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Journal : Tropical Plantation Journal

Antibacterial Activity and Preliminary Phytochemical Screening of Forest Chili Leaf (Piper caninum Bl.) Ethanol Extract against Staphylococcus epidermidis Shanzet, Flavia Fionessa Falenda; Darmayasa, Ida Bagus Gede; Suriani, Ni Luh; Wiadnyani, Anak Agung Istri Sri; Ho, Ting Seng; Rusdianasari, Rusdianasari; Mariani, Mariani
Tropical Plantation Journal Vol 3, No 1 (2024): TROPICAL PLANTATION JOURNAL
Publisher : Akademi Komunitas Perkebunan Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56125/tpj.v3i1.34

Abstract

Forest chili leaves (Piper caninum Bl.) has a potential to become an alternative to conventional antibiotics. This study aims to determine the Minimum Inhibitory Concentration (MIC) of forest chili leaf extract, assess the Lethal Concentration (LC50), and analyze the phytochemical composition of the extract. This study also conducted a Completely Randomized Design (CRD) with four repetitions. The agar well diffusion method is used in this study with various concentrations such as T1 ethanol 96% (negative control), T2 (5% concentration), T3 (10% concentration), T4 (15% concentration), T5 (20% concentration), T6 (25% concentration), and T7 Ciprofloxacin 1% (positive control). Data were subjected to ANOVA at a significance level of 5% and further analyzed using Duncan's test. The results showed that all concentrations of forest chili leaf extract (P. caninum Bl.) exerted a statistically significant effect (P 0.05) against Staphylococcus epidermidis bacteria. The research found that the most effective concentration to inhibits S. epidermidis is at 25%, which generates an inhibitory zone of 25.38 ± 0.52 mm. The estimated MIC value for forest chili leaf extract against S. epidermidis was found to be 0.2%, producing an inhibitory zone of 6.38 ± 0.32 mm. Additionally, the calculated LC50 value was 0.26%. Phytochemical screening revealed the presence of various bioactive compound groups in the forest chili leaf extract, including alkaloids, flavonoids, phenols, tannins, and steroids.
Co-Authors ABDUL ROHMAN Abdul Rohman Abu Hasan Adjie Pangestu, Wahyu Agustin, Delliana Ahmad Fudholi Ahmad Taqwa Aida Syarif AIDA SYARIF Amalia, Kania Yusriani Amanah, Tria Rizki Anak Agung Istri Sri Wiadnyani Arissetyadhi, Iwan Arza, Tasya Dwi Putri Aziz Pramito, Akbar Ismi Azzahra, Keyla Bambang, Muhammad Refo Barena, Meiwa Bow, Yohandi Bramantio, Iqbal Dewi, Tresna Faroja, Anas Fatahul Arifin, Fatahul Febrianti, Helena - Firdaus, Suryadhi Firdiansyah Hanitama, Muhammad Rivaldo Harahap, Muhammad Rayyan Herawati Budiastuti Hilwatullisan Ho, Ting Seng Husaini, A Ida Bagus Gede Darmayasa Idha Silviyati Indah Purnamasari Indrayani Jaksen M.A Jamil, Maizun Binti Kalsum, Leila Kania Pusriani Amalia Kinia Eldwita Leila Kalsum Mariani Mariani Minora, Padmarani Muhammad Yerizam Mujiyanti, Apri Nainggolan, Hetty S Nasyta, Nabila Putri Ni Luh Suriani Nor, Siti Najdah Binti Mohd Novarini, N Octhaviana, Vivi Paramitha, Tifa Pendawa, Fajar Pola Risma Putra, Asri Eka Putri Arza, Tasya Dwi Putri Arza Rachmawati, Anissa Nurul Rahmawati, Aisyah Auliya RD Kusumanto Reska, Tiara Rifa'i, Ahmad Imam Risdzuan, Aiman Arif Bin Rizka Amalia Robert Junaidi Ronaldo Sakuraba, Takahiro Saputra, Yureski Belly Sardewi, Tri Sari, Desti Erwita Sari, Febby Fitria Shanzet, Flavia Fionessa Falenda Sigit Kurniawan Siswanto Susanto, Susy Mardiana Suyadi, M. Ilham Andri Syafitri, Dwi Syahrian, Nur Mutiara Syakdani, Adi Syalsabila, Jihan Syaritri, Dwi Taqwa, Ahamad Tresna Dewi Trirahayu, Dhyna Analyes Vivi Octhaviana Yohandri Bow Yordan Hasan Yunsari, Sandhy Yurni Oktarina Zaman, Muhammad Zhafarina, Imas Ning