebelum menegakan diagnosis dan terapi.Tujuan. Penelitian ini bertujuan untuk mengetahui perbandingan pola kepekaan antibiotik bakteri penghasil Extended Spectrum Beta-Lactamase dan Non-Extended Spectrum Beta-Lactamase penyebab Infeksi Saluran Kemih pada anak di Rumah Sakit Umum Pusat Dr. M. Djamil Padang tahun 2018 – 2020.Metode. Jenis penelitian yang digunakan adalah analitik observasional dengan desain potong lintang pada uji sensitivitas bakteri penyebab infeksi saluran kemih pada anak menggunakan VITEK®2. Usia, jenis kelamin, penyakit dasar, bakteri, ESBL, dan pola kepekaan telah diteliti. Teknik pengambilan sampel menggunakan teknik simple random sampling dengan jumlah sampel 98 orang.Hasil. Hasil penelitian menemukan kasus ISK anak paling banyak pada anak perempuan. Kelompok usia terbanyak adalah 0 – 1 tahun dengan usia rerata 4,5 tahun (standar deviasi, SD ± 5,8 tahun). Tipe infeksi yang banyak ditemukan adalah infeksi saluran kemih simpleks. Selain itu, juga ditemukan kasus kompleks dengan penyakit terbanyak yang mendasari adalah hidronefrosis. Bakteri yang umum menjadi penyebab adalah Escherichia coli (40,3%) dan Klebsiella pneumoniae (26,88%), dengan prevalensi bakteri penghasil enzim extended spectrum beta-lactamase masing-masing 72,7% dan 67,4%. Terdapat perbedaan yang signifikan antara pola kepekaan bakteri Escherichia coli pada antibiotik ampisilin, aztreonam, seftazidim, siprofloksasin, seftriakson, seftazidim, sefepim, nitrofurantoin, gentamisin, dan trimetoprim/sulfametoksazol. Terdapat perbedaan yang signifikan antara pola kepekaan bakteri Klebsiella pneumonia pada antibiotik aztreonam, siprofloksasin, seftriakson, ertapenem, dan meropenem.Kesimpulan. Penyebab paling umum infeksi saluran kemih pada anak adalah bakteri enterik Gram-negatif dan terdapat penurunan sensitivitas antibiotik pada bakteri penghasil ESBL. 
Gangguan Ginjal Akut akibat Keracunan Jengkol Idha Yulfiwanti; Aumas Pabuti; Fitrisia Amelin; Ronaldi Noor
Majalah Kedokteran Andalas Vol 46, No 7 (2023): Supplementary December 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p1238-1246.2023

Abstract

Jengkolic acid intoxication is one of the causes of acute kidney injury in children. This case report discusses the diagnosis and management of jenkol intoxication in children. We reported a 12-year-old boy with painful urination accompanied by low back pain and urine was initially whitish-colored sand then turned red-colored urine accompanied by reduced urine volume after consuming jengkol. The patient was diagnosed with acute kidney injury due to jenkolic acid intoxication, urinary tract infection, and bilateral hydronephrosis with initial conditions of oliguria, elevated urea, the impression of an estimated glomerular filtration rate (GFR) was stage failure, and planned emergency hemodialysis. The patient was managed with bicarbonate sodium and other symptomatic therapy. During monitoring of patients with increased urine output, decreased ureum and increased estimated GFR, hemodialysis was not performed. The patient was treated for 6 days and recommended for control at the pediatric clinic.
SYSTEMATIC LITERATURE REVIEW HUBUNGAN KONSUMSI NATRIUM DENGAN KEJADIAN HIPERTENSI PADA REMAJA Delfilaura, Asyifa; Amelin, Fitrisia; Machmud, Rizanda
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 1 No. 4 (2024): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Desember 2024
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/n8nv1f94

Abstract

Background : Hypertension does not only occur in adults but also in adolescents, it will be very risky to develop into serious early disease. One of the risk factors for hypertension is the habit of consuming high amounts of sodium, especially in adult hypertension. However, the relationship between sodium intake and the incidence of hypertension in children and adolescents is still controversial and the literature review studies found are still few.  Objective : This research aim to assess the relationship between sodium intake with hypertension in adolescents based on literature review. Methods : This research is a systematic literature review. A literature search was conducted on the Pubmed and Google Scholar databases using inclusion and exclusion criteria. The data synthesis in this literature review was carried out quantitatively. Results : A total of 8 studies were included in the systematic which 4 studies from them is carried out a meta-analysis. The average adolescent consumes sodium above the requirement ranging from 1503 mg per day to 4000 mg per day. The average prevalence of hypertension in adolescents is 2.2% - 35.8%. From the results of the meta-analysis, it was found that there was a significant relationship between sodium consumption and the incidence of hypertension in adolescents with a value of P = 0.00001 (P <0.05). Conclusion : Most adolescents consume sodium above the nutritional recommendation. The prevalence of adolescent hypertension continues to increase. There is a significant relationship between sodium intake and hypertension in adolescents.
HUBUNGAN OBESITAS DENGAN KEJADIAN HIPERTENSI PADA REMAJA : SEBUAH TINJAUAN NARATIF Maryan, Siti; Amelin, Fitrisia
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.995

Abstract

Abstrak Latar Belakang Hipertensi yang berlaku semasa remaja akan berterusan sehingga dewasa dan meningkatkan risiko morbiditi dan kematian. Hipertensi disebabkan oleh banyak faktor antaranya umur, genetik, status pemakanan dan lain-lain. Tinjauan ini bertujuan untuk mengetahui perkaitan antara obesiti dengan kejadian hipertensi terutamanya dalam kalangan remaja. Objektif Tinjauan naratif ini dilakukan untuk mengetahui hubungan obesitas dengan kejadian hipertensi pada remaja. Metode Artikel dikumpulkan dari dua pangkalan data, yaitu Pubmed dan Google Scholar dengan menggunakan kata kunci Obesity, Hypertension, Adolescents, Nutrition, Narrative review. Pencarian artikel ini dilakukan secara online pada bulan  April 2021. Artikel yang didapatkan harus memenuhi kriteria inklusi dan eksklusi yang telah didapatkan. Hasil Dari 6397 artikel yang didapatkan hanya 7 artikel yang memenuhi kriteria inklusi dan eksklusi. Kejadian obesitas pada remaja menurut artikel yang dikaji bervariasi. Mulai dari 2.4%-55% remaja mengalami obesitas. Kejadian hipertensi pada remaja menurut artikel yang dikaji bervariasi. Mulai dari 8,3%-76,9% remaja mengalami hipertensi. Terdapat hubungan yang bermakna antara obesitas dan kejadian hipertensi pada remaja. Kesimpulan Terdapat enam dari artikel yang dikaji mendapati bahwa terdapat hubungan yang positif antara obesitas pada remaja dengan hipertensi. Sedangkan, hanya satu artikel yang ditemukan tidak berhubungan antara obesitas dengan hipertensi. Sebanyak 10,485 orang remaja yang dikaji di dalam tinjauan naratif ini tetapi hanya sebanyak 60 remaja yang didapati hasilnya belum konklusif karena pada sampel tersebut ada beberapa faktor yang mempengaruhi seperti besar sampel dan sebagainya
DETEKSI DINI KOMPLIKASI KEHAMILAN, PERILAKU HIDUP BERSIH DAN SEHAT SERTA DETEKSI DINI GANGGUAN PERTUMBUHAN DAN PERKEMBANGAN BAYI DAN BALITA DI WILAYAH KERJA PUSKESMAS PEGAMBIRAN KOTA PADANG Aldina Ayunda Insani; Erda Mutiara; Fitrisia Amelin; Yulizawati Yulizawati; Lusiana El Sinta Bustami; Feni Andriani
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 2 No. 4 (2019)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v2i4.129

Abstract

Puskesmas Pegambiran is located in Lubuk Begalung Sub-district, Padang City has five villages with a pregnancy complication rate of 19.9% and neonatal complications of 11.74% (2016). The general objective that will be achieved is to increase the number of better health degrees for pregnant women, infants, toddlers, and pre-school age children through promotive and preventive activities. The method used is by conducting surveys and interviews, conduct counseling, demonstrate clean and healthy living habits, anthropometric measurements of infants, toddlers, and pre-school children, observation, pregnancy checks, hemoglobin checks, and counseling. The results obtained were counseling and demonstrations on clean and healthy living behaviors in pre-school age children at Alya Zahira Kindergarten, which all students could participate in and run smoothly. 98% of kindergarten students demonstrated healthy hygiene habits, including washing hands, brushing teeth, and mentioning healthy snacks. Anthropometric measurements of infants and toddlers and pre-school age children showed that weight for age was within normal limits, height/length according to age, and expected limits. 3.7% thin and short toddlers and 1.2% of toddlers have speech delays, 1.2% children under five with a history of epilepsy, and need further treatment, so referrals are made. 1.2% of children under five were referred to because they did not recognize colors. All pregnant women (100%) have normal hemoglobin levels (10 g / dl), and pregnancy conditions are appropriate for their gestational age. It is hoped that further community service activities will be carried out by applying the partnership midwifery practice model (mentoring) to the above targets for several months. There are changes in behavior patterns for promotive and preventive actions that have been given.
Bacterial Patterns and Sensitivity to Antibiotics in Neonatorum Sepsis Patients at Dr. M. Djamil Padang General Hospital in the Period 2018–2021 Fenty Primadhani; Linosefa, Linosefa; Fitrisia Amelin; Almurdi, Almurdi; Elly Usman; Rahmi Lestari
Jurnal EduHealth Vol. 16 No. 02 (2025): Jurnal EduHealt, Edition April - June , 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Neonatal sepsis is one of the leading causes of morbidity and mortality in neonates. Bacteria are the most common cause of neonatal sepsis. The appropriate empirical therapy is given based on the bacterial pattern and sensitivity at the site. The appropriate use of empirical antibiotics can help reduce the neonatal mortality rate. This study aimed to evaluate bacterial patterns and antibiotic sensitivity in neonatal sepsis patients at RSUP Dr. M. Djamil Padang period 2018-2021. This study is a descriptive study that used a total sampling method with 63 samples that met the inclusion criteria. The results showed that neonatal sepsis was most commonly found in neonates aged 4-28 days, which were mostly male, had a birth weight < 2500 grams, had a mortality rate of 25.4%, and neonatal pneumonia was the most comorbid disease. The most common causative bacteria were Klebsiella pneumoniae and Staphylococcus haemolyticus. Klebsiella pneumoniae is sensitive to amikacin, tigecycline, meropenem, and ertapenem. Staphylococcus haemolyticus was sensitive to tigecycline, nitrofurantoin, vancomycin, linezolid, and quinupristin / dalfopristin. This study concluded that the most common bacteria causing neonatal sepsis were Klebsiella pneumoniae and Staphylococcus haemolyticus. Klebsiella pneumoniae was sensitive to amikacin, tigecycline, meropenem, and ertapenem. Staphylococcus haemolyticus was sensitive to tigecycline, nitrofurantoin, vancomycin, linezolid, and quinupristin / dalfopristin. Clinicians are expected to review the clinical practice guidelines for neonatal sepsis to suit bacterial patterns and their sensitivity to antibiotics.
Gangguan Ginjal Akut akibat Keracunan Jengkol Yulfiwanti, Idha; Pabuti, Aumas; Amelin, Fitrisia; Noor, Ronaldi
Majalah Kedokteran Andalas Vol. 48 No. 3 (2025): MKA July 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i3.p364-372.2025

Abstract

Jengkolic acid intoxication is one of the causes of acute kidney injury in children. This case report discusses the diagnosis and management of jenkol intoxication in children. We reported a 12-year-old boy with painful urination accompanied by low back pain and urine was initially whitish-colored sand then turned red-colored urine accompanied by reduced urine volume after consuming jengkol. The patient was diagnosed with acute kidney injury due to jenkolic acid intoxication, urinary tract infection, and bilateral hydronephrosis with initial conditions of oliguria, elevated urea, the impression of an estimated glomerular filtration rate (GFR) was stage failure, and planned emergency hemodialysis. The patient was managed with bicarbonate sodium and other symptomatic therapy. During monitoring of patients with increased urine output, decreased ureum and increased estimated GFR, hemodialysis was not performed. The patient was treated for 6 days and recommended for control at the pediatric clinic.
PROFIL KLINIS DAN BAKTERIOLOGIS INFEKSI SALURAN KEMIH PADA ANAK DI RSUP DR. M. DJAMIL PADANG TAHUN 2017 – 2021 Bari'ah, Puti Asma; Amelin, Fitrisia; Putra, Andani Eka; Izzah, Amirah Zatil; Welan, Rahmani
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 5 (2025): SINERGI : Jurnal Riset Ilmiah, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i5.1214

Abstract

Urinary Tract Infection (UTI) is the most common bacterial infection in children which is characterized by an increase in bacteria in the urine. The purpose of this study was to determine the clinical and bacteriological profiles of urinary tract infection patients in children at Dr. M. Djamil Padang in 2017-2021. This type of research is descriptive with a total sample method of 52 children with a retrospective approach on patient medical record data and urine culture results. The variables studied included age, gender, nutritional status, urinary tract abnormalities, clinical symptoms, physical examination, supporting examinations, and types of bacteria in pediatric urinary tract infection patients. The results of this study showed that most cases of UTI occurred in children aged 0-1 years (59,2%) with more male cases than females, good nutritional status (56,8%), with the most congenital abnormality in males is phimosis (37,9%). Based on physical examination, it was found that most of the patients did not have a fever (50%). The results of investigations showed that the patient had leukocyturia (61,5%) on urinalysis, leukocytosis (61,5%) on blood scan, cystitis (47.8%) on ultrasound, and nephrolithiasis (33%) on CT scan. Bacterial culture results show that the most common cause of UTIs in boys is Klebsiella pneumoniae (37.9%) and in girls Escherichia coli (87.0%). Based on this study, most results were obtained in the form of uncomplicated UTI. Gram-negative bacteria are the most common type of bacteria that cause UTIs.
HUBUNGAN STATUS IMUNISASI BCG DENGAN MORTALITAS DAN DERAJAT SEVERITAS MENINGITIS TUBERKULOSIS ANAK DI RSUP DR. M. DJAMIL PADANG PERIODE 2018 – 2021 Nixon, Poety Elberta Husna; Lestari, Rahmi; Intan, Shinta Ayu; Amelin, Fitrisia; Ermayanti, Sabrina; Adrial, Adrial
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 6 (2025): SINERGI : Jurnal Riset Ilmiah, Juni 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i6.1314

Abstract

Objective: This study aims to determine the relationship between BCG immunization status with mortality and severity of TB meningitis in children at RSUP Dr. M. Djamil Padang. Method: This study used a cross-sectional design in children with TB meningitis and used the Kolmogorov-Smirnov and Chi-Square statistical tests. Sampling using total sampling technique with a total sample of 58 people. Data obtained from the medical records of RSUP Dr. M. Djamil Padang in 2018 – 2021. Result: This study shows that most pediatric TB meningitis patients with the condition are women (53%), aged 0-4 years (48%), good nutritional status (40%), not in direct contact with TB patients (74%), received BCG immunization (55%), severe degree (59%), and alive (76%). There is a relationship between BCG immunization status and degree of severity (p=0.046) and mortality (p=0.047) of pediatric TB meningitis patients at RSUP Dr. M. Djamil Padang in 2018 – 2021. Conclusion: The conclusion of this study is that there is a relationship between BCG immunization status and the degree of severity and mortality of TB meningitis in children at RSUP Dr. M. Djamil Padang in 2018 – 2021.
Co-Authors Adrial Adrial, Adrial Afdhila , Irhamni Nur Almurdi Almurdi Amirah Zatil Izzah Amizah Zatil Izzah Andani Eka Putra Aumas Pabuti Aumas Pabuti Aumas Pabuti Aumas Pabuti, Aumas Bari'ah, Puti Asma Delfilaura, Asyifa Desy Nofita Sari Devi Novriyanti Didik Hariyanto Diska Yulia Trisiana Elly Usman Erda Mutiara Ermayanti, Sabrina Eti Yerizel Evita Pratiwi Fathiyyatul Khaira Feni Andriani Fenty Anggraini Fenty Primadhani Finny Fitry Yani Gardenia Akhyar Hardisman Idha Yulfiwanti Insani, Aldina Ayunda Intan, Shinta Ayu Irhamni Nur Afdhila Irvan Medison Leona, Denada Florencia Lestari, Rahmi Linosefa Linosefa Lusiana El Sinta Bustami Mahata, Liganda Endo Maryan, Siti Nice Rachmawati Masnadi Nixon, Poety Elberta Husna Noor, Ronaldi Pratita Jati Permatasari Rahmat Syawqi Rahmi Lestari Rizanda Machmud Ronaldi Noor Santilla Lovia Sylvia Alicia Salim Yefri Zulfiqar Yelly Oktavia Sari Yollanda Vonitania Yulfiwanti, Idha Yulizawati .