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All Journal Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Acta Pharmaceutica Indonesia Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Media Kesehatan Politeknik Kesehatan Makassar JPSCR : Journal of Pharmaceutical Science and Clinical Research Journal of Pharmaceutical and Medicinal Sciences Jurnal Ilmiah Farmasi Farmasyifa Jurnal farmasi UIN Alauddin Makassar Current Research on Biosciences and Biotechnology Jurnal Pengabdian Kefarmasian Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan

Syamsu Nur

Sekolah Tinggi Ilmu Farmasi Makassar

Author-ID : 3511797

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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AKTIVITAS ANTIOKSIDAN EKSTRAK LAMUN (Enhalus acoroides) ASAL PULAU LAE-LAE MAKASSAR TERHADAP RADIKAL ABTS Fitriyanti Jumaetri Sami; Syamsu Nur; Amriani Sapra; Libertin Libertin
Media Kesehatan Politeknik Kesehatan Makassar Vol 15, No 2 (2020): Media Kesehatan
Publisher : Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v15i2.1613

Antioxidants are compounds that can inhibit or prevent oxidation reactions, which are the result of chemical reactions and metabolic processes that occur in the body. Enhalus acoroides is a type of seagrass found in Indonesian waters, generally living in sandy sediments with high bioturbation. Lamun has good nutrition and fiber so that it can be a source of food and medicine. The aim of this study was to examine the antioxidant activity of the seagrass extract Enhalus acoroides against ABTS radicals (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid). The results of the study of seagrass extract using ethanol solvents had a very strong antioxidant category ie 38,008 µg /ml, the smaller the absorbance value, the higher the inhibitory value in which the antioxidant activity of the extract is higher, but when compared with the routine compound control of 0.500 µg /ml, seagrass ethanol extract is still lower.

Profil Aktivitas Antioksidan dari Ekstrak Buah Kersen (Muntingia calabura L.) dengan Metode TAC dan CUPRAC Syamsu Nur; Muhammad Aswad; Rifah Yulianty; Asril Burhan; William Johanes Dian Patabang; Alfat Fadri; Nursamsiar Nursamsiar
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 7, No 1 (2022)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v7i1.56653

Kondisi stress oksidatif dapat mempengaruhi makromolekul seluler dan ekstraseluler (protein, lipid, asam nukleat dan DNA) sehingga dapat mengalami kerusakan oksidatif pada jaringan tubuh yang memicu terjadinya penyakit degeneratif melalui beberapa jalur oksidasi didalam tubuh. Penelitian ini bertujuan untuk menentukan aktivitas antioksidan dari ekstrak buah kersen dengan metode TAC dan CUPRAC. Sampel segar buah kersen dikumpulkan kemudian dilakukan proses pembuatan simplisia yang kemudian dilakukan proses ekstraksi dengan menggunakan metode maserasi untuk dilakukan proses penyarian dengan pelarut etanol 70% hingga diperoleh ekstrak kental buah kersen (EE). Ekstrak kental buah kersen kemudian dilakukan proses pemisahan dengan metode ekstraksi cair-cair menggunakan pelarut n-heksan, etil asetat dan etanol-air (1:9) sehingga diperoleh fraksi n-heksan (HF), fraksi etil asetat (EAF) dan fraksi etanol-air (EF). Kemudian masing-masing sampel di uji aktivitas antioksidan dengan menggunakan metode Total Antioxidant Capacity (TAC) dan Cupric ion Power Reducing Antioxidant Capacity (CUPRAC). Hasil yang diperoleh yaitu pada metode TAC, EAF memiliki aktivitas yang lebih baik dengan nilai Quercetin Equivalen Antioxidant Capacity (QEAC) 57,1±1,03 µM/mg dibandingkan dengan EE, EF dan HF. Sedangkan pada metode CUPRAC diperoleh hasil bahwa EAF memiliki aktivitas antioksidan dalam mereduksi Cu yang lebih baik dengan nilai Gallic Acid Equivalen Antioxidant Capacity (GAEAC) 13,13±0,008 µM/mg dibandingkan dengan EE, EF dan HF. Hal ini menunjukkan bahwa buah kersen memiliki potensi aktivitas antioksidan yang baik. Fraksi etil asetat (EAF) dari buah kersen memiliki potensi sebagai antioksidan dalam mereduksi Mo dan ion Cu dengan menggunakan metode TAC dan CUPRAC. Adanya data ilmiah dari penelitian ini dapat memberikan kontribusi dalam pengembangan buah kersen sebagai food suplement antioksidan yang berguna untuk kesehatan masyarakat.

AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN BEROMA (Cajanus cajan (L.) Milps) Mirnawati Salampe; Zulfaidah Rahma; Syamsu Nur; Sukamto S Mamada
Majalah Farmasi dan Farmakologi Vol. 23 No. 1 (2019): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Daun beroma (Cajanus cajan (L.) Milps) berpotensi sebagai antioksidan dikaitkan dengan kandungan senyawa kimia yaitu flavanoid dan fenolik. Aktivitas antioksidan dari ekstrak etanol 70% daun Cajanus cajan (L.) Milps dilakukan menggunakan metode 1,1- diphenyl-2-picrylhydrazyl (DPPH) dan 2,2’-azino-bis- [3- ethylbenzothiazoline sulphonate] (ABTS). Nilai IC50 pada pengujian metode DPPH yaitu 86,34 mg/ml dan IC50 pada metode ABTS yaitu 20,53 mg/ml. Berdasarkan nilai IC50 tersebut, dapat disimpulkan bahwa ekstrak etanol daun Cajanus cajan (L.) Milps mempunyai aktivitas antioksidan yang sangat kuat.

IDENTIFIKASI DAN PENENTUAN KADAR KATEKIN DARI SEDUHAN DAN EKTRAK ETANOL PRODUK TEH HIJAU (Camelia sinensi L) KOMERSIAL SECARA SPEKTROFOTOMETRI UV-VISIBLE Syamsu Nur
Majalah Farmasi dan Farmakologi Vol. 24 No. 1 (2020): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Teh hijau merupakan salah satu jenis minuman kesehatan yang mengandung golongan senyawa polifenol dan memiliki banyak manfaat. Jenis senyawa polifenol yang banyak ditemukan pada teh hijau adalah kandungan katekin. Pada penelitian ini telah dikaji kandungan senyawa katekin dari produk teh hijau kemasan yang merupakan produk komersial dari Indonesia (A), Thailand (B) dan Jepang (C). Teh hijau kemasan diekstraksi dengan cara diseduh pada suhu dan waktu yang berbeda serta ekstraksi dengan cara maserasi menggunakan pelarut etanol 70%. Identifikasi kandungan katekin dilakukan menggunakan reagen kimia dan spektrofotometer UV-Vis serta penentuan kadarnya dilakukan secara spektrofotometri UV-Vis. Hasil yang diperoleh menunjukkan bahwa teh hijau mengandung senyawa epigallocatechin-3-gallate (EGCG) sesuai dengan adanya perubahan warna berdasarkan reagen kimia dan spektrum UV yang memiliki λmax pada kisaran 270-274 nm. Hasil uji kuantitatif secara spektrofotometri UV-Vis menunjukkan bahwa ekstraksi dengan cara penyeduhan pada teh hijau B memiliki kadar katekin tertinggi yang diikuti berturut-turut pada sampel A dan C. Sedangkan kadar katekin dari hasil maserasi menggunakan etanol 70% pada teh hijau A memiliki kadar katekin tertinggi diikuti teh hijau C dan B.

Edukasi Jajanan Sehat Dan Deteksi Dini Boraks Menggunakan Bumbu Dapur Astuti Amin; Nursamsiar Nursamsiar; Syamsu Nur; Fitriyanti Sami; Megawati Megawati; Fhahri Mubarak; Noer Rahman; Imrawati Imrawati; Lukman Muslimin; Andi puanguce Paluseri
Jurnal Pengabdian Kefarmasian Vol 3, No 1 (2022): JURNAL PENGABDIAN KEFARMASIAN
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/jpk.v3i1.2830

Education About Healthy School Snacks and Early Identification of Borax Using SpiceNutrition for school-age children are a significant factor in developing small and medium-scale food businesses. Unfair competition in the food business encourages the addition of hazardous chemicals to extend the shelf life of foods such as borax and formalin. This community service aims to understand students, parents, and teachers about healthy snacks and how to identify borax content in food using spices (turmeric). This community service is carried out at Ali Imran Kindergarten, Rappocini District, Makassar. Forty students attended this counselling, 35 parents and eight teachers. This activity begins with the presentation about the importance of healthy snacks and the dangers of borax and formalin. A demonstration of the use of turmeric to detect the presence of borax was carried out in front of parents and teachers. In the end, they were allowed to practice. The results showed an increase in the ability of parents and teachers (100%) to identify borax in food using turmeric.Keywords : Borax, Healthy snack, Turmeric, CounselingKebutuhan siswa akan makanan dan jajanan merupakan faktor utama berkembangnya usaha makanan skala kecil dan menengah. Pesatnya perkembangan usaha makanan tersebut bukan tidak mungkin mendorong timbulnya persaingan antar pedagang yang kurang sehat termasuk penambahan bahan kimia berbahaya untuk memperpanjang masa simpan makanan seperti boraks dan formalin. Pengabdian masyarakat ini bertujuan untuk memberikan edukasi terhadap siswa, orang tua dan guru mengenai pentingnya jajanan sehat dan cara mengidentifikasi kandungan boraks dalam jajanan menggunakan bumbu dapur. Pengabdian ini dilakukan di Taman Kanak-kanak (TK) Ali Imran, Kecamatan Rappocini, Makassar. Penyuluhan ini diikuti oleh 45 orang siswa, 40 orang tua siswa dan 6 orang guru. Kegiatan ini diawali dengan pemaparan materi mengenai pentingnya jajanan sehat serta bahaya boraks dan formalin. Demonstrasi penggunaan kunyit (Curcuma domestica) untuk mendeteksi adanya boraks dilaksanakan di depan orang tua siswa serta guru dan di akhir kegiatan mereka diberikan kesempatan untuk mempraktikkan. Hasil penyuluhan menunjukkan adanya peningkatan kemampuan orang tua siswa dan guru untuk mengidentifikasi boraks dalam makanan menggunakan kunyit yang ditunjukkan dengan semua peserta (100%) berhasil mempraktikkan.Kata kunci: Boraks, Jajanan, Kunyit, Penyuluhan

Anthocyanin From Rosella Petals (Hibiscus sabdariffa L.) as Anion Chemosensory Syamsu Nur; Imrawati Imrawati; Fitriyanti Jumaetri Sami; Alfat Fadri; Megawati Megawati
Jurnal Farmasi dan Ilmu Pengobatan Vol 6 No 2 (2021): JPMS Volume 6 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v6i2.132

Rosella plants are a type of hibiscus plant and can be used as a health drink for various diseases. Rosella flowers have the potential to be used as a source of natural dyes in food. The purpose of this study is to determine the anthocyanin of rosella petals as a chemosensory anion compound. To be used as a chemosensory anion compound, testing needs to be done. The ethanol extract of rosella flower petals was extracted by sonication and the filtrate was evaporated to obtain a red extract. From the results of the extract obtained a rendition of 2.9%. Then the extract was tested as an anion chemosensory with the stages of determining the total anthocyanin content, solvatochromic test, and chemosensory test for saturated anions. The total anthocyanin content obtained was 7.648 grams / 100 grams and the chemosensor test results for saturated anions showed a significant change with the addition of KSCN from pink to clear color. Anthocyanin contained in rosella petals can be used as a chemosensor cyanide anion compound.

PENGARUH METODE EKSTRAKSI TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN KARAMUNTING (Rhodomyrtus Tomentosa (Aiton) Hassk) DENGAN METODE DPPH Marwati Marwati; Syamsu Nur; Nur Khairi; Nursamsiar Nursamsiar
Jurnal Ilmiah Farmasi Farmasyifa Vol 5, No 2 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v5i2.9053

Karamunting (Rhodomyrtus tomentosa (Aiton) Hassk) merupakan tanaman yang telah banyak dimanfaatkan masyarakat dalam pengobatan berbagai penyakit. Daun karamunting diketahui memiliki kandungan senyawa kimia fenolik, flavonoid, tanin, saponin dan terpenoid. Penelitian ini bertujuan untuk mengetahui pengaruh metode ekstraksi terhadap aktivitas antioksidan daun karamunting dalam meredam radikal DPPH. Daun karamunting diektraksi dengan metode dingin (maserasi dan sonikasi) dan metode panas (refluks) menggunakan pelarut etanol 70% dan pengujian aktivitas antioksidan dengan spektrofotometri Uv-Vis pada panjang gelombang 515 nm. Hasil ekstraksi diperoleh rendemen metode maserasi, sonikasi dan refluks berturut-turut 15,6%; 3,4% dan 6,4%. Pengujian aktivitas antioksidan diperoleh nilai IC50 sebesar 15,33 µg/mL;6,1815 µg/mL dan 6,9720 µg/mL. Metode ekstraksi mempengaruhi aktivitas antioksidan dari daun karamunting dalam meredam radikal bebas DPPH.

Isolation, identification and biochemical studies of gallic acid from Turbinaria decurrens Bory Fitriyanti Jumaetri Sami; Syamsu Nur
Current Research on Bioscences and Biotechnology Vol. 4 No. 1 (2022)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2022.4.1/X7DD09RY

Cancer is one of the diseases that cause the biggest death in the world. The research for natural compounds derived from marine is very developed at this time, especially in algae. Brown algae have more phenolic content than other types of algae, T. decurrens Bory is one of the brown algae that had taken from the Indonesian island of Dutungan, South Sulawesi. Phenolic groups are also known to be able to inhibit the growth of cancer cells. The purpose of this study is to isolate and identify compounds using spectrophotometer instruments. The isolates obtained were tested for anticancer activity against H460 and MCF-7 cells. Extraction was carried out by maceration method, fractionation was done by chromatography column eluent n-hexane:EtOAc: MeOH by increasing polarity. The structure determination is done based on the interpretation of FT-IR, 1D-NMR 1H,13C, and ESI-LCMS spectra data and anticancer activity test used MTT bioassay. The isolate is known as gallic acid, and the isolate was tested for anticancer activity against H460 and MCF-7 cells. The result is obtained IC50 value for H460 cells 5.69 μg/ml and MCF-7 cells 4.63 μg/ml. As a positive control used cisplatin with an IC50 value of 5.81 μg/ml against H460 cells and MCF-7 cells with a value of 5.59 μg/ml. Gallic acid has a higher toxic effect compared to cisplatin. One phenolic compound has been found in T. decurrens Bory which is gallic acid. Gallic acid has a higher toxic effect than cisplatin, this compound can be used as an anticancer agent.

Cytotoxic Effect of the Paku Atai Merah (Angiopteris ferox Copel) Fraction on MCF-7 and HeLa Cells and its Compound Profile by GC-MS Syamsu Nur; Andi Nur Aisyah; Endang Lukitaningsih; Rumiyati Rumiyati; Alfat Fadri; Marwati Marwati
Borneo Journal of Pharmacy Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i1.2943

Cancer is a condition of abnormal cell proliferation of tissue cells in the body that becomes malignant. It can attack other parts of the body and affect the normal function of the body organs. The sample used in this study was tubers of paku atai merah (Angiopteris ferox Copel), then extracted using 96% ethanol eluent to obtain a thick extract. The ethanolic extract of A. ferox was fractionated using column chromatography to get the active fraction to characterize the compound using thin-layer chromatography and gas chromatography-mass spectroscopy (GC-MS) and tested its cytotoxic effectiveness on MCF-7 and HeLa cancer cells. The results of this study were obtained from fractionation using the column chromatography method to get sub-fraction C and the results of compound characterization using GC-MS and obtained variations in the class of compounds contained in the sample: amino acids, glucosinolates, alkaloids, flavonoids, and terpenoids. Based on the cytotoxic effect test of sub-fraction C on MCF-7 cells, the results obtained moderate cytotoxic effects with an IC50 value of 61.027 µg/mL, and HeLa cells had an IC50 value of 521.03 µg/mL, which was categorized as having a weak cytotoxic effect. Based on the results obtained from this study, it can be concluded that sub-fraction C of A. ferox tubers has a cytotoxic effect on MCF-7 cells to be used as a reference for tracing pure compounds from A. ferox tuber.

Phenolic and Flavonoid Content of Black Mulberry (Morus nigra L.) Stem and Their Evaluation Antioxidant and Cytotoxic Profile Syamsu Nur; Fitriyanti Jumaetri Sami; Marwati Marwati; Nursamsiar Nursamsiar; Alfat Fadri; Khairuddin Khairuddin
Borneo Journal of Pharmacy Vol. 5 No. 4 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i4.3760

The black mulberry (Morus nigra) plant has been widely developed for its bioactivity as natural medicine. This study evaluated plant extracts' total phenolic and flavonoid content and their correlation to M. nigra stem's antioxidant activity and toxicity. Dry powder from the M. nigra stem was extracted by maceration with 96% ethanol to obtain a thick extract (TE) and fractionated using hexane (HF), ethyl acetate (EAF), and ethanol-aqueous (EF). The samples were analyzed for a compound using reagents and the determination of total phenolic and flavonoid content. The samples were evaluated for antioxidant activity using several parameters and their cytotoxic effects using the BSLT method. Identification of compounds in EAF was confirmed to contain phenolic, flavonoids, alkaloids, saponins, tannins, steroids, and terpenoids. EAF showed higher phenolic and flavonoid content than others. The evaluation of antioxidant activity showed that extracts and fractions from M. nigra stems showed the ability to reduce ions and free radicals. EF sample has activity in reducing Mo (IV) ion by TAC method of 98.82±0.53 µM/mg, indicating substantial antioxidant capacity. In addition, EAF samples showed potential activity in reducing DPPH, hydroxyl, and peroxide radicals in the β-carotene bleaching method with IC50 values of 12.13, 42.06, and 57.6 µg/mL, respectively. Similar activity was also seen in the cytotoxic effect of a robust EAF sample with an LC50 value of 16.31 µg/mL. The results show that EAF can be developed as a raw material for traditional medicine as an antioxidant and anticancer candidate with a significant flavonoid and phenolics content.

Co-Authors Aiyi Asnawi Akbar Awaluddin Alfat Fadri Alfat Fadri Alfat Fadri Alfat Fadri Alfrida Tandilolo Ali Djamhuri Amriani Sapra Andi Anggriani Andi Nur Aisyah Andi puanguce Paluseri Asril Burhan Asril Burhan Astuti Amin Budi Sutrisno Burhanuddin Taebe Ega Lilingan Elisabeth Pabontong Endang Lukitaningsih Endang Lukitaningsih Fhahri Mubarak Fitriyanti Jumaetri Sami Fitriyanti Jumaetri Sami Fitriyanti Jumaetri Sami Fitriyanti Sami Imrawati Imrawati Imrawati Imrawati Junaedy Aryanto Baitanu Khairi, Nur Khairuddin Khairuddin Khairuddin Khairuddin Libertin Libertin Marwati Marwati Marwati Marwati Maya M. Mangande Megawati Megawati Melkisedek D. Tiboyong Mirnawati Salampe Muhammad Aswad Naimah Ramli Noer Rahman Nursamsiar Nursamsiar Radhia Riski Rifah Yulianty Rizky Dharmayanti Rumiyati Rumiyati Rumiyati Rumiyati Sahibuddin A Gani Sukamto Salang Mamada Sukriani Kursia Suwahyuni Mus Trito Reski Sidupa William Johanes Dian Patabang Zulfaidah Rahma

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