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All Journal International Journal of Public Health Science (IJPHS) Jurnal Sain Peternakan Indonesia Journal of Biomedicine and Translational Research Majalah Obstetri dan Ginekologi Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Global Health Management Journal Journal of Nursing Care Livestock and Animal Research Berita Kedokteran Masyarakat Jurnal Info Kesehatan
Noor Pramono
Departement of Obsterics and Gynecology
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Low sEng Level in Preeclampsia with MFTHFR Gene Polymorphism Suggesting a Protective Factor Pramono, M. Besari Adi; Faradz, Sultana MH; Suhartono, Suhartono; Susanto, Hardhono; Rachmawati, Banundari; Pramono, Noor
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.29375

Abstract

Background: Preeclampsia is one of the most serious complications of pregnancy and the leading cause of maternal and fetal mortality. Various studies have shown that Glutathione Peroxidase (GPx) deficiency and increased Soluble endoglin (sEng) level are consistently associated with the incidence of preeclampsia. Several studies also show the role of MTHFR A1298C and C677T gene polymorphisms in preeclampsia.Objective: This study investigated association between blood GPx, sEng levels, MTHFR A1298C and C677T gene polymorphisms in Preeclampsia.Methods: This analytic observational case-control study was conducted on 70 cases of preeclampsia and 70 controls. Blood GPx and sEng levels were measured using Enzyme Linked Immunosorbent Assay (ELISA). MTHFR A1298C and C677T gene polymorphism was genotyped using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The data obtained were analyzed using the Mann-Whitney U test, chi-square test, and independent T-test.Results: There were no significant differences in GPx levels or MTHFR A1298C/C677T genotype distribution between groups. sEng levels were significantly higher in the preeclampsia group than controls (p=0.001). ROC analysis identified a cut-off of 7.75 ng/mL. Among preeclampsia patients, those with the MTHFR 1298AC/CC genotypes had lower sEng levels than wildtype (p=0.027), suggesting a potential protective effect. No association was found for C677T.Conclusion: We found no significant difference in GPx level, MTHFR A1298C and C677T gene polymorphism between preeclampsia and control group. Soluble endoglin (sEng) level in the preeclampsia group (mean: 11.0±5.22) were significantly different (p=0.001) compared to the control group (mean: 8.1±5.31). Increased level of sEng is associated with incidence of preeclampsia. A key finding in this study is the significantly lower sEng levels observed in preeclampsia patients carrying the MTHFR 1298AC and 1298CC alleles compared to the control group (p=0.027). This indicates a protective factor where in preeclampsia with MTHFR gene alleles 1298AC and 1298CC sEng levels are lower compared to wildtype.
Baseline hemoglobin as a prognostic factor for radiotherapy outcomes and survival in advanced cervical cancer at Dr. Kariadi General Hospital, Semarang, Indonesia Marpaung, Mona Galatia; Iskandar, Teukur Mirza; Pramono, Noor; Suhartono
Majalah Obstetri & Ginekologi Vol. 34 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V34I12026.16-22

Abstract

HIGHLIGHTS Baseline hemoglobin level is a relevant predictive factor in cervical cancer management, emphasizing the importance of maintaining optimal hematological status to enhance therapeutic effectiveness and improve patient survival. Patients with hemoglobin levels =11 g/dL demonstrated higher two-year survival rates and longer median survival times compared with those with levels <11 g/dL, supporting the role of hemoglobin as an important prognostic indicator of long-term clinical outcomes.   ABSTRACT Objective: This study aimed to evaluate the relationship between baseline hemoglobin concentration and the effectiveness of radiotherapy in patients with advanced cervical cancer, with emphasis on survival outcomes and therapeutic response. Materials and Methods: A retrospective observational study was conducted using medical records from the Oncology Clinic and Radiotherapy Unit between January 2017 and December 2022. Eligible subjects included women diagnosed with stage IIB–IIIB cervical cancer who had completed radiotherapy, either alone or combined with chemotherapy. Hemoglobin levels were compared between treatment groups using the chi-square test. Survival probabilities were assessed using Kaplan–Meier analysis and compared with the log-rank test, with p <0.05 considered statistically significant. Results: A total of 939 patients met the inclusion criteria. Among them, 89 patients received box system radiotherapy and 850 underwent brachytherapy. Hemoglobin levels <11 g/dL were observed in 55.1% of patients in the box system group and 42.7% in the brachytherapy group. Conversely, hemoglobin levels ≥11 g/dL were more frequent in the brachytherapy group (57.3%) than in the box system group (44.9%) (p = 0.034). Patients with hemoglobin levels ≥11 g/dL had a higher two-year survival rate (67.4%) compared with those with hemoglobin levels <11 g/dL (54.9%). Mean survival time was also longer in patients with higher hemoglobin levels (19.8 vs 17.4 months). Conclusion: Baseline hemoglobin level is significantly associated with radiotherapy outcomes and survival in advanced cervical cancer. Higher hemoglobin levels (≥11 g/dL) are associated with improved survival and reduced mortality, highlighting its role as an important prognostic indicator. Maintaining adequate hemoglobin levels may improve treatment effectiveness and clinical outcomes.
Experimental animal models for polycystic ovarian syndrome (methods, effects, and implications) Kurniawati, Erna Yovi; Pramono, Noor; Hidayat, Syarief Thaufik; Mahati, Endang
Livestock and Animal Research Vol 22, No 1 (2024): Livestock and Animal Research
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/lar.v22i1.79197

Abstract

Many studies have replicated the clinical and genetic features of polycystic ovarian syndrome (PCOS) using a range of experimental animal models to improve treatment outcomes. This article aims to present an overview of the various experimental animal models that have been used in PCOS research. In this study, we conducted a systematic review of relevant research articles on the induced animal model PCOS. We searched research articles in Indonesian and English published over the last five years through three databases: PubMed, ScienceDirect, Google Scholar. We use established inclusion and exclusion criteria to select suitable articles. Out of 19 research articles included in our systematic review, we found the animal model PCOS based Rotterdam criteria, PCOS-IR model, PCOS-Inflammation model, PCOS-Gut microbiota model and PCOS-syndrome metabolic model. Androgen agents such as testosterone propionate, free testosterone, DHEA, and letrozole, as well as sodium valproate, are effective in the induction of PCOS phenotypes based on the Rotterdam criteria (oligo/amenorrhea, hyperandrogenic, and polycystic ovaries).
Co-Authors - Anggorowati Annastasia Ediati Ari Suwondo Bambang Cahyono Banundari Rachmawati Barirah, Barirah Deviana, Meli Endang Mahati Hardhono Susanto Hertanto Wahyu Subagio Hidayat, Syarief Thaufik Iskandar, Teukur Mirza Kurniawati, Erna Yovi M. Besari Adi Pramono, M. Besari Adi Marpaung, Mona Galatia Martha Irene Kartasurya Mohammad Hakimi Nunung Nurjanah Sari Sudarmiati Sera, Agnescia Clarissa Soejoenoes, Ariawan Sri Wahyuni Suhartono Suhartono Suharyo Hadisaputro Sultana MH Faradz Susilani, Amalina Tri Teuku Mirza Iskandar, Teuku Mirza Yuni Purwati Yuniarti Yuniarti