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Dwi Retnowati
Prodi Magister Pendidikan Matematika, Pascasarjana, FKIP – UNS
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Veterinary Other

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UTILIZATION OF INDONESIAN STRAIN ACTINOBACTERIA TO FACE THE THREAT OF BIOFILM AS THE MAIN CAUSE OF HEALTH CARE ASSOCIATED INFECTION Cahyo, Bian Dwi; Retnowati, Dwi; Lisdiyanti, Puspita
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 2 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.13111

Abstract

Health Care Associated Infection (HCAI) is one of the global infectious diseases that is expected to cause around 10 million deaths by 2050. One of the main causes is biofilm, an exopolysaccharide layer formed by bacteria, often found on medical equipment such as catheters, and has high resistance to antibiotics. Prevention efforts can be made through the search for antibiofilm compounds. Actinobacteria are known to produce potential bioactive compounds. This study utilized Actinobacteria strains from the waters of Bitung, North Sulawesi (code BT-023-026) to explore their antibiofilm potential through isolation, laboratory tests, and genetic analysis, followed by expert confirmation in the fields of intelligence, BPOM, and microbiology. The results show the great potential of BT-023-026 as an antibiofilm agent to prevent antibiotic resistance due to HCAI, while playing a strategic role in biodefense and strengthening health security through early warning and early detection.
Co-Authors : Samwilson Slamet, : Samwilson Berlian Yuli Saputri Cahyo, Bian Dwi Chang, Helen Cordova, Datu Muhammad Filailla, Euis Harjito - Herminaju, Ketjuk Imam Sujadi Jepri Agung Priyanto, Jepri Agung Khairani, Hafifatunil Kusoro Siadi Mudinillah, Adam Muhamad Ali Oky Hermansyah Permatasari, Vera Prastya, Muhammad Eka Primahana, Gian PUSPITA LISDIYANTI Putra, Rayhan Helmyana RIA ANGGRAINI Rizna Triana Dewi Sri Pujiyanto Sri Subanti Suci Rahmawati, Suci SUKIRNO Yuswan, Apriza Zahra, Aliya Azkia