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All Journal Medical Journal of Indonesia Indonesian Journal of Cancer Indonesian Journal of Rheumatology World Nutrition Journal Indonesian Journal of Cancer eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Ikhwan Rinaldi
Divisi Hematologi Onkologi Medik, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia, Rumah Sakit Dr. Cipto Mangunkusumo
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Indonesian Journal of Rheumatology

 1 
Correlation between Interleukin-6 and E-Selectin as a Marker of Endothelial Dysfunction in Rheumatoid Arthritis Patient without Traditional Cardiovascular Risk Factor Jerry Eddya Putra Boer; Rudy Hidayat; Ika Prasetya Wijaya; Ikhwan Rinaldi
Indonesian Journal of Rheumatology Vol. 10 No. 2 (2018): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.443 KB) | DOI: 10.37275/ijr.v10i2.98

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease which has recently been recognized to manifest as not only intraarticular but also extraarticular symptoms. Cardiovascular events, presented either subclinically or clinically, were discovered more in AR patients. Atherogenic inflammatory mediator in AR including interleukin-6 (IL-6) was thought to be one of nontraditional cardiovascular risk factor contributing to increase the endothelial dysfunction biomarker such as E-Selectin. This study was purposed to determine the correlation between inflammatory mediator and endothelial dysfunction event, especially between IL-6 and E-Selectin, in RA patient without traditional cardiovascular risk factor. A cross-sectional study was performed to 40 RA patients of Rheumatology Clinic of Cipto Mangunkusumo National General Hospital, Indonesia from September to November 2017. Measurement of the level of IL-6 and E-Selectin were performed using enzyme-linked immunosorbent assay (ELISA). Bivariate correlation analysis was performed to determine the correlation between those two biomarkers. The mean age of this study subjects was 44.9 (13.1) years and median of disease duration was 36 months. This study showed weak correlation between IL-6 and E-Selectin level, but not statistically significant.232, p=0.149). There is weak correlation between IL-6 and sE-Selectin in rheumatoid arthritis patient without traditional risk factor cardiovascular Keywords: traditional risk factor cardiovascular, E-Selectin, interleukin-6, pro inflammatory mediator, rheumatoid arthritis
Co-Authors Achmad Fauzy, Achmad Adhiatma, Kresna Adityo Susilo, Adityo Adna, Rury Maharani Afifah Is Andhika Rachman Andri Sanityoso Sulaiman Anna Rozaliyani Ari Fahrial Syam Arif Harryanto Reksodiputro Arif Harryanto Reksodiputro, Arif Harryanto Arini Setiawati Arry Haryanto Reksodiputro Artati Murwaningrum, Artati Bambang Setyohadi Bambang Setyohadi Birry Karim C Rinaldi A Lesmana Ceva W. Pitoyo Cleopas Martin Rumende Cleopas Martin Rumende Dadang Makmun Dewi Mira Ratih Diana Sunardi Djatikusumo, Ari Dono Antono E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edy Rizal Wahyudi Em Yunir Em Yunir, Em Endy Novianto Endy Novianto, Endy Evy Yunihastuti Findy Prasetyawati Findy Prasetyawati, Findy Gurmeet Singh Hasan Maulahela, Hasan Henry Ratno Diono Silalahi Henry Ratno Diono Silalahi, Henry Ratno Diono HILMAN TADJOEDIN, HILMAN Ika Prasetya Wijaya Iris Rengganis Jerry Eddya Putra Boer Juferdy Kurniawan Kaka Renaldi Karmel L Tambunan, Karmel L Kuntjoro Harimurti Kusumaningrum, Profitasari Kusumowidagdo, Gladys Lestari, Regina Lisnawati Rachmadi Lugyanti Sukrisman Lukman Edwar Marbun, Maruhum Bonar Hasiholan Mardianto, Umar Muhadi Muhadi Muhadi Muhadi, Muhadi Muningtya Philiyanisa Alam Murdani Abdullah Murdani Abdullah Mustopa, Inna Intani Nabil Mubtadi Falah Nabil Mubtadi Falah, Nabil Mubtadi Noto Dwimartutie Pratiwi, Amalia Nur Pringgodigdo Nugroho, Pringgodigdo Purwita Wijaya Laksmi Rahmat Cahyanur Rahmat Cahyanur Rasco Sandy Sihombing Rasco Sandy Sihombing, Rasco Sandy Ratih, Dewi Mira Regina Lestari Reinaldo Alexander Reksodiputro, Arry H. Reza Yogaswara Rino Alvani Gani Robert Sinto Rudi Putranto Rudi Putranto Rudy Hidayat Rudy Hidayat Sabrina Munggarani Yusuf Sepmeitutu, Iwandheny Shufrie Effendi, Shufrie Sukamto Koesnoe Sulaiman, Andri Andri T. Djumhana Atmakusuma, T. Djumhana Tengku Riza Zarzani N Tri Juli Edi Tarigan Triyanta Yuli Pramana Yogaswara, Reza Yudantha, Anggun R.