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MINYAK ATSIRI DARI Toona sinensis DAN UJI AKTIVITAS INSEKTISIDA Adlis Santoni; Hazli Nurdin; Yunazar Manjang; Sjamsul A. Achmad
Jurnal Riset Kimia Vol. 2 No. 2 (2009): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v2i2.142

Abstract

ABSTRACT Volatile components from leafs of Toona sinensis (Meliaceae) were isolated by distillation water-vapour method and analyzed using GC/MS. Forty-eight component were identified, and eight major components are Germacrene-D, Germacrene-B, α-Terpinene, α-Humulene, β-Caryophyllene,  α-Elemene, Bicyclogermacrene and α-copaene. Insect activity of the essential oil against Crosidolomia pavonana were tested. The activity of the essential oil with concentration 25% (mortality 73.3%), concentration 50% (mortality 83.3%) and concentration 75% (mortality 90%). Keywords : Toona sinensis (Meliaceae), essential oil, Crosidolomia pavonana, and mortality.    
ISOLASI DAN ELUSIDASI STRUKTUR SENYAWA TRITERPENOID DARI KULIT BATANG AMBACANG (Mangifera foetida L.) SERTA UJI BRINE SHRIMP LETALITY TEST (BSLT) Adlis Santoni; Sabariah -; Mai Efdi
Jurnal Riset Kimia Vol. 9 No. 1 (2015): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v9i1.252

Abstract

A brine shrimp toxic compound has been isolated from Mangifera foetida L. steam bark. Based on spectroscopic data (IR,1H- NMR, 13C-NMR 1D and 2D), the structure of this compound was identified as mangiferenes B, C30H47O2. In this study, the n-hexane, ethyl acetate, methanol extracts and isolated compound showed toxic effects (LC50 471.9543; 534.5209, 678.4421, and 22.1615 μg/mL, respectively). The toxicity degree among the three extracts and isolated compound is isolated compound > n-hexane extract > ethyl acetate extract > methanol extract.
Identifikasi Senyawa Metabolit Sekunder, Uji Antimikroba dan Antioksidan Ekstrak Akar Gantung Hornstedtia Scyphifera Var. Fusiformis Holttum (Sijangkang) Adlis Santoni; Mai Efdi; Akmel Suhada
Jurnal Riset Kimia Vol. 10 No. 2 (2019): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v10i2.264

Abstract

Hornstedtia scyphifera var. fusiformis Holttum is endemic plant of Zingiberaceae family that distributed in Sumatera. Hornstedtia scyphifera var. fusiformis Holttum contained some secondary metabolite such as phenolic, saponin, triterpenoid and alkaloid. The biological activity of methanol, ethyl acetate, and n-hexane extracts from Hornstedtia scyphifera var. fusiformis Holttum suspended roots was tested for antibacterial and antioxydant activity. Antioxidant activity was analized by DPPH method. The antibacterial activity  was tested by used disk difussion method againts Staphylococcus aureus bacteria (gram-positive bacteria) and Escherichia coli (gram-negative bacteria). Almost all of Hornstedtia scyphifera var. fusiformis Holttum suspended roots extract were given antibacterial activity, nonetheless the biggest inhibition zone of Escherichia coli that was inhibited by n-hexane and ethyl acetate extracts which have inhibtion zone 10 mm at  concentration 500 mg/L and also againts Staphylococcus aureus, the biggest inhibition by ethyl acetate and n-hexane extracts which have inhibition zone 10.30 mm at concentration 500 mg/L. Among all extracts tested, methanol extract of the possessed moderate free radical scavenging activity with IC50 = 51.89 mg/L.
Antibacterial Activity and Structure Elucidation of Salicin from Stem Bark of Salix tetrasperma ROXB. Sari Ramadhani; Adlis Santoni; Mai Efdi
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 4, No 2 (2019): June 2019
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v4.i2.47

Abstract

Salix tetrasperma Roxb. (Family Salicacaeae) is a plant that used as traditional medicine for anti-inflammatory, analgesic, reduces fever, and itching medicine. In this study was carried out extraction, isolation, structure elucidation of salicin from Salix tetrasperma Roxb. stem bark and it’s antibacterial activity. The extraction method was used the maceration method by n-hexane, ethyl acetate, and methanol solvents. Isolation of compound from ethyl acetate extract of Salix tetrasperma Roxb. stem bark using chromatography methods and obtained white solid (15 mg). The structure was elucidated using spectroscopic analysis, including Ultraviolet (UV), Infrared (IR), Nuclear Magnetic Resonance (NMR) and comparative literature, identified as salicin compound with molecule formula C13H18O7. Antibacterial activity was evaluated against Escherichia coli and Staphylococcus aureus bacteria using disk diffusion method. This compound has a great an antibacterial activity against Staphylococcus aureus bacteria with clear zone diameter of 10.2 ± 0.3 mm. This shows that the Salix tetrasperma Roxb. stem bark has great potential as a source of antibacterial compound
Isolation of Flavonoid Compound and Antioxidant Activity of Salix tetrasperma Roxb. Leaves Ria Januarti; Adlis Santoni; Mai Efdi
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 4, No 2 (2019): June 2019
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v4.i2.42

Abstract

Salix Tetrasperma Roxb. is a plant that found in Indonesia were used as traditional medicine such as diabetes and wound healing. In this study, a flavonoid compound of the ethyl acetate extract of Salix tetrasperma Roxb. leaves was isolated by chromatography technique and the antioxidant activity was determined by DPPH assay. The isolation led to obtain 5,7-dihydroxy-3'-methoxyflavone based on NMR spectra. The ethyl acetate extract exhibited the highest antioxidant activity with the IC50 is 65.89 µg/mL. This study shows that the Salix tetrasperma Roxb. has good potential as source of antioxidant agent.
Degradation of Paracetamol by Photolysis Using C-N-codoped TiO2 Vanny Yulia Safitri; Adlis Santoni; Diana Vanda Wellia; Khoiriah Khoiriah; Safni Safni
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (410.615 KB) | DOI: 10.20884/1.jm.2017.12.2.378

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Paracetamol is generally used as analgesic and antipyretic drugs. Contamination paracetamol in the environment can occur because of waste material disposal from production site and immediate disposal of household that cause water pollution. Paracetamol is degraded by photolysis method under irradiation 10 watt UV-light (λ=365 nm), visible-light (Philips LED 13 watt 1400 lux) and solar-light with and without addition C-N-codoped TiO2catalyst. The solution is analyzed by UV-Vis spectrophotometer at λ 200-400 nm. Optimum weight of C-N-codoped TiO2 catalyst obtained is 20 mg under UV-light photolysis. Paracetamol 4 mg/L is degraded 45.48% after 120 minutes under UV-light irradiation without catalyst, and increases to be 69.31% by using 20 mg catalyst. While degradation percentage of paracetamol is 16.96 % without catalyst, the percentage increases to be 34.29% after using 20 mg catalyst for 120 minutes photolysis under visible-light. Degradation of paracetamol by solar light achieves only 12.27% in absance of catalyst for 120 minutes irradiation, but it increases significantly until 70.39% in presence of 20 mg catalyst.
Major Anthocyanin Pigments in the Ficus padana Fruits: HPLC-DAD-ESI-MS Identification and Antioxidant Activity Daimon Syukri; Djaswir Darwis; Adlis Santoni
Indonesian Journal of Chemistry Vol 14, No 3 (2014)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.042 KB) | DOI: 10.22146/ijc.21242

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The anthocyanins in Ficus padana were extracted and identified by using high-performance liquid chromatography/diode array detection and electrospray ionization/mass spectrometry (HPLC-DAD-ESI-MS). The individual anthocyanins were identified by comparing between their mass spectral data and published data. The first compound (peak 1) was identify as a pelargonidin 3-(6”-p-coumarylglucoside)-5-(4”’-Malonylglucoside) and the second compound was identify as a pelargonidin 3-(6’’-Malonylglucoside). The second one is a major compound that taking up to 91% of the total anthocyanin content in F. padana extract. The antioxidant activity was determined with 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays and results showed that extract possessed high antioxidant capacity.
PENENTUAN KANDUNGAN FENOLIK TOTAL, SIFAT ANTIOKSIDAN DAN TOKSISITAS DARI EKSTRAK KULIT BATANG RENGAS (Gluta renghas L.) Emil Salim; Adlis Santoni; Nindi Antika Febriana
Jurnal Zarah Vol. 8 No. 2 (2020): Jurnal Zarah
Publisher : Jurnal Zarah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31629/zarah.v8i2.2416

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Tujuan penelitian ini untuk menentukan jumlah kandungan fenolik total, sifat antioksidan dan toksisitas dari ekstrak kulit batang rengas (Gluta renghas L.). Sampel kulit batang rengas diekstraksi secara bertahap menggunakan pelarut n-heksan, etil asetat dan metanol pada temperatur ruang. Jumlah kandungan fenolik total ditentukan dengan metode Folin-Ciocalteau, sifat antioksidan ditentukan dengan metode DPPH (1,1-diphenyl-2-pycrilhydrazil), dan sifat toksisitas ditentukan dengan metode BSLT (Brine Shimp Lethality Test). Ekstrak metanol kulit batang rengas memiliki kandungan fenolik total paling tinggi (20,042 mg GAE/g ekstrak kering) dibandingkan ekstrak etil asetat dan n-heksan. Sifat antioksidan dari ekstrak metanol dan etil asetat tergolong sangat kuat dengan nilai IC50 12,252 mg/L dan 48,151 mg/L secara berturut-turut, sedangkan ekstrak n-heksan besifat lemah dengan nilai IC50 206,06 mg/L. Sifat toksisitas kulit batang rengas menunjukkan bahwa semua ekstrak bersifat toksik, dimana ekstrak metanol memiliki sifat toksisitas paling kuat dengan nilai LC50 54,113 mg/L. Senyawa aktif dari ekstrak kulit batang rengas ini selanjutnya dapat dilakukan isolasi untuk mengetahui strukturnya.
Pelatihan Pembuatan Desinfektan dan Hand Sanitizer Non-Alkohol di Kelurahan Seberang Padang, Kota Padang Yulizar Yusuf; Hermansyah Aziz; Adlis Santoni; Syukri Syukri; Novesar Jamarun; Bustanul Arifin; Olly Norita Tetra; Norman Ferdinal; Matlal Fajri Alif
Warta Pengabdian Andalas Vol 27 No 3 (2020)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.27.3.213-218.2020

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Seberang Padang Village, South Padang District, is next to Padang City, which has approximately 200 families. This location is a crossing area between Padang-Painan, in West Sumatra. The community consists of two existing traditional markets that sell daily necessities. Besides that, there is also one elementary school, two junior high schools, and one high school. The global Covid-19 pandemic certainly affects the community's daily activities and learning activities, including children, elementary school students, middle and high school students, and the village community to fulfil their basic needs. Furthermore, the main problem of Covid-19 is not only about the effects caused by the virus on sufferers but also about its high-speed transmission. Therefore, to educate the community around the Seberang Padang village, several Chemistry Lecturers and students at the Faculty of Mathematics and Natural Sciences at Andalas University did a community engagement. They taught the community about making disinfectants and hand sanitizers without alcohol that can overcome the occurrence of Covid-19 transmission. In addition, face masks were provided for the community, and the alms of food for underprivileged residents to push down the negative impact of Covid-19.
DETERMINATION OF SECONDARY METABOLITE CONTENT, TOTAL PHENOLIC ANTIOXIDANT TEST, AND TOXICITY OF ULIN LEAF EXTRACT (Eusideroxylon zwageri Teijsm. & Binn) Yayan Rabbani Kurniawan; adlis santoni; suryati suryati
Akta Kimia Indonesia Vol 7, No 2 (2022)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j25493736.v7i2.14346

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Ulin leaf (Eusideroxylon zwageri Teijsm. & Binn) is one of the traditional Indonesian medicinal plants. In this research, the secondary metabolite content, antioxidant activity, cytotoxic and total phenolic content were tested. The extraction process by maceration starts from hexane, ethyl acetate and methanol. The content of secondary metabolites of ironwood leaves are flavonoids, phenolics, steroids, terpenoids, and alkaloids. The results of the antioxidant activity test using the DPPH method (1,1-Diphenyl-2-Picrylhydrazil), methanol extract showed very strong activity IC50 10.96 mg/L, moderate ethyl acetate extract 115,409 mg/L and weak hexane extract IC50 368,555 mg/L. L. This result correlated with the total phenolic yield, methanol extract had the highest value of 162.95 mg GAE/Gram, followed by ethyl acetate extract of 96.7 mg GAE/Gram and hexane with a value of 19.85 mg GAE/Gram. The results of the cytotoxic test using the (BSLT) method on hexane extract had very strong toxicity LC50 82.1675 mg/L, methanol extract and weak ethyl acetate LC50, respectively; 683,282; and 812.456 mg/L.Key word : Ulin, Antioxidants, Total Phenolic, cytotoxic