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All Journal International Journal of Public Health Science (IJPHS) Jurnal Sain Peternakan Indonesia Journal of Biomedicine and Translational Research Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Global Health Management Journal Journal of Nursing Care Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Berita Kedokteran Masyarakat Jurnal Info Kesehatan
Noor Pramono
Departement of Obsterics and Gynecology
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Maternal Determinants of Preeclampsia Incidence in Arjawinangun Hospital, Cirebon District, West Java: A Case Study Nurjanah, Nunung; Pramono, Noor; -, Anggorowati; Soejoenoes, Ariawan
Journal of Nursing Care Vol 8, No 3 (2025): Journal of Nursing care
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jnc.v8i3.64167

Abstract

Most of these complications develop during pregnancy. The main complications accounting for 80% of maternal deaths are severe bleeding (mostly postpartum hemorrhage), infection (usually after delivery), high blood pressure during pregnancy (pre-eclampsia and eclampsia) and unsafe abortion. This was an analytic observational study with a case control design. The data taken were the medical records of patients diagnosed with preeclampsia from Januari to Desember 2024. The population of pregnant women at RSUD Arjawinangun, Cirebon was 2.780 pregnant women. The sample size was obtained by random sampling technique as many as 350 pregnant women in accordance with the inclusion and exclusion criteria determined for the study. The result that Age (p-value 0.001, OR 5.678), Parity (p-value 0.001, OR 2.606), Occupation (p-value 0.026, OR 2.053), Pregnancy distance (p-value 0.002, OR 2.005), Nutritional Status (p-value 0.001, OR 3.898), History of Preeclampsia (p-value 0.001, OR 14.462), MAP (p-value 0.001, OR 7.644). Age, Gravida, Interpregnancy interval, BMI, History of preeclampsia, MAP, occupation are factors contributing to the occurrence of preeclampsia in pregnant women at Arjawinangun Hospital, Cirebon Regency. Pregnant women with a history of preeclampsia have a 153.342 times higher chance of experiencing preeclampsia in their current pregnancy. Age, Gravida, Interpregnancy interval, BMI, History of preeclampsia, MAP, occupation are factors contributing to the occurrence of preeclampsia in pregnant women at Arjawinangun Hospital, Cirebon Regency.   
Low sEng Level in Preeclampsia with MFTHFR Gene Polymorphism Suggesting a Protective Factor Pramono, M. Besari Adi; Faradz, Sultana MH; Suhartono, Suhartono; Susanto, Hardhono; Rachmawati, Banundari; Pramono, Noor
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.29375

Abstract

Background: Preeclampsia is one of the most serious complications of pregnancy and the leading cause of maternal and fetal mortality. Various studies have shown that Glutathione Peroxidase (GPx) deficiency and increased Soluble endoglin (sEng) level are consistently associated with the incidence of preeclampsia. Several studies also show the role of MTHFR A1298C and C677T gene polymorphisms in preeclampsia.Objective: This study investigated association between blood GPx, sEng levels, MTHFR A1298C and C677T gene polymorphisms in Preeclampsia.Methods: This analytic observational case-control study was conducted on 70 cases of preeclampsia and 70 controls. Blood GPx and sEng levels were measured using Enzyme Linked Immunosorbent Assay (ELISA). MTHFR A1298C and C677T gene polymorphism was genotyped using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The data obtained were analyzed using the Mann-Whitney U test, chi-square test, and independent T-test.Results: There were no significant differences in GPx levels or MTHFR A1298C/C677T genotype distribution between groups. sEng levels were significantly higher in the preeclampsia group than controls (p=0.001). ROC analysis identified a cut-off of 7.75 ng/mL. Among preeclampsia patients, those with the MTHFR 1298AC/CC genotypes had lower sEng levels than wildtype (p=0.027), suggesting a potential protective effect. No association was found for C677T.Conclusion: We found no significant difference in GPx level, MTHFR A1298C and C677T gene polymorphism between preeclampsia and control group. Soluble endoglin (sEng) level in the preeclampsia group (mean: 11.0±5.22) were significantly different (p=0.001) compared to the control group (mean: 8.1±5.31). Increased level of sEng is associated with incidence of preeclampsia. A key finding in this study is the significantly lower sEng levels observed in preeclampsia patients carrying the MTHFR 1298AC and 1298CC alleles compared to the control group (p=0.027). This indicates a protective factor where in preeclampsia with MTHFR gene alleles 1298AC and 1298CC sEng levels are lower compared to wildtype.
Co-Authors - Anggorowati Annastasia Ediati Ari Suwondo Bambang Cahyono Banundari Rachmawati Barirah, Barirah Deviana, Meli Dewi Puspitasari, Vannya Endang Mahati Endang Sri Lestari Hardhono Susanto Hertanto Wahyu Subagio Hidayat, Syarief Thaufik Kurniawati, Erna Yovi M. Besari Adi Pramono, M. Besari Adi Marpaung, Mona Galatia Martha Irene Kartasurya Mohammad Hakimi Nunung Nurjanah Sari Sudarmiati Sera, Agnescia Clarissa Soejoenoes, Ariawan Sri Wahyuni Suhartono Suharyo Hadisaputro Sultana MH Faradz Susilani, Amalina Tri Teuku Mirza Iskandar, Teuku Mirza Yuni Purwati Yuniarti Yuniarti