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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding Jurnal Medik Veteriner Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Berkala Penelitian Hayati Jurnal Tumbuhan Obat Indonesia Indonesian Journal of Jamu Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Sumi WIjaya, Sumi
Fakultas Farmasi Unika Widya Mandala Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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Formulasi Sediaan Krim Pelembab Ekstrak Air Buah Semangka (Citrullus lanatus) Ekayanti, Ni Luh Putu Serly; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 1 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2011

Abstract

Watermelon is a tropical fruit which rich of carbohydrates such as sucrose, glucose and fructose that can moisturized the skin. Carotenoids such as lycopene in watermelons can acts as an antioxidant which protected skin from free radicals. Moisturizer are preparations used to improve dry skin. These preparations may decrease the Trans Epidermal Water Loss (TEWL) by forming a thin layer of fat on the surface of the skin as a barrier and restore skin softness. Watermelon extracts in this study are formulated into moisturizing cream. This study aims to determine the effect of the increasing concentration of the watermelon extract against its physical quality, effectiveness, safety, acceptability and cream stability. The watermelon extract obtained using is fresh fruit juice thickened with waterbath thermostat temperature ≤ 800C. Watermelon extract concentration used was 10% (Formula 1), 20% (Formula 2) and 30% (Formula 30. Evaluation of the cream includes the physical quality test; effectiveness test which; safety test; acceptability test and stability test. The results of this study showed the increasing concentrations of watermelon extract affect the results of the evaluation of moisturizing cream were organoleptic, pH, viscosity, dispersive power, adhesion, water washing power, effectiveness, and aseptability. Preparations which have the best quality are formula 3 containing extract 30%.
Formulasi Sediaan Krim Pelembab Ekstrak Air Buah Pepaya (Carica Papaya L.) Ningsih, Kadek Sri Utami; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 1 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2013

Abstract

Sucrose in papaya fruit was used as a moisturizer because it has worked as humectants, which reduce water evaporation on the surface of the skin. The purpose of this research was to determine the effect of the increasing concentrations of water extract of papaya fruit to evaluate its physical quality, effectiveness, safety, acceptability, and stability of the moisturizing cream water extract of papaya (Carica papaya L.). In this study, it used 3 formulas containing the extract of papaya fruit at concentration of 10% (formula 1), 20% (formula 2), 30% (formula 3), also blank containing base only, and base without extract and without moisturizing agent. The physical quality tests include organoleptic, pH, viscosity test, emulsion type test, dispersive power test, homogeneity, water washed power and adhesion test. The effectiveness of mouisturizer effect on the skin was tested with in vitro method: Sorption Desorption Test. Savety testing include irritation test and acceptability test. The data was analyzed using oneway ANOVA then continued with post hoc Tukey. The results showed that the increasing concentrations of the extract provides significant effect on efectivity, wherein the greater the concentration of water extract of papaya fruit (Carica papaya L.) were added, then the higher the ability to moisturize the skin and produce of moisturizer cream with pH test 6.04, viscosity 159710 cps, dispersive power 3.63 cm, water washed power 13.48 ml, adhesion 6005 second, and moisturizer cream stable during storage. The best formula is the formula 3 with a concentration extract of 30%.
Formulasi Sediaan Eyeshadow Ekstrak Air Buah Syzygium cumini dalam Bentuk Compact Powder Dwiwulandari, Fransisca Yunita; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 1 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i1.2048

Abstract

Coloring substance are needed in eyeshadow. It is used to give colors, shadows, and glittery effect on eyes. The trend in beauty world nowadays is using a natural dye because of safety issues. Antocyanine, which is contained in “juwet” fruit (Syzygium cumini), is one of the potential natural dyes. The aim of this research is to know the effect of Syzygium cumini in different concentration (20%, 25% dan 30%) on the physical quality and ffectiveness of the eyeshadow. The extract of Syzygium cumini fruit was formulated into compact powder eyeshadow. This type of preparation is the dominant dosage form used because it has good adhesiveness to the skin. The extract was obtained by extracting the juice and evaporated it using thermostatic water bath in the temperature of 40-60°C. The result showed that the increase in extract concentration significantly affected the physical quality test results (organoleptic, pH, particle size, friability and hardness), but did not affect the color dispersion and effectiveness. Based on the evaluation, formula II (extract of Syzyium cumini 25 %) was chosen as the best formula.
Standarisasi Simplisia Kering Daun Kelor (Moringa oleifera) Dari Tiga Daerah Berbeda Bata, Maria H C; Wijaya, Sumi; Setiawan, Henry K
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 1 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i1.2055

Abstract

Miracle tree (Moringa oleifera) is known for its many benefits, and has been used in traditional medicine. This study aims to determine macroscopic and microscopic characteristics of Miracle tree leaves and to determine specific and non specific parameter os standardization of Miracle tree dried powder. Miracle tree dried powder was obtained from three different locations (Batu, Bogor and Pacet). Determination of specific parameter of Miracle tree dried powder include macroscopic, microscopic, determination of soluble extract, chromatogram pattern determination by TLC, determination of infrared spectrum profile (IR), determination of UV spectrum profile and determination of quantitative secondary metabolite compounds. Non specific parameters including determination of total ash content, ash content water soluble, acid soluble ash content, drying shrinkage and pH. Determinations of quantitative secondary metabolite compounds were done using colorimetric method. Based on the results, Miracle tree dried powder contain alkaloid, flavonoids, polyphenols, saponins, tannins, steroids and triterpenoids. Ethyl acetate: n-hexan (7: 3 v / v) can be used as eluent on thin layer chromatography. Miracle tree dried powder gave wave number of 3277 – 3281, 2917 – 2918, 2849 – 2850, 1603 – 1607, 1408, 1235 – 1236, 1048 – 1051, 889, 534 – 536 and 452 - 455. Miracle tree dried powder gave standardization value of dried shrink rate 5.5% w/ w and total alkaloid content> 1.0% w/w.
Standarisasi dari Daun Kirinyuh (Chromolaena odorata) dan Simplisia Kering dari Tiga Daerah yang Berbeda Ance, Paulina Erlianda; Wijaya, Sumi; Setiawan, Henry Kurnia
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 2 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i2.2140

Abstract

Siam wead (Chromolaena odorata) is used traditionally for treatment lesoin, amenorrhea, antidiabetic and antimicrobial. Based on previous research, there is no reference about the standardization Siam Weed leaves dried powder. This study aims to determine macroscopic and microscopic of siam weed leaves fresh plant obtained from, Surabaya, to determine the spesific and non spesific quality profile of dried powder of siam weed leaves dried powder obtained from different areas (Bogor, Malang and Surabaya). The spesific parameter that used were identity, organoleptic, microscopic, determination of soluble extract, phytochemical screening, determination chromatogram profile using Thin Layer Chromatography, determination spectrum profile using spektrophotometer UV-Vis and Infrared, determination of alkaloid, phenol and flavonoid content. Non spesific parameters that used were the determination of total ash value, water soluble ash value, acid insoluble ash value, drying losses and pH. Based on result of the study, it was concluded that siam weed fresh plant leaves have elliptico-oblongus shape, acutus shape for the upper and lower base, green colored for the top and bottom surfaces, adge shape for the wavy , 6.4-11.8 (L), 3.3-5.9 (W), wavely leaf rib, fluffy leaf texture, and the position of facing a single, microscopically have the fragments as same as the dried powder fragments, ethanol soluble concentration ≥ 12%, water soluble concentration ≥ 20%, solvent can be used for chromatogram profile in TLC is chloroform : ethyl acetate (15:1), spectral profile with spectrophotometer UV-Vis have wavelength 533.5 nm, 500 nm, 534.5 nm, 501.5 nm, 284.5 nm, 289 nm and 292 nm, spectral profile with IR spectrophotometers have wavenumber 3266.28 cm-1-3282.21 cm-1, 1416.01 cm-1, 1514.53 cm-1, 1514.93 cm-1, 1245.35 cm-1, 1249.52 cm-1 dan 1251.27 cm-1, flavonoid content ≥ 0.4%, phenol content ≥ 1.0% and alkaloid content ≥ 1.0%, total ash content ≤ 14%, water ash soluble ≤ 5%, acid unsoluble ash ≤ 10%, drying losses ≤ 11% and range pH 5-7.
Studi pendahuluan: Korelasi Aktivitas Antikolesterol dengan Aktivitas Antioksidan Ekstrak Etanol Daun Salam (Syzygium polyanthum) Wijaya, Sumi; Yonas, Stefani Maureen Kasih; Hartanti, Lanny; Setiawan, Henry K.; Soegianto, Lisa
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 5 No. 2 (2018)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v5i2.2143

Abstract

Bay leaf leaves (Syzygium polyanthum) are known to have anti-cholesterol activity, with the mechanism inhibited HMG-CoA Reductase enzyme. The purpose of this study was to determine the correlation between anticholesterol activity of bay leaf ethanol extract obtained by percolation method and its antioxidant activity. The parameter used to measure anticolesterol activity is the IC50 value. Antioxidant activity was evaluated by DPPH and Frap methods. The results showed that the ethanolic extract of bay leaves had an IC50 value of 49.50 ± 0.70 ppm. Ethanol extract of bay leaf showed antioxidant activity with IC50 value of 888.0835 ppm and equality of values with 1 mM FeSO4 of 295 ppm. Based on the results of the analysis, the anticholesterol activity of Bay leaf ethanol extract in inhibiting the HMG-CoA Reductase enzyme did not have a linear correlation with its antioxidant activity.
Formulasi Sediaan Pemerah Pipi Ekstrak Air Buah Syzygium cumini dalam Bentuk Compact Powder Letelay, Yulia Riani; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 1 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i1.2171

Abstract

One of the fruits in Indonesia that can be used in the field of decorative cosmetics is Syzygium cumini. Blackish purple appearance of the fruit indicates the high content of anthocyanin, a natural pigment dye in decorative cosmetic formulations, especially for blusher. Compact powder blusher has the advantage of easy to use and has a better adhesion to the skin. Isopropyl myristate is a binder that is commonly used for compact powder blusher because of its properties which can increase adhesivity. The purpose of this study was to determine the effect of the concentration of isopropyl myristate as a binder on physical quality and effectiveness and to determine the best formula that fulfil the requirement of the physical quality, effectiveness, safety and acceptability. The compact powder blusher containing water extract of Syzygum cumini was formulated using wet granulation method with varying concentrations of isopropyl myristate 0.5%, 0.75% and 1.0%. The Evaluation of the product includes organoleptic, homogeneity, particle size, pH, friability and hardness, rubbing test, irritation test and acceptability test. The results showed an increase in the concentration of isopropyl myristate had a significant effect on decreasing the pH value, decreasing particle size, and affecting the ability of the blusher to be smeared. The compact powder blusher with 0.75% isopropyl myristate was the best formula that meets the specifications based on physical quality, effectiveness, and safety parameters.
Uji Aktivitas Inhibitor Xanthin Oksidase dari Fraksi Ekstrak Etanol Herba Peperomia pellucida Prihastuti, Angelina Ajeng; Wijaya, Sumi; Hartanti, Lanny
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 1 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i1.2174

Abstract

Peperomia pellucida (L.) Kunth known as Suruhan is a potential medicinal plants, used traditionally to treat gout. Suruhan herb (Peperomia pellucida (L.) Kunth) had been studied in vivo, and found to be able to lowering uric acid levels in the blood. Ethanol extract of Peperomia pellucida (L.) Kunth herb also had been studied in vitro, and found to be potential to inhibit xanthine oxidase. The purpose of this study is to know the potential of fraction from ethanol extract of Peperomia pellucida (L.) Kunth. herb as xanthine oxidase inhibitor compared to allopurinol and its ethanolic extract. Ethanol extract of Peperomia pellucida (L.) Kunth herb was obtained by percolation method using ethanol 96%. The fractionation is done by column chromatography method using silica as stationary phase and n-hexane, n-hexane-ethyl acetate, ethyl acetate, ethyl acetate-ethanol, and ethanol as mobile phases. The fraction which contained flavonoid compounds was tested its xanthine oxidase inhibition potency using UV spectrophotometer at λ 290 nm. The absorbance was observed every 10 seconds for 10 minutes for extract and fraction with the concentration of 0.25 ppm - 5 ppm, while allopurinol was determined with the concentration of 0.2 ppm - 3.2 ppm. The result showed that ethyl acetate-ethanol fraction potentially inhibited xanthine oxidase with IC50 value of 5.00 ± 0.06 ppm, while ethanolic extract of Peperomia pellucida (L.) Kunth herb and allopurinol have IC50 value 0.33± 0.07 ppm and 0.84 ± 0.02 ppm respectively. Thus it can be concluded that ethyl acetateethanol fraction had potential as xanthine oxidase inhibitor, but the potential is lower than the ethanolic extract of Peperomia pellucida (L.) Kunth herb.
Standarisasi Spesifik dan Non Spesifik dari Ekstrak Etanol Daun Beluntas (Pluchea indica L. Less.) Wijaya, Sumi; Setiawan, Henry Kurnia; Ano, Lucyanna Ayu Lestari
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 1 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i1.2178

Abstract

Indian fleabane (Pluchea indica (L.) Less.), on of the species in Asteraceae family, is widely used for traditional medicine. A standardization process is needed as an effort to improve the quality and safety of products, so that it is expected to increase the trust in drugs derived from natural ingredients. This study aims to determine the morphology and anatomy of Indian fleabane leaves and to determine the standardization value of the ethanol extract of Indian fleabane leaves. Dried powder of Indian fleabane leaves are obtained from three different regions (Bogor, Malang and Surabaya). The extract was obtained by maceration method using 96% ethanol as a solvent. Specific standardization includes identity, macroscopic, determination of soluble extract, phytochemical screening, TLC (Thin Layer Chromatography) pattern determination, determination of infrared spectrum profile, determination of UV-Vis spectrum profile, and determination of flavonoid, phenol and alkaloid total content. Nonspecific standardization includes determination of total ash content, water soluble ash content, acid insoluble ash content, drying losses, specific gravity and pH. Organoleptic observations showed the ethanol extract of Indian fleabane leaves has blackish brown and aromatic odour. The mobile phase being used for TLC profile chromatogram was n-hexane: ethyl acetate (7: 3). Based on the results, the screening results of Indian fleabane contain alkaloids, flavonoids, polyphenols, tannins, saponins, steroids and triterpenoids. The Infra red spectrophotometer analysis showed the range of wave numbers of 2924 - 2925, 1515 - 1516, 1259 - 1260, 1159 - 1162, 1112 - 1115, 1046 - 1048, 811 - 812, 505 - 506 and 452 - 454 cm- 1. The standardization value of Indian fleabane ethanol extract showed ethanol soluble extract> 65%, water soluble extract> 49%, water content
Formulasi Sediaan Lipstik Ekstrak Air Buah Syzygium cumini Dalam Bentuk Liquid Sari, Dwi Augusnita; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2179

Abstract

Now-a-days decorative cosmetics are essential needs for women especially lipstick. Lipstick is one of the cosmetics products which is used to increasing the aesthetic of facial make-up. A local tradable fruit called Syzygium cumini can be used as an alternative in conventional lipstick. Syzygium cumini anthocyanin-rich fruit contain 892 mg anthocyanins per 100g of fresh fruit. The purpose of this research was to find out the increasing of difference (HPMC) in liquid lipstick and to find out influence of the best formulation based on physical test, effectiveness test, safety test and acceptability test. Lipstick in liquid form was chosen because it has advantages such as can be easy to attached, easy to apply and easy to dry so that the formulation required a thickening agent that has properties to fulfill the characteristics of liquid lipstick. HPMC is a thickening agent and can help improve the viscosity of formulation liquid lipstick. The concentration of Syzygium cumini fruit extract was used 20% formulated using HPMC at a concentration of 0.75%; 1% and 2%. The results showed that the increasing concentration of HPMC significantly affect on pH test, viscosity, adhesion, and drying time; the decreasing of spreadness and the smearness of liquid lipstick. The best formula was the formula contained HPMC 2%, based on physical test (viscosity, homogeneity), effectiveness test (smearness, spreadness, stickiness, drying time), safety test and acceptability test.
Co-Authors Albrian, Diga Ance, Paulina Erlianda Ano, Lucyanna Ayu Lestari Ardani, Yonas Bianityo Bata, Maria H C Bata, Maria H C Bindharawati, Nina Bindharawati, Nina Chomariyah, Nur Chomariyah, Nur Dwiwulandari, Fransisca Yunita Dwiwulandari, Fransisca Yunita Ekayanti, Ni Luh Putu Serly Ekayanti, Ni Luh Putu Serly Farida L Darsono Farida Lanawati Darsono Filania S. Kanja Hendrata, Adi Pramono Henry Kurnia Setiawan Kuncorojakti, Suryo Kurnia Setiawan, Henry Lanny Hartanti Letelay, Yulia Riani Lisa Soegianto Lisa Soegianto Lisa Soegianto Martha Ervina Mellisa Laura Mintoro Miftahul Jannah Monica S.W Ningsih, Kadek Sri Utami Ningsih, Kadek Sri Utami Novita, Bernadette Dian Paul L Tahalele Prasety, Oda Shantina Prihastuti, Angelina Ajeng Purnama, Veronica Bella Sari, Diyan Maya Sari, Dwi Augusnita Setiawan, Henry K Setiawan, Henry K Setiawan, Henry K. Sianty Dewi Soediono, Endang Isbandiati Talia, Sela Tjahjono, Yudy Valeri, Sepvan Valeri, Sepvan Wedharga, I Gede Putu Adhi Wijaya, Hendy Yonas, Stefani Maureen Kasih