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All Journal Media Penelitian dan Pengembangan Kesehatan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Kedokteran: Media Informasi Ilmu Kedokteran dan Kesehatan Proceeding ISETH (International Summit on Science, Technology, and Humanity) Academic Hospital Journal Neurona Indonesian Journal of Biomedicine and Clinical Sciences Sanus Medical Journal Indonesian Journal of Pharmacology and Therapy
Abdul Gofir
Department Of Neurology, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta,
Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Kejadian Delirium pada Pasien Penderita Covid-19 dan Kemungkinan Perburukannya menjadi Gejala Demensia Pandhita S, Gea; Abdul Gofir
Sanus Medical Journal Vol. 2 No. 2 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v2i2.7452

Abstract

Delirium merupakan suatu sindrom neurobehavioral (perubahan perilaku terkait gangguan neurologis) yang disebabkan oleh gangguan sementara aktivitas neuron (sel saraf otak) sebagai akibat sekunder dari gangguan sistemik. Prevalensi delirium pada pasien yang dirawat inap di rumah sakit cukup tinggi. Kejadian delirium lebih tinggi pada pasien dengan kasus kritis dan pada pasien penderita Covid-19. Kejadian delirium pada pasien dengan kasus kritis yang dirawat di rumah sakit adalah sekitar 31,8%. Angka kejadian ini meningkat menjadi sekitar 55% pada penderita Covid-19. Beberapa penelitian menunjukkan bahwa terdapat mekanisme patofisiologi delirium pada pasien penderita Covid-19 yang serupa dengan kejadian delirium pada pasien non-Covid-19. Bukti epidemiologi menunjukkan keterkaitan kejadian delirium pada pasien non-Covid-19 dengan kejadian demensia beberapa periode waktu setelahnya (Probabilitas sekitar 30%). Bukti radiologis dan patologi anatomi juga menunjukkan adanya proses patologis di otak akibat Covid-19 yang dapat mengakibatkan gangguan saraf otak ireversibel dan berkontribusi pada penurunan kognitif jangka panjang. Hal-hal tersebut menunjukkan kemungkinan besar dapat terjadi keterkaitan antara kejadian delirium yang dialami pasien penderita Covid-19 dengan kejadian demensia di masa mendatang.
The Successfulness of A Multidisciplinary Approach For Obstructive Sleep Apnea Susianti, Noor Alia; Nathania, Caroline Evanthe; Prodjohardjono, Astuti; Vidyanti, Amelia Nur; Gofir, Abdul; Setyaningsih, Indarwati; Setyaningrum, Cempaka Thursina Srie; Sutarni, Sri
Academic Hospital Journal Vol 7, No 1 (2025)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v7i1.103305

Abstract

Background: Obstructive Sleep Apnea (OSA) is a global problem that has an impact on health and quality of life (QOL). There are a lot of risk factors for OSA, i.e. anatomical abnormality and comorbidity. A multidisciplinary approach can improve the symptoms and the impact of OSA and QOL too.Materials and methods: This case report is structured according to The CARE (Case Report) guideline.Case: A male, 37 years old, came with the chief complaint of snoring for 6 years. The patient felt unfit and dissatisfied with his sleep (Sleep Condition Indicator: 2.5). This impacted the daily activities and caused excessive daytime sleepiness. He could fall asleep while doing activities (Epsworth Sleepiness Scale: 24). The condition was worsening and he was often found apnea during sleep. The patient’s body mass index was 38.3kg/m2 (type I obesity) and the neck diameter was 43 cm. The polysomnography showed sleep architectural abnormality and the patients suffered from moderate OSA (Apnea-Hipopnea Index: 23.7). The patient was hospitalized for 7 days and got a Continuous Positive Airway Pressure Device (CPAP). Anatomical abnormality was investigated but none needed surgical intervention. Metabolic syndrome intervention includes therapy for hypertension, dyslipidemia, and diabetes. Collaboration with a clinical nutritionist for nutritional intervention. After 7 days, the sleep quality, the symptoms, and the SCI score were improved (7.1). Conclusion: OSA risk factors are varied and needed to be identified. In addition to definitive therapy, management of comorbidities, such as metabolic syndrome, should be addressed. A multidisciplinary approach can thereby improve OSA, patient’s health, and QOL.
Correlation between D-dimer and first-ever acute ischemic stroke (AIS) severity in Dr. Sardjito General Hospital, Yogyakarta Abdul Gofir; Hiztien Fahrurriza; Yudhanto Utomo; Amelia Nur Vidyanti; Anton Darmawan
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i4.16770

Abstract

Acute ischemic stroke (AIS) continuing to be an entity causing morbidity and mortality worldwide. The National Institutes of Health Stroke Scale (NIHSS) is a largely used as clinical assessment instrument to measure neurological deficit of stroke. Studies concerned that D-dimer, a fibrin degradation product, has as a potential biomarker in predicting stroke severity and prognosis. This study aimed to investigate the correlation between D-dimer levels and NIHSS score in patients with a first-ever AIS. This cross-sectional study used the stroke registry data of the Dr. Sardjito General Hospital, Yogyakarta from October 2021 to December 2022. A total 83 patients who met the inclusion and exclusion criteria were involved. The blood D-dimer level was measured during admission. The NIHSS scores were assessed within 24 hr of admission. The correlation between D-dimer levels and NIHSS scores were analysed using Spearman’s test. Multiple analysis was performed to evaluate the association of non-dependent risk factors using multiple logistic regression. The mean age of subjects was 60.77±11.08 yr, with a slightly males predominant (54.2%). The mean value of NIHSS score was 6.59 ± 7.00 and D-dimer level was 712.02 ± 1159.2 ng/mL. A significant positive correlation between D-dimer and NIHSS score (r= 0.475; p= 0.01) was observed. Furthermore, D-dimer remained showing an independent association with on-admission NIHSS score (p= 0.026). In conclusion, D-dimer level in stroke patients is associated with more severe on-admission NIHSS score.
High Blood Osmolality is Associated with Poor Neurological Status in Acute Ischemic Stroke Patient on Admission Silalahi, Lothar Matheus Manson Vanende; Sutarni, Sri; Gofir, Abdul
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5519

Abstract

Purpose: The purpose of this study is to evaluate the association between high blood osmolality and neurological status in acute ischemic stroke. Methodology: This is a cross-sectional study. Subjects of this study are acute ischemic stroke patients admitted at Dr. Sardjito Hospital. Subjects who met the inclusion and exclusion criteria were analysed mainly the blood osmolality and NIHSS score at the time of admission. Results: The study involved 58 participants, with 29 (50%) exhibiting blood osmolality exceeding 300 mOsm/kg. A bivariate analysis revealed several factors significantly linked to poor neurological condition upon admission. These included elevated blood osmolality (OR=5,296, p=0,014, 95% CI, 1,29-21,7), presence of infection (OR=11,67, p=0,007, 95% CI, 1,95-6,99), increased white blood cell count (OR=4,750, p=0,028, 95% CI, 1,21-18,5), and an ASPECT Score below 7 (OR=14, p<0,001, 95%CI, 3,34-59). Multivariate analysis revealed that high blood osmolality (p=0,031) significantly associated with poor neurological status at the time of hospital admission. Applications: This study highlighted the importance of evaluating blood osmolality in acute ischemic stroke patients as it is associated with neurological deficit.
SKOR ISAN SEBAGAI PREDIKTOR IN-HOSPITAL MORTALITY PADA PASIEN DENGAN STROKE-ASSOCIATED PNEUMONIA Mara Ditta, Adist Azizy; Gofir, Abdul; Satiti, Sekar; Hanif, Faishal
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 2 (2024): Vol 40 No 2 (2024): Volume 40, No 2 - Maret 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.497

Abstract

Introduction: Stroke-associated pneumonia (SAP) is attributed as the most common cause of death in acute stroke. ISAN score is a potential tool for predicting SAP in acute stroke care since it is easy to use. Several clinical risk such as age and pre-stroke disability has been proposed to contribute mortality in SAP patients. Aims: This study aims to determine the relationship between ISAN score and in-hospital mortality in acute stroke patients at RSUP Dr. Sardjito. Methods: This study is an analytic observational study with a retrospective cohort design using data from the stroke registry of the Stroke Unit of RSUP Dr. Sardjito from 2021 - 2023. Patients who were clinically diagnosed with SAP at the time of acute phase stroke treatment were included in the study. ISAN scores were divided into 0-5, 6-10, 11-14, and >14 with the interpretation of low, medium, high, and very high respectively. The data was analysed using SPSS v22.. Results: A total of 147 stroke patients with SAP (55% male, mean age 64.9 ± 13.4 years) were included in this study. Death occurred in 61 study subjects and was more prevalent in the high ISAN group (n=30). On bivariate analysis, mortality was significantly associated with ISAN score (p=0.002), gender (p=0.003) and NIHSS score (p=0.002). High ISAN scores have been associated with mortality of stroke patients with SAP, according to multivariate analysis. (aOR=3.94, IK95% 1.31-11.84, p=0.015). Discussion: A high ISAN score at admission is significantly associated with mortality of stroke patients with SAP. Keywords: Pneumonia, stroke, mortality, acute stroke, ISAN score
HUBUNGAN POLIMORFISME MTHFR c.677C>T DENGAN FUNGSI KOGNITIF PADA PASIEN STROKE ISKEMIK AKUT DI RSUP DR. SARDJITO Haq, Arinal; Gofir, Abdul; Ar Rochmah, Mawaddah; Amelia Nur Vidyanti; Yogik Onky Silvana Wijaya, Yogik Onky Silvana Wijaya
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 2 (2024): Vol 40 No 2 (2024): Volume 40, No 2 - Maret 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.511

Abstract

Introduction: Ischemic stroke is an acute cerebrovascular event with cognitive impairment presents as its prevalent manifestation and complication. Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in folate metabolism through an integral process of cellular metabolism in DNA, RNA and protein methylation. MTHFR c.677C>T polymorphism is considered an important genetic risk factor for stroke and cognitive dysfunction in some populations. Aim: This study aimed to investigate the association between the MTHFR c.677C>T polymorphism and cognitive function in acute ischemic stroke patients in Dr. Sardjito General Hospital Yogyakarta. Methods: We performed a cross-sectional study in 42 consecutive acute ischemic stroke patients. PCR R-FLP was used to examine MTHFR c.677C>T polymorphism. Cognitive function was determined using MoCA-Ina within 24 hours of each patient’s admission, with score 24 is the cut off for cognitive impairment. Results: Of 42 patients, 12 patients (28.6%) showed MTHFR c.677C>T variant. There were 3 patients (25%) with homozygous variant of MTHFR c.677C>T. Cognitive dysfunction was found in 7 patients (16.7%) with MTHFR c.677C>T variant and 18 patients (42.9%) with wild type MTHFR. However, no significant association was found between MTHFR c.677C>T with cognitive function in acute ischemic stroke patients (p=0.921). Discussion: The frequency of MTHFR c.677C>T polymorphism in this study was 28.6% with a quarter of them showing homozygous variant. There was no association between MTHFR c.677C>T polymorphism with cognitive function in acute ischemic stroke patients.
Potential neurological applications of Centella asiatica: a brief review Gofir, Abdul; Wibowo, Samekto; Hakimi, Mohammad
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1693

Abstract

Centella asiatica (C. asiatica) or gotu kola has been used traditionally in many Asian countries as herbal medicines for many conditions, such as headache, asthma and memory enhancement. Centella asiatica has been also widely investigated for its neuroprotective effects in animal disease model including epilepsy, Alzheimer’s and Parkinson’s diseases. A brief review of neurological effects studies of C. asiatica in animal model was reported. Eligible studies published through December 2020 from PubMed and EMBASE journal data base were collected. Any keywords related to C. asiatica or gota kola AND neurological conditions were used. The results showed that several experimental studies concerning the neuroprotective properties of C. asiatica have been reported. Phytochemical studies reported that C. asiatica contained many bioactive compounds in which triterpenoids are the most identified. Furthermore, the triterpenoids have proven to have neuroprotective effect due to their effects of anti-inflammatory, antioxidant, improvement of mitochondrial dysfunctions, and increased brain-derived neurotrophic factors. Further studies are needed to investigate the neuroprotective mechanisms of C. asiatica. In conclusion, C. asiatica might have potential as an alternative medicine for neurological conditions, such as stroke, epilepsy, Alzheimer’s and Parkinson’s disease.
The effect of Centella asiatica L. Urban. and Curcuma longa L. extracts combination in improving memory performance in stroke model rats and its acute toxicity Gofir, Abdul; Ar Rochmah, Mawaddah; Wibowo, Samekto; Hakimi, Mohammad; Mustofa
Indonesian Journal of Pharmacology and Therapy Vol 2 No 2 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1765

Abstract

Post-stroke cognitive impairment involves memory, visuoconstructional, and spatial dysfunctions. Centella asiatica L. Urban. and Curcuma longa L. are both well-known herbs in South and South-East Asia countries that are believed to possess neuroprotective properties as memory enhancers. This study aimed to investigate the effects of C. asiatica L. Urban. and C. longa L. extracts combination in improving memory performance in stroke model rats and its acute toxicity. Twenty-five Wistar rats underwent transient bilateral common carotid artery occlusion. Y-maze pre-test was performed 24 h after the occlusion. The rats were then divided into five groups i.e. Group 1 received NaCMC dilution, Group 2 received donepezil 0. 7 mg/kg BW/day, and Groups 3, 4, and 5 received the extracts combination with dose of 59; 118; and 236 mg/kg BW/day, respectively. Y-maze post-test was performed 24 h after the last dose had been given. Spontaneous alternation behavior was used as the indicator of working memory measurement. The fixed-dose method according to OECD Guideline was used to estimate the LD50 in acute toxicity testing on Wistar rats. There was a significant difference in the delta spontaneous alternation percentage among groups tested (p<0. 05). Group 1 had significant difference with any other group (compared to Groups 2 to 5; p<0.05). No significant difference could be found between groups of the extracts combination and donepezil group suggesting that the effect is not more inferior nor dose-dependent in improving memory performance. The extracts combination at a single dose of 2000 mg/kg BW did not show related signs of toxicity or mortality in any of the rats during the 14-day observation period. In conclusion, the C. asiatica L. Urban. and C. longa L. extracts combination can improve performance of memory on stroke model animal. According to Globally Harmonized Classification System, the extracts combination can be classified as Category 5/unclassified.
PERAN LABELATOL DALAM MANAJEMEN HIPERTENSI EMERGENSI PADA STROKE AKUT Setyopranoto, Ismail; Gofir, Abdul; Paryono
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.862

Abstract

PENCEGAHAN PERBURUKAN PADA PENYAKIT PARKINSON: PENDEKATAN FARMAKOLOGIS DAN NON-FARMAKOLOGIS Subagya; Rohma, Novita Nur; Gofir, Abdul; Ar Rochmah, Mawaddah
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.870

Abstract

Parkinson's disease (PD) is a complex neurodegenerative disorder with a progressive course. Most patients experience symptom deterioration over time, although the rate of progression varies between individuals. PD is the second most common neurodegenerative disease worldwide, with prevalence exceeding ~1% in people over 60 and ~5% in those over 85. Its incidence is rising globally with aging populations, and the number of PD cases is projected to double by 2040 compared to 2015. Despite significant advances in symptomatic treatments, no intervention has been proven to halt or reverse the underlying pathology of PD. This therapeutic gap underscores the importance of strategies aimed at preventing disease progression in order to preserve functional capacity and improve patients’ quality of life. This review provides an overview of the progressive nature of PD, current challenges in its management, and both pharmacological and non-pharmacological approaches aimed at preventing further deterioration. Keywords: Prevention, Parkinson’s disease, progressive, neurodegenerative
Co-Authors Amelia Nur Vidyanti Anton Darmawan Astuti Prodjohardjono Dini Khairunnisa Fatoni, Rismi Gea Pandhita S Hanif, Faishal Haq, Arinal Hemi Sinorita Hidayah Karuniawati Hiztien Fahrurriza Ika Puspitasari Ika Puspitasari Indera Indera Ismail Setyopranoto Ismail Setyopranoto Khairunnisa, Dini Mara Ditta, Adist Azizy Mawaddah Ar-Rochmah Mohammad Hakimi Mohammad Hakimi Mohammad Hakimi Mustofa Mustofa Mustofa Nadhilla, Nyimas Farisa Nathania, Caroline Evanthe Noor Alia Susanti Pandhita S, Gea Paryono Probosuseno Probosuseno Prodjohardjono, Astuti Rismi Fatoni Rohma, Novita Nur Rohmania Setiarini Samekto Wibowo Samekto Wibowo Samekto Wibowo Satiti, Sekar Sedjatiningsih, Wahyu Setyaningrum, Cempaka Thursina Srie Setyaningsih, Indarwati Setyawan, Tommy Rachmat Silalahi, Lothar Matheus Manson Vanende Siti Aisyah Affiati Siti Farida Sri Sutarni Sri Sutarni Subagya Sugiyanto - Sugiyanto Sugiyanto Susianti, Noor Alia Wahyu Sedjatiningsih Yogik Onky Silvana Wijaya Yudhanto Utomo Zullies Ikawati