Garuda - Garba Rujukan Digital

Nora Ramkita

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Author-ID : 357478

Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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PKM Bantuan Hidup Dasar (BHD) untuk meningkatkan pengetahuan menolong korban henti jantung di Pondok Pesantren Modern IGM AL-Ihsaniyah Palembang. Mastan, Soraya Sagita Desmaradd; Rizki, Aulia Annisa; Kurniawati, Nyiayu Fauziah; Oktari, Desyani; Ramkita, Nora
Jurnal Abdimas Mandiri Vol. 10 No. 1 (2026): On Progress
Publisher : UNIVERSITAS INDO GLOBAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36982/jam.v10i1.6817

Henti jantung merupakan kondisi kegawatdaruratan medis yang dapat menyebabkan kematian dalam waktu singkat apabila tidak segera ditangani. Tindakan Bantuan Hidup Dasar (BHD) terbukti mampu meningkatkan peluang keselamatan korban henti jantung, namun pengetahuan dan keterampilan masyarakat awam, termasuk santri di lingkungan pondok pesantren, masih terbatas. Kegiatan Pengabdian kepada Masyarakat ini dilaksanakan sebagai bagian dari peringatan International Pathology Day dengan tujuan meningkatkan pengetahuan dan keterampilan santri, ustad, dan ustadzah mengenai Bantuan Hidup Dasar sebagai upaya meningkatkan kesiapsiagaan dalam menolong korban henti jantung di Pondok Pesantren Modern IGM Al-Ihsaniyah Palembang. Metode pelaksanaan kegiatan meliputi edukasi kesehatan melalui ceramah interaktif, demonstrasi audiovisual, serta praktik langsung Bantuan Hidup Dasar menggunakan manekin. Evaluasi keberhasilan kegiatan dilakukan menggunakan kuesioner pre-test dan post-test untuk menilai tingkat pengetahuan peserta sebelum dan sesudah dilakukannya edukasi. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan yang signifikan, ditandai dengan peningkatan kategori pengetahuan baik dari 14,7% sebelum edukasi menjadi 66,2% setelah edukasi, serta penurunan kategori pengetahuan kurang dari 58,8% menjadi 4,4%. Temuan ini menunjukkan bahwa edukasi Bantuan Hidup Dasar yang disertai demonstrasi dan praktik langsung efektif dalam meningkatkan pemahaman dan kesiapsiagaan peserta. Kegiatan ini dapat berkontribusi dalam meningkatkan kemampuan masyarakat pondok pesantren dalam memberikan pertolongan awal pada kejadian henti jantung sebelum bantuan medis lanjutan tiba.

Rhodomyrtus tomentosa Leaf Extract Cream Suppresses MMP-1 Expression and Epidermal Thickening in UVB-Irradiated Swiss Webster Mice Defa Agripratama Ali; Zen Hafy; Veny Larasati; Nora Ramkita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1609

Background: Ultraviolet B (UVB) radiation induces matrix metalloproteinase-1 (MMP-1) expression and epidermal hyperplasia, contributing to photoaging. Rhodomyrtus tomentosa (karamunting) is rich in polyphenolic compounds with documented antioxidant properties, but its in vivo photoprotective effects remain unexplored. Methods: We investigated the effects of R. tomentosa leaf extract cream at varying concentrations (0%, 12.5%, 25%, 50%) on UVB-irradiated Swiss Webster mice (n=4 per group). UVB exposure was standardized at approximately 150 mJ/cm² per session over seven consecutive days. Vitamin E cream served as a positive control. Immunohistochemical staining quantified MMP-1 expression as a percentage of positive cells, while hematoxylin-eosin histology measured epidermal thickness. Results: Kruskal-Wallis testing revealed significant differences in both MMP-1 expression (H=10.43, p=0.015) and epidermal thickness (H=10.88, p=0.012). The 25% extract concentration optimally suppressed MMP-1 expression (mean 45.94% of positive cells) compared to the untreated UVB control (89.53%). A biphasic dose-response pattern emerged, with hormetic effects observed at 50% concentration (76.45%), suggesting polyphenol pro-oxidant activity at excessive concentrations. Epidermal thickness normalized with 25% treatment (71.8 μm) versus UVB control (93.4 μm). Immunohistochemical intensity decreased progressively with treatment intensification through 25%, supporting suppression of MMP-1-mediated collagen degradation. Conclusion: R. tomentosa leaf extract cream at 25% concentration effectively suppresses MMP-1 expression and normalizes UVB-induced epidermal thickening in mice. The hormetic response at higher concentrations highlights the importance of dose optimization in phytotherapeutic development. This work establishes the first in vivo evidence for karamunting leaf extract as a photoprotective agent and supports further clinical translation.

Rhodomyrtus tomentosa Leaf Extract Cream Suppresses MMP-1 Expression and Epidermal Thickening in UVB-Irradiated Swiss Webster Mice Defa Agripratama Ali; Zen Hafy; Veny Larasati; Nora Ramkita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1609

Background: Ultraviolet B (UVB) radiation induces matrix metalloproteinase-1 (MMP-1) expression and epidermal hyperplasia, contributing to photoaging. Rhodomyrtus tomentosa (karamunting) is rich in polyphenolic compounds with documented antioxidant properties, but its in vivo photoprotective effects remain unexplored. Methods: We investigated the effects of R. tomentosa leaf extract cream at varying concentrations (0%, 12.5%, 25%, 50%) on UVB-irradiated Swiss Webster mice (n=4 per group). UVB exposure was standardized at approximately 150 mJ/cm² per session over seven consecutive days. Vitamin E cream served as a positive control. Immunohistochemical staining quantified MMP-1 expression as a percentage of positive cells, while hematoxylin-eosin histology measured epidermal thickness. Results: Kruskal-Wallis testing revealed significant differences in both MMP-1 expression (H=10.43, p=0.015) and epidermal thickness (H=10.88, p=0.012). The 25% extract concentration optimally suppressed MMP-1 expression (mean 45.94% of positive cells) compared to the untreated UVB control (89.53%). A biphasic dose-response pattern emerged, with hormetic effects observed at 50% concentration (76.45%), suggesting polyphenol pro-oxidant activity at excessive concentrations. Epidermal thickness normalized with 25% treatment (71.8 μm) versus UVB control (93.4 μm). Immunohistochemical intensity decreased progressively with treatment intensification through 25%, supporting suppression of MMP-1-mediated collagen degradation. Conclusion: R. tomentosa leaf extract cream at 25% concentration effectively suppresses MMP-1 expression and normalizes UVB-induced epidermal thickening in mice. The hormetic response at higher concentrations highlights the importance of dose optimization in phytotherapeutic development. This work establishes the first in vivo evidence for karamunting leaf extract as a photoprotective agent and supports further clinical translation.

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