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Pembuatan Teh Daun Kelor untuk Peningkatan Ekonomi Masyarakat di Kecamatan Ulakan Tapakis, Padang Pariaman Matlal Fajri Alif; Yulizar Yusuf; Emriadi Emriadi; Deswati Deswati; Mai Efdi; Novesar Jamarun; Syukri Arief; Adlis Santoni; Bustanul Arifin; Suryati Suryati; Yetria Rilda; Safni Safni; Zilfa Zilfa; Olly Norita Tetra
Warta Pengabdian Andalas Vol 31 No 4 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.4.682-688.2024

The Moringa plant, a tropical species, exhibits prolific growth and is abundantly present in Indonesia and other tropical regions worldwide. An extended lifespan, continuous flowering, and a high tolerance for elevated temperatures characterize it. Utilizing its components, including leaves, bark, seeds, and roots, this multifaceted plant is renowned for its therapeutic properties. The plant's antioxidants and various nutrients, including vitamins and minerals (iron, magnesium, vitamin B6, vitamin B2, vitamin C, and vitamin A), have led to studies on the plant's potential health benefits. In order to develop the local economy in Ulakan village, Padang Pariaman Regency, Moringa plants were processed by using the plant leaves to manufacture herbal tea, which can then be sold. This community service program was significant given the widespread presence and ease of cultivation of Moringa plants within the local region. The program involved the planning and selection of the activity site, the implementation of training sessions, and the assessment of the program's outcomes. The result of this community engagement initiative was the demonstrated interest of many participants in producing Moringa leaf tea.

Pembuatan Teh Daun Kelor untuk Peningkatan Ekonomi Masyarakat di Kecamatan Ulakan Tapakis, Padang Pariaman Matlal Fajri Alif; Yulizar Yusuf; Emriadi Emriadi; Deswati Deswati; Mai Efdi; Novesar Jamarun; Syukri Arief; Adlis Santoni; Bustanul Arifin; Suryati Suryati; Yetria Rilda; Safni Safni; Zilfa Zilfa; Olly Norita Tetra
Warta Pengabdian Andalas Vol 31 No 4 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.4.682-688.2024

The Moringa plant, a tropical species, exhibits prolific growth and is abundantly present in Indonesia and other tropical regions worldwide. An extended lifespan, continuous flowering, and a high tolerance for elevated temperatures characterize it. Utilizing its components, including leaves, bark, seeds, and roots, this multifaceted plant is renowned for its therapeutic properties. The plant's antioxidants and various nutrients, including vitamins and minerals (iron, magnesium, vitamin B6, vitamin B2, vitamin C, and vitamin A), have led to studies on the plant's potential health benefits. In order to develop the local economy in Ulakan village, Padang Pariaman Regency, Moringa plants were processed by using the plant leaves to manufacture herbal tea, which can then be sold. This community service program was significant given the widespread presence and ease of cultivation of Moringa plants within the local region. The program involved the planning and selection of the activity site, the implementation of training sessions, and the assessment of the program's outcomes. The result of this community engagement initiative was the demonstrated interest of many participants in producing Moringa leaf tea.

Eksplorasi Aktivitas Antioksidan dan Profil Fenolik dari Ekstrak dan Fraksi Daun Lantana camara L Yoan De Nanda Herru; Adlis Santoni; Suryati Suryati; Anna Anggraini; Rahmi Vika Ulia
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i2.5945

This study aimed to evaluate the antioxidant activity and total phenolic content of methanolic extract and column chromatography fractions of Lantana camara L. leaves. Antioxidant activity was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging method, while total phenolic content was determined by the Folin–Ciocalteu assay. The methanolic extract exhibited strong antioxidant activity (IC₅₀ = 23.25 mg/L) and a total phenolic content of 2927.4 mg/L gallic acid equivalents (GAE). Fractionation yielded nine fractions (A–I), among which Fraction E demonstrated the highest antioxidant activity (IC₅₀ = 11.58 mg/L) and the greatest phenolic content (5200 mg/L GAE). A strong negative correlation (R² = 0.9485) was observed between phenolic content and IC₅₀ values, indicating that phenolic compounds are the major contributors to the antioxidant activity. These findings highlight L. camara leaves as a promising natural source of antioxidants and support their potential application in the development of functional foods and plant-based pharmaceutical formulations.

Beta-sitosterol glycoside from Paraboea leuserensis and Cytotoxicity Test against MCF-7 Human Breast Cancer Cells Harfita, Nur Laily; Santoni, Adlis; Suryati, Suryati
Riset Informasi Kesehatan Vol 12 No 2 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i2.826

Background: Paraboea leuserensis, a plant endemic to the Leuser Mountain in the provinces of Aceh and North Sumatra, has been traditionally used for medicinal purposes by chewing or boiling, addressing conditions such as stomachaches and providing stamina enhancement. This study aimed to isolate secondary metabolite compounds from Paraboea leuserensis and conduct in vitro anticancer tests. Method: The ethyl acetate extract was isolated through column chromatography, yielding beta-sitosterol glycoside, and was tested for bioactivity against human breast cancer cells MCF-7 using the MTT method. Results: The compound demonstrated activity against breast cancer cells (MCF-7) with an IC50 value of 24.83 mg/L. Conclusion: Paraboea leuserensis exhibits potential anticancer activity. The isolation of beta-sitosterol glycoside from the plant and its demonstrated activity against MCF-7 human breast cancer cells suggest a promising avenue for further exploration of the plant's anticancer properties.

STUDYING α-TERPINENE, β-CARYOPHILLENE, α-ELEMENE AND α-HUMULENE COMPOUNDS AS CORROSION INHIBITORS USING THE DENSITY FUNCTIONAL THEORY (DFT) METHOD Triranti, Bunga Mainur; Emriadi; Adlis Santoni
JURNAL KATALISATOR Vol. 9 No. 1 (2024): Jurnal Katalisator Volume 9 No.1, April 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i1.2933

The compounds α-Terpinene, β-Caryophillene, α-Elemene and α-Humulene are the main components of Toona sinensis leaf essential oil and have the highest % area from the research results of Toona sinensis leaf essential oil components. This research uses the Gaussian 16W program package with the Density Functional Theory (DFT) calculation method and the B3LYP/6-31G database which produces the optimal structure of the inhibitor molecule, the Highest Occupied Molecular Orbital (HOMO) contour, the Lowest Unoccupied Molecular Orbital (LUMO) contour, EHOMO, ELUMO and mulliken charge density. The inhibitor molecules analyzed were the compounds α-Terpinene, β-Charyophillene, α-Elemene and α-Humulene. Analysis of the reactivity of inhibitor molecules was carried out in the gas phase and with water as a solvent medium. Calculation of quantum chemical parameter values in the form of bandgap (∆E), electronegativity (χ), ionization potential (I), hardness (ɳ), softness (σ), electrophilicity (ω), nucleophilicity (ε), charge transfer (∆N), interaction energy (∆ѱ), back donation energy (∆Eb-d). Based on the parameter results obtained, the best compound with potential as a corrosion inhibitor is α-Terpinen. Data on bond energy, Gibbs free energy (ΔG) and entropy (ΔS), bond length and bond angle were used to determine the interaction of α-Terpinene with Fe. The interaction that occurs is a chemical interaction because the ΔG value obtained is small from -40 kJ/mol, namely -201.142 kJ/mol.

COMPUTATIONAL STUDY OF ANTIOXIDANT, TOXICITY, DRUG SCORING AND MOLECULAR DOCKING OF THE STRUCTURE OF CATECINS Anggriany, Martania; Adlis Santoni; Emriadi; Imelda
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3049

Chronic disorders such as cancer can be caused by an imbalance in free radical production with antioxidant defenses in the body. This research aims to obtain the best compounds as future drug candidates. The potential of catechin compounds and their derivatives as cancer drug candidates has been studied through antioxidant properties, toxicity, drug scores and molecular docking. In this research, antioxidant activity was studied using the DFT (Density Functional Theory)/B3LYP/3-31G method in the gas phase. Toxicity and drug scores were analyzed using OSIRIS Property Explorer software. Analysis of the interaction of catechin and modified catechin compounds with 5KYK cell protein using MOE (Molecular Operating Environment) software. The research results show that the antioxidant properties are well explained through the antioxidant reaction mechanism which occurs more easily in the Single Electron Transfer – Proton Transfer (SET – PT) mechanism. The total energy produced by IP (Ionization Potential) + PDE (Proton Dissociation Enthalphy) is smaller. Catechin compounds and their derivatives are not toxic (no risk) for gene mutations, tumors, irritation and reproduction. Catechin compounds and modified catechins (1-5) have a drug score value of (0.453-0.871). It is estimated that catechin compounds and their derivatives can be used as potential antioxidants without side effects on biological systems. From the pharmacophore study, it was found that the compound that had the best interaction with the 5KYK receptor was compound 1.

Sintesis Karbon Aktif Dari Batang Jagung(Zea mays L.) dengan Metoda Dehidrasi Asam Untuk Aplikasi Elektroda Superkapasitor Tetra, Olly Norita; Syukri, Syukri; Santoni, Adlis; Deswati, Deswati; Fajarandi, Nabiel; Emriadi, Emriadi
Jurnal Fisika Unand Vol 13 No 6 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jfu.13.6.834-842.2024

Activated carbon from corn stalks (Zea mays L.) has been successfully synthesized by the dehydration method and used as a supercapacitor electrode. Corn stalk powder was dehydrated with 1 MH2SO4 and activated with 5 M NaOH at a carbon and activator mass ratio of 1:4 with a heating temperature of 800°C and an N2 gas heating rate of 10°C/minute for 1 hour. SEM characterization results show that heterogeneous pores have formed on the surface of corn stalk-activated carbon. EDX results showed a carbon percentage of 54.82%; this data is supported by FTIR results, which show several functional groups containing C and O atoms on the surface of activated carbon. Based on desorption adsorption isotherm analysis, the activated carbon shows H4 type with a specific surface area of 117.973m2/g, average pore diameter of 1.730 nm and total pore volume of 0.1021 cm3/g. Measurement of the electrochemical properties of corn stalk activated carbon with a three-electrode system and 3 M KOH electrolyte showed a specific capacitance value of 133.9 F/g, power density 225.2 W/kg and energy density 0.863 Wh/kg. The synthesis of activated carbon through the dehydration method offers advantages in terms of simplicity in preparation, low cost, shorter synthesis time and being environmentally friendly.

Bioactivity of Red Leaf Extract of Pucuk Merah Plant (Syzygium myrtifolium Walp.) Suryati; Santoni, Adlis; Arifin, Bustanul; Aisya, Nurul; Frisky, Sintia; Aisyah, Siti
Jurnal Riset Kimia Vol. 16 No. 1 (2025): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v16i1.760

Syzygium myrtifolium Walp. is an ornamental plant traditionally used as an herbal medicine. Ethanol extract of Syzygium myrtifolium Walp. has been reported to have activities as an antioxidant, anticancer, and antimicrobial. In this study, Syzygium myrtifolium Walp is extracted. Leaves were carried out using a multistage maceration method using methanol, ethyl acetate, and hexane solvents. Antioxidant, antimicrobial, and toxicity tests were performed, and secondary metabolite compounds, total flavonoid content, and total phenolic content were identified on red leaf extract. Total phenolic content was tested using the Folin-Ciocalteau reagent, total flavonoids with the AlCl3 reagent, antioxidants with the DPPH method, antimicrobial using the disc diffusion method, and toxicity tested using the BSLT method. The result showed that Syzygium myrtifolium Walp. Red leaf extract contained a secondary metabolite of triterpenoids, steroids, phenolics, flavonoids, alkaloids, and coumarins. The ethyl acetate and methanol extract's total phenolic and flavonoid content were 311.0520 and 420.360 mg GAE/g extract and 211.788 and 105.360 mg QE/g extract. Antioxidant activity of ethyl acetate and methanol showed that the extracts were highly antioxidant with IC50 of 19.606 and 12.0656 mg/L. The antimicrobial activity showed that the hexane extract was resistant to the bacteria Staphylococcus aureus and Propionibacterium acnes and the fungus Candida albicans. However, no inhibition zones were produced for Pseudomonas aerigunosa and Escherichia coli bacteria. The toxicity test showed that the hexane and ethyl acetate extract had strong toxic properties with LC50 of 56.65 and 16.79 mg/L, and the methanol extract was toxic with LC50 of 224.2846 mg/L.

Chemical Composition Analysis of CitrusÃ—limon (L) Osbeck Leaf Essential Oil and Its Activity as an Anti-Cervical Cancer Agent Afif, Iffat Syafiqoh; Suryati, Suryati; Santoni, Adlis
Hydrogen: Jurnal Kependidikan Kimia Vol. 12 No. 1 (2024): February 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i1.10772

Cervical cancer is a life-threatening disease. The use of synthetic drugs for its treatment can have serious adverse effects on the body. Therefore, it is necessary to search for natural drugs that are safe for the body. One of the secondary metabolites contained in plants is essential oils (EO), EO are known to have activity as anti-cervical cancer. Genus Citrus is known for containing EO compounds, one of the species of the genus is CitrusÃ—lemon (L) Osbeck. The purpose of this study is to identify the chemical components of the EO isolated from the leaves of CÃ—limon and to evaluate its cytotoxic activity against cervical cancer. EO was isolated from CÃ—limon leaves collected in Padang City, Indonesia using the hydrodistillation method. EO was then analyzed by GC-MS. To determine its cytotoxicity, BSLT was conducted, followed by molecular docking and MTT assays. The experiment yielded a yellow liquid with a density of 0,8684 g/mL and a yield of 0,181%. GC-MS analysis of the EO identified 56 chemical components, with the main compounds are (-)-Î²-pinene (7.32%), (-)-limonene (28.40%), geranial (5.54%), caryophyllene (5.22%). The EO showed high toxicity against Artemia salina L larvae, with an LC50 value of 3,697 Âµg/mL. Through molecular docking, it is known the (-)-limonene, geranial, (-)Î²-pinene and caryophyllene compounds as the main compounds in of EO are known to bind to form complexes with cervical cancer proteins (HPV18E6). MTT assay showed weak cytotoxic activity of EO against HeLa cells, with an IC50 of 218.9 Âµg/mL.

Phytochemical Screening and In Vitro Antidiabetic Test of Ethyl Acetate Fraction of Tigerâ€™s Betel (Piper porphyrophyllum) Hanifah, Nurul; Santoni, Adlis; Efdi, Mai
Hydrogen: Jurnal Kependidikan Kimia Vol. 12 No. 5 (2024): October 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i5.13118

Piper porphyrophyllum or known as tigerâ€™s betel, is a medicinal plant of the Piper genus that is quite widespread in Indonesia, especially on Java, Sumatra, and Kalimantan island. Tigerâ€™s betel is widely used traditionally to treat headaches, bone pain, chest tightness, skin diseases, relieve inflammation, and diabetes mellitus. This study aims to determine the type of secondary metabolite compounds contained in the ethyl acetate fraction of tigerâ€™s betel and determine its antidiabetic activity. Determination of the type of compound is conducted by phytochemical screening by a qualitative test using various reagents to identify flavonoids, phenolics, saponins, triterpenoids, steroids, alkaloids, and coumarins. The antidiabetic assay was carried out by inhibiting Î±-glucosidase activity and the results were reported as IC50 values. The ethyl acetate fraction of tigerâ€™s betel positively contains alkaloids, flavonoids, and phenolics. The antidiabetic activity is classified as very strong, with an IC50 value of 14.06 Âµg/mL.

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