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All Journal JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Medica Hospitalia Diponegoro International Medical Journal (DIMJ) Jurnal Kesehatan dr. Soebandi Ophthalmologica Indonesiana
Fifin Luthfia Rahmi
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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PUPIL CYCLE TIME AND PERIPAPILLARY PERFUSION IN ANGLE CLOSURE GLAUCOMA: Oral Presentation - Observational Study - Resident Muhammad Alfin Kamal; Fifin Luthfia Rahmi; Denti Puspasari; Maharani Cahyono
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/3hjtkn18

Abstract

Introduction & ObjectivesOne of important roles in the pathogenesis of glaucoma is vascular condition. To enhance glaucomamanagement, the clinical assessment of ocular perfusion is required. The pupillary light reflex'safferent or efferent pathways may become impaired as a result of pupil cycle time (PCT) elongation.PCT is a simple objective method to measure the function of optic nerve, including glaucoma. Thepurpose of this study is to evaluate the connection between pupil PCT and peripapillary perfusion. MethodsA cross-sectional study from Kariadi Hospital included 26 eyes with angle closure glaucoma and 26eyes of healthy patients. Complete ophthalmologic examinations, PCT measurements, and OCTperipapillary angiography were performed on each patient. Patients with history of drugs use thatcan affect pupillary reflexes such as barbiturates, methyldopa, anaesthetics, and antidepressant, andpatients with history of glaucoma attack are excluded. The comparisons between the two groupswere examined, with a p<0.05 indicating statistical significance. ResultsThe mean PCT of normal subjects was 943,4ms (882,4ms – 993,4ms) and angle closure glaucomasubject was 1789,5ms (1060ms – 4600ms). There were statistically significant difference of PCTvalue in angle closure glaucoma compared to normal subjects (P<0,05). Peripapillary flow index andperipapillary vessel density in closed angle glaucomatous eyes were lower than normal eyes(P<0.05). There is a significant relationship between PCT with peripapillary flow index andperipapillary vessel density. (P<0,05). ConclusionIn angle closure glaucoma, prolonged PCT associated with decreased peripapillary perfusion asshown by decreases in peripapillary flow index and peripapillary vascular density.
Trabeculectomy Versus Tube Outcome in Neovascular Glaucoma: Oral Presentation - Observational Study - Resident Daisy Syakhsiatusy Syahiqoh; Fifin Luthfia Rahmi; Denti Puspasari; Maharani
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/73qxtp82

Abstract

Introduction & ObjectivesNeovascular glaucoma (NVG) is known to be a refractory form of glaucoma, which frequentlyrequires the integrated use of medical, laser and incisional surgery. Tube-shunt implantation andtrabeculectomy with antifibrotic agent are the two most-popular incisional procedures for managingrefractory glaucoma. This study aims to compare surgical outcome between patients who underwenttrabeculectomy versus tube-shunt implantation for the treatment of NVG. MethodsA retrospective study was held of NVG patients that underwent trabeculectomy and tube-shuntimplantation between January 2020 - December 2022 at Dr. Kariadi Hospital, Semarang. IOPoutcome and success rate was measured at 3 months post operatively. Statistical analysis was usedto compare the outcome between groups, p<0.05 was considered significant. ResultsThere were no significant differences in characteristics between groups at baseline. Mean IOPmeasured at 3 months post operatively was 18.58 ± 5.53 and 15.94 ± 10.79 in trabeculectomy andtube group respectively (p=0.04), complete success rate was 18.8% in trabeculectomy and 25% intube group, qualified success rate was 37.5% in trabeculectomy and 56.3% in tube group. Greaterfailure rate was observed in trabeculectomy group (43.8%). ConclusionCompared to trabeculectomy, tube-shunt implantation has lower IOP at 3 months post operatively inNVG. Greater failure rate was observed in trabeculectomy.
DERAJAT APOPTOSIS SEL GANGLION RETINA PASCA PEMBERIAN TAMBAHAN EKSTRAK MORINGA OLEIFERA ORAL DIBANDINGKAN DENGAN TERAPI STANDAR Studi Eksperimental pada Tikus Wistar Model Methanol Toxic Optic Neuropathy: Oral Presentation - Experimental Study - Resident ADELIA BAYU ISFANDIARI; RISKI PRIHATNUNGTIAS; FIFIN LUTHFIA RAHMI
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/t5yryf15

Abstract

Abstract Introduction & Objectives : Methanol toxic optic neuropathy can lead to retinal ganglion cell apoptosis which causes visual disturbance. Moringa oleifera has been reported to have an anti-inflamatorry effect that can prevent inflammatory mediators from being relased in methanol toxic optic neuropathy Methods : Twenty-one Wistar methanol toxic optic neuropathy were divided into 3 groups, namely base line group, control group that given intravenous methylprednisolone 4.5mg/6 hours for 3 days, and given standard theraphy and additional administration of oral Moringa oleifera 300mg/kgbodyweight/day for 4 weeks. Assessment of the degree of apoptosis by Anatomical Pathology with histopatolocigal scaoring. The study used Mann Whitney comparative hypothesis test (Significant p<0.05) Results : The degree of retinal ganglion cell apoptosis was significantly lower in the treatment and standard therapy groups compared to the base line group. The treatment group compared to the standard therapy group was not significantly different (p = 1,000) Conclusion : The degree of retinal ganglion cell apoptosis in rat model methanol toxic optic neuropathy was not significantly different between the group that was given additional oral Moringa oleifera extract compared to the standard theraphy group
Perbedaan Skor OSDI Pre dan Post Senam "PERMATA-KU" pada Computer Vision Syndrome Uyun, Fuadah; Rahmi, Fifin Luthfia; Saubig, Arnila Novitasari; Julianti, Hari Peni
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.013 KB) | DOI: 10.36408/mhjcm.v8i2.543

Abstract

ABSTRACT DIFFERENCE OF OSDI SCORE BEFORE AND AFTER ‘SENAM PERMATA-KU’ IN COMPUTER VISION SYNDROME Background: Computer Vision Syndrome (CVS) is a group of symptoms that affects the eye and vision due to prolonged use of computer, cellphone, tablet, and e-reader. Dry eye is one of the symptoms that appear in CVS. In this study we did ‘senam PERMATA-KU’ (Pelihara Mata–Kendorkan Bahu) as additional exercise to reduce dry eye in CVS. Aim: Observe there is any improvement of OSDI (Ocular Surface Disease Index) score before and after doing “senam PERMATA-KU” in CVS. Methods: This was a Pre-Post with Control Design quasi experimental study. The subjects were students of Faculty of Medicine of Diponegoro University who had CVS and met the inclusion and exclusion criteria that were divided randomly into control group and experimental group. The experimental group were given an education about using computer ergonomically and ‘senam PERMATA-KU’ for 14 days. The control group were given an education about using computer ergonomically. OSDI score were measured before and after intervention was given using Ocular Surface Disease Index questionnaire. Result: The subjects were 32 students with 16 students in the experimental group and 16 students in the control group. One student in the control group and one student in the experimental group dropped out because they could not complete the procedure so that only 30 subjects were analyzed. OSDI score after intervention in experimental group was decreased significantly (p<0.05). OSDI score after intervention in experimental group was better compared to control group (p<0.05). OSDI score improvement in experimental group was higher compared to control group but statistically is not significant (p=0.595). Conclusion: ‘senam PERMATA-KU’ that was done for 14 days can improve OSDI score in Computer Vision Syndrome. Keywords: Computer Vision Syndrome (CVS), Ocular Surface Disease Index (OSDI), dry eye, ‘senam PERMATA-KU’
The Effectiveness Of E-Backnshou Exercise To The Improvement Of Neck, Shoulder And Back Pain In Computer Vision Syndrome Patient Julianti, Hari Peni; Nugroho, Trilaksana; Kesoema, Tanti Ajoe; Susilaningsih, Neni; Rahmi, Fifin Luthfia; Pritadesya, Maharani Prizka
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.1017

Abstract

BACKGROUND : Extra-ocular complaints of Computer Vision Syndrome (CVS) are neck, shoulder, back pain.  The 20-20-20 rule and E-BACKNSHOU exercise are expected to improve accommodative mechanisms, ocular surface of the eye and extra ocular symptoms of CVS. AIMS :  Proving the effectiveness of E-BACKNSHOU exercise for the improvement of neck, shoulder and back pain in CVS patient. METHOD : The research design was Pre-Post Test with Control Design. Subjects were 30 medical students of Faculty of Medicine, Diponegoro University, Semarang, Indonesia who experienced CVS and neck, shoulder and back pain. The treatment group got the 20-20-20 rule and E-BACKNSHOU exercise and the control group got the 20-20-20 rule for 1 month. Pain was measured by Visual Analogue Scale (VAS). Statistical test was conducted using paired t-test, unpaired t-test and chi square. Value of significance p<0.05. RESULT :  There were significant differences in VAS score of neck, shoulder, upper back pain (p=0.00), and low back pain (p=0.022) before and after the intervention in the treatment group and VAS score of neck (p=0,002), shoulder (p=0.020), upper back (p=0.011), and low back pain (p=0.019) in the control group. Delta VAS score of the treatment group was greater than the control group and there was a significant difference in delta VAS score of shoulder pain (p=0,030), but there were no significant differences in delta VAS score of neck (p=0,934), upper back (p=0,356), and low back pain (p=0,150). CONCLUSION : The effectiveness of 20-20-20 rule and E-BACKNSHOU exercise is better than the 20-20-20 rule alone on treating neck, shoulder and back pain in CVS patient.
The Reduction of Oxidative Stress in Dyslipidemic Sprague Dawley Rats with Exposure to Mulberry Leaf Extract and Simvastatin Purnama, Yugi Hari Chandra; Fifin Luthfia Rahmi; Banundari Rachmawati
Jurnal Kesehatan dr. Soebandi Vol 12 No 1 (2024): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v12i1.575

Abstract

Dyslipidemia induces oxidative stress, leading to the subendothelial accumulation of atherogenic lipoproteins and the initiation of reactive oxygen species (ROS) formation. Secondary metabolites such as flavonoids found in mulberry leaves can act as antioxidants, suppressing the production of free radicals responsible for oxidative stress. This study aims to evaluate the impact of mulberry leaf extract and simvastatins on MDA levels in dyslipidemic Sprague Dawley rats. This research is a true experimental type with a pre-post test with control group design. The samples in this study were mulberry leaves and Sprague Dawley rats. Mulberry leaves were extracted using the maceration method with 70% ethanol solvent, then continued with antioxidant testing using DPPH. The number of samples in this study was 30 male rats which were divided into 5 groups; group P1 (HFD + mulberry leaf extract), P2 (HFD + simvastatin), P3 (HFD + mulberry leaf extract + simvastatin) as well as the normal group and the negative control group. Mulberry leaf ethanol extract has an IC50 value of 5.61 ppm which is very strong category. The intervention was carried out for 8 weeks. MDA levels were checked before and after intervention. The results showed a significant decrease in MDA levels in treatment groups P1, P2 and P3. Changes in MDA levels between groups were tested using one way ANOVA with significant results p=0.000 (p < 0,05). Administration of mulberry leaf extract which is rich in flavonoids and simvastatin significantly reduces MDA levels in the blood of rats.
INCIDENT OF DRY EYE IN FK UNDIP STUDENTS USING SMARTPHONES Purnomo, Adella Setyo; Wildan, Arief; Rahmi, Fifin Luthfia; Saubig, Arnila Novitasari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 1 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i1.41988

Abstract

Background: Smartphone use is increasing over time and often causes Dry Eye Syndrome (DES). Dry Eye Syndrome (DES) is a multifactorial disease of the ocular surface characterized by loss of homeostasis and causes various ocular symptoms. The Schirmer test is a measurement of the tears quantity to diagnose DES. Objective: To determine the effect of smartphone use on the results of Schirmer test measurements. Methods: This was a quasi-experimental research with a pre-test and post-test design. The research subjects consisted of 36 students selected based on inclusion and exclusion criteria using consecutive sampling. The experimental group (n=18) used a smartphone for 2 hours by watching the video (film), while the control group (n=18) did not use the smartphone. Schirmer tests were carried out before and after observation for 5 minutes using Schirmer paper strips. Statistical tests used the Shapiro-Wilk test with a meaning value of p ≥ 0,05, Chi-square test, Paired t-test, Wilcoxon test, and Mann-Whitney test with a meaning value of p < 0,05. Results: There was a significant decrease in the Schirmer test results (p = 0,020) by 1,334 ± 0,8937 mm in the experimental group and a non-significant increase (p = 0,582) in the control group by 0,362 ± 0,4086 mm. There was a significant difference in the decrease of Schirmer test results between the experimental group compared to the control group (p = 0,048). Conclusion: The use of smartphones influences the decrease in Schirmer test measurement results.
The Characteristics of Eye Diseases at Merpati Eye Clinic Dr Kariadi Hospital Semarang in 2020-2022 Rahmi, Fifin Luthfia; Wildan, Arief; Maharani, Maharani; Prihatningtias, Riski; Nugroho, Trilaksana; Rikiandraswida, Zahira; Ryamizard, Rizal
Diponegoro International Medical Journal Vol 4, No 1 (2023): July 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i1.17677

Abstract

Background: The COVID -19 pandemic that has occurred since 2020 has changed and affected all aspects of life. In health services, the pandemic has limited patients from coming to health facilities. Recording of ophthalmology cases in health facilities has an important role in providing information about eye health problems that often occur in the community to identify what are the main challenges faced in the field of eye care.Objective: This study aims to identify the characteristics of eye diseases at the Merpati Eye Polyclinic Dr Kariadi Hospital Semarang in 2020-2022.Methods: This study was a retrospective descriptive study. The clinical characteristic data (gender, age, diagnosis, and Clinic) are retrieved from the medical records of patients suffering from eye diseases who underwent treatment at the Merpati Eye Clinic, Dr. Kariadi Hospital Semarang and was diagnosed in 2020-2022. The data obtained were processed and analyzed using the google sheets program.Results: There were 2961 newly diagnosed patients with the 10 most diagnosed diseases are Refractive disorders (12,87%), Cataracts (11,21%), Glaucoma (10,40%), Diabetic Retinopathy (6,75%), Pseudophakia (5,30%), Papile Atrophy (5,10%), Retinal Vein Occlusion (4,22%), Corneal Ulcer (3,92%), Retinal Detachment (3,71%) and Uveitis (3,51%). Based on age category, the most patients were 51-60 years old (22,29%). Based on gender category, female gender (50,35%) is more than male (49,65%).Conclusion: Of all patients, the 10 most diagnosed diseases were Refractive Disorders, Cataracts, Glaucoma, Diabetic Retinopathy, Pseudophakia, Papillary Atrophy, Retinal Vein Occlusion, Corneal Ulcers, Retinal detachment and Uveitis.
Effect of Moringa Oleifera on Tumor Necrosis Factor-Alpha and Extracellular Matrix Trabecular Meshwork of Glaucoma Model Wistar Rats Maharani, Maharani; Astuti, Ratih Kusuma; Rahmi, Fifin Luthfia; Prihatningtias, Riski; Istiadi, Hermawan; Wildan, Arief
Journal of Biomedicine and Translational Research Vol 11, No 1 (2025): April 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i1.24127

Abstract

Background: Elevated intraocular pressure (IOP) induces inflammation in the trabecular meshwork (TM) through increases in tumor necrosis factor-alpha (TNF-α) expressions by activating nuclear factor kappa B (NF-κB). Mechanical injury to the TM, such as increased IOP, can cause extracellular matrix (ECM) remodeling, impacting the permanent outflow of aqueous humor. Moringa oleifera (MO) leaf extract is an anti- inflammatory agent that inhibits NF-κB activation and has been studied to have antioxidant effects.Objective: to analyze the effects of MO leaf extract on TNF- α expression and the thickness of the trabecular meshwork ECM in a Wistar rat glaucoma model. Methods: Fourteen male Wistar rats were divided into two groups (n=7): the glaucoma group received oral MO leaf extract at 300 mg/kg body weight for four weeks, and the control group. TNF-α expressions were measured by immunohistochemical stain, and the thickness of the ECM was examined with hematoxylin eosin staining. P-values of less than 0.05 were considered to represent statistical significance.Results: The mean of TNF-α expressions in the treatment group was 4.29 ± 0.76, and the control group was 5.29 ± 0.49. There was a significant difference in TNF-α expressions between the two groups (p=0.015). The mean thickness of the ECM TM experimental group and control group were 155.65 ± 28.72μm and 218.63 ± 40.85μm respectively. The extracellular matrix TM experimental group was statistically significantly thinner than the control group (p=0.006).Conclusion: MO could protect TM from damage caused by high IOP by suppressed TNF- α expression and ECM thickness in the TM Wistar glaucoma model. 
Screening of Refractive Disorders and Eye Health Awareness: Knowledge, Attitudes, and Behaviors of Elementary School Children in Semarang Saubig, Arnila Novitasari; Nugroho, Trilaksana; Rahmi, Fifin Luthfia; Dharma, Andhika Guna
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.23477

Abstract

Introduction: Refractive disorders are the leading cause of visual impairment. Uncorrected refractive errors in children can significantly impact their development, especially regarding education and psychosocial growth.Objective: This study aims to determine the prevalence of refractive disorders and to assess the knowledge, attitudes, and behaviors related to eye health among elementary school children at SemarangMethodology: This is a descriptive study involving 200 students from SDN Wonotingal Semarang as the sample. The study included eye examinations to identify refractive disorders in students and a questionnaire to collect data on their knowledge, attitudes, and behaviors regarding eye health. Data were collected through school-based eye screening and were analyzed using Microsoft Excel and SPSS version 26.Results: The prevalence of refractive disorders among children at SDN Wonotingal Semarang was 14%, with Astigmatism Myopia Compositus being the most common type of refractive disorder at 67.9%. Among the 28 children with refractive disorders, the majority were 11 years old (75%). Refractive disorders were more prevalent in females (64.29%) than males (35.71%). The questionnaire data revealed that a large number of children had poor knowledge about eye health (97.9%). However, most children exhibited good attitudes (79.5%) and behaviors (66.0%) regarding eye health.Conclusion: The prevalence of refractive disorders among children at SDN Wonotingal Semarang is 14%, with Astigmatism Myopia Compositus being the most common type. A significant number of children still have poor knowledge about eye health.
Co-Authors ADELIA BAYU ISFANDIARI Arief Wildan Arief Wildan, Arief Astuti, Ratih Kusuma Azhar Wirayudha Banundari Rachmawati Daisy Syakhsiatusy Syahiqoh Denti Puspasari DEWI WULANSARI Dharma, Andhika Guna Dwi Retnoningrum Hari Peni Julianti Hermawan Istiadi Inez Sharfina Primadiani Johanes Jethro Nugroho Luthfinnisa, Fryta Ameilia Maharani Maharani Cahyono Maharani Maharani Maharani Maharani, Maharani Muhammad Alfin Kamal Neni Susilaningsih novika pristiwati novika pristiwati Nugroho, Trilaksana Nur Muhammad Ichsan Pritadesya, Maharani Prizka Purnama, Yugi Hari Chandra Purnomo, Adella Setyo Rikiandraswida, Zahira Riskha Pangestika Riski Prihatningtias Riski Prihatningtias, Riski RISKI PRIHATNUNGTIAS Ryamizard, Rizal Saubig, Arnila Novitasari Singgih Pratama Tanti Ajoe Kesoema, Tanti Ajoe Trilaksana Nugroho Tusita Devi Uyun, Fuadah Wulansari, Arin