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All Journal VALENSI Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Media Gizi Kesmas Current Research on Biosciences and Biotechnology
Salsabila, Syefira
Bandung Institute Of Technology
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Potensi Antibakteri Ekstrak Metanol dan Senyawa Aromatik dari Buah Wualae (Etlingera elatior) Sahidin Sahidin; Syefira Salsabila; Wahyuni Wahyuni; Fristiohady Adryan; Imran Imran
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 5, No. 1, May 2019
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (576.334 KB) | DOI: 10.15408/jkv.v5i1.8658

Abstract

Buah tanaman wualae (bahasa Tolaki) atau Etlingera elatior digunakan oleh masyarakat Tolaki (Sulawesi Tenggara) sebagai bumbu masak dan obat tradisional. Untuk mengungkap potensi tersebut, khususnya buah wualae, dilakukan kajian fitokimia dan farmakologi buah wualae. Kajian fitokimia meliputi isolasi dan penentuan struktur dikerjakan dengan metode kromatografi (kromatografi vakum cair dan kromatografi radial) dan spektroskopi (1H dan 13C NMR). Kajian farmakologi meliputi uji aktivitas biologi terhadap enam jenis bakteri (Bacillus subtilis FNCC 0060, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Salmonella enterica ATCC 14028, Staphylococcus aureus ATCC 25923, dan Streptococcus mutans ATCC 25175). Hasilnya menunjukkan tiga senyawa fenolik telah berhasil diisolasi dan diidentifikasi dari buah wualae yaitu asam vanilat (1), asam p-hidroksibenzoat (2), dan asam kumarat (3). Ketiga senyawa tersebut pertama kali dilaporkan berhasil diisolasi dari buah E. elatior. Aktivitas antibakteri ekstrak metanol buah wualae dan tiga senyawa hasil isolasi menunjukkan bahwa sampel tersebut paling aktif terhadap bakteri S. mutans. Dengan demikian aktivitas senyawa-senyawa hasil isolasi dari buah E. elatior  berkorelasi dengan aktivitas ekstrak metanol buah E. elatior  terhadap S. mutans, dimana senyawa paling aktif adalah asam vanilat. Ekstrak yang dominan mengandung asam vanilat dari tanaman ini dapat dikembangkan sebagai herbal antibakteri S. mutans seperti herbal karies gigi dan obat kumur. Kata kunci: Etlingera elatior, wualae, buah, senyawa aromatik, antibakteri. The fruits of wualae (Tolakinese) or Etlingera elatior is utilized by Tolakinese (Sulawesi Tenggara) as spices and traditional medicine. To reveal the potencies, a study on phytochemical and pharmacological aspects have been carried out. The phytochemical study includes isolation and structure determination used chromatography methods (vacuum liquid chromatography and radial chromatography) and spectroscopy methods (1H NMR and 13C NMR). Biological activity was evaluated against some bacteria that are Bacillus subtilis FNCC 0060, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Salmonella enterica ATCC 14028, Staphylococcus aureus ATCC 25923, and Streptococcus mutans ATCC 25175). The results showed that three aromatic compounds had been isolated and identified that are vanillic acid (1), p-hydroxybenzoic acid (2) and coumaric acid (3). All compounds are firstly reported that successfully isolated from fruits of Wualae. Antibacterial potency indicated that the methanol extracts and the isolated compounds are the most active towards S. mutans and have good activity correlation between the extracts and the compounds. Vanillic acid is the most active compound from E. elatior fruits. Thus, the extracts contain dominantly vanillic acid from          E. elatior fruits can be developed to be antibacterial herbals caused by S. mutans. Keywords: Etlingera elatior, wualae, fruits, aromatic compounds, antibacterial activity.
Mitragynine: a review of its extraction, identification, and purification methods Amrianto; Sumail Sidik Ode Ishak; Nanda Putra; Syefira Salsabila; Laode Muhammad Ramadhan Al Muqarrabun
Current Research on Bioscences and Biotechnology Vol. 3 No. 1 (2021)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2021.3.1/TMPNSA4H

Abstract

Mitragynine is one of the dominant alkaloids present in Mitragyna speciosa. The compound possesses several pharmacological properties such as antinociceptive, anti-inflammatory, and anti-cancer. Studies have reported various methods in extracting mitragynine, both conventional and renewable technology combined with acid-base techniques for the enrichment and purification of mitragynine from M. speciosa. Several chromatography and spectroscopy instruments such as HPLC, LC-MS, GC-MS, and NMR have been used to identify mitragynine and its content in both the extract and fraction mixtures. In this review, we aim to provide insight on how the methods of extraction, purification, and identification of mitragynine have been developed over the last few decades. This report shows comparison among the various approaches in extracting mitragynine and points out the facts that different methods gave different yields of the compound.
Isolation of bioactive compounds with tyrosinase inhibitory activity from the methanol extract of meniran herb (Phyllanthus niruri Linn.) Syefira Salsabila; Rika Hartati; Laode M.R. Al Muqarrabun; Nurinanda Prisky Qomaladewi; Ariranur Haniffadli; Andi Rifki Rosandy; Agus Chahyadi; Elfahmi
Current Research on Bioscences and Biotechnology Vol. 3 No. 2 (2022)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2022.3.2/GOO6ZULV

Abstract

Meniran (Phyllanthus niruri L.) is a wild plant in the Euphorbiaceae family which grows in tropical climates. The plant is known to possess antioxidant activity and is rich in phenolic compounds. Since plants with high phenolic content and high antioxidant activity are known to exhibit high tyrosinase inhibitory activity, the purpose of this study is to determine the inhibitory activity of the tyrosinase enzyme by the methanol extract of meniran (P. niruri L.) and to isolate secondary metabolites from the extract and fractions which exhibit inhibitory activity against tyrosinase. The in vitro tyrosinase inhibitory activity assay was conducted using the 96-well microplate method with kojic acid as the positive control, while the separation and purification of compounds were carried out using chromatography techniques. The methanol extract and n-hexane fraction showed tyrosinase inhibitory activity with IC50 of 11.05±0.16 and 2.57±0.08 mg/ml, respectively. Three bioactive compounds were succesfully isolated from the n-hexane fraction. Based on the UV and NMR spectra, compounds 1, 2, and 3 were identified as phyllanthin, phyltetralin, and hypophyllanthin, respectively. Furthermore, phyllanthin (1) was shown to demonstrate inhibitory activity against tyrosinase with IC50 of 0.6322 mM. In conclusion, both meniran extract and phyllanthin (1) were found to exhibit inhibitory acitivity against the tyrosinase enzyme. In the future they can be candidates for the treatment against hyperpigmentation and also as an active ingredient in skincare formulations.
Development of analysis method of andrographolide from Andrographis paniculata using UPLC-PDA Syefira Salsabila; Diah Astari Salam; Sumail Sidik Ode Ishak; Amrianto
Current Research on Bioscences and Biotechnology Vol. 4 No. 2 (2023)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2023.4.2/I9YWKM9X

Abstract

Andrographis paniculata is an herbaceous plant belonging to the family Acanthaceae dan also known as the “King of Bitters”. It has been utilized as traditional medicines by the local people in India and Southeast Asia. Many studies have been reported regarding the pharmacological activities of A. paniculata and Andrographolide. Currently, in addition to compound isolation and bioactivity assays, validation of analysis method is also required. Validation is used to demonstrate that the method used is appropriate and the results are precise and accurate. The method used needs to be simple, concise, precise, accurate, and widely used. The analysis in this study was carried out using Ultra-Performance Liquid Chromatography because the instrument operates at high pressure. In addition, the system uses fine particles which can reduce column length as well as solvent and time consumption. This study aims to validate analytical methods in determining the contents of andrographolide in an A. paniculata Leaves. The analytical method was validated through a Waters Alliance UPLC System with photodiode array (PDA) detector. The A. paniculata extract and standard solutions of Andrographolide were analyzed using reverse-phase C18 column which was maintained at 40°C. A mobile phase of 0.1% formic acid in acetnotirile and 0.1% formic acid in water was used at flow rate of 0.3 mL/min to achieve gradient elution. The linearity of the andrographolide showed excellent results (R2= 0.9999) in the concentration range of 7.8–250.0 µg/mL. The LOD and LOQ values of andrographolide were 0.068 µg/mL and 0.205 µg/mL, respectively. The intra-day and inter-day relative standard deviation (RSD) and relative error (RE) accuracy values of andrographolide were <±15. The quantitative analysis found that A. paniculata extract contained 12.45 ±0.06 mg/g of Andrographolide. This developed UPLC-PDA method was proven to be precise, specific, sensitive, and accurate for routine quality assessment of raw material of Andrographis paniculata leaves content.
Development and validation of analysis method for sennoside B in Cassia angustifolia using UPLC-MRM/MS Amrianto; Kurnia Nastira Ningsih; Sumail Sidik Ode Ishak; Ula Aulia Fitrian; Syefira Salsabila; Diah Astari Salam
Current Research on Bioscences and Biotechnology Vol. 4 No. 2 (2023)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2023.4.2/22AMMLH7

Abstract

Cassia angustifolia is a commonly found wild plant from the family Caesalpinaceae that originates from Yemen and Hadramaut province in Southern Arabia, where it is called Arabian senna. The leaves of the plant have been used to treat a variety of ailments such as constipation, malaria, anemia, loss of appetite, and indigestion. Sennosides A and B are the major glycosides found in the leaves and pods of C. angustifolia and are important ingredients in purgative medicines. These compounds are considered as the major active components of Cassia plants and are responsible for their therapeutic activities. To assess the quality and quantity of sennosides A and B, an appropriate analytical method is required, which must be simple, accurate, precise, and widely used. The UPLC-ESI-MRM/MS method was used in this study to validate the analytical method in determining the contents of Sennoside B in senna leaves extract. The validation parameters included specificity, system suitability, linearity, sensitivity (LOD, LOQ), accuracy, and precision. The results indicated that the optimization of MRM using the direct infusion method provided good separation when eluted using liquid chromatography. The validation parameters for system suitability obtained RSD under 2%. The linearity of sennoside B showed excellent results (R2 = 0.999) in the concentration range of 0.98–62.5 µg/ml. The LOD and LOQ values of sennoside B were 0.011 µg/mL and 0.034 µg/ml, respectively. The accuracy values of sennoside B met the predetermined criteria, with RSD < 2% and % recovery of 97-102%. The quantitative analysis revealed that Cassia angustifolia extract contained 0.43 ±0.06 mg/g of sennoside B.
Liquid chromatography-mass spectrometric analysis of some bioactive compounds in commercial herbal products derived from Moringa oleifera L. Amrianto; Salsabila, Syefira; Salam, Diah Astari
Current Research on Biosciences and Biotechnology Vol. 7 No. 1 (2025)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2025.7.1/XR8PKR5P

Abstract

Moringa oleifera is widely recognized as a “miracle tree” due to its nutritional, medicinal, and environmental benefits. Its diverse phytochemical content underlies significant pharmacological effects. However, conventional HPLC methods for analyzing multi-component compounds in M. oleifera are often time-consuming and lack sensitivity, particularly for compounds present at low concentrations. To address this, we developed and validated an analytical method using UPLC-ESI-MRM/MS combined with ultrasound-assisted extraction (UAE). Method validation covered linearity, sensitivity (LOD, LOQ), accuracy, and precision, while UAE was optimized using Response Surface Methodology (RSM) with Box-Behnken Design. Seven phytochemical compounds—rutin, hyperoside, nicotiflorin, astragalin, niazirin, quercetin, and kaempferol—were quantified in various M. oleifera products including dried powder, herbal tea, extracts, and capsules. The validated method showed linearity between 1.56–500 µg/mL, LOD values of 0.036–0.094 µg/mL, LOQ values of 0.0108–0.2850 µg/mL, with accuracy and precision within ±15%. Optimal extraction was achieved at a solvent ratio of 1:30, temperature of 40 °C, and extraction time of 17.85 min. UPLC-ESI-MRM/MS enabled rapid separation and detection of all seven compounds within 15 minutes, significantly improving resolution compared to UV-based HPLC. In addition, three abundant flavonoids were confirmed as the main flavonoids present in Moringa, mainly rutin, hyperoside and nicotiflorin. On the other hand, niazirin can be considered as the specific marker for Moringa leaves. These results demonstrate that UPLC-ESI-MRM/MS, coupled with optimized UAE, provides a sensitive, rapid, and reliable approach for profiling M. oleifera phytochemicals, supporting its quality assessment and potential applications in nutraceutical and pharmaceutical industries.
The Effect Of Nutrition Literacy Education on Food Labels through Audio Visual Media on the Behavior of Student at SMA Negeri 4 Kendari in Choosing Packaged Foods Dewi, Radya Permala; Lisnawaty, Lisnawaty; Salsabila, Syefira
Media Gizi Kesmas Vol 14 No 2 (2025): MEDIA GIZI KESMAS (DECEMBER 2025)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgk.v14i2.2025.201-208

Abstract

Background: Packaged food is a very popular food among teenagers because it is part of teenage socialization. Teenage consumers generally choose food according to taste without paying attention to nutritional content. The ability to understand labels on food products is expected to increase teenagers awareness of being more selective in choosing packaged foods. Increased understanding is achieved through nutrition education in an effort to improve food label reading behavior. Audio-visual learning media was chosen because it is able to activate the senses of sight and hearing, thus helping to increase focus in learning. Objectives: The purpose of this study was to determine the effect of food label literacy nutrition education through audiovisuals on the behavior of high school students of SMA Negeri 4 Kendari in choosing packaged food. Method: This research used a pre-experimental method with one group pretest-posttest, which involved 93 students of classes X and XI in SMA Negeri 4 Kendari. Samples were selected using proportional random sampling. Data analysis in this study was carried out with the McNemar test at the α=0.05 significance level. The event took place at SMA Negeri 4 Kendari using audiovisual media. A validated questionnaire instrument was used to measure food labeling behavior before and after the intervention. Results: Based on the research, it was found that all respondents had sufficient knowledge (100%), good attitudes (100%), and good actions (100%). Thus, there is an effect of food label literacy nutrition education through audiovisual on knowledge (ρ=0.000), attitudes (ρ=0.000), and actions (ρ=0.000) in choosing packaged food at SMA Negeri 4 Kendari students. Conclusion: Thus, food label literacy nutrition education through audio visuals can significantly affect knowledge, attitudes, and actions about food labels in choosing packaged foods.
THE SYNERGY OF PEER EDUCATION AND DIGITAL TECHNOLOGY IN STRENGTHENING THE IMPLEMENTATION OF SMOKE-FREE AREAS Salsabila, Syefira; Suhadi, Suhadi; Nurmaladewi, Nurmaladewi; Rezal, Farit; Hikmawati, Zainab; Indriani, Della
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 9 No. 4 (2025): DESEMBER
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/abdidos.v9i4.3108

Abstract

This program aims to strengthen the role of students as peer educators and to develop digital campaigns supporting the implementation of SFA within schools and at home. The activities began with initial coordination and a needs assessment conducted in collaboration with the principal and supervising teachers to map students’ readiness and interests. Based on the selection results, fifteen students were chosen as SFA Ambassadors. The subsequent stages included peer educator training, followed by the production of educational digital content, in which students created digital comics using the Canva application. The comics featured themes such as the dangers of smoking, peer influence, the benefits of healthy living, and the importance of SFA implementation in schools. These were then disseminated through digital campaigns and peer education activities. The program concluded with monitoring and evaluation, including surveys of students and parents, analysis of digital engagement, and reflections from the peer educators. The results of this community service activity successfully achieved its primary objectives, namely enhancing students’ capacity and role as agents of change in creating a smoke-free school environment. Through training, mentoring, and digital campaigns, students demonstrated improved understanding of the dangers of smoking, awareness of the importance of smoke-free policies, and developed communication and creative skills in delivering health messages to their peers and the surrounding community
Co-Authors Agus Chahyadi Amrianto Amrianto Amrianto Andi Rifki Rosandy Ariranur Haniffadli Dewi, Radya Permala Diah Astari Salam Elfahmi Elfahmi, Elfahmi Fristiohady Adryan Imran Imran Indriani, Della Kurnia Nastira Ningsih Laode M.R. Al Muqarrabun Laode Muhammad Ramadhan Al Muqarrabun Lisnawaty Lisnawaty, Lisnawaty Nanda Putra Nurinanda Prisky Qomaladewi Nurmaladewi, Nurmaladewi Rezal, Farit Rika Hartati Sahidin Sahidin Salam, Diah Astari Suhadi Suhadi Sumail Sidik Ode Ishak Sumail Sidik Ode Ishak Sumail Sidik Ode Ishak Ula Aulia Fitrian Wahyuni Wahyuni Zainab Hikmawati, Zainab