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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding Jurnal Medik Veteriner Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Berkala Penelitian Hayati Jurnal Tumbuhan Obat Indonesia Indonesian Journal of Jamu Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Sumi WIjaya, Sumi
Fakultas Farmasi Unika Widya Mandala Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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Standarisasi Simplisia Kering Daun Beluntas (Pluchea indica L.) dari Tiga Daerah Berbeda Talia, Sela; Wijaya, Sumi; Setiawan, Henry Kurnia
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 2 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i2.2181

Abstract

Indian Fleabane (Pluchea indica L.) are commonly used as hedgerows and traditionally the leaves are used as fresh salad or medicines to eliminate body odor, febrifuge, cough medicine, and antidiarrheal drugs. Along with the increasing technology of natural materials and the tendency of people to use products derived from natural materials, especially medicinal plants, a reference which contains the requirements for the quality of natural ingredients that are suitable for use as medicinal ingredients is needed. This research aims to determine the profile of specific and non specific standardization of dried powder of indian fleabane leaves. Standardization of indian fleabane leaves covers specific parameters and non specific parameters, characterization of microscopic characteristics of indian fleabane (Pluchea indica L.) leaves, characterization of the content of secondary metabolites using thin layer chromatography (TLC), determination of spectrum profiles using infrared spectrophotometer (IR), and determination of the levels of secondary metabolites by spectrofotometry. The data obtained is descriptive data that reflect the acquisition of data from 3 different locations. Based on microscopic observations indian fleabane leaf dried powder has vascular bundles with spiral thickening, anomocytic stomata, and multicellular trichomes. Ethanol solubility of dried powder indian fleabane is ≥5% while water solubility in water is ≥26%. The results of phytochemical screening showed positive results on the observations of alkaloids, flavonoids, phenols, steroids and terpenes. Total ash content is
Standarisasi Spesifik dan Non Spesifik dari Ekstrak Etanol Daun dandang Gendis (Clinacanthus nutans) Wijaya, Sumi; Setiawan, Henry Kurnia; Purnama, Veronica Bella
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 2 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i2.2224

Abstract

Standardization of natural materials is needed as an effort to improve the quality and safety of products that are expected to further increase trust in medicines derived from natural ingredients. Snake grass leaf has several pharmacological activities including antioxidants, anticancer, anti-inflammatory, analgesic, enhancing the immune system, antibacterial, antivenom, even there are also uses in the cosmetics field. In this study macroscopic and microscopic observation of Snake grass leaves and determination of specific and non-specific standardization on ethanol extracts of Snake grass leaves have been done. The parameters tested on Snake grass leaf extract include the identity of the extract, organoleptic, ethanol soluble extract, water soluble extract, phytochemical screening, chromatogram profile using TLC, spectrum profile using UV-Vis spectrophotometer, spectrum profile using IR (infrared)spectrophotometer, determination of secondary metabolite content, total ash content, water soluble ash content, acid insoluble ash content, water content, pH, and specific gravity. The results showed the characteristics of ethanol extract of Snake grass leaf in the form of green-black extract, aromatic distinctive odor; ethanol soluble extract content> 54%; water soluble extract content> 37%; phytochemical screening results showed the presence of alkaloid compounds, flavonoids, polyphenols, saponins, steroids and terpenoids; the results of IR spectrophotometer analysis show spectrum profiles in the range wave of numbers 3325-3351 cm-1, 2924-2919 cm-1, 1622 -1633 cm-1, 1341-1345 cm-1 and 1020-1047 cm-1; total phenol levels> 0.16%; total flavonoid levels> 0.11%; total alkaloid levels> 0.03%; water content
Uji Aktivitas Antibakteri dan Antibiofilm Fraksi Biji Kelengkeng (Euphoria longan Lour. Steud.) terhadap Staphylococcus aureus ATCC 6538 Prasety, Oda Shantina; Soegianto, Lisa; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 2 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i2.2235

Abstract

Longan (Euphoria longan Lour. Steud.) has an antibacterial potential. Longan seed is one part of Longan that has antibacterial activity. This study was conducted to determine the antibacterial and antibiofilm activity of longan seed fraction (Euphoria longan Lour. Steud.) against Staphylococcus aureus ATCC 6538. In this study, the extract was obtained from maceration using 96% ethanol and it was fractionated by liquid-liquid solvent method using nhexane, ethyl acetate, and water. Each fraction prepared at concentration 100000 ppm, and then the antibacterial activity on Staphylococcus aureus was determined by well diffusion method, antibiofilm activity using microdilution method, and phytochemical screening to determine the metabolite compounds that have antibacterial and antibiofilm activity using thin layer chromatography. The results showed that the diameter of growth inhibition in ethyl acetate fraction with a concentration of 100000 ppm was 14.59 mm ± 0.01, n-hexane fraction at 7.15 mm ± 0.63 and water fraction of 12.52 mm ± 0.40. Antibiofilm test results showed that the percentage of growth inhibition of biofilm on the fraction of ethyl acetate with a concentration of 100000 ppm was 99.08%. Phytochemical screening using thin layer chromatography carried out on the fraction of ethyl acetate and showed that the fraction contains tannin/polyphenols, triterpenoid saponins and flavonoids.
Uji Aktivitas Antibakteri dan Antikuorum Sensing Fraksi dari Ekstrak Etanol Daun Salam (Eugenia polyantha Wight.) Ardani, Yonas Bianityo; Soegianto, Lisa; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 1 No. 1 (2013)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v1i1.2343

Abstract

Eugenia polyantha is being used as empirical plant for antiseptic, anthelmintic, anesthetic, keratolytic and also has properties protein in bacterial cells. The antibacterial activity of extract of Eugenia polyantha has been proved in previous study, therefore this research was conducted to know the antibacterial and antiquorum sensing from fractions of ethanolic extract of Eugenia polyantha. The extraction was prepared by maceration and fraction was prepared by liquid-liquid fractionation method with n-hexane (non polar), ethyl acetate (semipolar) and water (polar). Bioautography method with thin layer chromatography and chloroform as mobile phase was conducted to determine the active fraction. The diameter of inhibition zone was measured or determined by diffusion method, while concentration of minimum inhibition (MIC) and bactericidal concentration (MBC) were determined using broth and agar dilution methods. Antiquorum sensing activity for P. aeruginosa was carried on, using pigment survey and motility method~ The antibacterial activities showed that ethyl acetate fraction 2596 gave diameter of growth inhibition zone greater than others, 1:1.48 mm against S. aureus and 9.03 mm against P. aeruginosa. The MIC of ethyl acetate fraction gave value of :1.56% against S. aureus and 12.5% against P. Aeruginosa, meanwhile the MBC was 3.1396 against S. aureus and more than 12.5% against P. aeruginosa. The result showed that ethyl acetate fraction has potential antiquorum sensing activity on concentration of 2.5 %. The active fraction of ethanolic extract of Eugenia polyantha which has antibacterial and antiquorum sensing activity was ethyl acetate fraction.
Fraksinasi dan Identifikasi SenyawaAntioksidan pada Eksb-ak Etanol buah Goji beny(Lycium barbarum linn.) secaraKromatografi Kolom Albrian, Diga; Wijaya, Sumi; Setiawan, Henry Kurnia
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 1 No. 1 (2013)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v1i1.2346

Abstract

Goji berry fruit (Lycium barbarum), familia Solanac'eae, is a red berry fruit. The chemical compounds contained in this fruit are polysaccharides, zeaxanthin and beta-carotene. Activity of the chemical compounds is still considered as a family of antioxidant compounds, which are used as a medicine to cure the diseases caused by the presence of free radicals such a~ atherosclerosis, cancer, liver cirrhosis, hypertension and diabetes. The research will be carried on fractionation and identification of the ethanol extract of Goji berry fruit to obtain compounds that have antioxidant power using chromatographic column method and DPPH method. The isolated compounds will be identified using methods phytochemica/s screening, TLC, UV-Vis spectrophotometer and infrared spectrophotometer. The result showed that secondary metabolites of Goji berry fruit which are potential as antioxidant compound were flavonoid (flavono/s or flavones). The isolated compound had higher antioxidant activity compare to the ethanol extract of Goji berry fruit Flavonoids are the major compounds that have antioxidant capacity. Whereas, the ethanol fraction of Goji berry fruits has the best antioxidant activity than the ethanol extract Keywords: Antioxidant, Goji berry, DPPH and chromatographic column
Standarisasi Simplisia Daun Kenikir (Cosmos caudatus Kunth) Dari Tiga Daerah Berbeda Jannah, Miftahul; Wijaya, Sumi; Setiawan, Henry Kurnia
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 8 No. 1 (2021): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v8i1.3087

Abstract

Kenikir dipercaya sebagai obat penurun suhu tubuh, memperbaiki sirkulasi darah, mengobati diabetes, sebagai anti-aging dan menjaga kekuatan tulang. Saat ini telah banyak produk serbuk daun kenikir dalam bentuk kapsul di pasaran, tetapi belum ada data standarisasi dari simplisia daun kenikir, sehingga penelitian ini dilakukan bertujuan untuk mendapatkan profil standarisasi spesifik dan non-spesifik dari simplisia daun kenikir. Parameter spesifik terdiri dari identitas simplisia, organoleptis, kadar sari laut air, kadar sari larut etanol, penetapan profil kromatografi dengan menggunakan KLT, penetapan profil spektrum dengan menggunakan spektrofotometer infrared dan UV-Vis serta penetapan kadar senyawa metabolit sekunder. Parameter non spesifik meliputi susut pengeringan, kadar abu total, kadar abu tak larut asam, kadar abu larut air, pH, dan persen bahan asing. Data yang diperoleh merupakan data deskriptif yang diperoleh dari 3 lokasi berbeda. Hasil pengamatan mikroskop daun segar kenikir menunjukkan tipe berkas pembuluhnya adalah kolateral terbuka, jaringan bunga karang atau palisade, dengan tipe stomata anomositik, rambut penutup non-glandullar, kristal Ca-oksalat bentuk pisma dan tipe daun dorsiventral. Hasil kadar sari larut etanol > 23,3%, kadar sari larut air > 13,15%. Hasil skrining fitokimia menunjukkan adanya senyawa flavonoid, saponin, polifenol, steroid dan triterpenoid. Hasil pengamatan profil kromatogram secara KLT dengan fase diam silika gel F254 dan fase gerak yang terpilih adalah n-heksan : etil asetat (7:3). Hasil penetapan kadar flavonoid total > 1,30%, fenol > 2,18%. Nilai susut pengeringan ≤13,5%, sedangkan hasil kadar abu total ≤6,0% dengan kadar abu larut air ≤5,0% dan kadar abu tak larut asam ≤2,0%, pH simpisia untuk pelarut air yaitu 6- 7 dan pada pelarut etanol 4 – 6.
Antidiarrheal Activity of The Combination of Ethanol Extracts of Turmeric Rhizomes, Gall oak Leaves, Guava Leaves and Meniran Herbs Wijaya, Sumi; Soegianto, Lisa
Jurnal Jamu Indonesia Vol. 2 No. 3 (2017): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v2i3.38

Abstract

Diarrheal disease is an endemic disease in Indonesia and also a potential disease that can cause death. In practice, the use of traditional medicines derived from plants still being considered by society due to its viability, economic factors and safety reasons. Several plants worked as antidiarrheal agents with the mechanism actions of (1) antibacterial (inhibited the growth of Escherichia coli, Shigella dysenteriae, Shigella flexneri, Staphylococcus aureus and Salmonella Typhi); (2) reduced the contraction of intestinal as results in the reduction of pain and the reduction of frequency of defecation or; (3) both mechanism of actions. Thus the purpose of the present study is to evaluate antidiarrheal activity of the combination of plant extracts which have been proved to have antidiarrheal activity. Turmeric (Curcuma domestica) rhizomes, gall oak (Quercus lusitanica) leaves, guava (Psidium guajava) leaves and meniran (Phyllanthus niruri) herbs were used for this combination. The purpose of this combination was to minimize the doses (based on literature reviews turmeric at 5% and Meniran 10% inhibited the growth of Escherichia coli and Staphylococcus aureus, meanwhile guava leaves at 150 mg/kg BW and gall oak leaves at 10% reduced diarrhea in animal tested). Maceration was chosen for the extraction method using ethanol 96% as the solvent. Protection and transit intestinal method with loperamide HCl as comparison drug and castor oil for the induction of diarrhea were used for antidiarrheal activity, meanwhile diffusion and dilution methods using, inhibition zones, minimum inhibition concentration and minimum bactericidal concentration parameters were used for antibacterial activity. Tetracycline HCl with the concentration of 30 µg was used for the control. The results revealed that the combination of plant extract with the doses of 200 mg/KgBW (1:1:1:1) reduced diarrhea in mice with relaxation of smooth muscle and showed weak antibacterial effects on Eschericia coli and Staphylococcus aureus but strongly inhibited the growth of Salmonella Typhi.
Morphology Profile, Anatomy and Phytochemistry of Beluntas Leaves (Pluchea indica): Profil Morfologi dan Anatomi dari Daun Beluntas (Pluchea Indica) serta Perbedaan Profil Kandungan Kimia dari Daun Beluntas pada Kondisi Geografis yang Berbeda Wijaya, Sumi; Kurnia Setiawan, Henry
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 2 (2023): December 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i2.885

Abstract

Beluntas (Pluchea indica), is one of species in Asteraceae family, traditionally used to increase appetite, to treat indigestion, rheumatism and body odor problems. This study aims to provide morphological and anatomical profiles of Beluntas leaves which are often used in medicine, to determine the chemical content of Beluntas leaves using phytochemical screening tests and thin layer chromatografic profiles, and also to determine flavonoids, polyphenols and alkaloids contents. The observation results showed Beluntas leaves are an oval leaf shape with pinnate leaf reinforcement. Anatomical observation of the leaves, found that the leaf type is equifacial with collateral vascular bundles, the presence of non glandulair multicellular trichomes with constricted in the cross wall, papillae and glandular Compositae trichomes. Tube method results and thin layer chromatography profiles showed Beluntas leaves contained polyphenols, saponins, alkaloids, flavonoids, steroids and essential oils. The chromatogram profile with infrared spectrophotometry shows the wave numbers in the fingerprint region 1515 – 1516, 1259 – 1260, 1159 – 1162, 1112 – 1115, 1046 – 1048, 811 – 812, 505 – 506 and 452 – 454 cm-1. The total amounts of polyphenols, flavonoid and alkaloid contained in Beluntas leaves were 3.1 - 7.7% w/w, 0.5 - 1.2% w/w and 0.03 – 0.08% w/w, respectively.
Co-Authors Albrian, Diga Ance, Paulina Erlianda Ano, Lucyanna Ayu Lestari Ardani, Yonas Bianityo Bata, Maria H C Bata, Maria H C Bindharawati, Nina Bindharawati, Nina Chomariyah, Nur Chomariyah, Nur Dwiwulandari, Fransisca Yunita Dwiwulandari, Fransisca Yunita Ekayanti, Ni Luh Putu Serly Ekayanti, Ni Luh Putu Serly Farida L Darsono Farida Lanawati Darsono Filania S. Kanja Hendrata, Adi Pramono Henry Kurnia Setiawan Kuncorojakti, Suryo Kurnia Setiawan, Henry Lanny Hartanti Letelay, Yulia Riani Lisa Soegianto Lisa Soegianto Lisa Soegianto Martha Ervina Mellisa Laura Mintoro Miftahul Jannah Monica S.W Ningsih, Kadek Sri Utami Ningsih, Kadek Sri Utami Novita, Bernadette Dian Paul L Tahalele Prasety, Oda Shantina Prihastuti, Angelina Ajeng Purnama, Veronica Bella Sari, Diyan Maya Sari, Dwi Augusnita Setiawan, Henry K Setiawan, Henry K Setiawan, Henry K. Sianty Dewi Soediono, Endang Isbandiati Talia, Sela Tjahjono, Yudy Valeri, Sepvan Valeri, Sepvan Wedharga, I Gede Putu Adhi Wijaya, Hendy Yonas, Stefani Maureen Kasih