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All Journal Majalah Kedokteran Bandung Jurnal Anestesi Perioperatif Althea Medical Journal Global Medical and Health Communication Universa Medicina Syntax Literate: Jurnal Ilmiah Indonesia SOEPRA Jurnal Hukum Kesehatan Alignment: Journal of Administration and Educational Management Interdental Jurnal Kedokteran Gigi (IJKG) PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal PORKES Journal of Economics and Business UBS Jurnal Ilmiah Wahana Pendidikan ProBisnis : Jurnal Manajemen Service Management Triangle : Jurnal Manajemen Jasa Jurnal Riset Manajemen dan Bisnis Scientia Regendi Research of Service Administration Health and Sains Healthys Indonesian Journal of Cancer Business Management Media Bina Ilmiah Innovative: Journal Of Social Science Research International Journal of Law and Society J-CEKI
Agus Hadian Rahim
Department Of Orthopaedic And Traumatology Faculty Of Medicine Universitas Padjadjaran / Dr. Hasan Sadikin Hospital Bandung
Religion Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Universa Medicina

 1 
Assessment of microarchitecture and crystal structure of hydroxyapatite in osteoporosis Noor, Zairin; Sumitro, Sutiman B; Hidayat, Mohammad; Rahim, Agus Hadian; Taufiq, Ahmad
Universa Medicina Vol 30, No 1 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.29-35

Abstract

Osteoporosis is characterized by lower bone mineral density (BMD) and microarchitectural degeneration, which tends to increase bone fragility and fracture risk. Bone microstructure depends on interactions between the mineral atoms, which may perform substitution or incorporation into bone crystals, and may dynamically take over the function of calcium or may become a complementary part. The mineral atoms may also become a composite in the hydroxyapatite crystals. The aim of this study was to find an association between the bone microstructure and hydoxyapatite crystal structure in osteoporosis, in comparison to normal bone. The subjects of this study were surgery patients at the Department of Orthopedics of Ulin General Hospital in Banjarmasin and other centers. Inclusion criteria consisted of the presence of fracture of trabecular bone, normal or osteoporotic BMD values, and no past history of chronic disease. Bone was obtained from fracture patients during surgery. The characteristics of the hydroxyapatite crystals were analyzed by X-ray diffraction (XRD) and the microarchitecture by scanning electron microscopy (SEM). SEM showed degeneration of the microarchitecture of osteoporotic bone, in comparison with normal bone. On XRD there was a peak of hydoxyapatite crystals only and no other crystal phases. Diffraction patterns showed a larger crystal size in osteoporotic bone as compared to normal bone, indicating higher porosity. It may be concluded that there is a difference in crystal size and morphologic distribution of hydoxyapatite in osteoporotic bone, determining bone microarchitecture.
Bone microstructure and atomic periodic disharmonization in osteoporosis Zairin Noor; Mohammad Hidayat; Agus Hadian Rahim; Sutiman B. Sumitro
Universa Medicina Vol. 31 No. 2 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.96-104

Abstract

BackgroundBoth cortical and cancellous bone display a complex, porous microstructure whose properties depend on the macrostructure of bone as well as age and health of the individual. The aim of this study was to compare the microstructure and characteristics of mineral atoms in osteoporotic and normal bone. MethodsA prospective laboratory experimental study was conducted from August to December 2010 at several hospitals in Banjarmasin. Twenty patients with osteoporosis and twenty six normal patients were involved in this study. Bone obtained from surgery was analyzed for microstructure by scanning electron microscopy (SEM), while mapping of mineral atoms was performed by means of SEM-Energy dispersive X-ray spectroscopy (SEM-EDAX) at the Brawijaya University, Malang.     ResultsThe osteoporotic subjects with mean age of 64.65 ± 16.41 years were older than the normal bone subjects with mean age of 39.38 ± 17.16 years. The body mass index was similar in both groups of subjects. From SEM-EDAX results, three patterns of mineral atoms were apparent in osteoporotic and normal bone. In osteoporotic bone, these patterns were indicative of a disordered substitution or incorporation process. SEM results showed degeneration of microarchitecture (resorption cavities, perforations, and prominent granules) in osteoporotic but not in normal bone. There was a significant difference in microstructure between osteoporotic and normal bone, which was caused by differences in atomic properties.    ConclusionsMicrostructural abnormalities of bone and disharmonization of mineral atoms in the periodic system were found in osteoporosis.
Co-Authors . Trisnowahyuni A. Rohendi A. Rohendi, A. A.A. Ketut Agung Cahyawan W Abdul Kadir Hadar Ahmad Arif Nurrahman Ahmad Ramdan Ahmad Ramdan Ahmad Ramdan Ahmad Ramdan Ahmad Rizal Ganiem, Ahmad Rizal Ahmad Taufiq Anggi Fauziani Anisah Anisah Ari indra Susanti Ariyanto, Iwan Arnold David Pardamean Bambang Tiksnadi Cahayani, Nadia Brigita Carolus Ronald Dadang Kusnadi Dey Ravena Dhewy, Galuh Kusuma Doddy Putra Pratama Sudjana Dwi Permana Putra Eddie Imanuel Doloksaribu Egypti, Lubna Ekwandini, Dhona Rizky Erliany Syaodih Farhan Anwary Farhan Anwary Ghuna Arioharjo Utoyo Haryadi, Pande Made Doddy Hendy Rachmat Primana Herry Herman idyasanthi, Komang Ayu Sri W Johanes C. Mose Kahar Mulyani Kevin Aldio Putra Khotimah , Khusnul Laksono Trisnantoro Mohammad Hidayat Mohammad Hidayat Muhardi Ningsih, Desy Kartika Nucki N. Hidayat Nucki Nursjamsi Hidajat Nugraha, Fitrahadi Nugraha, Yudi Purnama Purwadhi Purwadhi Rahayu, Tri Wachyuni Rinawati Rinawati RohendiH, A. Sagala, Rolles Samuel Jason Rolando Tua Setiawanto, Teguh Sibarani, Tagor Sofiati Dian Sri Suwarsi Sujarwinata, Tio Hara Sundari Sundari Susiarno , Hadi Sutiman B. Sumitro Sutiman B. Sumitro Tarawan , Vita Murniati Tri Yuyun Apriliandika Simak Veranita , Mira Veranita, Mira Widia Hafsyah Sumarlina Ritonga, Widia Hafsyah Sumarlina Yohanes Firmansyah Yoyos Dias Ismiarto Yusnan Yusuf Zairin Noor Zairin Noor