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UTILIZATION OF INDONESIAN STRAIN ACTINOBACTERIA TO FACE THE THREAT OF BIOFILM AS THE MAIN CAUSE OF HEALTH CARE ASSOCIATED INFECTION Cahyo, Bian Dwi; Retnowati, Dwi; Lisdiyanti, Puspita
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 2 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.13111

Abstract

Health Care Associated Infection (HCAI) is one of the global infectious diseases that is expected to cause around 10 million deaths by 2050. One of the main causes is biofilm, an exopolysaccharide layer formed by bacteria, often found on medical equipment such as catheters, and has high resistance to antibiotics. Prevention efforts can be made through the search for antibiofilm compounds. Actinobacteria are known to produce potential bioactive compounds. This study utilized Actinobacteria strains from the waters of Bitung, North Sulawesi (code BT-023-026) to explore their antibiofilm potential through isolation, laboratory tests, and genetic analysis, followed by expert confirmation in the fields of intelligence, BPOM, and microbiology. The results show the great potential of BT-023-026 as an antibiofilm agent to prevent antibiotic resistance due to HCAI, while playing a strategic role in biodefense and strengthening health security through early warning and early detection.
UTILIZATION OF INDONESIAN STRAIN ACTINOBACTERIA TO FACE THE THREAT OF BIOFILM AS THE MAIN CAUSE OF HEALTH CARE ASSOCIATED INFECTION Cahyo, Bian Dwi; Retnowati, Dwi; Lisdiyanti, Puspita
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 2 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.13111

Abstract

Health Care Associated Infection (HCAI) is one of the global infectious diseases that is expected to cause around 10 million deaths by 2050. One of the main causes is biofilm, an exopolysaccharide layer formed by bacteria, often found on medical equipment such as catheters, and has high resistance to antibiotics. Prevention efforts can be made through the search for antibiofilm compounds. Actinobacteria are known to produce potential bioactive compounds. This study utilized Actinobacteria strains from the waters of Bitung, North Sulawesi (code BT-023-026) to explore their antibiofilm potential through isolation, laboratory tests, and genetic analysis, followed by expert confirmation in the fields of intelligence, BPOM, and microbiology. The results show the great potential of BT-023-026 as an antibiofilm agent to prevent antibiotic resistance due to HCAI, while playing a strategic role in biodefense and strengthening health security through early warning and early detection.
Analisis Ancaman Fenomena LGBT dalam Perspektif Intelijen Medik Cristie, Laura; Retnowati, Dwi; Bela, Budiman
J-CEKI : Jurnal Cendekia Ilmiah Vol. 5 No. 3: April 2026
Publisher : CV. ULIL ALBAB CORP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/j-ceki.v5i3.15691

Abstract

Penelitian ini dilatarbelakangi oleh meningkatnya perhatian terhadap dinamika keberagaman orientasi seksual di Indonesia serta implikasinya terhadap kesehatan dan keamanan masyarakat. Studi ini bertujuan untuk menganalisis potensi implikasi fenomena tersebut terhadap aspek kesehatan dan keamanan manusia, serta merumuskan strategi penanganan dari perspektif intelijen medik. Penelitian menggunakan pendekatan kualitatif dengan teknik pengumpulan data melalui studi dokumentasi, wawancara, observasi, serta pendekatan Analytical Hierarchy Process untuk mendukung perumusan strategi. Analisis dilakukan secara deskriptif guna memahami pola perkembangan fenomena dan implikasinya terhadap aspek kesehatan fisik, psikologis, dan sosial. Hasil penelitian menunjukkan bahwa perkembangan fenomena ini dipengaruhi oleh dinamika sosial, media digital, serta interaksi dengan wacana global mengenai hak asasi manusia dan kesetaraan. Implikasi yang diidentifikasi mencakup potensi risiko kesehatan, baik fisik maupun psikologis, serta dampaknya terhadap dimensi keamanan kesehatan dan keamanan manusia. Penelitian ini merumuskan strategi penanganan berbasis fungsi intelijen yang meliputi upaya pencegahan, penangkalan, dan penanggulangan. Pencegahan difokuskan pada penguatan literasi kesehatan dan edukasi publik, penangkalan pada mitigasi risiko sosial dan psikologis, serta penanggulangan pada penanganan dampak yang telah terjadi. Penelitian ini menegaskan pentingnya pendekatan multidisipliner yang berbasis kesehatan masyarakat, edukasi, dan kebijakan yang inklusif serta berbasis bukti dalam merespons dinamika sosial yang kompleks, guna menjaga keseimbangan antara perlindungan kesehatan dan stabilitas sosial.